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1. 发明授权

US5400354A Laminated upper cladding structure for a light-emitting device 失效
标题翻译：用于发光器件的层压上包层结构
公开(公告)号：US5400354A
公开(公告)日：1995-03-21
申请号：US193681
申请日：1994-02-08
申请人： Michael Ludowise , Nick Holonyak, Jr. , Stephen J. Caracci , Michael R. Krames , Fred A. Kish
发明人： Michael Ludowise , Nick Holonyak, Jr. , Stephen J. Caracci , Michael R. Krames , Fred A. Kish
IPC分类号： H01L21/338 , H01L21/74 , H01L21/8252 , H01L29/10 , H01L29/51 , H01L33/30 , H01S5/00 , H01S5/20 , H01S5/22 , H01S5/223 , H01S5/323 , H01S3/19
CPC分类号： H01L29/513 , H01L21/746 , H01L21/8252 , H01L29/1054 , H01L29/517 , H01L29/66863 , H01L33/30 , H01S5/20 , H01S5/22 , H01S5/2231 , H01S5/2059 , H01S5/2205 , H01S5/2214 , H01S5/32391
摘要： A fabrication method for providing a semiconductor light-emitting device includes growing a plurality of layers on a semiconductor substrate, including forming a lower cladding layer and an active region for generating lightwaves. A laminated cladding structure is formed on the active region. The laminated cladding structure includes a lower layer that is substantially aluminum-free to inhibit oxidation and includes an upper layer that is aluminum-bearing in order to promote oxidation. The upper layer of the lamination is oxidized along selected first regions and is selectively masked to prevent oxidation for second regions. The oxidation of the first region is carried out under conditions such that a native oxide is formed throughout the thickness of the first regions. Electrical current to the active region for operating the light-emitting device is channeled via the unoxidized region of the upper layer of the lamination. In a preferred embodiment, the device is an InGaAsP-AlInAs-InP laser. Other electronic devices, such as FETs, can be also formed using the top-down approach. Preferably, oxidation is limited to an upper III-V semiconductor layer by forming a lower III-V semiconductor layer that includes In and/or P. Lateral oxidation can also be realized using this approach.
摘要翻译：一种用于提供半导体发光器件的制造方法包括在半导体衬底上生长多个层，包括形成下覆盖层和用于产生光波的有源区。在有源区上形成层叠包层结构。层压包覆结构包括基本上不含铝的下层以抑制氧化，并且包括为了促进氧化而成为铝的上层。叠层的上层被沿选定的第一区氧化，并被选择性地掩蔽以防止第二区的氧化。第一区域的氧化在使得在第一区域的整个厚度上形成天然氧化物的条件下进行。通过层压的上层的未氧化区域引导到用于操作发光器件的有源区的电流。在优选实施例中，器件是InGaAsP-AlInAs-InP激光器。也可以使用自顶向下的方法形成诸如FET的其它电子器件。优选地，通过形成包括In和/或P的下III-V半导体层，氧化被限制在上III-V半导体层。也可以使用这种方法实现侧向氧化。

2. 发明申请

US20090247427A1 LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD 失效
标题翻译：无标签的高通量生物分子筛选系统和方法
公开(公告)号：US20090247427A1
公开(公告)日：2009-10-01
申请号：US12480886
申请日：2009-06-09
申请人： Stephen J. Caracci , Volker H.O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
发明人： Stephen J. Caracci , Volker H.O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
IPC分类号： C40B60/12
CPC分类号： G01N35/028 , G01N2035/00158 , G01N2035/00356 , G01N2035/0097
摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.
摘要翻译：本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。

3. 发明授权

US5403775A Method of making semiconductor devices and techniques for controlled optical confinement 失效
标题翻译：制造半导体器件的方法和控制光限制的技术
公开(公告)号：US5403775A
公开(公告)日：1995-04-04
申请号：US260067
申请日：1994-06-15
申请人： Nick Holonyak, Jr. , Fred A. Kish , Stephen J. Caracci
发明人： Nick Holonyak, Jr. , Fred A. Kish , Stephen J. Caracci
IPC分类号： H01L21/316 , H01S5/026 , H01S5/10 , H01S5/40 , H01L21/20
CPC分类号： H01L21/02178 , H01L21/02241 , H01L21/02255 , H01L21/31666 , H01S5/10 , H01S5/1021 , H01S5/026 , H01S5/1028 , H01S5/1071 , H01S5/4031 , H01S5/4056 , H01S5/4068
摘要： The disclosure is directed to improved techniques and devices employing an aluminum-bearing III-V semiconductor material and a native oxide of aluminum that is formed in the semiconductor material. Effective optical confinement, tailored to obtain desired operating conditions, can be achieved with a thick native oxide of aluminum that extends through at least one-third of the thickness of the aluminum-bearing layer in which the native oxide is formed. The resultant lateral index step can be made quite large and employed for devices such as ring lasers.
摘要翻译：本公开涉及采用铝 - III型半导体材料和形成在半导体材料中的铝的天然氧化物的改进的技术和装置。用于获得所需操作条件而定制的有效光学限制可以通过延伸穿过其中形成天然氧化物的含铝层的厚度的至少三分之一的厚的铝的自然氧化物来实现。所得到的横向折射率步骤可以做得相当大，并且用于诸如环形激光器的器件。

4. 发明申请

US20120010105A1 LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD 审中-公开
标题翻译：无标签的高通量生物分子筛选系统和方法
公开(公告)号：US20120010105A1
公开(公告)日：2012-01-12
申请号：US13237316
申请日：2011-09-20
申请人： Stephen J. Caracci , Volker H.O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
发明人： Stephen J. Caracci , Volker H.O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
IPC分类号： C40B60/12 , C40B30/10 , C40B30/00
CPC分类号： G01N35/028 , G01N2035/00158 , G01N2035/00356 , G01N2035/0097
摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.
摘要翻译：本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。

5. 发明申请

US20100105148A1 MULTI-CHANNEL SWEPT WAVELENGTH OPTICAL INTERROGATION SYSTEM AND METHOD FOR USING SAME 失效
标题翻译：多信道切换波长光学系统及其使用方法
公开(公告)号：US20100105148A1
公开(公告)日：2010-04-29
申请号：US12256852
申请日：2008-10-23
申请人： Stephen J. Caracci , Michael J. Dailey, JR. , William J. Miller , Robert A. Modavis , Deepti J. Mudaliar , David A. Pastel , Michael B. Webb , Qi Wu
发明人： Stephen J. Caracci , Michael J. Dailey, JR. , William J. Miller , Robert A. Modavis , Deepti J. Mudaliar , David A. Pastel , Michael B. Webb , Qi Wu
IPC分类号： G01N21/00 , G01N21/45 , G01N21/41
CPC分类号： G01N21/253 , G01N21/39 , G01N21/45
摘要： A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation system comprises: (a) a tunable laser that emits an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period; (b) a distribution unit that splits the optical beam into a plurality of interrogation beams; (c) an array of optical interrogation units that receive and direct the interrogation beams towards an array of biosensors; (d) the array of optical interrogation units receive a plurality of reflected interrogation beams from the array of biosensors; (e) a data processing device that receives and processes information associated with the reflected interrogation beams to determine for example whether or not there was a biochemical interaction on anyone of the biosensors.
摘要翻译：本文描述了多通道扫频波长光询问系统和方法，其能够询问一个或多个生物传感器，例如其可位于微板的孔内。在一个实施例中，光学询问系统包括：（a）可调激光器，其在预定时间段内发射具有预定的不同波长序列的光束; （b）分配单元，其将光束分成多个询问光束; （c）光学询问单元的阵列，其接收并将询问光束定向到生物传感器的阵列; （d）光学询问单元的阵列从生物传感器阵列接收多个反射询问光束; （e）数据处理装置，其接收和处理与所反映的询问光束相关联的信息，以确定例如生物传感器中任何一个生化交互是否存在。

6. 发明申请

US20080213481A1 Method for creating a reference region and a sample region on a biosensor 审中-公开
标题翻译：用于在生物传感器上产生参考区域和样品区域的方法
公开(公告)号：US20080213481A1
公开(公告)日：2008-09-04
申请号：US12151510
申请日：2008-05-07
申请人： Stephen J. Caracci , Anthony G. Frutos , Jinlin Peng , Garrett A. Piech , Michael B. Webb
发明人： Stephen J. Caracci , Anthony G. Frutos , Jinlin Peng , Garrett A. Piech , Michael B. Webb
IPC分类号： B05D1/02 , B05D5/00 , B05D1/36
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00315 , B01J2219/00367 , B01J2219/00378 , B01J2219/00382 , B01J2219/00385 , B01J2219/00387 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00662 , B01J2219/00677 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01L2200/12 , B01L2200/148 , B01L2300/0636 , B01L2300/0829 , G01N21/553 , G01N21/7743 , G01N2035/00158
摘要： A method is described herein that can use any one of a number of deposition techniques to create a reference region and a sample region on a single biosensor which in the preferred embodiment is located within a single well of a microplate. The deposition techniques that can be used to help create the reference region and the sample region on a surface of the biosensor include: (1) the printing/stamping of a deactivating agent on a reactive surface of the biosensor; (2) the printing/stamping of a target molecule (target protein) on a reactive surface of the biosensor; or (3) the printing/stamping of a reactive agent on an otherwise unreactive surface of the biosensor.
摘要翻译：本文描述的方法可以使用多个沉积技术中的任何一种来在单个生物传感器上产生参考区域和样品区域，其在优选实施例中位于微板的单个孔内。可用于帮助创建生物传感器表面上的参考区域和样品区域的沉积技术包括：（1）在生物传感器的反应性表面上印刷/冲压钝化剂; （2）生物传感器的反应性表面上的靶分子（靶蛋白）的印刷/印模; 或（3）在生物传感器的其它非反应性表面上印刷/冲压反应剂。

7. 发明授权

US06928226B2 Fiber and lens grippers, optical devices and methods of manufacture 失效
标题翻译：纤维和镜片夹具，光学装置和制造方法
公开(公告)号：US06928226B2
公开(公告)日：2005-08-09
申请号：US10188584
申请日：2002-07-03
申请人： Stephen J. Caracci , Adam J. Fusco , Cheng-Chung Li
发明人： Stephen J. Caracci , Adam J. Fusco , Cheng-Chung Li
IPC分类号： G02B6/26 , G02B6/32 , G02B6/35 , G02B6/36 , G02B6/00
CPC分类号： G02B6/3582 , G02B6/262 , G02B6/264 , G02B6/266 , G02B6/32 , G02B6/351 , G02B6/3512 , G02B6/3532 , G02B6/3546 , G02B6/3636 , G02B6/364
摘要： Articles and methods for positioning lensed fiber elements and optical devices are disclosed. The articles and methods include a lens gripping element and a fiber gripping element disposed on a planar substrate. The articles and methods are useful for manufacturing optical fiber and lens arrays and waveguide devices.
摘要翻译：公开了用于定位透镜光纤元件和光学器件的物品和方法。制品和方法包括设置在平面基板上的透镜夹持元件和纤维夹紧元件。制品和方法对于制造光纤和透镜阵列和波导器件是有用的。

8. 发明授权

US06571033B2 Optical signal device 失效
标题翻译：光信号装置
公开(公告)号：US06571033B2
公开(公告)日：2003-05-27
申请号：US09966941
申请日：2001-09-28
申请人： Stephen J. Caracci , Sean M. Garner , Xuequn Hu , Edward L. Jones
发明人： Stephen J. Caracci , Sean M. Garner , Xuequn Hu , Edward L. Jones
IPC分类号： G02B6293
CPC分类号： G02B6/2938 , G02B6/29362 , G02B6/32 , G02B6/4215 , G02B6/4236 , G02B6/4237 , G02B6/4245 , G02B6/4246 , G02B6/4249 , G02B6/4259 , G02B6/4267
摘要： The present invention is an optical signal device having transceiver elements and interference filters held in a transparent mounting structure. The interference filters are deposited onto prisms, and may be individually held in the mounting structure, or assembled together as a subassembly. The present invention is especially useful as a transceiver for local area network and fiber to the home applications.
摘要翻译：本发明是一种光信号装置，其具有保持在透明安装结构中的收发器元件和干涉滤光器。干涉滤光器沉积在棱镜上，并且可以单独地保持在安装结构中，或者作为子组件组装在一起。本发明特别用作用于局域网和用于家庭应用的光纤的收发器。

9. 发明授权

US06563973B1 Low-index waveguide liquid crystal cross-connect 失效
标题翻译：低折射率波导液晶交叉连接
公开(公告)号：US06563973B1
公开(公告)日：2003-05-13
申请号：US09604039
申请日：2000-06-27
申请人： Stephen J. Caracci , Thomas M. Leslie , Robert G. Lindquist , Rui-Qing Ma , James V. Suggs
发明人： Stephen J. Caracci , Thomas M. Leslie , Robert G. Lindquist , Rui-Qing Ma , James V. Suggs
IPC分类号： G02B635
CPC分类号： G02F1/1326 , G02B6/353 , G02B6/3542 , G02B6/3546 , G02B6/3594 , G02F1/3137 , G02F2203/06
摘要： A non-blocking N×N cross-connect is provided that has an array of liquid crystal (LC) switches in a grid of planar optical waveguides within a light optical circuit (LOC). LC-filled trenches are used in a planar optical waveguide and each trench provides the functionality of a waveguide polarization splitter, a transverse electric (TE) switch cross-point, a transverse magnetic (TM) switch cross-point, or a waveguide polarization combiner. The planar optical waveguide has a refractive index substantially equal to the lowest index of refraction of the LC material. By combining these elements, a cross-connect system is fabricated. Also disclosed is a dynamically adjustable prism constructed with a liquid crystal material.
摘要翻译：提供了一种非阻塞NxN交叉连接，其在光学光学电路（LOC）内的平面光波导网格中具有液晶（LC）开关阵列。 LC平面光波导中使用LC填充的沟槽，并且每个沟槽提供波导偏振分离器，横向电（TE）开关交叉点，横向磁（TM）开关交叉点或波导偏振组合器。平面光波导的折射率基本上等于LC材料的最低折射率。通过组合这些元件，制造了交叉连接系统。还公开了一种用液晶材料构成的动态可调棱镜。

10. 发明授权

US06445838B1 Tunable optical component 失效
标题翻译：可调谐光学元件
公开(公告)号：US06445838B1
公开(公告)日：2002-09-03
申请号：US09676413
申请日：2000-09-29
申请人： Stephen J. Caracci , John D. Downie , Sean M. Garner , Christophe Nicolas
发明人： Stephen J. Caracci , John D. Downie , Sean M. Garner , Christophe Nicolas
IPC分类号： G02B612
CPC分类号： G02B6/29358 , G02B6/29359 , G02B6/29389 , G02B6/29395 , G02B6/3636 , G02B6/3652
摘要： Multiple uses are made available with an optical component (10) that is based on a fiber Fabry-Perot resonator (12). The optical component (10) includes substrate (14) having a variable length (16) for supporting and tuning the Fabry-Perot resonator (12) by varying the variable length (16) of the substrate (14) in response to a variable stimulus. A plurality of fiber retainers (22) are disposed on the substrate (14) for mounting and aligning the fiber Fabry-Perot resonator (12). To fix the position of the fiber Fabry-Perot resonator (12) relative to the substrate (14) and to define the variable length (16), a pair of binders (24) are disposed on the substrate (14) proximate selected opposed pairs (221 and 222) of the plurality of the fiber retainers (22).
摘要翻译：使用基于光纤法布里 - 珀罗谐振器（12）的光学部件（10）可用多种用途。光学部件（10）包括具有可变长度（16）的衬底（14），用于通过响应于可变刺激来改变衬底（14）的可变长度（16）来支撑和调谐法布里 - 珀罗谐振器（12）。多个光纤保持器（22）设置在基板（14）上，用于安装和对准纤维法布里 - 珀罗（Straffer-Perot）谐振器（12）。为了固定纤维法布里 - 珀罗共振器（12）相对于基底（14）的位置并且限定可变长度（16），一对粘合剂（24）设置在基底（14）上，邻近选定的相对对（221）和多个光纤保持器（22）。

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