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1. 发明公开

EP1047442A1 BONE MORPHOGENETIC PROTEINS AND THEIR USE IN BONE GROWTH 失效
标题翻译： KNOCHENMORPHOGENESEPROTEINEN及骨骼生长的推广应用
公开(公告)号：EP1047442A1
公开(公告)日：2000-11-02
申请号：EP98925128.5
申请日：1998-06-02
申请人： Nimni, Marcel E. , Hall, Frederick L. , Wu, Lingtao , Han, Bo , Shors, Edwin C.
发明人： Nimni, Marcel E. , Hall, Frederick L. , Wu, Lingtao , Han, Bo , Shors, Edwin C.
IPC分类号： A61K38/18 , C07H21/04 , C12N1/21 , C12P21/00 , G01N33/53
CPC分类号： A61L27/24 , A61K38/00 , A61L27/38 , A61L27/60 , A61L2430/02 , C07K14/495 , C07K14/51 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/50 , C07K2319/75 , C12N15/62 , G01N2333/51 , Y02A50/423
摘要： A bone morphogenetic fusion protein and a method of preparation of the bone morphogenetic fusion protein. The bone morphogenetic fusion protein comprises a purification tag and a bone morphogenetic active fragment. A method of preparing bone morphogenetic fusion protein comprises purifying and renaturing bone morphogenetic protein to provide an active bone morphogenetic fusion protein preparation. Methods of use of the bone morphogenetic fusion protein are also provided.

2. 发明公开

EP1047442A4 BONE MORPHOGENETIC PROTEINS AND THEIR USE IN BONE GROWTH 失效
标题翻译： KNOCHENMORPHOGENESEPROTEINEN及骨骼生长的推广应用
公开(公告)号：EP1047442A4
公开(公告)日：2002-01-02
申请号：EP98925128
申请日：1998-06-02
申请人： NIMNI MARCEL E , HALL FREDERICK L , WU LINGTAO , HAN BO , SHORS EDWIN C
发明人： NIMNI MARCEL E , HALL FREDERICK L , WU LINGTAO , HAN BO , SHORS EDWIN C
IPC分类号： A61K38/00 , A61L27/24 , A61L27/38 , A61L27/60 , C07K14/495 , C07K14/51 , C12N1/21 , C12N15/62 , A61K38/18 , C07H21/04 , C12P21/00 , G01N33/53
CPC分类号： A61L27/24 , A61K38/00 , A61L27/38 , A61L27/60 , A61L2430/02 , C07K14/495 , C07K14/51 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/50 , C07K2319/75 , C12N15/62 , G01N2333/51
摘要： A bone morphogenetic fusion protein and a method of preparation of the bone morphogenetic fusion protein. The bone morphogenetic fusion protein comprises a purification tag and a bone morphogenetic active fragment. A method of preparing bone morphogenetic fusion protein comprises purifying and renaturing bone morphogenetic protein to provide an active bone morphogenetic fusion protein preparation. Methods of use of the bone morphogenetic fusion protein are also provided.

3. 发明专利

AU7714898A Bone morphogenetic proteins and their use in bone growth 未知
公开(公告)号：AU7714898A
公开(公告)日：1998-12-21
申请号：AU7714898
申请日：1998-06-02
申请人： HALL FREDERICK L , HAN BO , NIMNI MARCEL E , SHORS EDWIN C , WU LINGTAO
发明人： NIMNI MARCEL E , HALL FREDERICK L , WU LINGTAO , HAN BO , SHORS EDWIN C
IPC分类号： A61K38/00 , A61L27/24 , A61L27/38 , A61L27/60 , C07K14/495 , C07K14/51 , C12N1/21 , C12N15/62 , A61K38/18 , C07H21/04 , C12P21/00 , G01N33/53
摘要： A bone morphogenetic fusion protein and a method of preparation of the bone morphogenetic fusion protein. The bone morphogenetic fusion protein comprises a purification tag and a bone morphogenetic active fragment. A method of preparing bone morphogenetic fusion protein comprises purifying and renaturing bone morphogenetic protein to provide an active bone morphogenetic fusion protein preparation. Methods of use of the bone morphogenetic fusion protein are also provided.

4. 发明专利

TR200503232A2 未知
公开(公告)号：TR200503232A2
公开(公告)日：2007-03-21
申请号：TR200503232
申请日：2005-08-12
申请人： HAN BO TRANS ISTANBUL TEKSTIL
发明人： DEDEMEN AHMET RIFAT
IPC分类号： B41M5/025 , D06P5/28 , D06P1/92

5. 发明专利

TR200503209A2 未知
公开(公告)号：TR200503209A2
公开(公告)日：2007-03-21
申请号：TR200503209
申请日：2005-08-10
申请人： HAN BO TRANS ISTANBUL TEKSTIL
发明人： DEDEMEN AHMET RIFAT
IPC分类号： D04H11/00 , B44C1/17

6. 发明公开

KR20200144373A 손가락 끼임 방지를 위한 경첩 审中-公开
公开(公告)号：KR20200144373A
公开(公告)日：2020-12-29
申请号：KR20190072366
申请日：2019-06-18
申请人： JOIL A R T CO LTD , HAN BO CHUL
发明人： HAN BO CHUL
IPC分类号： E05D5/04 , E06B7/36
摘要： 본발명은손가락끼임방지를위한경첩에관한것으로, 본발명은‘ㄷ’자형태로도어프레임에설치되는제1경첩부; 적어도일단이개구된중공의기둥형태로상기제1경첩부의끝단에배치되는지지부; 상기제1경첩부에대하여회동가능하게배치되는제2경첩부; 및상기제2경첩부로부터연장되며, 상기지지부를중심으로회동가능한회동부;를포함하고, 상기도어프레임과상기도어사이로삽입될때, 상기도어프레임에걸리도록상기지지부의외면에돌출된제1삽입제한턱; 및상기도어에걸리도록상기회동부의외면에돌출된제2삽입제한턱;을더 포함할수 있다. 본발명은도어프레임과도어사이의간격을더욱줄일수 있고, 도어프레임과도어사이에경첩을삽입할때 너무깊은삽입을제한할수 있으며, 도어프레임과도어모두에삽입제한턱이양방향으로돌출되므로경첩이균형있게지지될수 있다. 또한본 발명은외부로돌출되는길이를대폭줄임으로써사용자나행인의걸음방해를방지하거나안전사고를방지할수 있고, 도어가회동되면서도도어프레임과의사이간격을줄일수 있다.

7. 发明公开

KR20120067254A Cutting burger holder 审中-公开
标题翻译：切割刀架
公开(公告)号：KR20120067254A
公开(公告)日：2012-06-25
申请号：KR20100128740
申请日：2010-12-15
申请人： HAN BO RAM
发明人： HAN BO RAM
IPC分类号： A47J47/16 , B65D5/54
CPC分类号： B65D85/36 , A47J47/16
摘要： PURPOSE: A hamburger holder having a cutting line is provided to use regardless of size by cutting the holder according to the size, and to apply to not only hamburger but also other breads like sandwich by manufacturing various sizes and shapes. CONSTITUTION: A hamburger holder having a cutting line comprises covers and straps. The covers are formed into a shape of a disc corresponding to hamburger size. The straps connect the disc-shaped covers. The holder can tear off depending on the size and manufacture various shapes and sizes, thereby applying other breads like sandwich.
摘要翻译：目的：提供具有切割线的汉堡包支架，不管尺寸如何，通过根据尺寸切割保持器而使用，并且通过制造各种尺寸和形状不仅适用于汉堡包，还适用于像三明治的其他面包。构成：具有切割线的汉堡包支架包括盖和带。盖子形成为对应于汉堡包尺寸的圆盘的形状。带子连接盘形盖。保持器可以根据尺寸撕裂并制造各种形状和尺寸，从而应用其他面包如三明治。

8. 发明申请

WO2016054483A1 USE OF RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS 审中-公开
标题翻译：用FGFR4抑制剂使用环状双键二吡啶衍生物
公开(公告)号：WO2016054483A1
公开(公告)日：2016-04-07
申请号：PCT/US2015/053677
申请日：2015-10-02
申请人： NOVARTIS AG , FAIRHURST, Robin, Alec , FURET, Pascal , KNÖPFEL, Thomas , LEBLANC, Catherine , LIAO, Lv , MAH, Robert , NIMSGERN, Pierre , RIPOCHE, Sebastien , XIONG, Jing , ZHAO, Xianglin , HAN, Bo , WANG, Can , PORTER, Dale , BUSCHMANN, Nicole , GRAUS PORTA, Diana , HAEFLIGER, Carolina , MURAKAMI, Masato , PALMER, Michael , WANG, Youzhen , WEISS, Andreas
发明人： FAIRHURST, Robin, Alec , FURET, Pascal , KNÖPFEL, Thomas , LEBLANC, Catherine , LIAO, Lv , MAH, Robert , NIMSGERN, Pierre , RIPOCHE, Sebastien , XIONG, Jing , ZHAO, Xianglin , HAN, Bo , WANG, Can , PORTER, Dale , BUSCHMANN, Nicole , GRAUS PORTA, Diana , HAEFLIGER, Carolina , MURAKAMI, Masato , PALMER, Michael , WANG, Youzhen , WEISS, Andreas
IPC分类号： A61K31/4375 , A61K31/437 , A61K31/4353 , A61K31/506 , A61K31/5383 , A61K31/5377 , A61K31/501 , A61P35/00
CPC分类号： A61K31/4375 , A61K31/4545 , A61K31/496 , A61K31/55 , A61P35/00
摘要： The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐的治疗用途。

9. 发明申请

WO2016025608A1 METHOD AND SYSTEM FOR GENERATING AND AGGREGATING MODELS BASED ON DISPARATE DATA FROM INSURANCE, FINANCIAL SERVICES, AND PUBLIC INDUSTRIES 审中-公开
标题翻译：基于保险，金融服务和公共行业的不同数据生成和聚合模型的方法和系统
公开(公告)号：WO2016025608A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/044872
申请日：2015-08-12
申请人： MCMAHON, Andrew , WONG, Lawrence , BURRIESCI, Dr. Matthew , LEE, Martin , HAN, Bo
发明人： MCMAHON, Andrew , WONG, Lawrence , BURRIESCI, Dr. Matthew , LEE, Martin , HAN, Bo , CULEK, Erin
IPC分类号： G06Q10/04 , G06Q40/08
CPC分类号： G06N5/047 , G06N99/005 , G06Q10/04 , G06Q10/0637 , G06Q30/0201 , G06Q40/08
摘要： A method and system for making financial or medical decisions. The method comprises training sets of models using classification training with sets of data derived from segregated data sources. Overall weighting of each model within the sets of models are determined for each of the sub-datasets. The sets of models, the overall weighting of each model and a number of examples provided from the data for each of the datasets are transmitted to a central server over a communication network, wherein the central server is configured to determine the relative weights of each of the sets of models in the overall ensemble model based on the number of examples, combine the sets of models, receive new application data, and predict at least one of outcome variables, an uncertainty factor for the variables, and drivers of the outcome variables based on the new application data.
摘要翻译：制定财务或医疗决策的方法和系统。该方法包括利用分类数据源导出的数据集的分类训练来训练模型集合。为每个子数据集确定模型集合内每个模型的总体权重。模型集合，每个模型的总体权重以及从每个数据集的数据提供的多个示例通过通信网络传送到中央服务器，其中中央服务器被配置为确定每个模型的相对权重基于示例数量的整体集合模型中的模型集合，组合模型，接收新的应用数据，并且预测结果变量中的至少一个，变量的不确定因素以及基于结果变量的驱动因素对新的应用数据。

10. 发明申请

WO2012112690A3 TARGETING OF THERAPEUTIC DRUGS AND DIAGNOSTIC AGENTS EMPLOYING COLLAGEN BINDING DOMAINS 审中-公开
标题翻译：治疗药物和使用胶原蛋白结合域的诊断试剂的目标
公开(公告)号：WO2012112690A3
公开(公告)日：2014-04-24
申请号：PCT/US2012025261
申请日：2012-02-15
申请人： NIMNI MARCEL E , HAN BO , BOASBERG PETER , FABIUS BIOTECHNOLOGY
发明人： NIMNI MARCEL E , HAN BO , BOASBERG PETER
IPC分类号： C07K16/18 , A61K39/395 , C12P21/08
CPC分类号： A61K47/64
摘要： A targeting composition comprising: (1) a therapeutic agent; (2) an intermediate release linker bound to the therapeutic agent; and (3) a targeting moiety bound to the intermediate release linker, the targeting moiety for binding the targeting composition to native collagen fibers, provides an improved means of targeting therapeutic agents to cells, particularly malignant cells. The therapeutic agents can be, but are not limited to, anti-neoplastic agents or anti-inflammatory agents. The peptide motif can be a motif derived from the sequence present in von Willebrand's factor. The invention also encompasses pharmaceutical compositions and methods of treatment, as well as diagnostic compositions.
摘要翻译：一种靶向组合物，其包含：（1）治疗剂; （2）与治疗剂结合的中间释放连接体; 和（3）与中间释放连接物结合的靶向部分，用于将靶向组合物结合到天然胶原纤维的靶向部分提供了将治疗剂靶向细胞特别是恶性细胞的改进方法。治疗剂可以是但不限于抗肿瘤剂或抗炎剂。肽基序可以是衍生自von Willebrand因子中存在的序列的基序。本发明还包括药物组合物和治疗方法以及诊断组合物。

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