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1. 发明专利

JP2007534764A Antifungal drug delivery 审中-公开
公开(公告)号：JP2007534764A
公开(公告)日：2007-11-29
申请号：JP2007510881
申请日：2005-04-25
申请人：ニムニ、マーセルNIMNI, Marcel , パンディア、アナントPANDYA, Anant
发明人：ニムニ、マーセル , パンディア、アナント
IPC分类号： A61K31/137 , A61K9/00 , A61K47/10 , A61P17/00 , A61P31/10
CPC分类号： A61K31/343 , A61K9/0014 , A61K31/137 , A61K31/4174 , A61K31/496 , A61K45/06 , A61K47/10 , A61K2300/00
摘要：改善された皮膚および爪の局所的塗布用抗真菌組成物は、（１）アリルアミン抗真菌化合物と、（２）治療上有効濃度のアリルアミン抗真菌化合物が溶液で局所的に塗布され得る程度までアリルアミン抗真菌化合物が溶解する、芳香族置換基で置換された脂肪族アルコールと、（３）芳香族アルコールが溶解する低級脂肪族アルコールと、および（ｄ）水または水相溶性混合溶媒を含む。アリルアミン抗真菌化合物は、テルビナフィンまたはナフチフィンであり得る。芳香族置換基で置換された脂肪族アルコールは、ベンジルアルコールまたはフェネチルアルコールであり得る。低級脂肪族アルコールは、エチルアルコールまたはイソプロピルアルコールであり得る。代替例において、組成物はさらに、さらなる抗真菌化合物を含み得る。

2. 发明公开

EP0879044A4 ANTI-FUGAL NAIL LACQUER AND METHOD THEREFOR 失效
标题翻译：杀菌指甲油和相关方法
公开(公告)号：EP0879044A4
公开(公告)日：1999-03-31
申请号：EP96903559
申请日：1996-01-18
申请人： NIMNI MARCEL E
发明人： NIMNI MARCEL E
IPC分类号： A61K7/043
摘要： An anti-fugal nail lacquer composition containing a film-forming agent, a solvent therefor, and an anti-fungal amount of griseofulvin which can be either in suspension or solution in the nail lacquer composition. A method of using the anti-fungal nail lacquer composition includes applying the composition to a finger or toenail and allowing the composition to remain in contact with the nail until the solvents evaporate and a thin film of griseofulvin remains on the nail.

3. 发明公开

EP1047442A1 BONE MORPHOGENETIC PROTEINS AND THEIR USE IN BONE GROWTH 失效
标题翻译： KNOCHENMORPHOGENESEPROTEINEN及骨骼生长的推广应用
公开(公告)号：EP1047442A1
公开(公告)日：2000-11-02
申请号：EP98925128.5
申请日：1998-06-02
申请人： Nimni, Marcel E. , Hall, Frederick L. , Wu, Lingtao , Han, Bo , Shors, Edwin C.
发明人： Nimni, Marcel E. , Hall, Frederick L. , Wu, Lingtao , Han, Bo , Shors, Edwin C.
IPC分类号： A61K38/18 , C07H21/04 , C12N1/21 , C12P21/00 , G01N33/53
CPC分类号： A61L27/24 , A61K38/00 , A61L27/38 , A61L27/60 , A61L2430/02 , C07K14/495 , C07K14/51 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/50 , C07K2319/75 , C12N15/62 , G01N2333/51 , Y02A50/423
摘要： A bone morphogenetic fusion protein and a method of preparation of the bone morphogenetic fusion protein. The bone morphogenetic fusion protein comprises a purification tag and a bone morphogenetic active fragment. A method of preparing bone morphogenetic fusion protein comprises purifying and renaturing bone morphogenetic protein to provide an active bone morphogenetic fusion protein preparation. Methods of use of the bone morphogenetic fusion protein are also provided.

4. 发明申请

WO2010053918A1 COMPOSITE CONTAINING COLLAGEN AND ELASTIN AS A DERMAL EXPANDER AND TISSUE FILLER 审中-公开
标题翻译：包含胶原蛋白和弹性蛋白酶的复合物作为透气剂和组织填料
公开(公告)号：WO2010053918A1
公开(公告)日：2010-05-14
申请号：PCT/US2009/063132
申请日：2009-11-03
申请人： HANCOCK JAFFE LABORATORIES, INC. , HAN, Bo , NIMNI, Marcel
发明人： HAN, Bo , NIMNI, Marcel
IPC分类号： A61K31/74
CPC分类号： A61L27/227 , A61K8/64 , A61K38/39 , A61K2800/91 , A61L2400/06 , A61Q19/00
摘要： An injectable composition having dermal filling and tissue expanding activity comprises (1) a quantity of elastin sufficient to bring about dermal filling and tissue expansion when injected into a subject in need of dermal filling and tissue expansion, and (2) a pharmaceutically acceptable carrier. The composition can further comprise collagen, in other alternatives, the composition can further comprise hyaluronic acid, and one or more of the elastin, the collagen, and the hyaluronic acid, if present can be cross-linked, either intramolecularly or intermolecularly. The elastin, however, is the primary filler, even if collagen or hyaluronic acid are included in the composition
摘要翻译：具有皮肤填充和组织扩张活性的可注射组合物包括（1）当注射到需要皮肤填充和组织扩张的受试者中时，足以引起皮肤填充和组织扩张的弹性蛋白量，和（2）药学上可接受的载体。组合物可以进一步包含胶原，在其它替代方案中，组合物还可以包含透明质酸，并且弹性蛋白，胶原和透明质酸中的一种或多种（如果存在的话）可以在分子内或分子内交联。然而，弹性蛋白是主要的填充剂，即使胶原蛋白或透明质酸被包括在组合物中

5. 发明申请

WO2005105072A3 ANTIFUNGAL DRUG DELIVERY 审中-公开
标题翻译：抗真菌药物递送
公开(公告)号：WO2005105072A3
公开(公告)日：2006-03-02
申请号：PCT/US2005014246
申请日：2005-04-25
申请人： NIMNI MARCEL , PANDYA ANANT
发明人： NIMNI MARCEL , PANDYA ANANT
IPC分类号： A61K9/00 , A61K31/137 , A61K7/047 , A61K31/13 , A61K31/135
CPC分类号： A61K31/343 , A61K9/0014 , A61K31/137 , A61K31/4174 , A61K31/496 , A61K45/06 , A61K47/10 , A61K2300/00
摘要： An improved antifungal composition for topical application to the skin and nails comprises: (1) an allylamine antifungal compound; (2) an aliphatic alcohol substituted with an aromatic substituent in which the allylamine antifungal compound is soluble to a degree that a therapeutically effective concentration of the allylamine antifungal compound can be applied topically in solution; (3) a lower aliphatic alcohol in which the aromatic alcohol is soluble; and (d) water or a water-compatible solvent mixture. The allylamine antifungal compound can be terbinafine or naftifine. The aliphatic alcohol substituted with an aromatic substituent can be benzyl alcohol or phenethyl alcohol. The lower aliphatic alcohol can be ethyl alcohol or isopropyl alcohol. In an alternative, the composition can further comprise an additional antifungal compound. Another aspect of the invention is a method for treatment of a fungal infection of skin or nails comprising administering the antifungal composition of the present invention topically to the skin or nails in an amount therapeutically effective to treat the fungal infection.
摘要翻译：用于局部施用于皮肤和指甲的改进的抗真菌组合物包括：（1）烯丙胺抗真菌化合物; （2）被芳族取代基取代的脂肪族醇，其中烯丙胺抗真菌化合物可溶于可以在溶液中局部施用烯丙胺抗真菌化合物的治疗有效浓度的程度; （3）芳族醇可溶解的低级脂族醇; 和（d）水或与水相容的溶剂混合物。烯丙胺抗真菌化合物可以是特比萘芬或萘替芬。被芳族取代基取代的脂族醇可以是苄醇或苯乙醇。低级脂族醇可以是乙醇或异丙醇。替代方案中，组合物还可以包含另外的抗真菌化合物。本发明的另一方面是用于治疗皮肤或指甲的真菌感染的方法，其包括以治疗有效治疗真菌感染的量局部给予皮肤或指甲的本发明的抗真菌组合物。

6. 发明申请

WO0107059A9 MATRIX-TARGETED FUSION POLYPEPTIDES FOR TISSUE REGENERATION AND WOUND HEALING 审中-公开
标题翻译：用于组织再生和创伤治疗的基质定向融合多聚体
公开(公告)号：WO0107059A9
公开(公告)日：2002-09-06
申请号：PCT/US0020055
申请日：2000-07-21
申请人： UNIV SOUTHERN CALIFORNIA , HALL FREDERICK L , NIMNI MARCEL , GORDON ERLINDA M , BEART ROBERT W
发明人： HALL FREDERICK L , NIMNI MARCEL , GORDON ERLINDA M , BEART ROBERT W
IPC分类号： A61K35/12 , A61K38/00 , A61K48/00 , C07K14/485 , C07K14/755 , C12N5/02 , C12N5/071 , A61K35/36 , A61K35/37 , A61K35/38 , A61K38/27 , A61K38/43 , A61K39/395 , C07H21/04 , C07K1/00 , C07K14/00 , C07K16/00 , C07K19/00 , C12N5/00 , C12N15/00 , C12N15/62 , C12N15/63 , C12N15/85 , C12N15/86
CPC分类号： C12N5/0679 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/485 , C07K14/755 , C07K2319/00
摘要： The present invention relates to compositions and methods for promoting tissue repair and regeneration. The invention provides a fusion polypeptide useful for targeting tissues for regeneration and methods of use therefore.
摘要翻译：本发明涉及用于促进组织修复和再生的组合物和方法。本发明提供了可用于靶向用于再生的组织的融合多肽和因此使用的方法。

7. 发明申请

WO2012112690A3 TARGETING OF THERAPEUTIC DRUGS AND DIAGNOSTIC AGENTS EMPLOYING COLLAGEN BINDING DOMAINS 审中-公开
标题翻译：治疗药物和使用胶原蛋白结合域的诊断试剂的目标
公开(公告)号：WO2012112690A3
公开(公告)日：2014-04-24
申请号：PCT/US2012025261
申请日：2012-02-15
申请人： NIMNI MARCEL E , HAN BO , BOASBERG PETER , FABIUS BIOTECHNOLOGY
发明人： NIMNI MARCEL E , HAN BO , BOASBERG PETER
IPC分类号： C07K16/18 , A61K39/395 , C12P21/08
CPC分类号： A61K47/64
摘要： A targeting composition comprising: (1) a therapeutic agent; (2) an intermediate release linker bound to the therapeutic agent; and (3) a targeting moiety bound to the intermediate release linker, the targeting moiety for binding the targeting composition to native collagen fibers, provides an improved means of targeting therapeutic agents to cells, particularly malignant cells. The therapeutic agents can be, but are not limited to, anti-neoplastic agents or anti-inflammatory agents. The peptide motif can be a motif derived from the sequence present in von Willebrand's factor. The invention also encompasses pharmaceutical compositions and methods of treatment, as well as diagnostic compositions.
摘要翻译：一种靶向组合物，其包含：（1）治疗剂; （2）与治疗剂结合的中间释放连接体; 和（3）与中间释放连接物结合的靶向部分，用于将靶向组合物结合到天然胶原纤维的靶向部分提供了将治疗剂靶向细胞特别是恶性细胞的改进方法。治疗剂可以是但不限于抗肿瘤剂或抗炎剂。肽基序可以是衍生自von Willebrand因子中存在的序列的基序。本发明还包括药物组合物和治疗方法以及诊断组合物。

8. 发明申请

WO2005105072A2 ANTIFUNGAL DRUG DELIVERY 审中-公开
标题翻译：抗真菌药物递送
公开(公告)号：WO2005105072A2
公开(公告)日：2005-11-10
申请号：PCT/US2005/014246
申请日：2005-04-25
申请人： NIMNI, Marcel , PANDYA, Anant
发明人： NIMNI, Marcel , PANDYA, Anant
IPC分类号： A61K31/137
CPC分类号： A61K31/343 , A61K9/0014 , A61K31/137 , A61K31/4174 , A61K31/496 , A61K45/06 , A61K47/10 , A61K2300/00
摘要： An improved antifungal composition for topical application to the skin and nails comprises: (1) an allylamine antifungal compound; (2) an aliphatic alcohol substituted with an aromatic substituent in which the allylamine antifungal compound is soluble to a degree that a therapeutically effective concentration of the allylamine antifungal compound can be applied topically in solution; (3) a lower aliphatic alcohol in which the aromatic alcohol is soluble; and (d) water or a water-compatible solvent mixture. The allylamine antifungal compound can be terbinafine or naftifine. The aliphatic alcohol substituted with an aromatic substituent can be benzyl alcohol or phenethyl alcohol. The lower aliphatic alcohol can be ethyl alcohol or isopropyl alcohol. In an alternative, the composition can further comprise an additional antifungal compound. Another aspect of the invention is a method for treatment of a fungal infection of skin or nails comprising administering the antifungal composition of the present invention topically to the skin or nails in an amount therapeutically effective to treat the fungal infection.
摘要翻译：用于局部施用于皮肤和指甲的改进的抗真菌组合物包括：（1）烯丙胺抗真菌化合物; （2）被芳族取代基取代的脂肪族醇，其中烯丙胺抗真菌化合物可溶于可以在溶液中局部施用烯丙胺抗真菌化合物的治疗有效浓度的程度; （3）芳族醇可溶解的低级脂族醇; 和（d）水或与水相容的溶剂混合物。烯丙胺抗真菌化合物可以是特比萘芬或萘替芬。被芳族取代基取代的脂族醇可以是苄醇或苯乙醇。低级脂族醇可以是乙醇或异丙醇。替代方案中，组合物还可以包含另外的抗真菌化合物。本发明的另一方面是用于治疗皮肤或指甲的真菌感染的方法，其包括以治疗有效治疗真菌感染的量局部给予皮肤或指甲的本发明的抗真菌组合物。

9. 发明公开

EP1047442A4 BONE MORPHOGENETIC PROTEINS AND THEIR USE IN BONE GROWTH 失效
标题翻译： KNOCHENMORPHOGENESEPROTEINEN及骨骼生长的推广应用
公开(公告)号：EP1047442A4
公开(公告)日：2002-01-02
申请号：EP98925128
申请日：1998-06-02
申请人： NIMNI MARCEL E , HALL FREDERICK L , WU LINGTAO , HAN BO , SHORS EDWIN C
发明人： NIMNI MARCEL E , HALL FREDERICK L , WU LINGTAO , HAN BO , SHORS EDWIN C
IPC分类号： A61K38/00 , A61L27/24 , A61L27/38 , A61L27/60 , C07K14/495 , C07K14/51 , C12N1/21 , C12N15/62 , A61K38/18 , C07H21/04 , C12P21/00 , G01N33/53
CPC分类号： A61L27/24 , A61K38/00 , A61L27/38 , A61L27/60 , A61L2430/02 , C07K14/495 , C07K14/51 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/50 , C07K2319/75 , C12N15/62 , G01N2333/51
摘要： A bone morphogenetic fusion protein and a method of preparation of the bone morphogenetic fusion protein. The bone morphogenetic fusion protein comprises a purification tag and a bone morphogenetic active fragment. A method of preparing bone morphogenetic fusion protein comprises purifying and renaturing bone morphogenetic protein to provide an active bone morphogenetic fusion protein preparation. Methods of use of the bone morphogenetic fusion protein are also provided.

10. 发明公开

EP0121008A3 Coating for bioprosthetic device and method of making same 失效
标题翻译：用于生物装置的涂料及其制备方法
公开(公告)号：EP0121008A3
公开(公告)日：1985-03-27
申请号：EP83301774
申请日：1983-03-29
申请人： Nimni, Marcel E.
发明人： Nimni, Marcel E. , Cheung, David T.
IPC分类号： A61F01/00 , A61L17/00 , A01N01/02
CPC分类号： A61L33/0011 , A61F2/06 , A61F2/08 , A61F2/24 , A61K35/32 , A61K35/44 , A61L27/28 , A61L27/34 , A61L27/36 , A61L27/3687 , A61L27/54 , A61L2300/236 , A61L2300/42 , A61L2300/432 , A61L2300/606 , A61L2400/02 , C08L5/08 , C08L89/00
摘要： A coating and integral treatment for improving the biophysical stability of bioprosthetic devices after implantation, particularly with respect to calcification, and, specifically, a method for treating animal tissues, such as heart valves, to provide improved biophysical stability in allograft and heterograft transplanations. The increased stability results, in-part, from the creation of a three-dimensional matrix of a primary structural component of the prosthetic device and covalently attached calcification inhibitors. Other materials, some having additional stabilizing effects, may be utilized to form additional bridges or fill the interstitial gaps in the matrix. After implantation, the resultant modified device exhibits minimal surface for intramatrix growth of calcium phosphate crystals, and additionally, may inhibit platelet aggregation, enzymatic degradation and host rejection, while minimizing the risk of mechanical failure, in the host organism.

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