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1. 发明申请

US20110009481A1 MEDICAMENT FOR THE TREATMENT OF VIRAL SKIN AND TUMOUR DISEASES 有权
标题翻译：用于治疗病毒性皮肤病和肿瘤病的药物
公开(公告)号：US20110009481A1
公开(公告)日：2011-01-13
申请号：US12887250
申请日：2010-09-21
申请人： Yunik Chang , Robert Lathrop , Erwin Böhm , Irene Gander-Meisterernst , Regina Greger , Johanna Holldack , Ulrich Moebius
发明人： Yunik Chang , Robert Lathrop , Erwin Böhm , Irene Gander-Meisterernst , Regina Greger , Johanna Holldack , Ulrich Moebius
IPC分类号： A61K31/353 , A61P35/00 , A61P17/00
CPC分类号： A61K9/0014 , A61K31/23 , A61K31/353 , A61K47/06 , A61K47/10 , A61K47/14 , Y10S514/934 , Y10S514/947 , Y10S514/967 , Y10S514/969 , A61K2300/00
摘要： The invention relates to a medicament containing a compound of general formula (I), where R1=independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C11-C21 alkyl, alkylene or alkinyl group, preferably a C11-C15 alkyl, alkylene or alkinyl group, particularly a C11-C13 alkyl, alkylene or alkinyl group, most preferably a C13 alkyl group, R2=independently, a straight or branched C1-C8 alkyl, alkylene or alkinyl group, preferably a C1-C6 alkyl, alkylene or alkinyl group, in particular a C2-C4 alkyl, alkylene or alkinyl group, most preferably a C3 alkyl group, a —[CH2—(CH2)m-O]nH group with n=1 to 10, preferably n=1 to 5, to m=1 to 5, preferably m=1 to 3, a —CH2—[CH—(OH)]p[CH2—R3]- group, where R3=independently H or OH, p=1 to 7, preferably p=1 to 4, a pentose group or a hexose group, as therapeutically active agent, alone or in combination with one or several further pharmaceutical agents as a combination preparation for the treatment of viral skin diseases and/or tumor diseases, in particular caused by human papilloma virus (HPV) and/or herpes viruses and a topically acting medicament formulation and the use thereof.
摘要翻译：本发明涉及含有通式（I）化合物的药物，其中R 1独立地为直链或支链的，饱和的，单或多不饱和的任选取代的C 11 -C 21烷基，亚烷基或炔基，优选C 11 -C 15烷基，亚烷基或炔基，特别是C 11 -C 13烷基，亚烷基或炔基，最优选C 13烷基，R 2独立地为直链或支链C 1 -C 8烷基，亚烷基或炔基，优选C1- C 1 -C 6烷基，亚烷基或炔基，特别是C 2 -C 4烷基，亚烷基或炔基，最优选C 3烷基， - n = 1-10的α-[CH 2 - （CH 2）m O] n H基，优选n = 1至5，m = 1至5，优选m = 1至3，-CH 2 - [CH-（OH）] p [CH 2 -R 3] - 基，其中R 3独立地为H或OH，p = 7，优选p = 1〜4，戊糖基或己糖基作为治疗活性剂，单独或与一种或几种其它药剂组合，作为tre的组合制剂特别是由人乳头瘤病毒（HPV）和/或疱疹病毒和局部作用的药物制剂引起的病毒性皮肤病和/或肿瘤疾病的发生及其用途。

2. 发明授权

US07758809B2 Method and system for pretreatment of tissue slides 有权
标题翻译：组织玻片预处理方法与系统
公开(公告)号：US07758809B2
公开(公告)日：2010-07-20
申请号：US12630665
申请日：2009-12-03
申请人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
发明人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
IPC分类号： G01N1/28 , G01N1/30
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.
摘要翻译：本发明涉及通过施加试剂自动染色容纳在载玻片上的至少一个组织样本的方法和装置。该系统可以包括设置在滑架中的至少一个滑块，流体容纳元件，滑动夹持器，用于将滑块枢转到垂直位置的垂直滑动定位器，以及滑动式沉浸元件，以将垂直滑块浸入流体容纳物元素甚至浸渍槽。通过将幻灯片从水平方向枢转到垂直位置，可以提供用于在自动染色装置中进行预处理的自动化方法和装置。载玻片的枢转可以确保用于预处理和染色过程的载玻片的适当取向。

3. 发明申请

US20050064535A1 Method and apparatus for pretreatment of tissue slides 有权
标题翻译：组织玻片预处理方法和装置
公开(公告)号：US20050064535A1
公开(公告)日：2005-03-24
申请号：US10731316
申请日：2003-12-08
申请人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
发明人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
IPC分类号： B01L3/02 , B32B5/02 , G01M1/38 , G01N1/10 , G01N1/30 , G01N1/31 , G01N15/06 , G01N35/00 , G01N35/02 , G05B21/00 , G01N33/48 , C12M1/34
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.
摘要翻译：本发明涉及通过施加试剂自动染色容纳在载玻片上的至少一个组织样本的方法和装置。该系统可以包括设置在滑架中的至少一个滑块，流体容纳元件，滑动夹持器，用于将滑块枢转到垂直位置的垂直滑动定位器，以及滑动式沉浸元件，以将垂直滑块浸入流体容纳物元素甚至浸渍槽。通过将幻灯片从水平方向枢转到垂直位置，可以提供用于在自动染色装置中进行预处理的自动化方法和装置。载玻片的枢转可以确保用于预处理和染色过程的载玻片的适当取向。

4. 发明申请

US20130002456A1 In-Cab Communications Module 审中-公开
标题翻译：驾驶室通信模块
公开(公告)号：US20130002456A1
公开(公告)日：2013-01-03
申请号：US13598802
申请日：2012-08-30
申请人： Max L. Fuller , Kenneth W. Crane , Robert Lathrop , Scott Davison
发明人： Max L. Fuller , Kenneth W. Crane , Robert Lathrop , Scott Davison
IPC分类号： G08G1/13
CPC分类号： G06Q10/0833 , G01C21/362 , G01C21/3629 , G01C21/3632 , G06F3/0488 , G06Q10/08 , G06Q30/04 , G08G1/202
摘要： A communications module for conveying information to the driver of a truck is provided. The module is designed to reside in the cab of a truck that is carrying a full truckload of cargo. The communications module includes a user interface such as a screen. The communications module also has a modem. The modem is used for communicating with a host trucking management system through a wireless communications system. The communications module has a vehicle navigation system. The vehicle navigation system communicates with a GPS satellite system to generate maps on the user interface. The navigation system allows the driver to refer to a map on a screen for driving directions en route to a cargo pick-up location or other location. Further, the communications module includes a processing unit that is programmed to receive cargo delivery data sets from the host trucking management system.
摘要翻译：提供了一种用于将信息传送给卡车司机的通信模块。该模块设计用于驻车的卡车的驾驶室，该货车正在运载一整批货物。通信模块包括诸如屏幕的用户界面。通信模块还具有调制解调器。调制解调器用于通过无线通信系统与主机运输管理系统进行通信。通信模块具有车辆导航系统。车载导航系统与GPS卫星系统通信，在用户界面上生成地图。导航系统允许驾驶员参考屏幕上的地图，以便在到达货物接收位置或其他位置的途中行驶路线。此外，通信模块包括处理单元，其被编程为从主卡车管理系统接收货物传送数据集。

5. 发明授权

US07648678B2 Method and system for pretreatment of tissue slides 有权
公开(公告)号：US07648678B2
公开(公告)日：2010-01-19
申请号：US10731316
申请日：2003-12-08
申请人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
发明人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
IPC分类号： G01N1/28 , G01N1/30
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.

6. 发明申请

US20060093675A1 Intravaginal treatment of vaginal infections with metronidazole compositions 审中-公开
标题翻译：用甲硝唑组合物对阴道感染进行阴道内治疗
公开(公告)号：US20060093675A1
公开(公告)日：2006-05-04
申请号：US10978235
申请日：2004-10-29
申请人： Mathew Ebmeier , Robert Lathrop
发明人： Mathew Ebmeier , Robert Lathrop
IPC分类号： A61K9/14 , A61K31/4164
CPC分类号： A61K9/0034 , A61K31/4164
摘要： The present invention provides a buffered non-flowing composition suitable for the treatment of bacterial vaginosis. The composition includes metronidazole in a concentration of about 0.50% (w/w) to about 1.50% (w/w). The metronidazole is present together with a buffer system in a physiologically tolerable medium. The buffer system provides an acidic buffered pH value for the composition in the range of about 5.0 to about 6.0. The present invention also provides for a method for inhibiting a microorganism. The method includes contacting a microorganism with an effective amount of the composition of the present invention, for a period of time effective to inhibit the microorganism. The present invention also provides for a method for treating bacterial vaginosis in a human patient. The method includes intravaginal administration to a patient in need of such treatment an effective amount of the composition the present invention. The composition is introduced into the vagina at least once a day for a time period of at least one day.
摘要翻译：本发明提供了适用于治疗细菌性阴道病的缓冲非流动组合物。组合物包含浓度为约0.50％（w / w）至约1.50％（w / w）的甲硝唑。甲硝唑与缓冲系统一起存在于生理上可耐受的培养基中。缓冲系统为组合物提供约5.0至约6.0范围内的酸性缓冲pH值。本发明还提供了抑制微生物的方法。该方法包括使微生物与有效量的本发明组合物接触一段有效抑制微生物的时间。本发明还提供了一种在人类患者中治疗细菌性阴道病的方法。该方法包括对需要这种治疗的患者的阴道内施用有效量的本发明的组合物。每天至少一次将组合物引入阴道至少一天的时间。

7. 发明授权

US5733886A Compositions of clindamycin and benzoyl peroxide for acne treatment 失效
标题翻译：克林霉素和过氧化苯甲酰的组合物用于治疗痤疮
公开(公告)号：US5733886A
公开(公告)日：1998-03-31
申请号：US235125
申请日：1994-04-28
申请人： Lloyd J. Baroody , Gordon J. Dow , Debra A. Dow , Robert Lathrop
发明人： Lloyd J. Baroody , Gordon J. Dow , Debra A. Dow , Robert Lathrop
IPC分类号： A61K8/00 , A61K8/04 , A61K8/38 , A61K8/49 , A61K8/60 , A61K9/06 , A61K31/00 , A61K31/12 , A61K31/327 , A61K31/70 , A61K31/7056 , A61K45/06 , A61P17/00 , A61P17/10 , A61Q19/00
CPC分类号： A61K31/70 , A61K45/06 , A61K8/38 , A61K8/602 , A61K9/06 , A61Q19/00 , Y10S514/859
摘要： Compositions suitable for the treatment of acne by topical application comprise clindamycin and benzoyl peroxide. Kits for preparing the compositions include a solution of clindamycin in a first container and a gel suspension of benzoyl peroxide in a second container. Each component is stored at a pH which promotes stability, and the combination of the two components provides a final composition having a pH which promotes stability and enhances viscosity.
摘要翻译：适用于通过局部施用治疗痤疮的组合物包括克林霉素和过氧化苯甲酰。用于制备组合物的试剂盒包括克林霉素在第一容器中的溶液和过氧化苯甲酰在第二容器中的凝胶悬浮液。每个组分以促进稳定性的pH储存，并且两种组分的组合提供具有促进稳定性和增强粘度的pH的最终组合物。

8. 发明申请

US20100169199A1 Method for In-Cab Driver Operation 有权
标题翻译：驾驶员驾驶员操作方法
公开(公告)号：US20100169199A1
公开(公告)日：2010-07-01
申请号：US12648571
申请日：2009-12-29
申请人： Max L. Fuller , Kenneth W. Crane , Robert Lathrop , Scott Davison
发明人： Max L. Fuller , Kenneth W. Crane , Robert Lathrop , Scott Davison
IPC分类号： G06Q10/00 , G01C21/36 , G06Q50/00 , G06F3/048
CPC分类号： G08G1/202 , G06Q10/08 , G06Q10/0833 , G06Q30/04
摘要： A method for transporting cargo using a truck is provided. Preferably, the method is used in connection with full truckload operations. The method generally includes powering up a communications module residing within a cab of the truck. The communications module comprises a vehicle navigation system, a modem for receiving telecommunications signals, a processing unit for associating instructions for cargo delivery locations with geo-positioning coordinates, and a user interface. The method further includes receiving a cargo delivery data set at the communications module. The data set is sent from a host trucking management system. The data set provides at least a first cargo delivery location for the driver. The method then includes the driver acknowledging receipt of the first cargo delivery location through the user interface. Acknowledgment of receipt of the first cargo delivery location causes a signal to be sent from the communications module to the host trucking management system. The method also includes driving the truck and cargo to the first cargo delivery location. Upon arrival, the host trucking management system is informed. This is done by sending a first arrival signal from the communications module.
摘要翻译：提供了使用卡车运输货物的方法。优选地，该方法用于完全卡车运行。该方法通常包括为位于卡车驾驶室内的通信模块供电。通信模块包括车辆导航系统，用于接收电信信号的调制解调器，用于将货物传送位置的指令与地理定位坐标相关联的处理单元和用户界面。该方法还包括在通信模块处接收货物传送数据集。数据集是从主机运输管理系统发送的。该数据集为驾驶员提供至少一个第一货物运送位置。该方法然后包括驾驶员通过用户界面确认收到第一货物交货位置。确认收到第一个货运地点时，会将一个信号从通信模块发送到主机运输管理系统。该方法还包括将卡车和货物驾驶到第一货物运送位置。抵达后，主办货运管理系统通知。这是通过从通信模块发送第一到达信号来完成的。

9. 发明申请

US20100081167A1 Method and System for Pretreatment of Tissue Slides 有权
标题翻译：组织幻灯片预处理方法与系统
公开(公告)号：US20100081167A1
公开(公告)日：2010-04-01
申请号：US12630665
申请日：2009-12-03
申请人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
发明人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
IPC分类号： G01N1/30 , G01N33/48
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.
摘要翻译：本发明涉及通过施加试剂自动染色容纳在载玻片上的至少一个组织样本的方法和装置。该系统可以包括设置在滑架中的至少一个滑块，流体容纳元件，滑动夹持器，用于将滑块枢转到垂直位置的垂直滑动定位器，以及滑动式沉浸元件，以将垂直滑块浸入流体容纳物元素甚至浸渍槽。通过将幻灯片从水平方向枢转到垂直位置，可以提供用于在自动染色装置中进行预处理的自动化方法和装置。载玻片的枢转可以确保用于预处理和染色过程的载玻片的适当取向。

10. 发明申请

US20090030060A1 INTRAVAGINAL TREATMENT OF VAGINAL INFECTIONS WITH METRONIDAZOLE COMPOSITIONS 审中-公开
标题翻译：用METRONIDAZOLE组合物治疗阴道感染的腹腔内治疗
公开(公告)号：US20090030060A1
公开(公告)日：2009-01-29
申请号：US12176025
申请日：2008-07-18
申请人： Matthew Ebmeier , Robert Lathrop
发明人： Matthew Ebmeier , Robert Lathrop
IPC分类号： A61K31/4164 , A61P31/04
CPC分类号： A61K9/0034 , A61K31/4164
摘要： The present invention provides a buffered non-flowing composition suitable for the treatment of bacterial vaginosis. The composition includes metronidazole in a concentration of about 0.50% (w/w) to about 1.50% (w/w). The metronidazole is present together with a buffer system in a physiologically tolerable medium. The buffer system provides an acidic buffered pH value for the composition in the range of about 5.0 to about 6.0. The present invention also provides for a method for inhibiting a microorganism. The method includes contacting a microorganism with an effective amount of the composition of the present invention, for a period of time effective to inhibit the microorganism. The present invention also provides for a method for treating bacterial vaginosis in a human patient. The method includes intravaginal administration to a patient in need of such treatment an effective amount of the composition the present invention. The composition is introduced into the vagina at least once a day for a time period of at least one day.
摘要翻译：本发明提供了适用于治疗细菌性阴道病的缓冲非流动组合物。组合物包含浓度为约0.50％（w / w）至约1.50％（w / w）的甲硝唑。甲硝唑与缓冲系统一起存在于生理上可耐受的培养基中。缓冲系统为组合物提供约5.0至约6.0范围内的酸性缓冲pH值。本发明还提供了抑制微生物的方法。该方法包括使微生物与有效量的本发明组合物接触一段有效抑制微生物的时间。本发明还提供了一种在人类患者中治疗细菌性阴道病的方法。该方法包括对需要这种治疗的患者的阴道内施用有效量的本发明的组合物。每天至少一次将组合物引入阴道至少一天的时间。

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