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1. 发明申请

US20120010105A1 LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD 审中-公开
标题翻译：无标签的高通量生物分子筛选系统和方法
公开(公告)号：US20120010105A1
公开(公告)日：2012-01-12
申请号：US13237316
申请日：2011-09-20
申请人： Stephen J. Caracci , Volker H.O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
发明人： Stephen J. Caracci , Volker H.O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
IPC分类号： C40B60/12 , C40B30/10 , C40B30/00
CPC分类号： G01N35/028 , G01N2035/00158 , G01N2035/00356 , G01N2035/0097
摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.
摘要翻译：本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。

2. 发明授权

US06834138B2 Modular optical switch fabric 失效
标题翻译：模块化光交换矩阵
公开(公告)号：US06834138B2
公开(公告)日：2004-12-21
申请号：US10061766
申请日：2001-10-26
申请人： Mark F. Krol , Manish Sharma
发明人： Mark F. Krol , Manish Sharma
IPC分类号： G02B635
CPC分类号： G02B6/3512 , G02B6/3556 , G02B6/3582 , G02B26/0841
摘要： The present invention is a modular optical switch fabric that includes optical modules that are inserted into an optical chassis by way of plug-in electrical connectors. Each optical module includes a collimator panel and a beam steering panel secured to a frame member. The frame member is configured to position the collimator panel in fixed optical alignment relative to the beam steering panel. The modular optical switch fabric is upgradeable. The optical switch fabric allows users to expand the switch fabric capacity by simply adding switch fabric modules. The optical switch fabric also features modules that can be replaced and repaired without causing interruptions in service.
摘要翻译：本发明是一种模块化光交换结构，其包括通过插入式电连接器插入到光学机架中的光学模块。每个光学模块包括准直器面板和固定到框架构件的光束操纵面板。框架构件被配置成将准直器面板相对于光束转向面板固定光学对准。模块化光交换机面板可升级。光交换结构允许用户通过简单地添加交换矩阵模块来扩展交换矩阵的容量。光交换结构还具有可以更换和维修的模块，不会造成服务中断。

3. 发明授权

US06201237B1 Fiber optic sensor 有权
标题翻译：光纤传感器
公开(公告)号：US06201237B1
公开(公告)日：2001-03-13
申请号：US09344256
申请日：1999-06-25
申请人： George E. Berkey , Mark F. Krol , Daniel A. Nolan
发明人： George E. Berkey , Mark F. Krol , Daniel A. Nolan
IPC分类号： G01B902
CPC分类号： G01L1/242 , G01D5/344 , G01D5/3538 , G01K11/32 , G02B6/105
摘要： A fiber optic sensor for simultaneously and independently measuring temperature and axial stress. The fiber sensor includes a pair of polarization-maintaining fibers that have known strain and temperature response curves. Each fiber has a plurality of fiber segments in which the elliptical cores are rotated 45° relative to the preceding core segment. Thus, the phase shift induced by temperature or stress in each of the fibers is detected, and the strain and temperature are derived from the detected phase shift. The fiber optic sensor is capable of dual operation. As both a temperature sensor and an axial stress sensor.
摘要翻译：一种用于同时独立测量温度和轴向应力的光纤传感器。光纤传感器包括具有已知应变和温度响应曲线的一对偏振保持光纤。每个纤维具有多个纤维段，其中椭圆形芯相对于前一个芯段旋转45°。因此，检测由每个纤维中的温度或应力引起的相移，并且从所检测的相移导出应变和温度。光纤传感器能够进行双重操作。作为温度传感器和轴向应力传感器。

4. 发明申请

US20100225921A1 Screening system and method for analyzing a plurality of biosensors 有权
标题翻译：用于分析多个生物传感器的筛选系统和方法
公开(公告)号：US20100225921A1
公开(公告)日：2010-09-09
申请号：US11521771
申请日：2006-09-15
申请人： Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
发明人： Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
IPC分类号： G01N1/28 , G01N1/10 , G01B9/02 , G01J3/45 , G01N21/55
CPC分类号： G01N35/028 , G01J3/453 , G01N21/0332 , G01N21/553 , G01N21/7743 , G01N2035/00346 , G01N2035/00366
摘要： A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.
摘要翻译：本文描述了一种筛选装置和方法，其可以自动地处理和询问多个传感器载体（即，多孔板，微孔板），其具有多维布置的，温度补偿的或可温度补偿的光学传感器，同时保持在对传感器载体进行温度补偿的光学传感器周围相当长的周期内的基本恒定的温度梯度。

5. 发明申请

US20090247427A1 LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD 失效
标题翻译：无标签的高通量生物分子筛选系统和方法
公开(公告)号：US20090247427A1
公开(公告)日：2009-10-01
申请号：US12480886
申请日：2009-06-09
申请人： Stephen J. Caracci , Volker H.O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
发明人： Stephen J. Caracci , Volker H.O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
IPC分类号： C40B60/12
CPC分类号： G01N35/028 , G01N2035/00158 , G01N2035/00356 , G01N2035/0097
摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.
摘要翻译：本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。

6. 发明授权

US06370286B1 Tunable periodic filter 有权
标题翻译：可调周期滤波器
公开(公告)号：US06370286B1
公开(公告)日：2002-04-09
申请号：US09356217
申请日：1999-07-16
申请人： Mark F. Krol , Qi Wu
发明人： Mark F. Krol , Qi Wu
IPC分类号： G02B600
CPC分类号： G02B6/272 , G02B6/2706 , G02B6/2766 , G02B6/2773 , G02B6/29302 , G02B6/2935 , G02B6/29395
摘要： A polarization-interferometry based tunable periodic filter includes polarization defining components such as polarizing beam splitters or polarizing beam displacers located on the input and output sides of a phase retarder such as a birefringent crystal. A polarization independent input consisting of multiple optical channels having a periodic frequency spacing is converted to a branched output of optical channels in which each branch has a periodic frequency spacing that is different from that of the input, and which are interleaved with each other. The output period is tunable by adjusting the phase delay of orthogonal polarization components. A contrast ratio of ≧20 dB can be realized. The device allows the mux/demux of up to 200 WDM channels with a 50 GHz frequency spacing. Applications of the device include a band splitter, a wavelength selective cross-connect, and a wavelength monitor.
摘要翻译：基于偏振干涉测量的可调周期滤波器包括极化限定部件，例如位于诸如双折射晶体的相位延迟器的输入和输出侧上的偏振分束器或偏振光束位移器。由具有周期性频率间隔的多个光信道组成的偏振无关输入被转换成光信道的分支输出，其中每个分支具有与输入不同的周期性频率间隔，并且彼此交错。通过调整正交偏振分量的相位延迟可以调节输出周期。可以实现> = 20dB的对比度。该器件允许多达200个WDM通道的多路复用/解复用，频率间距为50 GHz。该装置的应用包括带分离器，波长选择性交叉连接和波长监视器。

7. 发明授权

US06351586B1 Wavelength dependent phase delay device 失效
标题翻译：波长相关相位延迟器件
公开(公告)号：US06351586B1
公开(公告)日：2002-02-26
申请号：US09473665
申请日：1999-12-29
申请人： Mark F Krol , Yongqian Liu
发明人： Mark F Krol , Yongqian Liu
IPC分类号： G02B626
CPC分类号： G02B6/29353 , G02F1/225 , G02F1/2252 , G02F2201/307
摘要： A Mach-Zehnder device includes a delay element in one arm which delays propagation of light at a first wavelength relative to propagation of light at a second wavelength. The delay element may be made up of a grating having a period which causes coupling of the first wavelength from a first mode into a second mode. In another aspect, the invention includes a second grating positioned downstream from the first grating and having a period which causes coupling of the portion of light from the second propagation mode back into the first propagation mode. Also disclosed is an optical waveguide in which light at a wavelength &lgr; can propagate in at least a first and a second mode. The waveguide has an effective index of refraction n1 with respect to the first propagation mode of &lgr;, and an effective index of refraction n2 with respect to the second propagation mode. A grating formed in said waveguide and having a period approximately equal to(&lgr;/2)(n1−n2).
摘要翻译：马赫 - 策德尔（Mach-Zehnder）装置包括一个臂中的延迟元件，该延迟元件相对于在第二波长处的光的传播来延迟第一波长的光的传播。延迟元件可以由具有使第一波长从第一模式耦合到第二模式的周期的光栅组成。在另一方面，本发明包括位于第一光栅下游的第二光栅，并且具有使来自第二传播模式的光部分的耦合返回到第一传播模式的周期。还公开了一种光波导，其中波长λ的光可以在至少第一和第二模式中传播。波导相对于羔羊的第一传播模式具有有效折射率n1，相对于第二传播模式具有有效的折射率n2。形成在所述波导中并且具有大约等于（lambd / 2）（n1-n2）的周期的光栅。

8. 发明授权

US06344911B1 Upgradable optical communication system module 失效
标题翻译：可升级光通信系统模块
公开(公告)号：US06344911B1
公开(公告)日：2002-02-05
申请号：US09474887
申请日：1999-12-29
申请人： Michael J. Dailey, Jr. , James J. Watkins , Mark F. Krol
发明人： Michael J. Dailey, Jr. , James J. Watkins , Mark F. Krol
IPC分类号： H04J1402
CPC分类号： G02B6/3897 , G02B6/29317 , G02B6/2935 , G02B6/29361 , G02B6/3502 , G02B6/3574 , G02B6/3582 , G02B6/4452
摘要： An component upgradable optical communications routing system using a base module and detachable opto-electronic modules for use in processing and directing optical signals in an optical communications system.
摘要翻译：一种使用基本模块和可拆卸光电模块的组件可升级光通信路由系统，用于在光通信系统中处理和引导光信号。

9. 发明授权

US6075907A Dual wavelength interrogation sensor employing long-period gratings 失效
标题翻译：采用长周期光栅的双波长询问传感器
公开(公告)号：US6075907A
公开(公告)日：2000-06-13
申请号：US149365
申请日：1998-09-08
申请人： Mark F. Krol
发明人： Mark F. Krol
IPC分类号： G01D5/353 , G01L1/24 , G02B6/00
CPC分类号： G01L1/246 , G01D5/35335 , G01D5/35387 , G01D5/3539
摘要： A sensor system based on Long Period Gratings (LPGs) and a dual-wavelength interrogation scheme for sensing changes in a physical parameter such as temperature or strain. The system comprises a dual-wavelength laser light source, an optical waveguide for propagating the light, a long-period grating disposed in the path of the light, and a detector and processor for correlating a change in resonance wavelength with a numerical value for the physical parameter sensed. Additionally, multiple sensor elements are easily multiplexed by either time-division techniques or optical time domain reflectometry.
摘要翻译：基于长周期光栅（LPG）的传感器系统和用于感测物理参数（如温度或应变）变化的双波长询问方案。该系统包括双波长激光光源，用于传播光的光波导，设置在光路中的长周期光栅;以及检测器和处理器，用于将谐振波长的变化与数值相关联物理参数检测。此外，多个传感器元件可以通过时分技术或光时域反射测量轻松复用。

10. 发明授权

US08231268B2 Screening system and method for analyzing a plurality of biosensors 有权
标题翻译：用于分析多个生物传感器的筛选系统和方法
公开(公告)号：US08231268B2
公开(公告)日：2012-07-31
申请号：US13034214
申请日：2011-02-24
申请人： Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
发明人： Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
IPC分类号： G01K3/00 , G01K7/00 , G01K11/00 , G01K1/00
CPC分类号： G01N35/028 , G01J3/453 , G01N21/0332 , G01N21/553 , G01N21/7743 , G01N2035/00346 , G01N2035/00366
摘要： A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.
摘要翻译：本文描述了一种筛选装置和方法，其可以自动地处理和询问多个传感器载体（即，多孔板，微孔板），其具有多维布置的，温度补偿的或可温度补偿的光学传感器，同时保持在对传感器载体进行温度补偿的光学传感器周围相当长的周期内的基本恒定的温度梯度。

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