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1. 发明申请

US20090030060A1 INTRAVAGINAL TREATMENT OF VAGINAL INFECTIONS WITH METRONIDAZOLE COMPOSITIONS 审中-公开
标题翻译：用METRONIDAZOLE组合物治疗阴道感染的腹腔内治疗
公开(公告)号：US20090030060A1
公开(公告)日：2009-01-29
申请号：US12176025
申请日：2008-07-18
申请人： Matthew Ebmeier , Robert Lathrop
发明人： Matthew Ebmeier , Robert Lathrop
IPC分类号： A61K31/4164 , A61P31/04
CPC分类号： A61K9/0034 , A61K31/4164
摘要： The present invention provides a buffered non-flowing composition suitable for the treatment of bacterial vaginosis. The composition includes metronidazole in a concentration of about 0.50% (w/w) to about 1.50% (w/w). The metronidazole is present together with a buffer system in a physiologically tolerable medium. The buffer system provides an acidic buffered pH value for the composition in the range of about 5.0 to about 6.0. The present invention also provides for a method for inhibiting a microorganism. The method includes contacting a microorganism with an effective amount of the composition of the present invention, for a period of time effective to inhibit the microorganism. The present invention also provides for a method for treating bacterial vaginosis in a human patient. The method includes intravaginal administration to a patient in need of such treatment an effective amount of the composition the present invention. The composition is introduced into the vagina at least once a day for a time period of at least one day.
摘要翻译：本发明提供了适用于治疗细菌性阴道病的缓冲非流动组合物。组合物包含浓度为约0.50％（w / w）至约1.50％（w / w）的甲硝唑。甲硝唑与缓冲系统一起存在于生理上可耐受的培养基中。缓冲系统为组合物提供约5.0至约6.0范围内的酸性缓冲pH值。本发明还提供了抑制微生物的方法。该方法包括使微生物与有效量的本发明组合物接触一段有效抑制微生物的时间。本发明还提供了一种在人类患者中治疗细菌性阴道病的方法。该方法包括对需要这种治疗的患者的阴道内施用有效量的本发明的组合物。每天至少一次将组合物引入阴道至少一天的时间。

2. 发明申请

US20070231358A1 INTRAVAGINAL TREATMENT OF VAGINAL INFECTIONS WITH METRONIDAZOLE COMPOSITIONS 审中-公开
标题翻译：用METRONIDAZOLE组合物治疗阴道感染的腹腔内治疗
公开(公告)号：US20070231358A1
公开(公告)日：2007-10-04
申请号：US11762636
申请日：2007-06-13
申请人： Matthew Ebmeier , Robert Lathrop
发明人： Matthew Ebmeier , Robert Lathrop
IPC分类号： A01N25/04 , A01N43/50
CPC分类号： A61K9/0034 , A61K31/4164
摘要： The present invention provides a buffered non-flowing composition suitable for the treatment of bacterial vaginosis. The composition includes metronidazole in a concentration of about 0.50% (w/w) to about 1.50% (w/w). The metronidazole is present together with a buffer system in a physiologically tolerable medium. The buffer system provides an acidic buffered pH value for the composition in the range of about 5.0 to about 6.0. The present invention also provides for a method for inhibiting a microorganism. The method includes contacting a microorganism with an effective amount of the composition of the present invention, for a period of time effective to inhibit the microorganism. The present invention also provides for a method for treating bacterial vaginosis in a human patient. The method includes intravaginal administration to a patient in need of such treatment an effective amount of the composition the present invention. The composition is introduced into the vagina at least once a day for a time period of at least one day.
摘要翻译：本发明提供了适用于治疗细菌性阴道病的缓冲非流动组合物。组合物包含浓度为约0.50％（w / w）至约1.50％（w / w）的甲硝唑。甲硝唑与缓冲系统一起存在于生理上可耐受的培养基中。缓冲系统为组合物提供约5.0至约6.0范围内的酸性缓冲pH值。本发明还提供了抑制微生物的方法。该方法包括使微生物与有效量的本发明组合物接触一段有效抑制微生物的时间。本发明还提供了一种在人类患者中治疗细菌性阴道病的方法。该方法包括对需要这种治疗的患者的阴道内施用有效量的本发明的组合物。每天至少一次将组合物引入阴道至少一天的时间。

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