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1. 发明申请

US20100317126A1 AGGLUTINATION ASSAY METHOD IN POROUS MEDIUM LAYER 审中-公开
标题翻译：多孔介质层中的AGAGUTINATION测定方法
公开(公告)号：US20100317126A1
公开(公告)日：2010-12-16
申请号：US12835832
申请日：2010-07-14
申请人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
发明人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
IPC分类号： G01N33/53
CPC分类号： G01N33/54346 , G01N33/525 , G01N33/587
摘要： An agglutination assay method for quantitatively determination of an analyte in an aqueous liquid sample using particles bearing an anti-analyte. The agglutination is conducted in the porous medium layer of the analysis element. A speedy quantitative analysis of the analyte can be conveniently attained with high sensitivity. When the particle-labeled anti-analyte is contained in the porous medium layer, the anti-analyte can be stored with higher stability in the dry state. A dry analysis element for enabling such analysis method is also provided.
摘要翻译：一种用于使用带有抗分析物的颗粒定量测定含水液体样品中的分析物的凝集测定方法。凝集在分析元件的多孔介质层中进行。可以方便地以高灵敏度获得分析物的快速定量分析。当颗粒标记的抗分析物包含在多孔介质层中时，抗分析物可以在干燥状态下以更高的稳定性储存。还提供了用于实现这种分析方法的干燥分析元件。

2. 发明授权

US06287785B1 Homogenous enzyme immunoassay process 失效
标题翻译：均质酶免疫测定法
公开(公告)号：US06287785B1
公开(公告)日：2001-09-11
申请号：US09488371
申请日：2000-01-20
申请人： Hiroshi Shinoki , Osamu Seshimoto
发明人： Hiroshi Shinoki , Osamu Seshimoto
IPC分类号： G01N33533
CPC分类号： G01N33/535 , G01N33/542 , G01N33/54306 , Y10S435/963 , Y10S435/964 , Y10S435/969 , Y10S435/972 , Y10S436/823 , Y10S530/866
摘要： An improved homogeneous enzyme immunoassay process for quantitatively analyzing an antigen by determining the change in the enzymatic activity caused by a reaction between the antigen and an enzyme-labeled antibody. The antigen is reacted with an enzyme-labeled antibody, followed by the reaction with a second antibody capable of recognizing and binding to a different epitope and then with a third antibody capable of recognizing and binding to the second antibody. The enzymatic activity of the labeling enzyme is determined by a water-insoluble substrate. Using the water-insoluble substrate, steric hindrance is enhanced. A highly-sensitive analysis can be carried out by a simple operation even when the antigen has a molecular weight falling within an intermediate range, for example, a range of M.W. 10,000 to 70,000.
摘要翻译：一种改进的均匀酶免疫测定方法，用于通过测定由抗原和酶标记的抗体之间的反应引起的酶活性的变化来定量分析抗原。使抗原与酶标记的抗体反应，然后与能够识别和结合不同表位的第二抗体反应，然后与能够识别和结合第二抗体的第三抗体反应。标记酶的酶活性由水不溶性底物决定。使用水不溶性底物，空间位阻增强。即使当抗原具有分子量落在中间范围内时，也可以通过简单的操作进行高灵敏度分析，例如，10,000至70000MW的范围。

3. 发明授权

US06280621B1 Blood filter cartridge with overflow receiver 失效
标题翻译：带有溢流接收器的滤芯
公开(公告)号：US06280621B1
公开(公告)日：2001-08-28
申请号：US09487679
申请日：2000-01-19
申请人： Kenichiro Yazawa , Takaki Arai , Osamu Seshimoto
发明人： Kenichiro Yazawa , Takaki Arai , Osamu Seshimoto
IPC分类号： B01D2905
CPC分类号： B01L3/502 , B01D61/18 , B01D61/20 , B01L3/0275 , B01L2300/0681 , G01N33/491
摘要： The blood filter cartridge of the invention can be used as a sample cup of an analyzer without sucking bubbles, which comprises a blood filtering material, a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, and a filtrate receiver for receiving filtrate discharged from the filtrate outlet, the filtrate receiver has an upper end having a difference in height or structure for returning the filtrate from the upper end of the filtrate receiver to the filtrate outlet.
摘要翻译：本发明的血液过滤器滤芯可用作分析器的样品杯而不吸入气泡，其包括血液过滤材料，含有血液过滤材料并具有血液入口和滤液出口的保持器，以及用于接收从滤液出口排出的滤液，滤液接收器具有高度或结构差的上端，用于将滤液从滤液接收器的上端返回到滤液出口。

4. 发明授权

US4842712A Device for measuring ion activity 失效
标题翻译：用于测量离子活性的装置
公开(公告)号：US4842712A
公开(公告)日：1989-06-27
申请号：US9470
申请日：1987-02-02
申请人： Osamu Seshimoto , Masaaki Terashima , Yoshio Saito
发明人： Osamu Seshimoto , Masaaki Terashima , Yoshio Saito
IPC分类号： G01N27/30 , G01N27/333
CPC分类号： G01N27/3335 , G01N27/307
摘要： In a device for measuring ion activity in a liquid sample such as a body fluid comprising at least one pair of ion-selective electrodes selectively responsive to a specific ion, a porous liquid distributing member for feeding a liquid sample to one electrode of the pair of electrodes, a porous liquid distributing member for feeding a reference liquid to another electrode of the pair of electrodes and a porous bridge for electrically connecting both liquids to each other, the improvement wherein the liquid distributing members are made of a nonwoven fabric composed of cellulosic long fibers.
摘要翻译：在用于测量诸如体液的液体样品中的离子活性的装置中，所述液体样品包括选择性地响应于特定离子的至少一对离子选择性电极，用于将液体样品供给到所述一对电极中的一个电极的多孔液体分配构件电极，用于将参考液体供给到该对电极中的另一个电极的多孔液体分配部件和用于将两个液体彼此电连接的多孔桥，其中液体分配部件由纤维素长的无纺布制成纤维。

5. 发明授权

US4734261A Duplex pipette 失效
标题翻译：双重移液器
公开(公告)号：US4734261A
公开(公告)日：1988-03-29
申请号：US823320
申请日：1986-01-28
申请人： Teruaki Koizumi , Yoshio Saito , Osamu Seshimoto
发明人： Teruaki Koizumi , Yoshio Saito , Osamu Seshimoto
IPC分类号： B01L3/02 , G01N35/10 , G01N1/14 , G01N1/16 , G01N1/26
CPC分类号： G01N35/1067 , B01L3/0217 , G01N2035/1069
摘要： A duplex pipette comprises a housing, a pair of cylinders separately formed in the housing to extend substantially in parallel to each other, first and second piston members each having a lower end portion slidably received in one of the cylinders and a handle portion projecting outside the cylinder, and a pair of pipette tips mounted on the lower end of the housing by way of a connecting member, each of the pipette tips having a passage which communicates one of the cylinders with the outside of the housing. The connecting member is arranged so that the distance between the distal ends of the pipette tips can be changed. One of the piston members is arranged to be movable separately from the other piston member and the other piston member is arranged to be movable only together with said one piston member.
摘要翻译：双相移液管包括壳体，一对气缸，其分别形成在壳体中以基本上彼此平行的方式延伸;第一和第二活塞构件，每个活塞构件具有可滑动地容纳在一个气缸中的下端部分;以及手柄部分，气缸，以及通过连接构件安装在壳体的下端上的一对移液管尖端，每个移液管吸头具有将气缸中的一个与壳体的外部连通的通道。连接构件被布置成使得移液管尖端的远端之间的距离可以改变。活塞部件中的一个被布置成可以与另一个活塞部件分离地移动，另一个活塞部件被布置成仅与所述一个活塞部件一起移动。

6. 发明授权

US4578173A Ion selective electrode and method of making ion selective electrodes 失效
标题翻译：离子选择电极和制造离子选择电极的方法
公开(公告)号：US4578173A
公开(公告)日：1986-03-25
申请号：US732368
申请日：1985-05-09
申请人： Osamu Seshimoto , Mitsuharu Nirasawa
发明人： Osamu Seshimoto , Mitsuharu Nirasawa
IPC分类号： G01N27/333 , G01N27/30
CPC分类号： G01N27/3335
摘要： An integral ion selective electrode for the analysis of a potassium ion comprising a support, an electroconductive metal layer such as a silver metal layer, a layer of a water-insoluble salt of said metal such as a silver chloride layer, an electrolyte layer which comprises an electrolyte salt of a potassium ion with the same anion as the anion of the water-insoluble salt, said electrolyte layer being substantially free from a binder, and an ion selective layer, which is characterized in that the electrolyte layer comprises crystalline electrolyte having a mean crystal size of not more than 60 .mu.m. Processes preferably employable for the preparation of the ion selective electrode are also disclosed.
摘要翻译：一种用于分析钾离子的积分离子选择性电极，包括载体，诸如银金属层的导电金属层，所述金属的水不溶性盐如氯化银层，电解质层，其包含具有与所述水不溶性盐的阴离子相同的阴离子的钾离子的电解质盐，所述电解质层基本上不含粘合剂，以及离子选择层，其特征在于，所述电解质层包含具有平均晶体尺寸不超过60亩。还公开了优选用于制备离子选择性电极的方法。

7. 发明授权

US07115195B2 Ion selective monoelectrode complex 有权
标题翻译：离子选择性单电极复合物
公开(公告)号：US07115195B2
公开(公告)日：2006-10-03
申请号：US10856650
申请日：2004-05-27
申请人： Masaaki Terashima , Osamu Seshimoto
发明人： Masaaki Terashima , Osamu Seshimoto
IPC分类号： G01N27/333
CPC分类号： G01N27/307 , Y10T29/49002
摘要： An ion selective monoelectrode complex which is favorably employable to manufacture an ion activity measuring apparatus, has on a common non-electroconductive support sheet, plural ion selective monoelectrodes each of which is composed of an electrode composite consisting of, in order, a silver metal layer, a silver halide layer, an electrolytic material layer, and an ion selective membrane, and an electroconductive terminal which is electrically connected to the silver metal layer and which has an exposed surface, under the condition that the ion selective monoelectrodes are aligned, without electric contact with each other, along an imaginary line bridging the electrode composite and the electroconductive terminal.
摘要翻译：有利地用于制造离子活性测量装置的离子选择性单电极配合物在普通的非导电性支持片上具有多个离子选择性单电极，它们由依次由银金属层，卤化银层，电解质层和离子选择性膜，以及在离子选择性单电极排列的情况下，电连接到银金属层并且具有暴露表面的导电端子，没有电沿着桥接电极复合体和导电端子的假想线彼此接触。

8. 发明申请

US20050106757A1 Agglutination assay method in porous medium layer 审中-公开
标题翻译：多孔介质层凝集测定法
公开(公告)号：US20050106757A1
公开(公告)日：2005-05-19
申请号：US11022510
申请日：2004-12-22
申请人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
发明人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
IPC分类号： G01N33/52 , G01N33/543 , G01N33/58 , G01N33/551
CPC分类号： G01N33/54346 , G01N33/525 , G01N33/587
摘要： An agglutination assay method for quantitatively determination of an analyte in an aqueous liquid sample using particles bearing an anti-analyte. The agglutination is conducted in the porous medium layer of the analysis element. A speedy quantitative analysis of the analyte can be conveniently attained with high sensitivity. When the particle-labeled anti-analyte is contained in the porous medium layer, the anti-analyte can be stored with higher stability in the dry state. A dry analysis element for enabling such analysis method is also provided.
摘要翻译：一种用于使用带有抗分析物的颗粒定量测定含水液体样品中的分析物的凝集测定方法。凝集在分析元件的多孔介质层中进行。可以方便地以高灵敏度获得分析物的快速定量分析。当颗粒标记的抗分析物包含在多孔介质层中时，抗分析物可以在干燥状态下以更高的稳定性储存。还提供了用于实现这种分析方法的干燥分析元件。

9. 发明授权

US06858392B2 Blocking of device for detecting biochemically active molecules 有权
标题翻译：用于检测生化活性分子的装置的阻断
公开(公告)号：US06858392B2
公开(公告)日：2005-02-22
申请号：US10021840
申请日：2001-12-13
申请人： Yoshihide Iwaki , Hiroshi Shinoki , Osamu Seshimoto
发明人： Yoshihide Iwaki , Hiroshi Shinoki , Osamu Seshimoto
IPC分类号： G01N33/53 , C07B61/00 , C12N15/09 , C12Q1/68 , G01N33/543 , G01N33/566 , G01N37/00 , C07H21/00 , C12P19/34
CPC分类号： G01N33/54393 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , C07B2200/11 , C40B40/00
摘要： A process for blocking a device for detection of biochemically active molecules is performed by the steps of: bringing in the presence of an aqueous medium a detection device having probe molecules, ionic reactive groups, and non-ionic reactive groups on its surface, into contact with compounds which react with the non-ionic reactive groups to produce covalent bondings and compounds which form electrostatic bondings with the ionic reactive groups, simultaneously or separately; and washing the surface of the detection device with an aqueous solvent or a water-miscible solvent.
摘要翻译：用于阻断用于检测生物化学活性分子的装置的方法通过以下步骤进行：使水性介质存在于其表面上具有探针分子，离子反应性基团和非离子反应性基团的检测装置接触与非离子反应性基团反应产生共价键的化合物和与离子反应基团形成静电键的化合物同时或分开; 并用水溶剂或水混溶性溶剂洗涤检测装置的表面。

10. 发明授权

US06664051B1 Fixation of nucleotide derivatives to solid carrier 有权
标题翻译：核苷酸衍生物固定于固体载体
公开(公告)号：US06664051B1
公开(公告)日：2003-12-16
申请号：US09706405
申请日：2000-11-03
申请人： Hiroshi Shinoki , Yukio Sudo , Osamu Seshimoto
发明人： Hiroshi Shinoki , Yukio Sudo , Osamu Seshimoto
IPC分类号： C07H2104
CPC分类号： C40B40/06 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00677 , B82Y30/00 , C40B50/06
摘要： A DNA chip or its analogue composed of nucleotide derivatives attached to a solid carrier is prepared by method of bringing nucleotide derivatives having a reactive group at each one terminal into contact with a solid carrier having thereon reactive groups in an aqueous phase in the presence of a transferase which is capable of producing a covalent bond by rearrangement of the reactive group of the nucleotide derivative and the reactive group of the solid carrier.
摘要翻译：通过以下方法制备DNA芯片或其由连接于固体载体上的核苷酸衍生物组成的类似物的方法：使得在每个末端具有反应性基团的核苷酸衍生物与其中具有反应性基团的固体载体在水相中存在下接触能够通过核苷酸衍生物的反应性基团和固体载体的反应性基团的重排而产生共价键的转移酶。

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