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1. 发明申请

US20100105148A1 MULTI-CHANNEL SWEPT WAVELENGTH OPTICAL INTERROGATION SYSTEM AND METHOD FOR USING SAME 失效
标题翻译：多信道切换波长光学系统及其使用方法
公开(公告)号：US20100105148A1
公开(公告)日：2010-04-29
申请号：US12256852
申请日：2008-10-23
申请人： Stephen J. Caracci , Michael J. Dailey, JR. , William J. Miller , Robert A. Modavis , Deepti J. Mudaliar , David A. Pastel , Michael B. Webb , Qi Wu
发明人： Stephen J. Caracci , Michael J. Dailey, JR. , William J. Miller , Robert A. Modavis , Deepti J. Mudaliar , David A. Pastel , Michael B. Webb , Qi Wu
IPC分类号： G01N21/00 , G01N21/45 , G01N21/41
CPC分类号： G01N21/253 , G01N21/39 , G01N21/45
摘要： A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation system comprises: (a) a tunable laser that emits an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period; (b) a distribution unit that splits the optical beam into a plurality of interrogation beams; (c) an array of optical interrogation units that receive and direct the interrogation beams towards an array of biosensors; (d) the array of optical interrogation units receive a plurality of reflected interrogation beams from the array of biosensors; (e) a data processing device that receives and processes information associated with the reflected interrogation beams to determine for example whether or not there was a biochemical interaction on anyone of the biosensors.
摘要翻译：本文描述了多通道扫频波长光询问系统和方法，其能够询问一个或多个生物传感器，例如其可位于微板的孔内。在一个实施例中，光学询问系统包括：（a）可调激光器，其在预定时间段内发射具有预定的不同波长序列的光束; （b）分配单元，其将光束分成多个询问光束; （c）光学询问单元的阵列，其接收并将询问光束定向到生物传感器的阵列; （d）光学询问单元的阵列从生物传感器阵列接收多个反射询问光束; （e）数据处理装置，其接收和处理与所反映的询问光束相关联的信息，以确定例如生物传感器中任何一个生化交互是否存在。

2. 发明授权

US07999944B2 Multi-channel swept wavelength optical interrogation system and method for using same 失效
标题翻译：多通道扫波波长光询问系统及其使用方法
公开(公告)号：US07999944B2
公开(公告)日：2011-08-16
申请号：US12256852
申请日：2008-10-23
申请人： Stephen J. Caracci , Michael J. Dailey, Jr. , William J. Miller , Robert A. Modavis , Deepti J. Mudaliar , David A. Pastel , Michael B. Webb , Qi Wu
发明人： Stephen J. Caracci , Michael J. Dailey, Jr. , William J. Miller , Robert A. Modavis , Deepti J. Mudaliar , David A. Pastel , Michael B. Webb , Qi Wu
IPC分类号： G01N21/55
CPC分类号： G01N21/253 , G01N21/39 , G01N21/45
摘要： A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation system comprises: (a) a tunable laser that emits an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period; (b) a distribution unit that splits the optical beam into a plurality of interrogation beams; (c) an array of optical interrogation units that receive and direct the interrogation beams towards an array of biosensors; (d) the array of optical interrogation units receive a plurality of reflected interrogation beams from the array of biosensors; (e) a data processing device that receives and processes information associated with the reflected interrogation beams to determine for example whether or not there was a biochemical interaction on anyone of the biosensors.
摘要翻译：本文描述了多通道扫频波长光询问系统和方法，其能够询问一个或多个生物传感器，例如其可位于微板的孔内。在一个实施例中，光学询问系统包括：（a）可调激光器，其在预定时间段内发射具有预定的不同波长序列的光束; （b）分配单元，其将光束分成多个询问光束; （c）光学询问单元的阵列，其接收并将询问光束定向到生物传感器的阵列; （d）光学询问单元的阵列从生物传感器阵列接收多个反射询问光束; （e）数据处理装置，其接收和处理与所反映的询问光束相关联的信息，以确定例如生物传感器中任何一个生化交互是否存在。

3. 发明申请

US20090219540A1 OPTICAL INTERROGATION SYSTEM AND METHOD FOR USING SAME 失效
标题翻译：光学互连系统及其使用方法
公开(公告)号：US20090219540A1
公开(公告)日：2009-09-03
申请号：US12402901
申请日：2009-03-12
申请人： Robert A. Modavis , Qi Wu , Stephen J. Caracci , David A. Pastel
发明人： Robert A. Modavis , Qi Wu , Stephen J. Caracci , David A. Pastel
IPC分类号： G01N21/55
CPC分类号： G01N21/253 , G01N21/39 , G01N21/7743 , G01N2021/4742 , G01N2201/08
摘要： An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.
摘要翻译：本文描述了光学询问系统和方法，其能够询问可以位于微板的孔内的一个或多个生物传感器。在一个实施例中，光学询问系统具有可调谐激光器，N-纤维发射，N型透镜和N个检测器，其被设置成询问N-生物传感器。在另一个实施例中，光学询问系统具有可调激光器，N-光纤发射，N + 1透镜和N个检测器，其被设置成询问N-生物传感器。

4. 发明授权

US07576333B2 Optical interrogation system and method for using same 失效
公开(公告)号：US07576333B2
公开(公告)日：2009-08-18
申请号：US11888495
申请日：2007-08-01
申请人： Stephen J. Caracci , Robert A. Modavis , David A. Pastel , Qi Wu
发明人： Stephen J. Caracci , Robert A. Modavis , David A. Pastel , Qi Wu
IPC分类号： G01J1/58 , G01N33/53 , G01N21/62 , C12Q1/04
CPC分类号： G01N21/253 , G01N21/39 , G01N21/7743 , G01N2021/4742 , G01N2201/08
摘要： An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.

5. 发明授权

US07741598B2 Optical interrogation system and method for using same 失效
标题翻译：光询问系统及其使用方法
公开(公告)号：US07741598B2
公开(公告)日：2010-06-22
申请号：US12402901
申请日：2009-03-12
申请人： Robert A. Modavis , Qi Wu , Stephen J. Caracci , David A. Pastel
发明人： Robert A. Modavis , Qi Wu , Stephen J. Caracci , David A. Pastel
IPC分类号： G01J1/04 , G01J1/58
CPC分类号： G01N21/253 , G01N21/39 , G01N21/7743 , G01N2021/4742 , G01N2201/08
摘要： An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.
摘要翻译：本文描述了光学询问系统和方法，其能够询问可以位于微板的孔内的一个或多个生物传感器。在一个实施例中，光学询问系统具有可调谐激光器，N-纤维发射，N型透镜和N个检测器，其被设置成询问N-生物传感器。在另一个实施例中，光学询问系统具有可调激光器，N-光纤发射，N + 1透镜和N个检测器，其被设置成询问N-生物传感器。

6. 发明申请

US20120064519A1 SYSTEM AND METHOD FOR DUAL-DETECTION OF A CELLULAR RESPONSE 审中-公开
标题翻译：用于双重检测细胞响应的系统和方法
公开(公告)号：US20120064519A1
公开(公告)日：2012-03-15
申请号：US13300029
申请日：2011-11-18
申请人： Ye Fang , Ann M. Ferrie , Joydeep Lahiri , Deepti J. Mudaliar , Qi Wu
发明人： Ye Fang , Ann M. Ferrie , Joydeep Lahiri , Deepti J. Mudaliar , Qi Wu
IPC分类号： C12Q1/68 , G01N33/566 , C12Q1/02
CPC分类号： G01N21/648 , G01N21/7743
摘要： A system and method as defined herein for dual-detection of evanescent-wave label-free light and evanescent-wave excited-fluorescent label-emitted light in an optical biosensor.
摘要翻译：本文所定义的系统和方法，用于在光学生物传感器中双重检测ev逝波无标记光和ev逝波激发荧光标记发射光。

7. 发明申请

US20090325211A1 System and method for dual-detection of a cellular response 审中-公开
标题翻译：用于双重检测细胞反应的系统和方法
公开(公告)号：US20090325211A1
公开(公告)日：2009-12-31
申请号：US12151179
申请日：2008-05-05
申请人： Ye Fang , Ann M. Ferrie , Joydeep Lahiri , Deepti J. Mudaliar , Qi Wu
发明人： Ye Fang , Ann M. Ferrie , Joydeep Lahiri , Deepti J. Mudaliar , Qi Wu
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： G01N21/648 , G01N21/7743
摘要： A system and method as defined herein for dual-detection of evanescent-wave label-free light and evanescent-wave excited-fluorescent label-emitted light in an optical biosensor.
摘要翻译：本文所定义的系统和方法，用于在光学生物传感器中双重检测ev逝波无标记光和ev逝波激发荧光标记发射光。

8. 发明授权

US08510082B2 Optimized method for LID biosensor resonance detection 失效
标题翻译： LID生物传感器共振检测的优化方法
公开(公告)号：US08510082B2
公开(公告)日：2013-08-13
申请号：US13151605
申请日：2011-06-02
申请人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
发明人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
IPC分类号： H03F1/26
CPC分类号： G01J3/28 , G01J3/02 , G01J3/0218 , G01J3/1895 , G01J3/2803 , G01N21/7743
摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.
摘要翻译：本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。在一个实施例中，光学询问系统能够询问生物传感器并使用过采样/平滑算法来减少由有问题的像素化效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件发生在生物传感器上。

9. 发明授权

US07979241B2 Optimized method for LID biosensor resonance detection 有权
标题翻译： LID生物传感器共振检测的优化方法
公开(公告)号：US07979241B2
公开(公告)日：2011-07-12
申请号：US12266060
申请日：2008-11-06
申请人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
发明人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
IPC分类号： H03F1/26
CPC分类号： G01J3/28 , G01J3/02 , G01J3/0218 , G01J3/1895 , G01J3/2803 , G01N21/7743
摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.
摘要翻译：本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。在一个实施例中，光询问系统能够询问生物传感器并使用低通滤波器算法来数字地去除包含在光学共振的光谱中的有问题的寄生反射，这使得更容易确定生物事件是否发生在生物传感器在另一个实施例中，光询问系统能够询问生物传感器并使用过采样/平滑算法来减少由问题像素化效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件发生在生物传感器上。

10. 发明申请

US20100296089A1 WAVELENGTH TRACKER FOR SWEPT WAVELENGTH SENSOR INTERROGATION SYSTEM 失效
标题翻译：用于SWEPT波长传感器互连系统的波长跟踪器
公开(公告)号：US20100296089A1
公开(公告)日：2010-11-25
申请号：US12394109
申请日：2009-02-27
申请人： Michael B. Webb , Qi Wu
发明人： Michael B. Webb , Qi Wu
IPC分类号： G01J3/28
CPC分类号： G01J3/2803 , G01J3/02 , G01J3/0208 , G01J3/4338 , G01N21/7743
摘要： A swept wavelength interrogation system includes a tunable light source for outputting a light beam that is tunable over a range of wavelengths and an optical reader head for distributing the light beam among a plurality of sensors and for measuring response spectra from the sensors. A wavelength-tracking device measures centroid wavelengths of the light beam. A processor calculates a centroid wavelength of the response spectra from the sensors based on the measured centroid wavelengths of the light beam.
摘要翻译：扫频波长询问系统包括用于输出可在波长范围内调节的光束的可调谐光源和用于在多个传感器之间分配光束并用于测量来自传感器的响应光谱的光学读取器头部。波长跟踪装置测量光束的质心波长。处理器基于所测量的光束的质心波长来计算来自传感器的响应谱的质心波长。

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