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1. 发明公开

EP0121008A3 Coating for bioprosthetic device and method of making same 失效
标题翻译：用于生物装置的涂料及其制备方法
公开(公告)号：EP0121008A3
公开(公告)日：1985-03-27
申请号：EP83301774
申请日：1983-03-29
申请人： Nimni, Marcel E.
发明人： Nimni, Marcel E. , Cheung, David T.
IPC分类号： A61F01/00 , A61L17/00 , A01N01/02
CPC分类号： A61L33/0011 , A61F2/06 , A61F2/08 , A61F2/24 , A61K35/32 , A61K35/44 , A61L27/28 , A61L27/34 , A61L27/36 , A61L27/3687 , A61L27/54 , A61L2300/236 , A61L2300/42 , A61L2300/432 , A61L2300/606 , A61L2400/02 , C08L5/08 , C08L89/00
摘要： A coating and integral treatment for improving the biophysical stability of bioprosthetic devices after implantation, particularly with respect to calcification, and, specifically, a method for treating animal tissues, such as heart valves, to provide improved biophysical stability in allograft and heterograft transplanations. The increased stability results, in-part, from the creation of a three-dimensional matrix of a primary structural component of the prosthetic device and covalently attached calcification inhibitors. Other materials, some having additional stabilizing effects, may be utilized to form additional bridges or fill the interstitial gaps in the matrix. After implantation, the resultant modified device exhibits minimal surface for intramatrix growth of calcium phosphate crystals, and additionally, may inhibit platelet aggregation, enzymatic degradation and host rejection, while minimizing the risk of mechanical failure, in the host organism.

2. 发明公开

EP0121008A2 Coating for bioprosthetic device and method of making same 失效
标题翻译： ÜberzugfürBioprothesenvorrichtung und Verfahren zu seiner Herstellung。
公开(公告)号：EP0121008A2
公开(公告)日：1984-10-10
申请号：EP83301774.2
申请日：1983-03-29
申请人： Nimni, Marcel E.
发明人： Nimni, Marcel E. , Cheung, David T.
IPC分类号： A61F2/02 , A61L17/00 , A01N1/02
CPC分类号： A61L33/0011 , A61F2/06 , A61F2/08 , A61F2/24 , A61K35/32 , A61K35/44 , A61L27/28 , A61L27/34 , A61L27/36 , A61L27/3687 , A61L27/54 , A61L2300/236 , A61L2300/42 , A61L2300/432 , A61L2300/606 , A61L2400/02 , C08L5/08 , C08L89/00
摘要： A coating and integral treatment for improving the biophysical stability of bioprosthetic devices after implantation, particularly with respect to calcification, and, specifically, a method for treating animal tissues, such as heart valves, to provide improved biophysical stability in allograft and heterograft transplanations. The increased stability results, in-part, from the creation of a three-dimensional matrix of a primary structural component of the prosthetic device and covalently attached calcification inhibitors. Other materials, some having additional stabilizing effects, may be utilized to form additional bridges or fill the interstitial gaps in the matrix. After implantation, the resultant modified device exhibits minimal surface for intramatrix growth of calcium phosphate crystals, and additionally, may inhibit platelet aggregation, enzymatic degradation and host rejection, while minimizing the risk of mechanical failure, in the host organism.
摘要翻译：用于改善植入后生物假体装置的生物物理稳定性的涂层和整体处理，特别是关于钙化，特别是用于治疗动物组织如心脏瓣膜的方法，以在同种异体移植物和异种移植物移植中提供改善的生物物理稳定性。增加的稳定性部分地导致从修复装置的主要结构部件的三维基质的产生和共价附着的钙化抑制剂。可以使用其它材料，一些具有额外的稳定作用，以形成额外的桥接或填充基体中的间隙。在植入后，所得到的修饰的装置表现出磷酸钙晶体的肌内生长的最小表面，此外，可以抑制血小板聚集，酶降解和宿主排斥，同时最小化宿主生物体内机械衰竭的风险。

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