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1. 发明申请

US20120004565A1 ISCHEMIA DETECTION USING A HEART SOUND SENSOR 有权
标题翻译：使用心音传感器进行ISCHEMIA检测
公开(公告)号：US20120004565A1
公开(公告)日：2012-01-05
申请号：US13231152
申请日：2011-09-13
申请人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina V. Brockway , Krzysztof Z. Siejko
发明人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina V. Brockway , Krzysztof Z. Siejko
IPC分类号： A61B5/02 , A61B5/0205
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/024 , A61B5/0452 , A61B5/0456 , A61B7/04 , A61N1/36578 , A61N1/395
摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.
摘要翻译：包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。心脏声音与患者心脏的机械活动有关。另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

2. 发明授权

US08041426B2 Selective resynchronization therapy optimization based on user preference 有权
标题翻译：基于用户偏好的选择性再同步治疗优化
公开(公告)号：US08041426B2
公开(公告)日：2011-10-18
申请号：US12565344
申请日：2009-09-23
申请人： Richard Fogoros , Jiang Ding , Yinghong Yu
发明人： Richard Fogoros , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method and system for calculating an atrio-ventricular delay interval based upon an inter-atrial delay exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may optimize the stroke volume exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may be blended with another atrio-ventricular delay interval that may optimize another performance characteristic, such as left ventricular contractility. Such blending may include finding an arithmetic mean, geometric mean, or weighted mean of two or more proposed atrio-ventricular delay intervals.
摘要翻译：一种用于根据患者心脏表现的心房间延迟来计算心房延迟间隔的方法和系统。上述的心室延迟间隔可以优化患者心脏展示的搏动量。上述房室延迟间隔可以与可以优化另一性能特征（例如左心室收缩力）的另一心房延迟间隔混合。这种混合可以包括找到两个或更多个提出的心房延迟间隔的算术平均值，几何平均值或加权平均值。

3. 发明申请

US20080177156A1 ISCHEMIA DETECTION USING PRESSURE SENSOR 审中-公开
标题翻译：使用压力传感器进行ISCHEMIA检测
公开(公告)号：US20080177156A1
公开(公告)日：2008-07-24
申请号：US11624974
申请日：2007-01-19
申请人： Yi Zhang , Krzysztof Z. Siejko , Richard Fogoros , Abhilash Patangay
发明人： Yi Zhang , Krzysztof Z. Siejko , Richard Fogoros , Abhilash Patangay
IPC分类号： A61B5/0205 , A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/0205 , A61B5/145
摘要： This document discusses, among other things, a system and method for sensing a pulmonary artery pressure (“PAP”) signal of a pulmonary artery (“PA”) and computing an indication of a reduction of blood supply to at least a portion of a heart using information from the PAP signal. The reduction of blood supply to at least a portion of the heart can be detected using a PAP signal characteristic or measurement, using a change in the PAP, using an interval between multiple PAP signal features, using a mitral valve performance, or using information from the PAP and information from a different physiological signal, including a cardiac signal, a heart sound signal, right ventricular pressure signal, a left ventricular pressure signal, a blood pressure signal, and an oxygen saturation signal.
摘要翻译：本文件尤其涉及用于感测肺动脉（“PA”）的肺动脉压（“PAP”）信号的系统和方法，并且计算将血液供应减少到至少一部分心脏使用来自PAP信号的信息。使用PAP信号特征或测量可以使用PAP信号特征或多个PAP信号特征之间的间隔，使用二尖瓣性能来使用PAP信号特征或测量来检测对心脏的至少一部分的血液供应，或使用来自 PAP和来自不同生理信号的信息，包括心脏信号，心音信号，右心室压力信号，左心室压力信号，血压信号和氧饱和度信号。

4. 发明授权

US07386344B2 Pacer with combined defibrillator tailored for bradycardia patients 失效
标题翻译：步行者联合除颤器为心动过缓患者量身打造
公开(公告)号：US07386344B2
公开(公告)日：2008-06-10
申请号：US10921777
申请日：2004-08-18
申请人： Joseph M. Bocek , Richard Milon Dujmovic, Jr. , Phil Foshee , Harley White , Jaeho Kim , Anthony Harrington , Richard S. Sanders , Douglas R. Daum , Paul De Coriolis , Joseph Smith , Richard Fogoros
发明人： Joseph M. Bocek , Richard Milon Dujmovic, Jr. , Phil Foshee , Harley White , Jaeho Kim , Anthony Harrington , Richard S. Sanders , Douglas R. Daum , Paul De Coriolis , Joseph Smith , Richard Fogoros
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3962
摘要： A combination pacer/defibrillator is tailored for bradycardia patients. In one example, its shock-delivery specificity exceeds its sensitivity to shockable ventricular tachyarrhythmias. In another example, its specificity exceeds 95%, or 99%, or even 99.5%. Sensitivity is programmed to a high desired sensitivity value, but only if it can be done without decreasing the specificity below the desired specificity threshold value. This can be conceptualized as “avoiding at all costs” delivering false shocks, even at the expense of failing to deliver a shock to a treatable ventricular tachyarrhythmia. Specificity enhancements include, among other things, inhibiting shock delivery when the patient is breathing or not supine, using multiple channels or a high rate VT/VF detection threshold. The present pacer/defibrillator device could potentially save the lives of bradyarrhythmia patients who are not presently clinically indicated for a defibrillator/pacer, but who have an increased risk of sudden cardiac death due to one or more risk factors.
摘要翻译：组合起搏器/除颤器是为心动过缓患者量身打造的。在一个例子中，其冲击传递特异性超过其对可震荡室性快速性心律失常的敏感性。在另一个实例中，其特异性超过95％，或99％，甚至99.5％。灵敏度被编程为高期望的灵敏度值，但是只有在不降低低于所需特异性阈值的特异性的情况下才能进行。这可以被概念化为“不惜一切代价”，提供虚假的冲击，即使以不能对可治疗的室性快速性心律失常发生冲击为代价。特异性增强包括，当患者呼吸或不仰卧时，使用多个通道或高速率的VT / VF检测阈值来抑制冲击输送。本发明的起搏器/除颤器装置可能潜在地节省目前临床指示用于除颤器/止痛器但是由于一个或多个危险因素引起的心脏猝死风险增加的缓慢心律失常患者的生命。

5. 发明申请

US20060264776A1 Detection of pleural effusion using transthoracic impedance 有权
标题翻译：使用经胸阻塞检测胸腔积液
公开(公告)号：US20060264776A1
公开(公告)日：2006-11-23
申请号：US11132109
申请日：2005-05-18
申请人： Jeffrey Stahmann , John Hatlestad , Jesse Hartley , Richard Fogoros
发明人： Jeffrey Stahmann , John Hatlestad , Jesse Hartley , Richard Fogoros
IPC分类号： A61B5/05
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0535 , A61B5/1116 , A61B5/4869 , A61N1/36521 , A61N1/36535
摘要： This patent document discusses systems, devices, and methods for increasing a sensitivity or specificity of thoracic fluid detection in a subject and differentiating between pleural effusion and pulmonary edema. In one example, a thoracic impedance measurement circuit senses a thoracic impedance signal. In another example, a processor receives the thoracic impedance signal and determines whether such thoracic impedance signal is “significant.” A significant thoracic impedance signal indicates the presence of thoracic fluid and may be recognized by comparing the thoracic impedance signal (or variation thereof) to a thoracic impedance threshold. When a significant thoracic impedance signal is recognized, the processor is adapted to detect one or both of: a pleural effusion indication and a pulmonary edema indication using one or a combination of: physiologic information, patient symptom information, and posture information. In another example, the thoracic impedance threshold is adjusted using such physiologic, patient symptom, or posture information.
摘要翻译：该专利文献讨论了用于增加受试者胸部液体检测的敏感性或特异性并区分胸腔积液和肺水肿的系统，装置和方法。在一个示例中，胸部阻抗测量电路感测胸部阻抗信号。在另一示例中，处理器接收胸部阻抗信号并确定这种胸部阻抗信号是否“显着”。显着的胸部阻抗信号表示胸腔液的存在，并且可以通过将胸部阻抗信号（或其变化）与胸部阻抗阈值进行比较来识别。当识别出显着的胸部阻抗信号时，处理器适合于使用生理信息，患者症状信息和姿势信息中的一个或组合来检测胸腔积液指示和肺水肿指示之一或两者。在另一个例子中，使用这种生理，患者症状或姿势信息来调整胸阻抗阈值。

6. 发明授权

US08758260B2 Ischemia detection using a heart sound sensor 有权
标题翻译：使用心脏声音传感器进行缺血检测
公开(公告)号：US08758260B2
公开(公告)日：2014-06-24
申请号：US13231152
申请日：2011-09-13
申请人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina V. Brockway , Krzysztof Z. Siejko
发明人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina V. Brockway , Krzysztof Z. Siejko
IPC分类号： A61B5/04
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/024 , A61B5/0452 , A61B5/0456 , A61B7/04 , A61N1/36578 , A61N1/395
摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.
摘要翻译：包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。心脏声音与患者心脏的机械活动有关。另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

7. 发明授权

US08036744B2 Cardiac rhythm management system with defibrillation threshold prediction 有权
标题翻译：心脏节律管理系统除颤阈值预测
公开(公告)号：US08036744B2
公开(公告)日：2011-10-11
申请号：US12631944
申请日：2009-12-07
申请人： Richard Milon Dujmovic, Jr. , Phil Foshee , Richard Fogoros , Joseph M. Smith , Douglas R. Daum , Weimin Sun
发明人： Richard Milon Dujmovic, Jr. , Phil Foshee , Richard Fogoros , Joseph M. Smith , Douglas R. Daum , Weimin Sun
IPC分类号： A61N1/08 , A61N1/39 , A61N1/365
CPC分类号： A61N1/3937 , A61N1/3943
摘要： A cardiac rhythm management device predicts defibrillation thresholds without any need to apply defibrillation shocks or subjecting the patient to fibrillation. Intravascular defibrillation electrodes are implanted in a heart. By applying a small test energy, an electric field near one of the defibrillation electrodes is determined by measuring a voltage at a sensing electrode offset from the defibrillation electrode by a known distance. A desired minimum value of electric field at the heart periphery is established. A distance between a defibrillation electrodes and the heart periphery is measured, either fluoroscopically or by measuring a voltage at an electrode at or near the heart periphery. Using the measured electric field and the measured distance to the periphery of the heart, the defibrillation energy needed to obtain the desired electric field at the heart periphery is estimated. In an example, the device also includes a defibrillation shock circuit and a stimulation circuit.
摘要翻译：心律管理装置预测除颤阈值，而不需要施加除颤电击或使患者起颤。血管内除颤电极植入心脏。通过施加小的测试能量，通过测量从除颤电极偏移已知距离的感测电极处的电压来确定除颤电极之一附近的电场。建立心脏周围电场的期望最小值。测量除颤电极和心脏周边之间的距离，通过荧光透视或通过测量心脏周围处或附近的电极处的电压。使用测量的电场和到心脏外围的测量距离，估计在心脏周边获得所需电场所需的除颤能量。在一个示例中，该装置还包括除颤电击电路和刺激电路。

8. 发明申请

US20100010557A1 SELECTIVE RESYNCHRONIZATION THERAPY OPTIMIZATION BASED ON USER PREFERENCE 有权
标题翻译：基于用户偏好的选择性修复治疗优化
公开(公告)号：US20100010557A1
公开(公告)日：2010-01-14
申请号：US12565344
申请日：2009-09-23
申请人： Richard Fogoros , Jiang Ding , Yinghong Yu
发明人： Richard Fogoros , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method and system for calculating an atrio-ventricular delay interval based upon an inter-atrial delay exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may optimize the stroke volume exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may be blended with another atrio-ventricular delay interval that may optimize another performance characteristic, such as left ventricular contractility. Such blending may include finding an arithmetic mean, geometric mean, or weighted mean of two or more proposed atrio-ventricular delay intervals.
摘要翻译：一种用于根据患者心脏表现的心房间延迟来计算心房延迟间隔的方法和系统。上述的心室延迟间隔可以优化患者心脏展示的搏动量。上述房室延迟间隔可以与可以优化另一性能特征（例如左心室收缩力）的另一心房延迟间隔混合。这种混合可以包括找到两个或更多个提出的心房延迟间隔的算术平均值，几何平均值或加权平均值。

9. 发明申请

US20080108907A1 DETECTION OF PLEURAL EFFUSION USING TRANSTHORACIC IMPEDANCE 有权
标题翻译：使用TRANSTHORACIC阻抗检测临时效应
公开(公告)号：US20080108907A1
公开(公告)日：2008-05-08
申请号：US11972405
申请日：2008-01-10
申请人： Jeffrey Stahmann , John Hatlestad , Jesse Hartley , Richard Fogoros
发明人： Jeffrey Stahmann , John Hatlestad , Jesse Hartley , Richard Fogoros
IPC分类号： A61B5/085
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0535 , A61B5/1116 , A61B5/4869 , A61N1/36521 , A61N1/36535
摘要： This patent document discusses systems, devices, and methods for increasing a sensitivity or specificity of thoracic fluid detection in a subject and differentiating between pleural effusion and pulmonary edema. In one example, a thoracic impedance measurement circuit senses a thoracic impedance signal. In another example, a processor receives the thoracic impedance signal and determines whether such thoracic impedance signal is “significant.” A significant thoracic impedance signal indicates the presence of thoracic fluid and may be recognized by comparing the thoracic impedance signal (or variation thereof) to a thoracic impedance threshold. When a significant thoracic impedance signal is recognized, the processor is adapted to detect one or both of: a pleural effusion indication and a pulmonary edema indication using one or a combination of: physiologic information, patient symptom information, and posture information. In another example, the thoracic impedance threshold is adjusted using such physiologic, patient symptom, or posture information.
摘要翻译：该专利文献讨论了用于增加受试者胸部液体检测的敏感性或特异性并区分胸腔积液和肺水肿的系统，装置和方法。在一个示例中，胸部阻抗测量电路感测胸部阻抗信号。在另一示例中，处理器接收胸部阻抗信号并确定这种胸部阻抗信号是否“显着”。显着的胸部阻抗信号表示胸腔液的存在，并且可以通过将胸部阻抗信号（或其变化）与胸部阻抗阈值进行比较来识别。当识别出显着的胸部阻抗信号时，处理器适合于使用生理信息，患者症状信息和姿势信息中的一个或组合来检测胸腔积液指示和肺水肿指示之一或两者。在另一个例子中，使用这种生理，患者症状或姿势信息来调整胸阻抗阈值。

10. 发明申请

US20070299356A1 DETECTION OF MYOCARDIAL ISCHEMIA FROM THE TIME SEQUENCE OF IMPLANTED SENSOR MEASUREMENTS 有权
标题翻译：从插入式传感器测量的时间序列检测心肌梗塞
公开(公告)号：US20070299356A1
公开(公告)日：2007-12-27
申请号：US11426835
申请日：2006-06-27
申请人： Ramesh Wariar , Veerichetty Kadhiresan , Richard Fogoros
发明人： Ramesh Wariar , Veerichetty Kadhiresan , Richard Fogoros
IPC分类号： A61B5/04
CPC分类号： A61B5/02 , A61B5/0402 , A61B5/0535 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/3702
摘要： A system including a plurality of implantable sensors, a processor, and a response circuit. Each sensor produces an electrical sensor signal related to physiologic cardiovascular events of a subject. The processor includes an event sequence detector to permit real-time detection of a time-wise sequential cascade of physiologic cardiovascular events related to myocardial ischemia of a subject and a decision module. The time-wise cascade includes at least first, second, and third physiologic cardiovascular events. The decision module declares whether an ischemic event occurred using at least one rule applied to a temporal relationship of the first, second, and third physiologic cardiovascular events. The response circuit provides a specified response if the ischemic event is declared.
摘要翻译：一种包括多个可植入传感器，处理器和响应电路的系统。每个传感器产生与受试者的生理心血管事件相关的电传感器信号。该处理器包括事件序列检测器，以允许实时检测与受试者和决策模块的心肌缺血相关的生理心血管事件的时间顺序级联。时间级联包括至少第一，第二和第三生理心血管事件。决策模块声明是否使用至少应用于第一，第二和第三生理心血管事件的时间关系的规则来发生缺血事件。如果声明缺血事件，则响应电路提供指定的响应。

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