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1. 发明授权

US4734261A Duplex pipette 失效
标题翻译：双重移液器
公开(公告)号：US4734261A
公开(公告)日：1988-03-29
申请号：US823320
申请日：1986-01-28
申请人： Teruaki Koizumi , Yoshio Saito , Osamu Seshimoto
发明人： Teruaki Koizumi , Yoshio Saito , Osamu Seshimoto
IPC分类号： B01L3/02 , G01N35/10 , G01N1/14 , G01N1/16 , G01N1/26
CPC分类号： G01N35/1067 , B01L3/0217 , G01N2035/1069
摘要： A duplex pipette comprises a housing, a pair of cylinders separately formed in the housing to extend substantially in parallel to each other, first and second piston members each having a lower end portion slidably received in one of the cylinders and a handle portion projecting outside the cylinder, and a pair of pipette tips mounted on the lower end of the housing by way of a connecting member, each of the pipette tips having a passage which communicates one of the cylinders with the outside of the housing. The connecting member is arranged so that the distance between the distal ends of the pipette tips can be changed. One of the piston members is arranged to be movable separately from the other piston member and the other piston member is arranged to be movable only together with said one piston member.
摘要翻译：双相移液管包括壳体，一对气缸，其分别形成在壳体中以基本上彼此平行的方式延伸;第一和第二活塞构件，每个活塞构件具有可滑动地容纳在一个气缸中的下端部分;以及手柄部分，气缸，以及通过连接构件安装在壳体的下端上的一对移液管尖端，每个移液管吸头具有将气缸中的一个与壳体的外部连通的通道。连接构件被布置成使得移液管尖端的远端之间的距离可以改变。活塞部件中的一个被布置成可以与另一个活塞部件分离地移动，另一个活塞部件被布置成仅与所述一个活塞部件一起移动。

2. 发明授权

US4613420A Apparatus for measuring ionic activity 失效
标题翻译：用于测量离子活性的装置
公开(公告)号：US4613420A
公开(公告)日：1986-09-23
申请号：US694220
申请日：1985-01-24
申请人： Osamu Seshimoto , Yoshio Saito , Teruaki Koizumi , Masaaki Terashima
发明人： Osamu Seshimoto , Yoshio Saito , Teruaki Koizumi , Masaaki Terashima
IPC分类号： G01N27/28 , G01N35/00
CPC分类号： G01N35/00029 , G01N2035/00138 , G01N2035/00376
摘要： An apparatus for measuring ionic activity has a nozzle connected to a reservoir containing a reference solution. The reference solution is pumped up from the reservoir without coming into contact with air, so as to be quantitatively dripped through the nozzle when a slide-type ionic activity measuring device is located at a position below the nozzle. After the reference and sample solutions are spotted on the ionic activity measuring device, at least one pair of probes comes into contact with the device so as to measure potential difference corresponding to ionic activity difference of at least one ion between the reference and sample solutions.
摘要翻译：用于测量离子活性的装置具有连接到包含参考溶液的储存器的喷嘴。参考溶液从储存器中泵送而不与空气接触，当滑动型离子活性测量装置位于喷嘴下方时，通过喷嘴定量滴下。在参考和样品溶液被点在离子活性测量装置上之后，至少一对探针与装置接触，以便测量对应于参考和样品溶液之间的至少一个离子的离子活性差异的电位差。

3. 发明授权

US4613421A Apparatus for measuring ionic activity 失效
标题翻译：用于测量离子活性的装置
公开(公告)号：US4613421A
公开(公告)日：1986-09-23
申请号：US694221
申请日：1985-01-24
申请人： Osamu Seshimoto , Teruaki Koizumi , Yoshio Saito , Akira Yamaguchi
发明人： Osamu Seshimoto , Teruaki Koizumi , Yoshio Saito , Akira Yamaguchi
IPC分类号： G01N27/28 , G01N35/00
CPC分类号： G01N35/00029 , G01N2035/00138 , G01N2035/00376
摘要： An apparatus for measuring ionic activity is comprised of a rotatable turret and at least one pair of vertically movable probes. The turret intermittently conveys slide-type ionic activity measuring devices, one by one, on each of which are spots of reference and sample solutions, to a measuring section where the probes come into contact with the measuring device so as to measure the potential difference corresponding to the difference in ionic activity of a specific ion between the reference and sample solutions. After measurement the turret further conveys the device to a discharging section where the device is automatically discharged.
摘要翻译：用于测量离子活性的装置包括可旋转转台和至少一对可垂直移动的探针。转台间隔地将滑动型离子活性测量装置一个接一个地传送到测量部分，其中探针与测量装置接触，以测量相应的电位差到参考和样品溶液之间的特定离子的离子活性的差异。测量后，转塔进一步将装置输送到装置自动排出的排放部分。

4. 发明授权

US4842712A Device for measuring ion activity 失效
标题翻译：用于测量离子活性的装置
公开(公告)号：US4842712A
公开(公告)日：1989-06-27
申请号：US9470
申请日：1987-02-02
申请人： Osamu Seshimoto , Masaaki Terashima , Yoshio Saito
发明人： Osamu Seshimoto , Masaaki Terashima , Yoshio Saito
IPC分类号： G01N27/30 , G01N27/333
CPC分类号： G01N27/3335 , G01N27/307
摘要： In a device for measuring ion activity in a liquid sample such as a body fluid comprising at least one pair of ion-selective electrodes selectively responsive to a specific ion, a porous liquid distributing member for feeding a liquid sample to one electrode of the pair of electrodes, a porous liquid distributing member for feeding a reference liquid to another electrode of the pair of electrodes and a porous bridge for electrically connecting both liquids to each other, the improvement wherein the liquid distributing members are made of a nonwoven fabric composed of cellulosic long fibers.
摘要翻译：在用于测量诸如体液的液体样品中的离子活性的装置中，所述液体样品包括选择性地响应于特定离子的至少一对离子选择性电极，用于将液体样品供给到所述一对电极中的一个电极的多孔液体分配构件电极，用于将参考液体供给到该对电极中的另一个电极的多孔液体分配部件和用于将两个液体彼此电连接的多孔桥，其中液体分配部件由纤维素长的无纺布制成纤维。

5. 发明授权

US4783251A Ionic activity measuring device 失效
标题翻译：离子活度测量装置
公开(公告)号：US4783251A
公开(公告)日：1988-11-08
申请号：US945644
申请日：1986-12-23
申请人： Osamu Seshimoto , Akira Yamaguchi , Yoshio Saito
发明人： Osamu Seshimoto , Akira Yamaguchi , Yoshio Saito
IPC分类号： G01N27/30 , G01N27/26
CPC分类号： G01N27/307
摘要： An ionic activity measuring device comprises ion selective electrodes, porous liquid distributing members for distributing a reference solution and a sample solution to the ion selective electrodes, a frame for housing the ion selective electrodes and the porous liquid distributing members and provided with a pair of liquid feed holes for feeding the reference solution and the sample solution to the porous liquid distributing members, and a porous bridge for achieving electrical conduction between the reference solution and the sample solution fed in drops to the liquid feed holes. The porous bridge is disposed in a recess formed in the surface of the frame so that the depth of the recess is not smaller than the height of the porous bridge. End portions of the porous liquid distributing members are protruded to regions under the liquid feed holes so that the fed solutions may enter from side faces of the end portions. The porous bridge may extend at positions deviated from centers of the liquid feed holes. The frame may be provided with holes for insertion of potential measuring probes, and air discharging holes.
摘要翻译：一种离子活性测量装置，包括离子选择性电极，用于将参考溶液分散的多孔液体分配部件和样品溶液到离子选择性电极，用于容纳离子选择性电极和多孔液体分配部件的框架，并具有一对液体用于将参考溶液和样品溶液供给到多孔液体分配构件的进料孔，以及用于实现将参比溶液和样品溶液滴入液体进料孔之间导电的多孔桥。多孔桥设置在形成在框架的表面中的凹部中，使得凹部的深度不小于多孔桥的高度。多孔液体分配构件的端部突出到液体供给孔下方的区域，使得供给的溶液可以从端部的侧面进入。多孔桥可以在从液体供给孔的中心偏离的位置延伸。框架可以设置有用于插入潜在测量探针的孔和排气孔。

6. 发明授权

US5555767A Liquid mixing method 失效
标题翻译：液体混合法
公开(公告)号：US5555767A
公开(公告)日：1996-09-17
申请号：US390035
申请日：1995-02-17
申请人： Yoshihiko Makino , Yoshio Saito , Osamu Seshimoto
发明人： Yoshihiko Makino , Yoshio Saito , Osamu Seshimoto
IPC分类号： G01N1/10 , G01N1/38 , G01N35/00 , G01N35/10
CPC分类号： G01N35/10 , G01N1/38 , G01N2035/00237 , G01N2035/1032 , G01N2035/1034 , G01N2035/106 , G01N35/00029 , Y10T436/25125 , Y10T436/25625
摘要： In a method for mixing a small amount of a liquid sample with a second liquid, the liquid sample is first fed into a mixing vessel. Thereafter, the second liquid is discharged from an orifice of a second liquid pipette tip into the vessel, and the liquid sample and the second liquid are thereby stirred with each other. The small amount of the liquid sample is thus efficiently stirred by the second liquid and is thereby uniformly mixed with the second liquid. Also, the liquid sample and the second liquid are mixed with each other in an accurate mixing ratio.
摘要翻译：在将少量液体样品与第二液体混合的方法中，首先将液体样品进料到混合容器中。此后，将第二液体从第二液体移液管尖端的孔排出到容器中，并使液体样品和第二液体彼此搅拌。因此，少量的液体样品被第二液体有效地搅拌，从而与第二液体均匀混合。此外，液体样品和第二液体以精确的混合比彼此混合。

7. 发明授权

US4801434A Dual pipette device 失效
标题翻译：双吸管装置
公开(公告)号：US4801434A
公开(公告)日：1989-01-31
申请号：US938192
申请日：1986-12-05
申请人： Keishiro Kido , Yoshio Saito , Takashi Koizumi , Osamu Seshimoto
发明人： Keishiro Kido , Yoshio Saito , Takashi Koizumi , Osamu Seshimoto
IPC分类号： B01L3/02 , G01N35/10
CPC分类号： B01L3/0217 , G01N35/1067 , G01N2035/1069
摘要： A dual pipette device comprises a pair of housings joined rotatably around a vertically extending axis or disposed for lateral movement, a pair of cylinders disposed respectively at lower sections of the housings, a pair of piston members extending vertically, supported by the housings or the cylinders, and respectively having lower end portions vertically slideable in the cylinders, and dropping tip fitting sections disposed at lower end of the housings or the cylinders so that the dropping tip fitting sections communicate with the cylinders. The piston members are provided with a lock member for locking them to each other when the housings are rotated or laterally moved and the distance between the piston members becomes not larger than a predetermined distance, so that the piston members are vertically slideable integrally with each other.
摘要翻译：双移液管装置包括一对围绕垂直延伸的轴线可转动地设置或设置用于横向运动的壳体，一对分别设置在壳体的下部的气缸，一对垂直延伸的活塞构件，由壳体或气缸并且分别具有在气缸中可垂直滑动的下端部，以及设置在壳体或气缸的下端的下降尖端配合部分，使得下降尖端配合部分与气缸连通。活塞构件设置有锁定构件，用于当壳体旋转或横向移动并且活塞构件之间的距离不大于预定距离时彼此锁定，使得活塞构件彼此一体地竖直滑动。

8. 发明授权

US4789435A Method and device of measuring ion activity 失效
标题翻译：测量离子活性的方法和装置
公开(公告)号：US4789435A
公开(公告)日：1988-12-06
申请号：US896888
申请日：1986-08-14
申请人： Osamu Seshimoto , Yoshio Saito
发明人： Osamu Seshimoto , Yoshio Saito
IPC分类号： G01N27/30
CPC分类号： G01N27/307
摘要： In a method of measuring ion activity of a liquid sample comprising steps of spotting a reference liquid and the liquid sample on surfaces of ion-selective membranes, respectively, of at least a pair of ion-selective electrode sheets which is electrically insulated from each other, said ion-selective membranes being provided on the top of said ion-selective electrode sheets; and measuring a potential difference between the ion-selective electrodes under the conditions that both liquids are electrically connected to each other by a bridge, the improvement wherein:said each ion-selective electrode sheet is arranged upside down in such a manner that the ion-selective membrane is positioned on the lowest side;andsaid each liquid spotted from the upper side is temporarily conveyed downwardly to the lower level than the surface of the ion-selective membrane or the spotting is done on the lower level than the surface of the ion-selective membrane, and then conveyed upwardly to the surface of the ion-selective membrane through an upward passage which has a side wall being clear of the surface of the ion-selective membrane under the condition that no capillary phenomenon occurs in the clearance between the top of said side wall and the surface of the ion-selective membrane, so as to reach the surface of the ion-selective membrane.
摘要翻译：在测量液体样品的离子活性的方法中，包括分别在至少一对离子选择性电极片彼此电绝缘的离子选择膜的表面上分离参考液体和液体样品的步骤所述离子选择膜设置在所述离子选择性电极片的顶部; 并且在两个液体通过桥接器彼此电连接的条件下测量离子选择性电极之间的电势差，其改进在于：所述每个离子选择电极片以这样一种方式被布置成：选择性膜位于最下面; 并且将从上侧点出的每个液体暂时向下传送到比离子选择膜的表面更低的水平，或者在比离子选择膜的表面更低的水平上进行点样，然后向上输送到通过向上通道的离子选择性膜的表面，其具有侧壁在离子选择性膜的表面之外，在所述侧壁的顶部和表面之间的间隙中不发生毛细现象的条件下离子选择性膜，以到达离子选择膜的表面。

9. 发明授权

US4684445A Method and device of measuring ion activity 失效
标题翻译：测量离子活性的方法和装置
公开(公告)号：US4684445A
公开(公告)日：1987-08-04
申请号：US881815
申请日：1986-07-03
申请人： Osamu Seshimoto , Mituharu Nirasawa , Masaaki Terashima , Yoshio Saito
发明人： Osamu Seshimoto , Mituharu Nirasawa , Masaaki Terashima , Yoshio Saito
IPC分类号： G01N27/28 , G01N27/406 , G01N27/30
CPC分类号： G01N27/333
摘要： In a method of measuring ion activity of a liquid sample comprising steps of spotting a reference liquid and the liquid sample on surfaces of ion-selective membranes, respectively, of at least a pair of ion-selective electrode sheets which is electrically insulated from each other, said ion-selective membranes being provided on the top of said ion-selective electrode sheets; and measuring a potential difference between the ion-selective electrodes under the conditions that both liquids are electrically connected to each other by a bridge, the improvement wherein:said each ion-selective electrode sheet is arranged upside down in such a manner that the ion-selective membrane is positioned on the lowest side; andsaid each liquid spotted from the upper side is temporarily conveyed downwardly to the lower level than the surface of the ion-selective membrane, and then conveyed upwardly to the surface of the ion-selective membrane so as to reach the surface of the ion-selective membrane. A device employable in the method is also disclosed.
摘要翻译：在测量液体样品的离子活性的方法中，包括分别在至少一对离子选择性电极片彼此电绝缘的离子选择膜的表面上分离参考液体和液体样品的步骤所述离子选择膜设置在所述离子选择性电极片的顶部; 并且在两个液体通过桥接器彼此电连接的条件下测量离子选择性电极之间的电势差，其改进在于：所述每个离子选择电极片以这样一种方式被布置成：选择性膜位于最下面; 并且将从上侧点出的每个液体暂时向下输送到比离子选择性膜的表面更低的水平，然后向上输送到离子选择性膜的表面，以到达离子选择性膜的表面，选择性膜。还公开了可用于该方法的装置。

10. 发明授权

US4655899A Probe assembly for an apparatus for measuring ionic activity 失效
标题翻译：用于测量离子活性的装置的探针组件
公开(公告)号：US4655899A
公开(公告)日：1987-04-07
申请号：US703396
申请日：1985-02-20
申请人： Yoshio Saito , Osamu Seshimoto
发明人： Yoshio Saito , Osamu Seshimoto
IPC分类号： G01N27/28 , G01N27/30 , G01N27/416 , G01N27/46
CPC分类号： G01N27/307
摘要： A probe assembly has at least two pairs of probes and a relay for switchably connecting any one pair of the probes to a single electric impedance lowering means. When the pairs of probes are brought into contact with terminals of at least two pairs of ion-selective electrodes of an ionic activity device, the potential difference generated between each pair of said electrodes is successively transferred to a measuring means by way of the electric impedance lowering means.
摘要翻译：探针组件具有至少两对探针和用于将任何一对探针可切换地连接到单个电阻抗降低装置的继电器。当成对的探针与离子活性器件的至少两对离子选择性电极的端子接触时，在每对所述电极之间产生的电位差通过电阻抗连续转移到测量装置降低手段。

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