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1. 发明申请

US20110009481A1 MEDICAMENT FOR THE TREATMENT OF VIRAL SKIN AND TUMOUR DISEASES 有权
标题翻译：用于治疗病毒性皮肤病和肿瘤病的药物
公开(公告)号：US20110009481A1
公开(公告)日：2011-01-13
申请号：US12887250
申请日：2010-09-21
申请人： Yunik Chang , Robert Lathrop , Erwin Böhm , Irene Gander-Meisterernst , Regina Greger , Johanna Holldack , Ulrich Moebius
发明人： Yunik Chang , Robert Lathrop , Erwin Böhm , Irene Gander-Meisterernst , Regina Greger , Johanna Holldack , Ulrich Moebius
IPC分类号： A61K31/353 , A61P35/00 , A61P17/00
CPC分类号： A61K9/0014 , A61K31/23 , A61K31/353 , A61K47/06 , A61K47/10 , A61K47/14 , Y10S514/934 , Y10S514/947 , Y10S514/967 , Y10S514/969 , A61K2300/00
摘要： The invention relates to a medicament containing a compound of general formula (I), where R1=independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C11-C21 alkyl, alkylene or alkinyl group, preferably a C11-C15 alkyl, alkylene or alkinyl group, particularly a C11-C13 alkyl, alkylene or alkinyl group, most preferably a C13 alkyl group, R2=independently, a straight or branched C1-C8 alkyl, alkylene or alkinyl group, preferably a C1-C6 alkyl, alkylene or alkinyl group, in particular a C2-C4 alkyl, alkylene or alkinyl group, most preferably a C3 alkyl group, a —[CH2—(CH2)m-O]nH group with n=1 to 10, preferably n=1 to 5, to m=1 to 5, preferably m=1 to 3, a —CH2—[CH—(OH)]p[CH2—R3]- group, where R3=independently H or OH, p=1 to 7, preferably p=1 to 4, a pentose group or a hexose group, as therapeutically active agent, alone or in combination with one or several further pharmaceutical agents as a combination preparation for the treatment of viral skin diseases and/or tumor diseases, in particular caused by human papilloma virus (HPV) and/or herpes viruses and a topically acting medicament formulation and the use thereof.
摘要翻译：本发明涉及含有通式（I）化合物的药物，其中R 1独立地为直链或支链的，饱和的，单或多不饱和的任选取代的C 11 -C 21烷基，亚烷基或炔基，优选C 11 -C 15烷基，亚烷基或炔基，特别是C 11 -C 13烷基，亚烷基或炔基，最优选C 13烷基，R 2独立地为直链或支链C 1 -C 8烷基，亚烷基或炔基，优选C1- C 1 -C 6烷基，亚烷基或炔基，特别是C 2 -C 4烷基，亚烷基或炔基，最优选C 3烷基， - n = 1-10的α-[CH 2 - （CH 2）m O] n H基，优选n = 1至5，m = 1至5，优选m = 1至3，-CH 2 - [CH-（OH）] p [CH 2 -R 3] - 基，其中R 3独立地为H或OH，p = 7，优选p = 1〜4，戊糖基或己糖基作为治疗活性剂，单独或与一种或几种其它药剂组合，作为tre的组合制剂特别是由人乳头瘤病毒（HPV）和/或疱疹病毒和局部作用的药物制剂引起的病毒性皮肤病和/或肿瘤疾病的发生及其用途。

2. 发明授权

US09770406B2 Medicament for the treatment of viral skin and tumour diseases 有权
公开(公告)号：US09770406B2
公开(公告)日：2017-09-26
申请号：US12887250
申请日：2010-09-21
申请人： Yunik Chang , Robert Lathrop , Erwin Böhm , Irene Gander-Meisterernst , Regina Greger , Johanna Holldack , Ulrich Moebius
发明人： Yunik Chang , Robert Lathrop , Erwin Böhm , Irene Gander-Meisterernst , Regina Greger , Johanna Holldack , Ulrich Moebius
IPC分类号： A61K31/20 , A61K31/12 , A61K31/35 , A61K9/00 , A61K31/23 , A61K31/353 , A61K47/06 , A61K47/10 , A61K47/14
CPC分类号： A61K9/0014 , A61K31/23 , A61K31/353 , A61K47/06 , A61K47/10 , A61K47/14 , Y10S514/934 , Y10S514/947 , Y10S514/967 , Y10S514/969 , A61K2300/00
摘要： The invention relates to a medicament containing a compound of general formula (I), where R1=independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C11-C21 alkyl, alkylene or alkinyl group, preferably a C11-C15 alkyl, alkylene or alkinyl group, particularly a C11-C13 alkyl, alkylene or alkinyl group, most preferably a C13 alkyl group, R2=independently, a straight or branched C1-C8 alkyl, alkylene or alkinyl group, preferably a C1-C6 alkyl, alkylene or alkinyl group, in particular a C2-C4 alkyl, alkylene or alkinyl group, most preferably a C3 alkyl group, a —[CH2—(CH2)m-O]nH group with n=1 to 10, preferably n=1 to 5, to m=1 to 5, preferably m=1 to 3, a —CH2—[CH—(OH)]p[CH2—R3]- group, where R3=independently H or OH, p=1 to 7, preferably p=1 to 4, a pentose group or a hexose group, as therapeutically active agent, alone or in combination with one or several further pharmaceutical agents as a combination preparation for the treatment of viral skin diseases and/or tumor diseases, in particular caused by human papilloma virus (HPV) and/or herpes viruses and a topically acting medicament formulation and the use thereof.

3. 发明授权

US07858662B2 Medicament for the treatment of viral skin and tumour diseases 有权
标题翻译：用于治疗病毒性皮肤和肿瘤疾病的药物
公开(公告)号：US07858662B2
公开(公告)日：2010-12-28
申请号：US10495889
申请日：2002-11-18
申请人： Yunik Chang , Robert Lathrop , Erwin Böhm , Irene Gander-Meisterernst , Regina Greger , Johanna Holldack , Ulrich Moebius
发明人： Yunik Chang , Robert Lathrop , Erwin Böhm , Irene Gander-Meisterernst , Regina Greger , Johanna Holldack , Ulrich Moebius
IPC分类号： A61K31/20 , A61K31/12 , A61K31/35 , A61P15/00
CPC分类号： A61K9/0014 , A61K31/23 , A61K31/353 , A61K47/06 , A61K47/10 , A61K47/14 , Y10S514/934 , Y10S514/947 , Y10S514/967 , Y10S514/969 , A61K2300/00
摘要： The invention relates to a medicament containing a compound of general formula (1), where R1=independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C11-C21 alkyl, alkylene or alkynyl group, preferably a C11-C15 alkyl, alkylene or alkynyl group, particularly a C11-C13 alkyl, alkylene or alkynyl group, most preferably a C13 alkyl group, R2=independently, a straight or branched C1-C8 alkyl, alkylene or alkynyl group, preferably a C1-C6 alkyl, alkylene or alkynyl group, in particular a C2-C4 alkyl, alkylene or alkynyl group, most preferably a C3 alkyl group, a —[CH2—(CH2)m—O]nH group with n=1 to 10, preferably n=1 to 5, m=1 to 5, preferably m=1 to 3, a —CH2—[CH—(OH)]p[CH2—(R3)]— group, where R3=independent H or OH, p=1 to 7, preferably p=1 to 4, a pentose group or a hexose group, as therapeutically active agent, alone or in combination with one or several further pharmaceutical agents as a combination preparation for the treatment of viral skin diseases and/or tumor diseases, in particular caused by human papilloma virus (HPV) and/or herpes viruses and a topically acting medicament formulation and the use thereof.
摘要翻译：本发明涉及含有通式（1）化合物的药物，其中R 1独立地为直链或支链的，饱和的，单或多不饱和的任选取代的C 11 -C 21烷基，亚烷基或炔基，优选C 11 -C 15烷基，亚烷基或炔基，特别是C 11 -C 13烷基，亚烷基或炔基，最优选C 13烷基，R 2独立地为直链或支链C 1 -C 8烷基，亚烷基或炔基， C 1 -C 6烷基，亚烷基或炔基，特别是C 2 -C 4烷基，亚烷基或炔基，最优选C 3烷基， - n = 1-10的α-[CH 2 - （CH 2）m -O] n H基团 n = 1至5，m = 1至5，优选m = 1至3，-CH 2 - [CH-（OH）] p [CH 2 - （R 3）] - 基，其中R 3 =独立的H或OH，p = 1至7，优选p = 1至4，戊糖基或己糖基，作为治疗活性剂，单独或与一种或几种其它药剂组合，作为tr的组合制剂特别是由人乳头状瘤病毒（HPV）和/或疱疹病毒引起的病毒性皮肤疾病和/或肿瘤疾病，以及局部作用的药物制剂及其用途。

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