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1. 发明授权

US08734439B2 Ablation apparatus and method 有权
标题翻译：消融装置和方法
公开(公告)号：US08734439B2
公开(公告)日：2014-05-27
申请号：US12041709
申请日：2008-03-04
申请人： Edward J. Gough , Alan A. Stein , Stuart D. Edwards
发明人： Edward J. Gough , Alan A. Stein , Stuart D. Edwards
IPC分类号： A61B18/14
CPC分类号： A61N1/06 , A61B18/1206 , A61B18/14 , A61B18/1402 , A61B18/1477 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00022 , A61B2017/00101 , A61B2018/00011 , A61B2018/00023 , A61B2018/00196 , A61B2018/00273 , A61B2018/00279 , A61B2018/00452 , A61B2018/00476 , A61B2018/00577 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00761 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1472 , A61B2018/162 , A61B2018/183 , A61B2218/002 , A61M3/0279 , A61M25/007 , A61N1/403 , A61N5/04
摘要： An ablation apparatus includes an ablation energy source producing an electromagnetic energy output. A multiple antenna device is included, and has a primary antenna with a longitudinal axis, a central lumen and a distal end, and a secondary antenna with a distal end. The secondary antenna is deployed from the primary antenna central lumen in a lateral direction relative to the longitudinal axis. The multiple antenna device is coupled to the ablation energy source.
摘要翻译：消融装置包括产生电磁能量输出的消融能量源。包括多天线装置，并且具有纵向轴线，中心腔和远端的主天线以及具有远端的辅助天线。辅助天线相对于纵向轴线从主天线中心腔沿横向展开。多天线装置耦合到消融能源。

2. 发明申请

US20130282006A1 APPARATUS AND METHODS FOR TREATING FEMALE URINARY INCONTINENCE 有权
标题翻译：用于治疗女性尿失禁的装置和方法
公开(公告)号：US20130282006A1
公开(公告)日：2013-10-24
申请号：US13917930
申请日：2013-06-14
申请人： Simon W. H. THOMAS , Peter S. EDELSTEIN , John T. TO , Benjamin T. NORDELL , Stuart D. EDWARDS
发明人： Simon W. H. THOMAS , Peter S. EDELSTEIN , John T. TO , Benjamin T. NORDELL , Stuart D. EDWARDS
IPC分类号： A61B18/00
CPC分类号： A61B18/00 , A61B17/0625 , A61B18/02 , A61B18/14 , A61B18/1477 , A61B18/1485 , A61B2017/00805 , A61B2017/00867 , A61B2018/00029 , A61B2018/00035 , A61B2018/00178 , A61B2018/00285 , A61B2018/00523 , A61B2018/00553 , A61B2018/00559 , A61B2018/00916 , A61B2018/1425 , A61B2018/143 , A61B2218/007 , A61N1/06 , A61N7/022 , C08L2201/12
摘要： Apparatus and methods are provided for treating female urinary incontinence by applying a form of energy to tissue in the vicinity of the urethra and/or bladder outlet to change tissue compliance without substantially narrowing the urethral and/or bladder outlet lumen. The apparatus comprises an elongated shaft having a means for treating urethral tissue and an expandable member deployable distal of the means for treating. The expandable member is configured to be anchored against the bladder outlet to dispose the means for treating at a desired treatment site in the urethra using only tactile feedback. The means for treating may include a needleless RF electrode, an ultrasound transducer, or a cryogenic probe configured to be advanced through a hollow needle, each of which are designed to reduce or eliminate symptoms associated with urinary incontinence.
摘要翻译：提供了用于通过向尿道和/或膀胱出口附近的组织施加能量来改变组织依从性而不使尿道和/或膀胱出口腔基本上变窄来治疗女性尿失禁的装置和方法。该装置包括细长轴，其具有用于治疗尿道组织的装置和可展开装置的可扩展构件。可膨胀构件被构造成锚固在膀胱出口上，以仅使用触觉反馈来将用于治疗的装置设置在尿道中的期望的治疗部位。用于治疗的装置可以包括无针RF电极，超声换能器或构造成通过中空针前进的低温探针，每个都被设计为减少或消除与尿失禁相关的症状。

3. 发明申请

US20120197247A1 APPARATUS AND METHODS FOR TREATING FEMALE URINARY INCONTINENCE 有权
标题翻译：用于治疗女性尿失禁的装置和方法
公开(公告)号：US20120197247A1
公开(公告)日：2012-08-02
申请号：US13443713
申请日：2012-04-10
申请人： Simon W. H. Thomas , Peter S. Edelstein , John T. To , Benjamin T. Nordell , Stuart D. Edwards
发明人： Simon W. H. Thomas , Peter S. Edelstein , John T. To , Benjamin T. Nordell , Stuart D. Edwards
IPC分类号： A61B18/18
CPC分类号： A61B18/00 , A61B17/0625 , A61B18/02 , A61B18/14 , A61B18/1477 , A61B18/1485 , A61B2017/00805 , A61B2017/00867 , A61B2018/00029 , A61B2018/00035 , A61B2018/00178 , A61B2018/00285 , A61B2018/00523 , A61B2018/00553 , A61B2018/00559 , A61B2018/00916 , A61B2018/1425 , A61B2018/143 , A61B2218/007 , A61N1/06 , A61N7/022 , C08L2201/12
摘要： Apparatus and methods are provided for treating female urinary incontinence by applying a form of energy to tissue in the vicinity of the urethra and/or bladder outlet to change tissue compliance without substantially narrowing the urethral and/or bladder outlet lumen. The apparatus comprises an elongated shaft having a means for treating urethral tissue and an expandable member deployable distal of the means for treating. The expandable member is configured to be anchored against the bladder outlet to dispose the means for treating at a desired treatment site in the urethra using only tactile feedback. The means for treating may include a needleless RF electrode, an ultrasound transducer, or a cryogenic probe configured to be advanced through a hollow needle, each of which are designed to reduce or eliminate symptoms associated with urinary incontinence.
摘要翻译：提供了用于通过向尿道和/或膀胱出口附近的组织施加能量来改变组织依从性而不使尿道和/或膀胱出口腔基本上变窄来治疗女性尿失禁的装置和方法。该装置包括细长轴，其具有用于治疗尿道组织的装置和可展开装置的可扩展构件。可膨胀构件被构造成锚固在膀胱出口上，以仅使用触觉反馈来将用于治疗的装置设置在尿道中的期望的治疗部位。用于治疗的装置可以包括无针RF电极，超声换能器或构造成通过中空针前进的低温探针，每个都被设计为减少或消除与尿失禁相关的症状。

4. 发明授权

US07947038B2 Obesity treatment system including inflatable balloon structures with micropores for transport of liquid 失效
标题翻译：肥胖治疗系统包括具有用于运输液体的微孔的可膨胀球囊结构
公开(公告)号：US07947038B2
公开(公告)日：2011-05-24
申请号：US12006908
申请日：2008-01-07
申请人： Stuart D. Edwards
发明人： Stuart D. Edwards
IPC分类号： A61B18/18
CPC分类号： A61F5/0026 , A61B18/1485 , A61B18/1492 , A61B2018/00029 , A61B2018/00065 , A61B2018/00214 , A61B2018/00232 , A61B2018/00238 , A61B2018/00261 , A61B2018/00482 , A61B2018/00654 , A61B2018/00797 , A61B2018/1467 , A61B2218/002 , A61B2218/007 , A61M25/1011 , A61M2025/105 , A61M2210/1053 , A61N1/0509 , A61N1/06 , A61N1/36007 , A61N1/36014
摘要： An obesity treatment system has a first treatment region sized and configured for deployment in a duodenum and a second treatment region sized and configured for deployment in a stomach. The first and second treatment regions are spaced apart a distance sized and configured to permit simultaneous deployment of the first treatment region in the duodenum and deployment of the second treatment region in the stomach. The first and second treatment regions each carry at least one electrode, which can deliver energy to ablate tissue in and the duodenum.
摘要翻译：肥胖症治疗系统具有第一治疗区域，其尺寸和构造用于部署在十二指肠中，第二治疗区域的尺寸和构造适于部署在胃中。第一和第二治疗区域间隔一定距离，其尺寸和构造允许在十二指肠中同时部署第一治疗区域并且部署第二治疗区域在胃中。第一和第二处理区域各自携带至少一个电极，其可以传送能量以消融十二指肠内的组织和十二指肠。

5. 发明授权

US07632268B2 System for tissue ablation 失效
标题翻译：组织消融系统
公开(公告)号：US07632268B2
公开(公告)日：2009-12-15
申请号：US11420712
申请日：2006-05-26
申请人： Stuart D Edwards , John Gaiser , David S Utley , Scott H West , Jay Qin
发明人： Stuart D Edwards , John Gaiser , David S Utley , Scott H West , Jay Qin
IPC分类号： A61B18/18 , A61F2/00
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems for treating a mucosal surface of an alimentary canal tissue region are provided. The systems can include an elongate support structure, an expandable member positionable at a distal portion of the support structure and one or more radio frequency (RF) ablation electrodes carried by the expandable member. The elongate support structure and the expandable member can be adapted to place the one or more electrodes in contact with a mucosal surface of an alimentary canal tissue region. The system can further include an RF energy source connected to the one or more electrodes.
摘要翻译：提供了用于治疗消化道组织区域的粘膜表面的系统。该系统可以包括细长的支撑结构，可定位在支撑结构的远端部分处的可扩张构件以及由可扩张构件承载的一个或多个射频（RF）消融电极。细长支撑结构和可扩张构件可适于将一个或多个电极与消化道组织区域的粘膜表面接触。该系统还可以包括连接到一个或多个电极的RF能量源。

6. 发明申请

US20080140114A1 Systems and methods for sealing a vascular puncture 有权
标题翻译：用于密封血管穿刺的系统和方法
公开(公告)号：US20080140114A1
公开(公告)日：2008-06-12
申请号：US12069773
申请日：2008-02-13
申请人： Stuart D. Edwards , Ronald Lax , Theodore L. Parker , Thomas C. Wehman , Theodore Kucklick , Eugene Skalnyi
发明人： Stuart D. Edwards , Ronald Lax , Theodore L. Parker , Thomas C. Wehman , Theodore Kucklick , Eugene Skalnyi
IPC分类号： A61B17/08
CPC分类号： A61B18/148 , A61B17/00491 , A61B17/0057 , A61B17/3415 , A61B18/1482 , A61B18/1485 , A61B18/1487 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00022 , A61B2017/00084 , A61B2017/00106 , A61B2017/003 , A61B2017/00495 , A61B2017/005 , A61B2017/00637 , A61B2017/0065 , A61B2017/22067 , A61B2017/3492 , A61B2017/4216 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00065 , A61B2018/00077 , A61B2018/00083 , A61B2018/00113 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00494 , A61B2018/00559 , A61B2018/00577 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00755 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00869 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/00982 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/1467 , A61B2018/1472 , A61B2090/064 , A61B2090/3614 , A61B2090/3782 , A61B2218/002 , A61M3/0279 , A61M16/0481 , A61M16/0858 , A61M25/0662 , A61M25/1002 , A61M2025/1052 , A61M2025/1086
摘要： Systems and methods introduce a closure material to seal a vessel puncture site. The system and methods provide a catheter adapted for passage through a tissue puncture and sized to occupy substantially all the tissue puncture. The catheter includes a lumen in fluid communication with a fluid delivery port adjacent the catheter distal end. One or more dispensers are in fluid communication with the catheter lumen for dispensing first and second fluid compositions in the catheter lumen. An actuator causes the first and second fluid compositions to be dispensed from the dispensers and mixed by flowing the first and second fluid compositions through a static mixer. The first and second fluid compositions are dispensed from the fluid delivery port as a fluid mixture that reacts in situ to form a nonfluent closure composition adjacent the vessel puncture site.
摘要翻译：系统和方法引入封闭材料以密封容器穿刺部位。该系统和方法提供适于通过组织穿刺的导管，并且尺寸适于占据基本上所有的组织穿刺。导管包括与邻近导管远端的流体输送端口流体连通的内腔。一个或多个分配器与导管内腔流体连通，用于分配导管内腔中的第一和第二流体组合物。致动器使得第一和第二流体组合物从分配器分配并通过使第一和第二流体组合物流过静态混合器而混合。第一和第二流体组合物作为流体混合物从流体输送端口分配，其在原位反应以在血管穿刺部位附近形成非流体封闭组合物。

7. 发明授权

US07022105B1 Treatment of tissue in sphincters, sinuses and orifices 失效
标题翻译：治疗括约肌，鼻窦和孔的组织
公开(公告)号：US07022105B1
公开(公告)日：2006-04-04
申请号：US09356110
申请日：1999-07-16
申请人： Stuart D. Edwards
发明人： Stuart D. Edwards
IPC分类号： A61M31/00
CPC分类号： A61N1/06 , A61N1/403
摘要： The invention provides a method and system for ablation of body structures or tissue in a sphincter, sinus or orifice such as the rectum, colon, esophagus, vagina, penis, larynx or pharynx. In one aspect of the invention, the environment surrounding the targeted ablation region can be isolated or controlled by blocking the flow of gases or liquids using an inflatable balloon positioned immediately adjacent to the tissue that is to be ablated. In a preferred embodiment, the inflatable balloon also serves to anchor the catheter in place and prevent the catheter from being expelled from the body. The inflatable balloon also insures that locally administered drug remain in the area where most needed. In a second aspect of the invention, positive pressure is used to inflate the balloon. Inflation of balloon triggers the extension of at least one curvilinear electrode into the targeted tissue. Negative pressure deflates the air sac and helps retract the curvilinear electrodes so as to allow the catheter to be removed from the body without damaging adjacent body structures. In a third aspect of the invention, the electrodes are coupled to sensors that measure properties of the target region such as temperature and impedance. Measurement of these properties permits the use of feedback technique to control delivery of the RF energy and administration of fluids for cooling and hydrating the affected tissues. In a fourth aspect of the invention, the catheter includes an optical path that can be coupled to external viewing apparatus. In this way, the position of the electrodes in the body can be determined by fluoroscopic or fiber optic techniques.
摘要翻译：本发明提供了一种用于消融括约肌，窦或孔如直肠，结肠，食管，阴道，阴茎，喉或咽部中的身体结构或组织的方法和系统。在本发明的一个方面，围绕目标消融区域的环境可以通过使用紧邻待烧伤组织定位的可充气气囊来阻止气体或液体的流动而被隔离或控制。在优选实施例中，可膨胀气囊还用于将导管锚定在适当位置并防止导管从身体排出。充气气囊还确保局部给药的药物保留在最需要的区域。在本发明的第二方面中，使用正压使气囊膨胀。球囊的充气触发了至少一个曲线电极延伸到目标组织中。负压使气囊缩小并帮助缩回曲线电极，以便允许导管从身体移除而不损坏邻近的身体结构。在本发明的第三方面中，电极耦合到测量目标区域的性质（诸如温度和阻抗）的传感器。这些性质的测量允许使用反馈技术来控制RF能量的传递和给予流体以冷却和保湿受影响的组织。在本发明的第四方面中，导管包括可以连接到外部观察装置的光路。以这种方式，电极在体内的位置可以通过荧光镜或光纤技术来确定。

8. 发明授权

US06974456B2 Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors 有权
标题翻译：通过检测和消融胃食管神经和受体来治疗胃反流的方法
公开(公告)号：US06974456B2
公开(公告)日：2005-12-13
申请号：US10156505
申请日：2002-05-28
申请人： Stuart D. Edwards , John W. Gaiser , David S Utley
发明人： Stuart D. Edwards , John W. Gaiser , David S Utley
IPC分类号： A61B18/00 , A61B17/00 , A61B18/02 , A61B18/04 , A61B18/12 , A61B18/14 , A61B19/00 , A61N1/06 , A61B18/18
CPC分类号： A61B18/1233 , A61B18/1477 , A61B18/1492 , A61B90/39 , A61B2017/00039 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00142 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00553 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00738 , A61B2018/00791 , A61B2018/00821 , A61B2018/00839 , A61B2018/00875 , A61B2018/00898 , A61B2018/0091 , A61B2018/00982 , A61B2018/0237 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2090/064 , A61B2090/3782 , A61B2218/002 , A61N1/06
摘要： The present invention comprises a method of treating a sphincter that provides a sphincter electropotential mapping device with at least one of a mapping electrode or a treatment electrode. The sphincter electropotential mapping device is introduced into at least a portion of the sphincter, the lower esophageal sphincter, stomach, the cardia or the fundus. Bioelectric activity causing a relaxation of the sphincter is detected and energy is delivered from either the mapping electrode or the treatment electrode to treat the bioelectric activity.In another embodiment of the method of the invention, a method of treating a sphincter that provides a sphincter electropotential mapping device with at least one of a mapping electrode or a treatment electrode. The sphincter electropotential mapping device is introduced into at least a portion of the sphincter, the lower esophageal sphincter, stomach, the cardia or the fundus. The sphincter, lower esophageal sphincter, stomach, cardia or fundus is stimulated to produce a transient relaxation of the sphincter. The portion of the sphincter, lower esophageal sphincter, stomach, cardia or fundus causing a relaxation of the sphincter is indentified. Energy is delivered from the sphincter electropotential mapping device to treat the portion the sphincter, lower esophageal sphincter, stomach, cardia or fundus causing the transient relaxation of the sphincter.
摘要翻译：本发明包括一种治疗括约肌的方法，所述括约肌具有至少一个映射电极或治疗电极提供括约肌电位映射装置。括约肌电位映射装置被引入至少一部分括约肌，食管下括约肌，胃，贲门或眼底。检测到引起松弛括约肌的生物电活性，并从映射电极或治疗电极传递能量以处理生物电活性。在本发明方法的另一个实施方案中，一种治疗括约肌的方法，所述括约肌提供具有映射电极或治疗电极中的至少一个的括约肌电位映射装置。括约肌电位映射装置被引入至少一部分括约肌，食管下括约肌，胃，贲门或眼底。括约肌，食管下括约肌，胃，贲门或眼底被刺激以产生括约肌的短暂松弛。括约肌部分，食管下括约肌，胃，贲门或眼底引起松弛的括约肌是确定的。能量从括约肌电位测绘装置输送到治疗括约肌，下食道括约肌，胃，贲门或眼底的部分，导致括约肌的暂时松弛。

9. 发明授权

US06866663B2 Method for treating a sphincter 失效
公开(公告)号：US06866663B2
公开(公告)日：2005-03-15
申请号：US10254471
申请日：2002-09-25
申请人： Stuart D Edwards , David S Utley , Ronald G Lax , John Gaiser
发明人： Stuart D Edwards , David S Utley , Ronald G Lax , John Gaiser
IPC分类号： A61B18/00 , A61B18/12 , A61B18/14 , A61B18/18
CPC分类号： A61B18/1492 , A61B18/1206 , A61B18/1477 , A61B18/18 , A61B2018/00011 , A61B2018/00029 , A61B2018/00047 , A61B2018/00214 , A61B2018/0022 , A61B2018/00494 , A61B2018/00553 , A61B2018/00666 , A61B2018/00678 , A61B2018/00684 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2218/002
摘要： A method for treating a sphincter provides a polymer material having a liquid state. The method also provides a catheter having a distal end, a tissue piercing device carried by the distal end, and an energy delivery device coupled to the tissue piercing device. The tissue piercing device has a lumen. The method introduces the catheter into an esophagus and pierces an exterior sphincter tissue surface within with the tissue piercing device. The method advances the tissue piercing device into an interior sphincter tissue site and conveys the polymer material while in a liquid state through the lumen into the interior sphincter tissue site. The method delivers energy to the tissue piercing device to transform the polymer material into a less liquid state within the interior sphincter tissue site, to thereby remodel the sphincter.

10. 发明授权

US06749607B2 Apparatus to treat esophageal sphincters 有权
标题翻译：食管括约肌治疗仪
公开(公告)号：US06749607B2
公开(公告)日：2004-06-15
申请号：US09971085
申请日：2001-10-04
申请人： Stuart D Edwards , David S Utley
发明人： Stuart D Edwards , David S Utley
IPC分类号： A61B1818
CPC分类号： A61B18/1477 , A61B5/4233 , A61B18/0218 , A61B18/1492 , A61B2017/3445 , A61B2017/345 , A61B2018/00267 , A61B2018/00488 , A61B2018/00553 , A61B2018/00589 , A61B2018/00648 , A61B2018/00702 , A61B2018/00821 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/00994 , A61B2018/0262 , A61B2018/0293 , A61B2018/046 , A61B2018/1861 , A61B2018/1869
摘要： A sphincter treatment apparatus has an introducer means including a distal portion means. An expandable device means includes a plurality of arm means. Each arm means of the plurality has a distal section means and a proximal section means. Each of distal sections means of the arm means are coupled and each of the proximal sections means of the arm means are coupled to the introducer means distal portion means. The expandable device means is configured to at least partially dilate a sphincter in a deployed state. An energy delivery device means is introduceable from the introducer means into a selected site of the sphincter. The energy delivery device means is configured to deliver sufficient energy to reduce a frequency of relaxation of the sphincter.
摘要翻译：括约肌治疗装置具有包括远端部分装置的导引装置。可扩张装置包括多个臂装置。多个臂的每个臂装置具有远端部分装置和近端部分装置。臂装置的每个远端部分装置联接，并且臂装置的每个近端部分装置联接到导引装置远端部分装置。可扩张装置装置构造成在展开状态下至少部分地扩张括约肌。能量输送装置装置可从导引器装置引入括约肌的选定部位。能量递送装置装置被配置为递送足够的能量以减少括约肌的松弛频率。

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