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1. 发明授权

US08177781B2 Apparatus and methods for treating female urinary incontinence 有权
标题翻译：女性尿失禁治疗的装置及方法
公开(公告)号：US08177781B2
公开(公告)日：2012-05-15
申请号：US11431213
申请日：2006-05-10
申请人： Simon W. H. Thomas , Peter S. Edelstein , John T. To , Benjamin T. Nordell , Stuart D. Edwards
发明人： Simon W. H. Thomas , Peter S. Edelstein , John T. To , Benjamin T. Nordell , Stuart D. Edwards
IPC分类号： A61B18/18
CPC分类号： A61B18/00 , A61B17/0625 , A61B18/02 , A61B18/14 , A61B18/1477 , A61B18/1485 , A61B2017/00805 , A61B2017/00867 , A61B2018/00029 , A61B2018/00035 , A61B2018/00178 , A61B2018/00285 , A61B2018/00523 , A61B2018/00553 , A61B2018/00559 , A61B2018/00916 , A61B2018/1425 , A61B2018/143 , A61B2218/007 , A61N1/06 , A61N7/022 , C08L2201/12
摘要： Apparatus and methods are provided for treating female urinary incontinence by applying a form of energy to tissue in the vicinity of the urethra and/or bladder outlet to change tissue compliance without substantially narrowing the urethral and/or bladder outlet lumen. The apparatus comprises an elongated shaft having a means for treating urethral tissue and an expandable member deployable distal of the means for treating. The expandable member is configured to be anchored against the bladder outlet to dispose the means for treating at a desired treatment site in the urethra using only tactile feedback. The means for treating may include a needleless RF electrode, an ultrasound transducer, or a cryogenic probe configured to be advanced through a hollow needle, each of which are designed to reduce or eliminate symptoms associated with urinary incontinence.
摘要翻译：提供了用于通过向尿道和/或膀胱出口附近的组织施加能量来改变组织依从性而不使尿道和/或膀胱出口腔基本上变窄来治疗女性尿失禁的装置和方法。该装置包括细长轴，其具有用于治疗尿道组织的装置和可展开装置的可扩展构件。可膨胀构件被构造成锚固在膀胱出口上，以仅使用触觉反馈来将用于治疗的装置设置在尿道中的期望的治疗部位。用于治疗的装置可以包括无针RF电极，超声换能器或构造成通过中空针前进的低温探针，每个都被设计为减少或消除与尿失禁相关的症状。

2. 发明授权

US08465482B2 Apparatus and methods for treating female urinary incontinence 有权
公开(公告)号：US08465482B2
公开(公告)日：2013-06-18
申请号：US13443713
申请日：2012-04-10
申请人： Simon W. H. Thomas , Peter S. Edelstein , John T. To , Benjamin T. Nordell , Stuart D. Edwards
发明人： Simon W. H. Thomas , Peter S. Edelstein , John T. To , Benjamin T. Nordell , Stuart D. Edwards
IPC分类号： A61B18/18
CPC分类号： A61B18/00 , A61B17/0625 , A61B18/02 , A61B18/14 , A61B18/1477 , A61B18/1485 , A61B2017/00805 , A61B2017/00867 , A61B2018/00029 , A61B2018/00035 , A61B2018/00178 , A61B2018/00285 , A61B2018/00523 , A61B2018/00553 , A61B2018/00559 , A61B2018/00916 , A61B2018/1425 , A61B2018/143 , A61B2218/007 , A61N1/06 , A61N7/022 , C08L2201/12
摘要： Apparatus and methods are provided for treating female urinary incontinence by applying a form of energy to tissue in the vicinity of the urethra and/or bladder outlet to change tissue compliance without substantially narrowing the urethral and/or bladder outlet lumen. The apparatus comprises an elongated shaft having a means for treating urethral tissue and an expandable member deployable distal of the means for treating. The expandable member is configured to be anchored against the bladder outlet to dispose the means for treating at a desired treatment site in the urethra using only tactile feedback. The means for treating may include a needleless RF electrode, an ultrasound transducer, or a cryogenic probe configured to be advanced through a hollow needle, each of which are designed to reduce or eliminate symptoms associated with urinary incontinence.

3. 发明授权

US06911027B1 Device for the ablation of tissue 失效
标题翻译：用于消融组织的装置
公开(公告)号：US06911027B1
公开(公告)日：2005-06-28
申请号：US09302055
申请日：1999-04-29
申请人： Stuart D. Edwards , James A. Filice , Benjamin T. Nordell , Brian O. Armijo
发明人： Stuart D. Edwards , James A. Filice , Benjamin T. Nordell , Brian O. Armijo
IPC分类号： A61B17/24 , A61B18/12 , A61B18/14 , A61B18/18
CPC分类号： A61B18/1477 , A61B2018/00755 , A61B2018/00821 , A61B2018/00875 , A61B2018/1253 , A61B2018/1475
摘要： A device for the ablation of tissue for use with the fingers of a human hand and a radio frequency power supply and controller providing a source of radio frequency energy and controls for controlling the application of radio frequency energy to the device comprising a handle sized so that is adapted to be grasped and supported by the human hand and having proximal and distal extremities. A single conductive needle formed of a conducting material is disposed in the distal extremity of the handle. An edge card is mounted in the handle and has edge mounted contacts with circuitry connected thereto. An edge mount board connector is mounted in the handle and is removably secured to the edge mounted contacts of the edge card. A cable is connected to the edge mount connector and extends from the proximal extremity of the handle and is adapted to be coupled to the radiofrequency power supply and controller. A second printed circuit board is mounted in the handle in a spaced-apart position from the edge card. A flex cable having conductive leads carried thereby extends between the edge card and the printed circuit board and is physically and electrically connected to the edge card. The proximal extremity of the needle is secured to the printed circuit board and makes electrical connections therewith.
摘要翻译：用于消除用于人类手指的组织的装置以及提供射频能量源的控制器和控制器，所述控制器控制射频能量对装置的应用，所述手柄的尺寸使得适于被人的手抓住并支撑，具有近端和远端。由导电材料形成的单个导电针设置在手柄的远端。边缘卡安装在手柄中，并且具有与其连接的电路的边缘安装的触点。边缘安装板连接器安装在手柄中，并可拆卸地固定到边缘卡的边缘安装的触点上。电缆连接到边缘安装连接器并从手柄的近端延伸并适于耦合到射频电源和控制器。第二印刷电路板以与边缘卡片隔开的位置安装在手柄中。由此承载的具有导电引线的柔性电缆在边缘卡和印刷电路板之间延伸并且物理地和电连接到边缘卡。针的近端被固定到印刷电路板并与其电连接。

4. 发明授权

US6045549A Tissue ablation apparatus and device for use therein and method 失效
标题翻译：组织消融装置及其使用的装置及方法
公开(公告)号：US6045549A
公开(公告)日：2000-04-04
申请号：US941401
申请日：1997-09-30
申请人： Rick T. Smethers , Benjamin T. Nordell, II
发明人： Rick T. Smethers , Benjamin T. Nordell, II
IPC分类号： A61B18/00 , A61B18/14 , A61B17/39
CPC分类号： A61B18/1477 , A61B2018/00023 , A61B2018/00577 , A61B2018/00654 , A61B2018/00791 , A61B2018/00797 , A61B2018/0091 , A61B2018/00916
摘要： A tissue ablation apparatus for minimally invasive treatment for disorders of the upper airway by the treatment of soft tissues in the upper airway comprising a hand-held device adapted to be held by the human hand. Radio frequency energy is delivered to the hand-held device. The hand-held device comprises a housing having a handle portion adapted to be grasped by the human hand and a probe portion. At least one guide tube is mounted in the probe portion and has a bore extending therethrough. A carrier block is slidably mounted in the housing relative to the guide tube. At least one needle assembly is mounted in the carrier block assembly and is movable with the carrier block assembly. The at least one needle assembly extends distally of the carrier block and is slidably disposed in the at least one guide tube. A slider is mounted on the housing exterior of the housing for slidable movement longitudinally of the housing and is adapted to be grasped by the thumb of the hand holding the housing. The slider is connected to the carrier block whereby when the slider is moved distally, the carrier block with the needle assembly is moved in the guide tube distally of the guide tube for entrance into the soft tissue.
摘要翻译：一种用于通过治疗上气道中的软组织来治疗上呼吸道疾病的微创治疗的组织消融装置，包括适于由人手保持的手持装置。射频能量传送到手持设备。手持式装置包括壳体，该壳体具有适于由人手抓握的手柄部分和探针部分。至少一个导管安装在探针部分中并且具有延伸穿过其中的孔。载体块相对于导管可滑动地安装在壳体中。至少一个针组件安装在承载块组件中并且可与承载块组件一起移动。所述至少一个针组件在所述承载块的远侧延伸并且可滑动地设置在所述至少一个引导管中。滑动件安装在壳体的壳体外部上，用于可滑动地移动到壳体的纵向，并且适于由握住壳体的手的拇指来抓握滑块。滑块连接到承载块，由此当滑块向远侧移动时，具有针组件的承载块在引导管中在引导管的远侧移动以进入软组织。

5. 外观设计

USD415665S Bending tool 失效
公开(公告)号：USD415665S
公开(公告)日：1999-10-26
申请号：US77246
申请日：1997-09-30
申请人： Benjamin T. Nordell, II , Rick T. Smethers
设计人： Benjamin T. Nordell, II , Rick T. Smethers

6. 发明授权

US07291129B2 Apparatus and methods for treating female urinary incontinence 失效
标题翻译：女性尿失禁治疗的装置及方法
公开(公告)号：US07291129B2
公开(公告)日：2007-11-06
申请号：US10207689
申请日：2002-07-25
申请人： Hong Li , Peter S Edelstein , John T To , Simon W. H. Thomas , Benjamin T Nordell
发明人： Hong Li , Peter S Edelstein , John T To , Simon W. H. Thomas , Benjamin T Nordell
IPC分类号： A61M5/178
CPC分类号： A61B18/1477 , A61B18/1485 , A61B2018/00029 , A61B2018/00285 , A61B2018/00523 , A61B2018/00553 , A61B2018/00916 , A61B2218/007 , A61N1/06
摘要： Apparatus and methods are provided for treating female urinary incontinence by injecting a bulking agent at the interface between the mucosal and submucosal layers of the urethral wall. The remodeling device comprises an elongated shaft preferably having means for forming a localized inward protrusion of the urethral wall, and a needle, movable between retracted and deployed positions, for delivering a bulking agent into the urethral wall in the vicinity of the localized inward protrusion to thereby reduce or eliminate symptoms associated with urinary incontinence.
摘要翻译：提供了通过在尿道壁的粘膜和粘膜下层之间的界面处注射填充剂来治疗女性尿失禁的装置和方法。重塑装置包括细长轴，优选地具有用于形成尿道壁的局部向内突出的装置，以及可在缩回和展开位置之间移动的针，用于将填充剂输送到局部向内突出部附近的尿道壁中，从而减少或消除与尿失禁相关的症状。

7. 发明授权

US5816095A Bending tool 失效
标题翻译：弯曲工具
公开(公告)号：US5816095A
公开(公告)日：1998-10-06
申请号：US941403
申请日：1997-09-30
申请人： Benjamin T. Nordell, II , Rick T. Smethers
发明人： Benjamin T. Nordell, II , Rick T. Smethers
IPC分类号： A61M5/32 , A61M5/34 , B21D7/06 , B21D7/022
CPC分类号： B21D7/063 , A61B18/1477 , A61B2018/1475 , A61M2005/341 , A61M5/32
摘要： A bending tool for use with a human hand for bending the distal extremity of a guide tube of a medical device having a needle assembly slidably mounted in the guide tube. The distal extremity of the guide tube has a tip. The bending tool is comprised of a shaft sized so that it is adapted to be grasped by the human hand to serve as a handle. The shaft has proximal and distal extremities and a longitudinal axis. A bending construction is mounted on the distal extremity of the shaft and provides a curved bending surface having width and a length and having a proximal and a distal extremity and extending at an angle with respect to the longitudinal axis. The bending construction also has an abutment surface at the distal extremity of the curved surface and extending generally perpendicular to the curved surface. The abutment surface has a hole therein extending in a direction generally perpendicular to the abutment surface and is sized so that it is adapted to receive the tip of the guide tube with the guide tube engaging the curved surface to permit bending of the guide tube by a swinging movement of the shaft in a direction at right angles to the abutment surface.
摘要翻译：一种用于人用手弯曲医疗装置的导管的远端的弯曲工具，其具有可滑动地安装在引导管中的针组件。导管的远端具有尖端。弯曲工具包括轴，其尺寸使得其适于被人的手抓住以用作手柄。轴具有近端和远端以及纵轴。弯曲结构安装在轴的远端上，并且提供具有宽度和长度的弯曲弯曲表面，并且具有近端和远端并且相对于纵向轴线以一定角度延伸。弯曲结构还在弯曲表面的远端处具有邻接表面并且大致垂直于弯曲表面延伸。邻接表面具有在大致垂直于邻接表面的方向上延伸的孔，并且其尺寸设计成使得其适于接收引导管的尖端，导管与弯曲表面接合以允许引导管弯曲轴在与邻接表面成直角的方向上摆动。

8. 发明授权

US5604130A Releasable multiwell plate cover 失效
标题翻译：可拆卸的多孔板盖
公开(公告)号：US5604130A
公开(公告)日：1997-02-18
申请号：US451025
申请日：1995-05-31
申请人： Brian D. Warner , Benjamin T. Nordell , Bruce J. Richardson , Amer El-Hage
发明人： Brian D. Warner , Benjamin T. Nordell , Bruce J. Richardson , Amer El-Hage
IPC分类号： C12M1/00 , B01L3/00 , B01L3/14 , G01N1/10 , G01N35/02 , C12M1/02 , C12M1/38
CPC分类号： B01L3/50851 , B01L3/50825 , B01L3/50853
摘要： A cover effective to releasably seal a multiwell container, such as a microtitration plate, is disclosed. The cover contains a pad, fashioned from a flexible polymer sheet, and a plurality of resiliently compressible ridges formed on the sheet. The ridges are deformable, such that application of pressure applied to the cover is effective to form a fluid-tight seal between the pad and the well openings. The ridges extend from the pad sufficiently to break the seal upon release of the pressure.
摘要翻译：公开了一种有效地可释放地密封诸如微量滴定板的多孔容器的盖子。该盖包括由柔性聚合物片制成的垫，以及形成在片上的多个可弹性压缩的脊。脊可变形，使得施加到盖上的压力有效地在垫和孔开口之间形成流体密封。脊从垫充分延伸，以释放压力而破坏密封。

9. 发明授权

US07722338B2 Peristaltic pump providing simplified loading and improved tubing kink resistance 有权
标题翻译：蠕动泵提供简化的负载和改善的扭结线圈阻力
公开(公告)号：US07722338B2
公开(公告)日：2010-05-25
申请号：US11056086
申请日：2005-02-10
申请人： Benjamin T. Nordell , Peter S. Edelstein , Simon W. H. Thomas
发明人： Benjamin T. Nordell , Peter S. Edelstein , Simon W. H. Thomas
IPC分类号： F04B45/06 , F04B43/12 , F04B43/08
CPC分类号： F04B43/1253
摘要： A peristaltic pump is provided that simplifies the loading of tubing and automatically self-centers the tubing relative to the pump wheel, wherein the pump includes an elongated arm having slotted pinch forks for engaging the tubing. The pinch forks are arranged substantially tangential to the pump wheel to reduce tubing kinking. The pump further includes a spring-loaded clamp that moves the elongated arm between engaged and disengaged positions, the clamp optionally including a sensor element used to detect when the pump is ready for operation.
摘要翻译：提供了一种蠕动泵，其简化了管道的装载并且自动使管道相对于泵轮自中心，其中泵包括细长的臂，其具有用于接合管道的开槽的夹紧叉。夹紧叉布置成基本上与泵轮相切，以减少油管扭结。泵还包括弹簧加载的夹具，其将细长臂移动在接合位置和脱离位置之间，夹具可选地包括用于检测泵何时准备运行的传感器元件。

10. 发明授权

US07306591B2 Apparatus and methods for treating female urinary incontinence 有权
公开(公告)号：US07306591B2
公开(公告)日：2007-12-11
申请号：US10273900
申请日：2002-10-16
申请人： Simon W. H. Thomas , Peter S. Edelstein , John T. To , Benjamin T. Nordell
发明人： Simon W. H. Thomas , Peter S. Edelstein , John T. To , Benjamin T. Nordell
IPC分类号： A61B18/18
CPC分类号： A61B18/00 , A61B17/0625 , A61B18/02 , A61B18/14 , A61B18/1477 , A61B18/1485 , A61B2017/00805 , A61B2017/00867 , A61B2018/00029 , A61B2018/00035 , A61B2018/00178 , A61B2018/00285 , A61B2018/00523 , A61B2018/00553 , A61B2018/00559 , A61B2018/00916 , A61B2018/1425 , A61B2018/143 , A61B2218/007 , A61N1/06 , A61N7/022 , C08L2201/12
摘要： Apparatus and methods are provided for treating female urinary incontinence by applying a form of energy to tissue in the vicinity of the urethra and/or bladder outlet to change tissue compliance without substantially narrowing the urethral and/or bladder outlet lumen. The apparatus comprises an elongated shaft having a means for treating urethral tissue and an expandable member deployable distal of the means for treating. The expandable member is configured to be anchored against the bladder outlet to dispose the means for treating at a desired treatment site in the urethra using only tactile feedback. The means for treating may include a needleless RF electrode, an ultrasound transducer, or a cryogenic probe configured to be advanced through a hollow needle, each of which are designed to reduce or eliminate symptoms associated with urinary incontinence.

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