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1. 发明申请

WO2007042510A2 PROCESS FOR THE PRODUCTION OF ARACHIDONIC ACID AND/OR EICOSAPENTAENOIC ACID 审中-公开
标题翻译：生产阿卡膦酸和/或异柠檬酸的方法
公开(公告)号：WO2007042510A2
公开(公告)日：2007-04-19
申请号：PCT/EP2006067223
申请日：2006-10-10
申请人： ROTHAMSTED RES , NAPIER JOHNATHAN A , SAYANOVA OLGA
发明人： NAPIER JOHNATHAN A , SAYANOVA OLGA
IPC分类号： C12N9/02 , C12N9/10 , C12N15/82
CPC分类号： C12N15/8247 , C12N9/0083 , C12N9/1029
摘要： The present invention relates to a new process for the production of arachidonic acid and/or eicosapentaenoic acid in plants through the co-expression of a ?-12-/?-15- desaturase, ?-9-elongase, ?-8-desaturase and a ?-5-desaturase and a process for the production of lipids or oils having an increased content of unsaturated fatty acids, in particular ?-3 and ?-6 fatty acids having at least two double bonds and a 18 or 20 carbon atom chain length. Preferably the arachidonic acid and eicosapentaenoic acid are produced in at least a 1 :2 ratio. The invention furthermore relates to the production of a transgenic plants, preferably a transgenic crop plant, having an increased content of arachidonic acid and/or ei¬ cosapentaenoic acid, oils or lipids containing Ciß- or C20- fatty acids with a double bond in position ? 5, 8, 9, 11 , 12, 14, 15 or dffthe fatty acid produced, respectively due to the expression of the ?-12-/?-15-desaturase, of the ?-9-elongase, of the ?-8- desaturase and of the ?-5-desaturase in the plant. The expression of the inventive ?- 12-/?-15-desaturase leads preferably to linoleic acid and linolenic acid as products having a double bond in the position ? 9, 12 and 15 of the fatty acid. The invention additionally relates to specific nucleic acid sequences encoding for pro¬ teins with ?-12-/?-15-desaturase-, ?-9-elongase-, ?-8-desaturase- or ?-5-desaturase- activity, nucleic acid constructs, vectors and transgenic plants containing said nucleic acid sequences.
摘要翻译：本发明涉及通过共同表达α-12 /β-15-去饱和酶，α-9-延长酶，α-8-去饱和酶，在植物中生产花生四烯酸和/或二十碳五烯酸的新方法和α-5-去饱和酶的制备方法和具有增加的不饱和脂肪酸含量的脂质或油的方法，特别是具有至少两个双键和18或20个碳原子的α-3和β-6脂肪酸链长。优选花生四烯酸和二十碳五烯酸以至少1:2的比例制备。本发明还涉及生产具有增加的花生四烯酸和/或二十碳五烯酸含量的转基因植物，含有具有双键位置的C 1 -C 20或C 20 - 脂肪酸的油或脂质的转基因植物？ 5，8，9，11，12，14，15，或分别由α-12- /β-15-去饱和酶表达β-9-延伸酶而产生的α- - 去饱和酶和植物中的α-5-去饱和酶。本发明的β-12- /β-15-去饱和酶的表达优选导致亚油酸和亚麻酸作为在位置β具有双键的产物。 9,12和15的脂肪酸。本发明还涉及编码具有α-12 - /β-15-去饱和酶 - ，β-延伸酶 - ，α-8-去饱和酶或α-5-去饱和酶 - 活性的核酸的特异性核酸序列酸构建体，载体和含有所述核酸序列的转基因植物。

2. 发明申请

WO2007051577A2 METHOD FOR THE PRODUCTION OF ?-LINOLENIC ACID AND/OR STEARIDONIC ACID IN TRANSGENIC BRASSICACEAE AND LINACEAE 审中-公开
标题翻译：用于生产？亚麻酸和/或在转基因亚麻十字花科和亚麻科
公开(公告)号：WO2007051577A2
公开(公告)日：2007-05-10
申请号：PCT/EP2006010408
申请日：2006-10-30
申请人： ROTHAMSTED RES , NAPIER JOHNATHAN A , SAYANOVA OLGA , VENEGAS CALERON MONICA
发明人： NAPIER JOHNATHAN A , SAYANOVA OLGA , VENEGAS CALERON MONICA
IPC分类号： C12N15/82 , C07K14/415
CPC分类号： C12N15/8247 , C12N9/0071
摘要： The invention relates to the production of ?-linolenic acid (18:3 ?6,9,12 ) or stearidonic acid (18:4 ?6,9,12,15 ) or ?-linolenic acid (18:3 ?6,9,12 ) and stearidonic acid (18:4 ?6,9,12,15 ) in transgenic plants of the brassicaceae family, said transgenic plants containing at least 10 percent by weight of oleic acid relative to the total fatty acid concentration and being provided with an increased ?-6-C 18 fatty acid concentration as a result of the activity of the ?-6 desaturases used in the method. The invention also relates to novel nucleic acid sequences coding for the ?-6 desaturases used in the method, gene constructs containing said nucleic acid sequences, a vector and transgenic plants containing at least one nucleic acid sequence or a gene construct.
摘要翻译：本发明涉及生产亚麻酸（18：3 ^{6,9,12 ？）或者十八碳四烯酸（18：4 ^{6,9,12,15- ）？？或亚麻酸（18：3 ^{6,9,12 α）和十八碳四烯酸：在十字花科的转基因植物（18 4 ^{6,9,12,15- ）其中至少10重量％，基于油酸以总脂肪酸含量和所用的方法的类型的转基因植物的？-6-去饱和酶的？-6-C _{18 包括脂肪酸的含量增加。此外，本发明涉及编码用于在方法中使用的新颖的草坪核酸序列？-6-去饱和酶，含有包含至少一种核酸序列或基因构建这些核酸序列，载体和转基因植物的基因构建体。}}}}}

3. 发明申请

WO2004057001A3 METHOD FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS 审中-公开
标题翻译：生产聚氨酯脂肪酸的方法
公开(公告)号：WO2004057001A3
公开(公告)日：2004-11-04
申请号：PCT/EP0314054
申请日：2003-12-11
申请人： UNIV BRISTOL , NAPIER JOHNATHAN A , SAYANOVA OLGA , LAZARUS COLIN M , QI BAOXIU , HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH
发明人： NAPIER JOHNATHAN A , SAYANOVA OLGA , LAZARUS COLIN M , QI BAOXIU , HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH
IPC分类号： C12N9/02 , C12N9/10 , C12N15/82 , C12P7/64
CPC分类号： C12N9/0083 , C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to an improved process for the specific production of poly-unsaturated omega-3 and omega-6 fatty acids and a process for the production of triglycerides having an increased content of unsaturated fatty acids, in particular omega-3 and omega-6 fatty acids having at least two double bonds and a 20 or 22 carbon atom chain length. The invention relates to the produc-tion of a transgenic organism, preferably a transgenic plant or a transgenic microorganism, hav-ing an increased content of fatty acids, oils or lipids containing C20- or C22- fatty acids with a delta-5, 7, 8, 10 double bond, respectively due to the expression of a delta-8-desaturase and a delta-9- elon-gase from organisms such as plants preferably Algae like Isochrysis galbana or Euglena gracilis. In addition the invention relates to a process for the production of poly unsaturated fatty acids such as Eicosapentaenoic, Arachidonic, Docosapentaenoic or Docosahexaenoic acid through the co- expression of a delta -8-desaturase, a delta-9-elongase and a delta-5 desaturase in organisms such as microorganisms or plants.The invention additionally relates to the use of specific nucleic acid sequences encoding for the aforementioned proteins with delta-8-desaturase-, delta-9-elongase- or delta-5-desaturase-activity, nucleic acid constructs, vectors and organisms containing said nucleic acid sequences. The invention further relates to unsaturated fatty acids and triglycerides having an increased content of at least 1 % by weight of unsaturated fatty acids and use thereof.

4. 发明申请

WO2010142522A3 NOVEL FATTY ACID ELONGATION COMPONENTS AND USES THEREOF 审中-公开
标题翻译：新型脂肪酸成分及其用途
公开(公告)号：WO2010142522A3
公开(公告)日：2011-04-14
申请号：PCT/EP2010056936
申请日：2010-05-20
申请人： BASF PLANT SCIENCE CO GMBH , ROTHAMSTED RES LTD , NAPIER JONATHAN A , SAYANOVA OLGA , BEAUDOIN FREDERIC
发明人： NAPIER JONATHAN A , SAYANOVA OLGA , BEAUDOIN FREDERIC
IPC分类号： C12N15/82 , C12N9/02
CPC分类号： C12N15/8247 , C12N9/001 , C12N9/88 , C12P7/6427 , C12P7/6472
摘要： The invention provides isolated nucleic acid molecules which encodes a novel fatty acid nECR. The invention also provides recombinant expression vectors containing nECR nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA.
摘要翻译：本发明提供编码新型脂肪酸nECR的分离的核酸分子。本发明还提供了含有nECR核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及大规模生产长链多不饱和脂肪酸（LCPUFA）如ARA，EPA和DHA的方法。

5. 发明申请

WO2007093776A3 NUCLEIC ACID 审中-公开
标题翻译：核酸
公开(公告)号：WO2007093776A3
公开(公告)日：2007-12-06
申请号：PCT/GB2007000491
申请日：2007-02-13
申请人： BASF PLANT SCIENCE GMBH , NAPIER JOHNATHAN , SAYANOVA OLGA , VENEGAS CALERON MONICA
发明人： NAPIER JOHNATHAN , SAYANOVA OLGA , VENEGAS CALERON MONICA
IPC分类号： C12N15/54 , A01H5/00 , C12N15/53 , C12P7/64
CPC分类号： C12N15/8247 , C12N9/0083 , C12N9/1029 , C12P7/6427 , C12P7/6472
摘要： The invention relates to nucleic acid derived from Perkinsus marinus which encodes a 9-elongase, a ?8-desaturase and a ?5-desaturase enzyme. All of the coding sequences can be transcribed as a single transcript.
摘要翻译：本发明涉及来源于编码9-延伸酶，α8-去饱和酶和α5-去饱和酶的Perkinsus marinus的核酸。所有编码序列都可以转录为单个转录本。

6. 发明专利

CL2011003104A1 Metodo para la elaboracion de acidos grasos no saturados, basado en el cultivo de una celula que expresa un polipeptido heterologo con actividad esaturasa/enoil-coa reductasa celula huesped, complejo elongasa que comprende dicho polipeptido y uso de la misma. 未知
公开(公告)号：CL2011003104A1
公开(公告)日：2012-06-01
申请号：CL2011003104
申请日：2011-12-07
申请人： ROTHAMSTED RES LTDA
发明人： SAYANOVA OLGA , NAPIER JONATHEN A , BEAUDOIN FREDERIC
IPC分类号： C12N15/82 , C12N5/00 , C12N9/02
摘要： Polinucleótido que comprende una secuencia de ácido nucleico que codifica un polipéptido con actividad deshidratasa/enoil-coa reductasa (necr); vector; célula huésped; método de elaboración; polipéptido; método para elaborar ácidos grasos no saturados y una composición de aceite, lípidos o ácidos grasos.

7. 发明专利

AU2013326297B2 Recombinant organisms 未知
公开(公告)号：AU2013326297B2
公开(公告)日：2019-07-11
申请号：AU2013326297
申请日：2013-10-01
申请人： ROTHAMSTED RES LIMITED
发明人： NAPIER JOHNATHAN A , SAYANOVA OLGA , HAMILTON MARY , VAEZI ROYAH
IPC分类号： C12N1/00
摘要： The invention relates to genetically modified organisms with enhanced production of omega-3 long chain polyunsaturated fatty acids.

8. 发明专利

AU2013246661B2 Production of omega-3 long chain polyunsaturated fatty acids 未知
公开(公告)号：AU2013246661B2
公开(公告)日：2018-12-20
申请号：AU2013246661
申请日：2013-04-12
申请人： ROTHAMSTED RES LTD
发明人： NAPIER JOHNATHAN , SAYANOVA OLGA , LOPEZ NOEMI RUIZ , HASLAM RICHARD
IPC分类号： C12N15/82 , C12N9/02 , C12N9/10
摘要： A recombinant camelina plant or cell comprising one or more polynucleotides encoding a Δ6-desaturase, a Δ6-elongase and a Δ5-desaturase operably linked with one or more regulatory sequences.

9. 发明专利

AU2013246661A1 Production of omega-3 long chain polyunsaturated fatty acids 未知
公开(公告)号：AU2013246661A1
公开(公告)日：2014-10-16
申请号：AU2013246661
申请日：2013-04-12
申请人： ROTHAMSTED RES LTD
发明人： NAPIER JOHNATHAN , SAYANOVA OLGA , LOPEZ NOEMI RUIZ , HASLAM RICHARD
IPC分类号： C12N15/82 , C12N9/02 , C12N9/10
摘要： A recombinant camelina plant or cell comprising one or more polynucleotides encoding a &Dgr;6-desaturase, a &Dgr;6-elongase and a &Dgr;5-desaturase operably linked with one or more regulatory sequences.

10. 发明专利

DE102005052551A1 未知
公开(公告)号：DE102005052551A1
公开(公告)日：2007-05-16
申请号：DE102005052551
申请日：2005-11-02
申请人： ROTHAMSTED RES HARPENDEN
发明人： NAPIER JONATHAN , SAYANOVA OLGA , VENEGAS CALERON MONICA
IPC分类号： C12N15/53 , A01H1/00 , C12N9/02 , C12N15/63 , C12P7/64
摘要： The present invention relates to the production of γ-linolenic acid (18:3&Dgr;6,9,12) or stearidonic acid (18:4&Dgr;6,9,12,15) or γ-linolenic acid (18:3&Dgr;6,9,12) and stearidonic acid (18:4&Dgr;6,9,12,15) in transgenic plants of the family Brassicaceae, where the transgenic plants comprise at least 10% by weight of oleic acid based on the total fatty acid content and, as the result of the activity of the &Dgr;6-desaturases used in the method, have an increased &Dgr;6-C18-fatty acid content. The invention furthermore relates to novel nucleic acid sequences which code for the &Dgr;6-desaturases used in the method, gene constructs comprising these nucleic acid sequences, a vector and transgenic plants comprising at least one nucleic acid sequence or a gene construct.

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