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1. 发明申请

US20110229931A1 Engineering intracellular sialylation pathways 有权
标题翻译：工程细胞内唾液酸化途径
公开(公告)号：US20110229931A1
公开(公告)日：2011-09-22
申请号：US12806292
申请日：2010-08-09
申请人： Donald Jarvis , Michael J. Betenbaugh , Shawn Lawrence , Yuan C. Lee , Timothy A. Coleman
发明人： Donald Jarvis , Michael J. Betenbaugh , Shawn Lawrence , Yuan C. Lee , Timothy A. Coleman
IPC分类号： C12P21/00 , C12N15/85 , C12N15/80 , C12N15/82 , C12P19/30 , C12N5/10 , C07K2/00
CPC分类号： C12P21/005 , C12N15/52
摘要： Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins.
摘要翻译：提供了在感兴趣的细胞中操纵碳水化合物处理途径的方法。方法是通过使用重组DNA技术和底物进料方法来操纵唾液酸化反应所涉及的多个途径，以使得能够在感兴趣的细胞中产生唾液酸化糖蛋白。这些碳水化合物工程的努力包括实施新的碳水化合物生物测定，检查昆虫细胞系的选择以及使用生物信息学来鉴定关键加工酶的基因序列。组合物包含感兴趣的细胞产生唾液酸化糖蛋白。所述方法和组合物可用于糖蛋白的异源表达。

2. 发明授权

US06864226B1 Endothelial-monocyte activating polypeptide III 失效
公开(公告)号：US06864226B1
公开(公告)日：2005-03-08
申请号：US08972301
申请日：1997-11-18
申请人： Timothy A. Coleman , Craig A. Rosen
发明人： Timothy A. Coleman , Craig A. Rosen
IPC分类号： C07K14/52 , A61K38/16 , C07K14/435
CPC分类号： C07K14/52
摘要： A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

3. 发明授权

US06783971B2 Human glycosylation enzymes 失效
标题翻译：人类糖基化酶
公开(公告)号：US06783971B2
公开(公告)日：2004-08-31
申请号：US09984205
申请日：2001-10-29
申请人： Timothy A. Coleman , Michael J. Betenbaugh
发明人： Timothy A. Coleman , Michael J. Betenbaugh
IPC分类号： C12N988
CPC分类号： C12N9/1241 , A61K48/00 , C07K2319/00 , C12N9/88 , C12N2799/026
摘要： The present invention relates to novel human glycosylation enzyme polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human glycosylation enzyme polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human glycosylation enzyme polypeptides.
摘要翻译：本发明涉及新的人糖基化酶多肽和含有编码这些多肽的基因的编码区的分离的核酸。还提供了用于产生人糖基化酶多肽的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人糖基化酶多肽有关的病症的诊断和治疗方法。

4. 发明授权

US06693077B1 Keratinocyte growth factor-2 失效
标题翻译：角质形成细胞生长因子-2
公开(公告)号：US06693077B1
公开(公告)日：2004-02-17
申请号：US09610651
申请日：2000-06-30
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian NI , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian NI , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K3818
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
摘要翻译：本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

5. 发明授权

US06566328B1 Human growth hormone 失效
标题翻译：人类生长激素
公开(公告)号：US06566328B1
公开(公告)日：2003-05-20
申请号：US09411657
申请日：1999-10-04
申请人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
发明人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
IPC分类号： A01N3718
CPC分类号： C07K14/61 , A61K38/00
摘要： The present invention relates to a method of treatment of patients by administration of human growth hormone. Also disclosed are DNA (or RNA) polynucleotide sequences that encode naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGV-3(53), as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type human growth hormone. The growth hormone variants of the present invention are of human origin and are useful for diagnostic, preventive and therapeutic purposes with respect to certain human diseases. Also disclosed is a method for producing the human growth hormone variants of the present invention by recombinant DNA techniques, as well as a method for generating antibodies directed against (and therefore inhibiting the activity of) wild-type growth hormone.
摘要翻译：本发明涉及通过给予人生长激素治疗患者的方法。还公开了编码人生长激素，hGHV-2（88）和hGV-3（53）的天然存在的剪接变体的DNA（或RNA）多核苷酸序列，以及其类似物和衍生物，其都缺乏通常存在的核苷酸序列在编码野生型人生长激素的基因中。本发明的生长激素变体是人源的，并且对于某些人类疾病的诊断，预防和治疗目的是有用的。还公开了通过重组DNA技术生产本发明的人生长激素变体的方法，以及用于产生针对（因此抑制）野生型生长激素的抗体的方法。

6. 发明授权

US06420138B1 Expression control sequences 失效
公开(公告)号：US06420138B1
公开(公告)日：2002-07-16
申请号：US09725460
申请日：2000-11-30
申请人： Reiner L. Gentz , Timothy A. Coleman
发明人： Reiner L. Gentz , Timothy A. Coleman
IPC分类号： C12P2102
CPC分类号： C12N15/72
摘要： Expression control sequences are provided for the expression of proteins from a gene of interest. The gene may express viral, prokaryotic, or eukaryotic proteins. These control sequences are produced by combining phage promoter and operator/repressor systems. Expression vectors containing such expression control sequences, microorganisms transformed with such expression vectors and methods for producing viral, prokaryotic, and eukaryotic proteins using the expression control sequences, expression vectors and transformed microorganisms are also provided.

7. 发明授权

US06191260B1 Brain-associated inhibitor of tissue-type plasminogen activator 有权
标题翻译：脑组织型纤溶酶原激活物抑制剂
公开(公告)号：US06191260B1
公开(公告)日：2001-02-20
申请号：US09348817
申请日：1999-07-08
申请人： Gregg A. Hastings , Timothy A. Coleman , Daniel A. Lawrence , Patrick J. Dillon
发明人： Gregg A. Hastings , Timothy A. Coleman , Daniel A. Lawrence , Patrick J. Dillon
IPC分类号： C07K1481
CPC分类号： C07K14/8132 , A61K38/00 , C07K14/8121
摘要： The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.
摘要翻译：本发明涉及一种新的BAIT蛋白，其是主要在脑组织中表达的丝氨酸蛋白酶超家族的成员。特别地，提供编码人BAIT蛋白的分离的核酸分子。还提供了BAIT多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明还涉及鉴定BAIT活性的激动剂和拮抗剂的筛选方法。还提供了用于检测神经系统相关疾病的诊断方法和用于治疗神经系统相关疾病的治疗方法。

8. 发明授权

US6008020A Brain-associated inhibitor of tissue-type plasminogen activator 失效
公开(公告)号：US6008020A
公开(公告)日：1999-12-28
申请号：US948997
申请日：1997-10-10
申请人： Gregg A. Hastings , Timothy A. Coleman , Daniel A. Lawrence , Patrick J. Dillon
发明人： Gregg A. Hastings , Timothy A. Coleman , Daniel A. Lawrence , Patrick J. Dillon
IPC分类号： A61K38/00 , C07K14/81 , C12P21/06 , C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C07K14/8132 , C07K14/8121 , A61K38/00
摘要： The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.

9. 发明授权

US5981215A Human criptin growth factor 失效
标题翻译：人类criptin生长因子
公开(公告)号：US5981215A
公开(公告)日：1999-11-09
申请号：US471371
申请日：1995-06-06
申请人： Paul S. Meissner , Timothy A. Coleman
发明人： Paul S. Meissner , Timothy A. Coleman
IPC分类号： A61K48/00 , C07K14/475 , C07K14/52 , C12N15/18 , C12N5/10 , C12N15/11
CPC分类号： C07K14/52 , C07K14/475 , A61K48/00
摘要： A human Criptin Growth Factor polypeptide (CGF) and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for wound healing or tissue regeneration, stimulating implant fixation and angiogenesis. Antagonist against such polypeptides and their use as a therapeutic to treat and/or prevent neoplasia such as tumors is also disclosed. Diagnostic assays for identifying mutations in CGF nucleic acid sequences and altered levels of the CGF for the detection of cancer are also disclosed.
摘要翻译：公开了编码这种多肽的人类Criptin生长因子多肽（CGF）和DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽用于伤口愈合或组织再生，刺激植入物固定和血管发生的方法。还公开了抗这些多肽的拮抗剂及其作为治疗和/或预防肿瘤形成如肿瘤的治疗剂的用途。还公开了用于鉴定CGF核酸序列突变和用于检测癌症的CGF的改变水平的诊断测定。

10. 发明授权

US5597709A Human growth hormone splice variants hGHV-2(88) and hGHV-3(53) 失效
标题翻译：人生长激素剪接变体hGHV-2（88）和hGHV-3（53）
公开(公告)号：US5597709A
公开(公告)日：1997-01-28
申请号：US187756
申请日：1994-01-27
申请人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
发明人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
IPC分类号： G01N33/53 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/27 , A61K39/395 , A61K48/00 , A61P3/00 , A61P3/04 , A61P5/00 , A61P13/12 , A61P19/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/61 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/18 , C12P21/02 , C12R1/19 , C07H21/02 , C12N15/63 , C12P21/06
CPC分类号： C07K14/61 , A61K38/00
摘要： There is provided a DNA (or RNA) polynucleotide sequences encoding naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGHV-3(53) as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type hGH. The growth hormone variants of the present invention are of human origin and are useful for diagnostic preventative and therapeutic purposes with respect to certain human diseases. The present invention is also related to a method for producing the human growth hormone variants by recombinant DNA techniques. A method of generating an antibody directed against and therefore inhibiting the activity of wild-type growth hormone is also provided.
摘要翻译：提供了编码人生长激素，hGHV-2（88）和hGHV-3（53）的天然存在的剪接变体的DNA（或RNA）多核苷酸序列以及其类似物和衍生物，其缺乏通常存在于编码野生型hGH的基因。本发明的生长激素变体是人源的，并且对于某些人类疾病的诊断预防和治疗目的是有用的。本发明还涉及通过重组DNA技术生产人生长激素变体的方法。还提供了产生针对并因此抑制野生型生长激素的活性的抗体的方法。

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