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1. 发明授权

US06541452B1 Brain-associated inhibitor of tissue-type plasminogen activator 有权
标题翻译：脑组织型纤溶酶原激活物抑制剂
公开(公告)号：US06541452B1
公开(公告)日：2003-04-01
申请号：US09722292
申请日：2000-11-28
申请人： Gregg A. Hastings , Timothy A. Coleman , Daniel A. Lawrence , Patrick J. Dillon
发明人： Gregg A. Hastings , Timothy A. Coleman , Daniel A. Lawrence , Patrick J. Dillon
IPC分类号： A61K3857
CPC分类号： C07K14/8132 , A61K38/00 , C07K14/8121
摘要： The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.
摘要翻译：本发明涉及一种新的BAIT蛋白，其是主要在脑组织中表达的丝氨酸蛋白酶超家族的成员。特别地，提供编码人BAIT蛋白的分离的核酸分子。还提供了BAIT多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明还涉及鉴定BAIT活性的激动剂和拮抗剂的筛选方法。还提供了用于检测神经系统相关疾病的诊断方法和用于治疗神经系统相关疾病的治疗方法。

2. 发明授权

US06191260B1 Brain-associated inhibitor of tissue-type plasminogen activator 有权
标题翻译：脑组织型纤溶酶原激活物抑制剂
公开(公告)号：US06191260B1
公开(公告)日：2001-02-20
申请号：US09348817
申请日：1999-07-08
申请人： Gregg A. Hastings , Timothy A. Coleman , Daniel A. Lawrence , Patrick J. Dillon
发明人： Gregg A. Hastings , Timothy A. Coleman , Daniel A. Lawrence , Patrick J. Dillon
IPC分类号： C07K1481
CPC分类号： C07K14/8132 , A61K38/00 , C07K14/8121
摘要： The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.
摘要翻译：本发明涉及一种新的BAIT蛋白，其是主要在脑组织中表达的丝氨酸蛋白酶超家族的成员。特别地，提供编码人BAIT蛋白的分离的核酸分子。还提供了BAIT多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明还涉及鉴定BAIT活性的激动剂和拮抗剂的筛选方法。还提供了用于检测神经系统相关疾病的诊断方法和用于治疗神经系统相关疾病的治疗方法。

3. 发明授权

US6008020A Brain-associated inhibitor of tissue-type plasminogen activator 失效
公开(公告)号：US6008020A
公开(公告)日：1999-12-28
申请号：US948997
申请日：1997-10-10
申请人： Gregg A. Hastings , Timothy A. Coleman , Daniel A. Lawrence , Patrick J. Dillon
发明人： Gregg A. Hastings , Timothy A. Coleman , Daniel A. Lawrence , Patrick J. Dillon
IPC分类号： A61K38/00 , C07K14/81 , C12P21/06 , C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C07K14/8132 , C07K14/8121 , A61K38/00
摘要： The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.

4. 发明授权

US07485459B2 Human neuronal attachment factor-1 antibodies 失效
标题翻译：人类神经元附着因子-1抗体
公开(公告)号：US07485459B2
公开(公告)日：2009-02-03
申请号：US10788346
申请日：2004-03-01
申请人： Gregg A. Hastings , Patrick J. Dillon
发明人： Gregg A. Hastings , Patrick J. Dillon
IPC分类号： C12N5/22 , A61K39/395 , C07K16/28
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/411
摘要： A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases and tumor angiogenesis, and stimulating wound repair. Antagonists are also disclosed which may be utilized to prevent malaria. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了一种编码这种蛋白质的人类F-脊椎样蛋白样蛋白和DNA（RNA）以及通过重组技术产生这种蛋白质的方法。还公开了通过促进神经细胞粘附和神经突延伸，抑制肿瘤转移和肿瘤血管发生以及刺激伤口修复来利用这种多肽来治疗脊髓损伤和损伤周围神经的方法。还公开了可用于预防疟疾的拮抗剂。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

5. 发明授权

US08017349B2 Human neuronal attachment factor-1 失效
标题翻译：人类神经元附着因子-1
公开(公告)号：US08017349B2
公开(公告)日：2011-09-13
申请号：US12364360
申请日：2009-02-02
申请人： Gregg A. Hastings , Patrick J. Dillon
发明人： Gregg A. Hastings , Patrick J. Dillon
IPC分类号： G01N33/68 , G01N33/563 , G01N33/577
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/411
摘要： A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases and tumor angiogenesis, and stimulating wound repair. Antagonists are also disclosed which may be utilized to prevent malaria. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了一种编码这种蛋白质的人类F-脊椎样蛋白样蛋白和DNA（RNA）以及通过重组技术产生这种蛋白质的方法。还公开了通过促进神经细胞粘附和神经突延伸，抑制肿瘤转移和肿瘤血管发生以及刺激伤口修复来利用这种多肽来治疗脊髓损伤和损伤周围神经的方法。还公开了可用于预防疟疾的拮抗剂。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

6. 发明授权

US07232667B2 Keratinocyte growth factor-2 polynucleotides 有权
标题翻译：角质形成细胞生长因子-2多核苷酸
公开(公告)号：US07232667B2
公开(公告)日：2007-06-19
申请号：US10733311
申请日：2003-12-12
申请人： Steven M. Ruben , Joachim R. Gruber , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Patrick J. Dillon , Reiner L. Gentz , Pablo Jimenez
发明人： Steven M. Ruben , Joachim R. Gruber , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Patrick J. Dillon , Reiner L. Gentz , Pablo Jimenez
IPC分类号： C12N1/21 , C12N5/10 , C12N15/12 , C12N15/63 , C07K14/50
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
摘要翻译：本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

7. 发明授权

US06903072B2 Keratinocyte growth factor-2 失效
公开(公告)号：US06903072B2
公开(公告)日：2005-06-07
申请号：US09345373
申请日：1999-07-01
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/50 , C12N5/02 , C12N15/18 , A61K38/18 , C12N1/21
CPC分类号： C07H21/00 , A61K38/00 , A61K48/00 , C07K14/50 , C12N2799/026 , Y10S514/925
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

8. 发明授权

US06916786B2 Keratinocyte growth factor-2 失效
公开(公告)号：US06916786B2
公开(公告)日：2005-07-12
申请号：US10075446
申请日：2002-02-15
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/50 , C12N5/02 , C12N15/18 , A61K38/18 , C12N1/20 , C12N5/10
CPC分类号： C07H21/00 , A61K38/00 , A61K48/00 , C07K14/50 , C12N2799/026 , Y10S514/925
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

9. 发明授权

US6077692A Keratinocyte growth factor-2 失效
公开(公告)号：US6077692A
公开(公告)日：2000-06-20
申请号：US23082
申请日：1998-02-13
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/50 , C12N5/02 , C12N15/18 , A61K38/18 , C12N15/63
CPC分类号： C07H21/00 , C07K14/50 , A61K38/00 , A61K48/00 , C12N2799/026 , Y10S514/925
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

10. 发明授权

US06693077B1 Keratinocyte growth factor-2 失效
标题翻译：角质形成细胞生长因子-2
公开(公告)号：US06693077B1
公开(公告)日：2004-02-17
申请号：US09610651
申请日：2000-06-30
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian NI , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian NI , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K3818
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
摘要翻译：本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

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