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1. 发明授权

US09737360B2 Devices, systems and methods for treating tissue regions of the body 有权
公开(公告)号：US09737360B2
公开(公告)日：2017-08-22
申请号：US14256979
申请日：2014-04-20
申请人： Scott H. West , John W. Gaiser , Robin Bek , David S. Utley , Patrick Rimroth
发明人： Scott H. West , John W. Gaiser , Robin Bek , David S. Utley , Patrick Rimroth
IPC分类号： A61B18/14 , A61B18/00
CPC分类号： A61B18/1492 , A61B1/00087 , A61B1/0014 , A61B1/273 , A61B2018/00029 , A61B2018/00214 , A61B2018/00267 , A61B2018/00797 , A61B2018/00821 , A61B2018/1425 , A61B2018/1475
摘要： Improved devices, systems and methods for treating a tissue region provide straightforward, yet reliable ways for installing diverse functional components within the confined space of a catheter-based instrument.

2. 发明授权

US08906010B2 Graphical user interface for association with an electrode structure deployed in contact with a tissue region 有权
标题翻译：图形用户界面，用于与部署为与组织区域接触的电极结构相关联
公开(公告)号：US08906010B2
公开(公告)日：2014-12-09
申请号：US12001091
申请日：2007-12-10
申请人： Stuart D Edwards , John W. Gaiser , David S Utley , Scott H. West , Jay Qin , Peter H Muller
发明人： Stuart D Edwards , John W. Gaiser , David S Utley , Scott H. West , Jay Qin , Peter H Muller
IPC分类号： A61B18/14 , A61B18/12 , A61B19/00 , A61B18/00 , A61B18/04
CPC分类号： A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems and methods deploy an electrode structure in contact with the tissue region. The electrode structure carries a sensor at a known location on the electrode structure to monitor an operating condition. The systems and methods provide an interface, which generate an idealized image of the electrode structure and an indicator image to represent the monitored operating condition in a spatial position on the idealized image corresponding to the location of the sensor on the electrode structure. The interface displays a view image comprising the idealized image and indicator image. The systems and methods cause the electrode structure to apply energy to heat the tissue region while the view image is displayed on the display screen.
摘要翻译：系统和方法部署与组织区域接触的电极结构。电极结构在电极结构上的已知位置处携带传感器以监测操作状态。系统和方法提供了一种接口，其产生电极结构的理想化图像和指示图像，以在对应于电极结构上的传感器的位置的理想化图像上的空间位置中表示监视的操作条件。界面显示包含理想图像和指示图像的视图。当视觉图像显示在显示屏上时，系统和方法使电极结构施加能量来加热组织区域。

3. 发明申请

US20110077550A1 Systems and methods for treating tissue regions of the body 审中-公开
标题翻译：用于治疗身体组织区域的系统和方法
公开(公告)号：US20110077550A1
公开(公告)日：2011-03-31
申请号：US12925148
申请日：2010-10-14
申请人： Robin Bek , John W. Gaiser , Scott H. West , Patrick Rimroth
发明人： Robin Bek , John W. Gaiser , Scott H. West , Patrick Rimroth
IPC分类号： A61M29/02 , A61B5/03
CPC分类号： A61B18/1492 , A61B5/037 , A61B5/06 , A61B5/7282 , A61B5/7405 , A61B5/742 , A61B18/02 , A61B18/16 , A61B18/1815 , A61B18/20 , A61B2018/00029 , A61B2018/00214 , A61B2018/00244 , A61B2018/00267 , A61B2018/00488 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00744 , A61B2018/00821 , A61B2018/00863 , A61B2018/00982 , A61B2018/00994 , A61B2018/1422 , A61B2018/1425 , A61B2018/1465 , A61B2018/1475 , A61B2018/1807 , A61B2034/2046 , A61B2218/002
摘要： Systems and methods deploy a therapeutic or diagnostic element into contact with a body tissue region. The systems and methods can sense position of the therapeutic or diagnostic element relative to a targeted tissue region without direct or indirect visualization, by sensing fluid pressure in a fluid path having an outlet located at or near the therapeutic or diagnostic element. The systems and methods can also inflate the therapeutic or diagnostic element during use, while taking steps to avoid over-inflation and/or while dynamically monitoring the pressure conditions within the expanded element.
摘要翻译：系统和方法将治疗或诊断元件部署成与身体组织区域接触。系统和方法可以通过检测具有位于治疗或诊断元件处或附近的出口的流体路径中的流体压力来感测治疗或诊断元件相对于目标组织区域的位置，而不需要直接或间接可视化。系统和方法还可以在使用期间使治疗或诊断元件膨胀，同时采取步骤以避免过度膨胀和/或在动态监测扩张元件内的压力状况的同时。

4. 发明申请

US20090254079A1 Methods for treating the cardia of the stomach 审中-公开
标题翻译：治疗胃贲门的方法
公开(公告)号：US20090254079A1
公开(公告)日：2009-10-08
申请号：US12456091
申请日：2009-06-11
申请人： Stuart D. Edwards , John Gaiser , David S. Utley , Scott H. West , Jay Qin
发明人： Stuart D. Edwards , John Gaiser , David S. Utley , Scott H. West , Jay Qin
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Methods treat a tissue region. In one arrangement, the methods deploy an endoscope in an esophagus and visualize with the endoscope a Z-line that marks a transition between esophageal tissue and stomach tissue by observing tissue color change at or near the Z-line. The methods deploy an electrode support structure over the endoscope at or near the Z-line visualized by the endoscope, wherein the endoscope serves as a guide for the electrode support structure. The methods introduce from the electrode support structure a tissue-piercing needle electrode into tissue at or near the Z-line and observe introduction of the tissue-piercing needle electrode using the endoscope. The methods couple the tissue-piercing electrode to a source of radio frequency energy to ohmically heat tissue and create a subsurface tissue lesion in tissue at or near the Z-line, and observe creation of the tissue lesion using the endoscope.
摘要翻译：方法治疗组织区域。在一种布置中，该方法在食道中部署内窥镜并且通过观察Z线处或附近的组织颜色变化，通过内窥镜观察标记食管组织和胃组织之间转变的Z线。该方法在由内窥镜可视化的Z线处或附近在内窥镜上部署电极支撑结构，其中内窥镜用作电极支撑结构的引导件。所述方法从电极支撑结构将组织穿刺针电极引入到Z线处或附近的组织中，并且使用内窥镜观察组织穿刺针电极的引入。该方法将组织刺穿电极耦合到射频能量源以欧姆加热组织并在Z线或其附近的组织中产生表面下组织损伤，并且使用内窥镜观察组织损伤的产生。

5. 发明授权

US07556628B2 Method for tissue ablation 失效
标题翻译：组织消融方法
公开(公告)号：US07556628B2
公开(公告)日：2009-07-07
申请号：US11420722
申请日：2006-05-26
申请人： David S Utley , John Gaiser , Stuart D Edwards , Scott H West , Jay Qin
发明人： David S Utley , John Gaiser , Stuart D Edwards , Scott H West , Jay Qin
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Methods of ablating mucosal tissue in an alimentary canal are provided. The methods can include the steps of (i) providing an ablation device comprising a tissue ablation source; (ii) positioning at least a portion of the ablation device at a mucosal tissue surface of the alimentary canal; (iii) delivering a sufficient amount of the source for tissue ablation to the mucosal tissue surface to create a lesion in the mucosal tissue. In one implementation the methods include a step of providing a radiofrequency (RF) energy delivery device.
摘要翻译：提供消化道中消融粘膜组织的方法。所述方法可以包括以下步骤：（i）提供包括组织消融源的消融装置; （ii）将消融装置的至少一部分定位在消化道的粘膜组织表面; （iii）将足够量的用于组织消融的来源输送到粘膜组织表面以在粘膜组织中产生损伤。在一个实现中，所述方法包括提供射频（RF）能量传递装置的步骤。

6. 发明授权

US06169916A Electrophysiology catheter with multifunctional wire and method for making 有权
标题翻译：多功能线电生理导管及制作方法
公开(公告)号：US06169916A
公开(公告)日：2001-01-02
申请号：US09384875
申请日：1999-08-27
申请人： Scott H. West
发明人： Scott H. West
IPC分类号： A61N105
CPC分类号： A61M25/0144 , A61B2018/00916 , A61B2018/00946 , A61B2018/00952 , A61M25/0136 , A61M25/0141 , A61M25/0147 , A61N1/0565
摘要： An electrophysiology catheter (2) includes a handle (4) and a catheter shaft (6) having a flexible tip portion (22) with one or more electrodes (26, 28). A radial deflection wire (42) connects the tip portion to a first manipulator (10) at the handle to radially deflect the tip portion to a curved shape. A multifunction wire (60) extends from a second manipulator (11) at the handle to the tip portion. The second manipulator slides the multifunction wire longitudinally to position the distal end (64) of the multifunction wire along the multifunction lumen (38). The distal end of the multifunctional wire and the multifunction lumen are configured to provide interfering torquing surfaces (68, 70) so that when a third manipulator (12) rotates or torques the proximal end (62) of the multifunctional wire, the torquing force exerted between the interfering torquing surface causes lateral deflection of the radially curved tip portion. The catheter is constructed so that lateral deflection of the radially deflected tip portion is totally or at least substantially in-plane lateral deflection.
摘要翻译：电生理学导管（2）包括手柄（4）和导管轴（6），其具有带有一个或多个电极（26,28）的柔性尖端部分（22）。径向偏转线（42）将尖端部分连接到手柄处的第一操纵器（10），以使尖端部分径向偏转弯曲形状。多功能线（60）从手柄处的第二操纵器（11）延伸到尖端部分。第二操纵器纵向滑动多功能线，以沿着多功能管腔（38）定位多功能线的远端（64）。多功能线材和多功能管腔的远端构造成提供干涉扭矩表面（68,70），使得当第三操纵器（12）旋转或扭转多功能线材的近端（62）时，施加的扭力在干涉扭转表面之间引起径向弯曲的尖端部分的横向偏转。导管被构造成使得径向偏转的尖端部分的横向偏转完全或至少基本上在平面内的横向偏转。

7. 发明授权

US6035224A Electrophysiology catheter with multifunction wire and method for making 失效
标题翻译：多功能电导电生理导管及制作方法
公开(公告)号：US6035224A
公开(公告)日：2000-03-07
申请号：US7376
申请日：1998-01-15
申请人： Scott H. West
发明人： Scott H. West
IPC分类号： A61M25/00 , A61M25/01 , A61N1/05
CPC分类号： A61M25/0144 , A61M25/0136 , A61M25/0141 , A61M25/0147 , A61N1/0565 , A61B2018/00916 , A61B2018/00946 , A61B2018/00952
摘要： An electrophysiology catheter (2) includes a handle (4) and a catheter shaft (6) having a flexible tip portion (22) with one or more electrodes (26, 28). A radial deflection wire (42) connects the tip portion to a first manipulator (10) at the handle to radially deflect the tip portion to a curved shape. A multifunction wire (60) extends from a second manipulator (11) at the handle to the tip portion. The second manipulator slides the multifunction wire longitudinally to position the distal end (64) of the multifunction wire along the multifunction lumen (38). The distal end of the multifunctional wire and the multifunction lumen are configured to provide interfering torquing surfaces (68, 70) so that when a third manipulator (12) rotates or torques the proximal end (62) of the multifunctional wire, the torquing force exerted between the interfering torquing surface causes lateral deflection of the radially curved tip portion. The catheter is constructed so that lateral deflection of the radially deflected tip portion is totally or at least substantially in-plane lateral deflection.
摘要翻译：电生理学导管（2）包括手柄（4）和导管轴（6），其具有带有一个或多个电极（26,28）的柔性尖端部分（22）。径向偏转线（42）将尖端部分连接到手柄处的第一操纵器（10），以使尖端部分径向偏转弯曲形状。多功能线（60）从手柄处的第二操纵器（11）延伸到尖端部分。第二操纵器纵向滑动多功能线，以沿着多功能管腔（38）定位多功能线的远端（64）。多功能线材和多功能管腔的远端被构造成提供干涉扭矩表面（68,70），使得当第三操纵器（12）旋转或扭转多功能线材的近端（62）时，施加的扭力在干涉扭转表面之间引起径向弯曲的尖端部分的横向偏转。导管被构造成使得径向偏转的尖端部分的横向偏转完全或至少基本上在平面内的横向偏转。

8. 发明授权

US5987344A Handle for catheter assembly with multifunction wire 失效
标题翻译：带多功能导线的导管组装手柄
公开(公告)号：US5987344A
公开(公告)日：1999-11-16
申请号：US920340
申请日：1997-08-27
申请人： Scott H. West
发明人： Scott H. West
IPC分类号： A61M25/00 , A61M25/01 , A61N1/05
CPC分类号： A61M25/0144 , A61M25/0136 , A61M25/0141 , A61M25/0147 , A61N1/0565 , A61B2018/00916 , A61B2018/00946 , A61B2018/00952
摘要： Multifunction and radial deflection wires (66, 64) extend from a catheter shaft (8) and into a handle (4). The multifunction wire is pulled and pushed longitudinally and is rotated about its axis to change the stiffness of and to laterally deflect the tip portion (12). A curve size manipulator (32) on the handle body (24) moves the multifunction wire longitudinally but does not hinder its rotational movement. Rotation of a lateral deflection manipulator (38) on the handle causes the proximal end (70) of the multifunction wire to rotate about its own axis; the free longitudinal movement of the proximal end is unhindered. Any initial corkscrewing or other deflection of the tip portion can be removed at assembly by rotating the proximal end (68) of the radial deflection wire. The longitudinal movement of the manipulators can be limited by movable stops (120). The longitudinal positions of the abutment faces (126, 128) of the stops preferably change according to their longitudinal (distal or proximal) orientation.
摘要翻译：多功能和径向偏转线（66,64）从导管轴（8）延伸到手柄（4）中。多功能线被纵向拉动并推动并围绕其轴线旋转以改变尖端部分（12）的刚性并使其侧向偏转。手柄主体（24）上的曲线尺寸操纵器（32）纵向移动多功能线，但不妨碍其旋转运动。横向偏转操纵器（38）在手柄上的旋转使得多功能线的近端（70）绕其自身的轴线旋转; 近端的自由纵向运动是不受阻碍的。通过旋转径向偏转线的近端（68）可以在组装时去除尖端部分的任何初始的触控或其它偏转。操纵器的纵向移动可以通过可动止动件（120）来限制。挡块的邻接面（126,128）的纵向位置优选地根据其纵向（远侧或近端）取向而改变。

9. 发明授权

US5807249A Reduced stiffness, bidirectionally deflecting catheter assembly 失效
标题翻译：降低刚度，双向导向组件
公开(公告)号：US5807249A
公开(公告)日：1998-09-15
申请号：US791129
申请日：1997-02-13
申请人： Jay J. Qin , Aurelio Valencia , Scott H. West
发明人： Jay J. Qin , Aurelio Valencia , Scott H. West
IPC分类号： A61B5/042 , A61M25/00 , A61M25/01 , A61M25/092 , A61B5/04
CPC分类号： A61M25/0147 , A61B5/0422 , A61B2562/0209 , A61B2562/043 , A61M2025/015 , A61M2025/0161 , A61M25/0054
摘要： A reduced stiffness, bidirectionally deflecting catheter assembly (2) includes a handle (4) and flexible catheter shaft (6) with a tip section (12) secured to its distal end (14). The tip section has a radially offset, longitudinally extending core wire lumen (42) through which a tapered core wire (24), extending from a core wire manipulator (56) on the handle, passes. The core wire manipulator can be moved in two different directions (58, 60) to pull or push on the core wire to cause the tip section to deflect axially in opposite directions in the same plane. The ends of the core wire are non-rotatably secured to the handle and the tip section so that rotating the handle about its axis (63) causes the tip section to deflect laterally due to torsionally forces exerted on the tip section by both the catheter shaft and the core wire. The taper on the core wire determines the size and shape of the curved tip section when the tip is axially deflected.
摘要翻译：减小刚度的双向偏转导管组件（2）包括具有固定到其远端（14）的尖端部分（12）的手柄（4）和柔性导管轴（6）。尖端部分具有径向偏移的纵向延伸的芯线管腔（42），从手柄上的芯线操纵器（56）延伸的锥形芯线通过该通孔。芯线操纵器可以在两个不同的方向（58,60）上移动以拉动或推动芯线，以使得尖端部分在相同平面中沿相反方向轴向偏转。芯线的端部不可旋转地固定到手柄和尖端部分，使得手柄围绕其轴线（63）旋转导致尖端部分由于导管轴线施加在尖端部分上的扭转力而侧向偏转和芯线。芯线上的锥度决定了当尖端轴向偏转时弯曲末端部分的尺寸和形状。

10. 发明授权

US5545200A Steerable electrophysiology catheter 失效
标题翻译：导向电生理导管
公开(公告)号：US5545200A
公开(公告)日：1996-08-13
申请号：US343310
申请日：1994-11-22
申请人： Scott H. West , Frank Nguyen
发明人： Scott H. West , Frank Nguyen
IPC分类号： A61B18/14 , A61M25/01 , A61N1/05 , A61M1/00 , A61B17/38
CPC分类号： A61M25/0144 , A61B18/1492 , A61M25/0136 , A61M25/0147 , A61N1/056 , A61B2017/003 , A61B2018/00065 , A61B2018/00357 , A61B2018/00392 , A61B2018/00577 , A61B2018/00839 , A61B2018/0091 , A61B2018/00946 , A61B2018/00952 , A61B2018/126 , A61B2018/1435 , A61B2018/1472 , A61B2218/002 , A61M2025/0063 , A61M2025/015 , A61M2025/0161 , A61M25/0141
摘要： An electrophysiology catheter (20) comprises a shaft (22) having a first bending stiffness and a deflectable tip (28) secured to the distal end (24) of the shaft with a second bending stiffness less than the first bending stiffness. At least one electrode (34, 36) is mounted to the tip for delivering current to or monitoring electrical activity of tissue. A manipulator wire (58) is coupled to the distal end of the deflectable tip, whereby the deflectable tip may be deflected by axial force applied to the manipulator wire. A stiffener member (66) is axially slidable relative to the tip so as to adjust the tip curvature without removing the catheter from the body. The catheter may further include a core wire (72) configured to rotate the deflectable tip about a longitudinal axis (2) without rotating the proximal end (26) of the catheter shaft, wherein the distal end of the deflectable tip remains in a substantially constant axial position, preferably in a plane perpendicular to the longitudinal axis.
摘要翻译：电生理学导管（20）包括具有第一弯曲刚度的轴（22）和固定到所述轴的远端（24）的可偏转尖端（28），其具有小于所述第一弯曲刚度的第二弯曲刚度。至少一个电极（34,36）安装到尖端以将电流传送到或监测组织的电活动。操纵杆（58）联接到可偏转尖端的远端，由此通过施加到机械手线的轴向力，可偏转尖端可能被偏转。加强件（66）相对于尖端可轴向滑动，以便调节尖端曲率而不从体内移除导管。该导管还可以包括芯线（72），该芯线被构造成围绕纵向轴线（2）旋转可偏转尖端，而不旋转导管轴的近端（26），其中可偏转尖端的远端保持基本上恒定优选地在垂直于纵向轴线的平面中。

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