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1. 发明专利

FR513214A 未知
公开(公告)号：FR513214A
公开(公告)日：1921-02-10
申请号：FR513214D
申请日：1919-10-14
申请人： HENRI MARCEL MULLER
发明人： MULLER HENRI-MARCEL
IPC分类号： B23K3/03

2. 发明专利

GB441743A Improvements in and relating to protective covers for books 未知
公开(公告)号：GB441743A
公开(公告)日：1936-01-24
申请号：GB1115035
申请日：1935-04-10
申请人： MARCEL MULLER
IPC分类号： B42D3/04 , B42D3/14
摘要： 441,743. Book-covers; bookmarkers ; paperknives. MULLER, M., 38, Rue de Flandre, Paris. April 10, 1935, No. 11150. Convention date, June 28, 1934. [Classes 16 and 146 (ii)] A protective cover for a book comprises a sheet of transparent material 10 having at its ends pieces 13, 14 of cardboard or like comparatively stiff material, and provided with a bookmarker or paper-cutter formed integral with one of the stiff portions and adapted to be detached therefrom when required for use. The bookmarker or papercutter 21 may be cut out of the portion 13, and retained along the edge 22 which is perforated. A lip 23 may be cut out of the member 21. In a modification, the bookmarker or paper-cutter consists of an extension of the portion 13. The sheet 10 may be reinforced at the top and bottom edges by strips 25 of paper or linen. Tongues 24 of soft metal may be provided on the portions 13, 14 which, when the protective cover has been placed on a book with the portions 13, 14 folded against the inside faces of the binding boards, are bent over between the sheet 10 and the binding boards to retain the cover in position.

3. 发明专利

GB443483A Improvements in and relating to protective covers for books 未知
公开(公告)号：GB443483A
公开(公告)日：1936-02-28
申请号：GB3268935
申请日：1935-11-25
申请人： MARCEL MULLER
IPC分类号： B42D3/04 , B42D3/14
摘要： 443,483. Book covers ; bookmarkers ; paperknives. MULLER, M., 38, Rue de Flandre, Paris. Nov. 25, 1935, No. 32689. Addition to 441,743. [Classes 16 and 146 (ii)] The protective book cover described in the parent Specification is modified in that the cover comprises an opaque sheet of paper or like flexible material provided at one or both extremities with a piece or pieces of cardboard or like comparatively stiff material, one or both of which has formed integral therewith a bookmarker or paper-cutter which is adapted to be detached therefrom when required for use. As shown, a sheet 3 is provided at one end with a strip 4 of cardboard which is adapted to lie between the binding board of the book and the first page thereof, and a bookmarker or paper-cutter 7 is cut out of the strip 4 and retained along a perforated edge 8 until required for use. To facilitate the use of the cut-out portion 7 as a bookmarker it is provided with a a slit 9. In a modification the bookmarker or paper-cutter may form detachable extension of the cardboard strip 4. The sheet 3 may be reinforced at the top and bottom edges, and provided with soft metal tongues as described in the parent Specification.

4. 发明专利

FR499113A 未知
公开(公告)号：FR499113A
公开(公告)日：1920-01-31
申请号：FR499113D
申请日：1919-04-17
申请人： JOSEPH PHILIPPS , MARCEL MULLER
发明人： PHILIPPS JOSEPH , MULLER MARCEL
IPC分类号： A47C23/32

5. 发明授权

US5973188A Acetic acid derivatives 失效
标题翻译：乙酸衍生物
公开(公告)号：US5973188A
公开(公告)日：1999-10-26
申请号：US963413
申请日：1997-11-03
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler Muller , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler Muller , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： C07D401/12 , A61K31/00 , A61K31/19 , A61K31/22 , A61K31/24 , A61K31/27 , A61K31/34 , A61K31/341 , A61K31/395 , A61K31/4418 , A61K31/445 , A61K31/47 , A61K31/472 , A61P7/00 , A61P7/02 , A61P19/00 , C07C237/32 , C07C251/24 , C07C251/48 , C07C257/18 , C07C259/18 , C07C271/06 , C07C271/62 , C07C271/64 , C07C323/42 , C07C323/50 , C07C333/04 , C07D207/12 , C07D211/00 , C07D211/20 , C07D211/34 , C07D211/46 , C07D211/58 , C07D211/94 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D267/14 , C07D271/06 , C07D271/07 , C07D307/68 , C07D309/12 , C07D413/02 , C07D413/06 , C07D413/10 , C07D413/12 , C07F9/24 , C07C229/28 , C07C229/02
CPC分类号： C07D213/82 , C07C237/32 , C07C257/18 , C07C259/18 , C07C271/64 , C07C323/42 , C07C333/04 , C07D207/12 , C07D211/46 , C07D217/02 , C07D271/07 , C07D309/12 , C07D401/12 , C07D413/12 , C07F9/2491 , C07C2101/02 , C07C2101/14 , Y02P20/55
摘要： Acetic acid derivatives of the formula ##STR1## wherein L, M, T and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell--cell adhesion, and are manufactured by cleaving protecting groups in the corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitrites.
摘要翻译：下式的乙酸衍生物其中L，M，T和Q具有描述中给出的含义，可用于治疗或预防由粘合蛋白与血小板结合和血小板聚集引起的疾病，细胞粘附，通过在相应的受保护化合物中裂解保护基团或通过将氰基转变成相应的亚硝酸盐中的脒基来制备。

6. 发明授权

US5658928A Amino acid derivatives 失效
标题翻译：氨基酸衍生物
公开(公告)号：US5658928A
公开(公告)日：1997-08-19
申请号：US310016
申请日：1994-09-21
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： A61K31/155 , A61K20060101 , A61K31/165 , A61K31/195 , A61K31/198 , A61K31/445 , A61K31/451 , A61P7/02 , A61P7/04 , C07C227/00 , C07C229/00 , C07C229/10 , C07C233/76 , C07C237/22 , C07C257/18 , C07C279/18 , C07D20060101 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/22 , C07D211/40 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07D451/06 , C07D453/06 , C07D211/56 , C07D211/62 , C07D211/92
CPC分类号： C07D451/06 , C07C257/18 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07C2101/12 , Y02P20/55
摘要： N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R'" and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion.
摘要翻译：其中L，R'至R“'和Q具有在说明书中给出的含义的式”IMAGE“I的N-酰基-α-氨基羧酸衍生物可用于治疗或预防由粘附蛋白与血小板的结合以及血小板聚集和细胞粘附。

7. 发明授权

US5039805A Novel benzoic and phenylacetic acid derivatives 失效
标题翻译：新型苯甲酸和苯乙酸衍生物
公开(公告)号：US5039805A
公开(公告)日：1991-08-13
申请号：US440949
申请日：1989-11-24
申请人： Leo Alig , Albrecht Edenhofer , Marcel Muller , Arnold Trzeciak , Thomas Weller
发明人： Leo Alig , Albrecht Edenhofer , Marcel Muller , Arnold Trzeciak , Thomas Weller
IPC分类号： A61K31/165 , A61K31/445 , A61K31/4465 , A61K38/00 , A61P7/02 , A61P9/06 , A61P9/08 , A61P9/10 , A61P29/00 , C07C231/12 , C07C237/40 , C07C237/42 , C07C237/44 , C07C249/00 , C07C257/18 , C07C257/22 , C07C271/22 , C07C277/08 , C07C279/14 , C07D211/34 , C07D211/98 , C07K1/06 , C07K5/02 , C07K5/06
CPC分类号： C07C237/42 , C07C237/40 , C07C237/44 , C07C257/18 , C07C271/22 , C07C279/14 , C07D211/34 , C07K5/0205 , C07C2101/14 , C07C2102/08
摘要： The compound of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 have the significance given in the description, can be used as medicaments for the therapy and prophylaxis of disorders such as thromboses, stroke, cardiac infarct, inflammations and arteriosclerosis as well as for the treatment of tumours.
摘要翻译：其中R1，R2和R3具有说明书中给出的含义的化合物可以用作治疗和预防诸如血栓形成，中风，心肌梗塞，炎症和动脉硬化的病症的药物以及治疗肿瘤。

8. 发明授权

US5017619A Phenethanolamine derivatives 失效
标题翻译：苯乙醇胺衍生物
公开(公告)号：US5017619A
公开(公告)日：1991-05-21
申请号：US285269
申请日：1988-12-16
申请人： Leo Alig , Marcel Muller
发明人： Leo Alig , Marcel Muller
IPC分类号： A23K1/16 , A61K31/135 , A61K31/27 , C07C217/62
CPC分类号： C07C217/62 , Y10S514/909 , Y10S514/91
摘要： The invention is directed to phenethanolamine derivatives and their pharmaceutically compatible salts, having the formula ##STR1## wherein n is the number 1 or 2; L.sup.1 and L.sup.2 are hydrogen, C.sub.1-3 -(alkyl)carbonyl or C.sub.1-3 (alkoxy) carbonyl; T is hydrogen or methyl; X.sup.1 and X.sup.2 are phenyl or phenyl which is monosubstituted in the m-position by Br, Cl, F, CF.sub.3 and NO.sub.2 ; Y is --(CH.sub.2).sub.1-6 --O--G, --(CH.sub.2).sub.1-6 --CH.dbd.CH--C(O)--Z, --C(O)--Z or --CH(COOR").sub.2 ; G is C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy-C.sub.1-4 -alkyl or --(CH.sub.2).sub.1-4 --Q; Q is phenoxy, phenyl, p-fluorophenyl or p-phenoxyphenyl; Z is a --OR or --N(R,R'); R and R' are hydrogen or C.sub.1-4 -alkyl or R and R' together with the N-atom to which they are attached form a 5- or 6-membered saturated ring which optionally contains an O-atom or an additional N-atom; and R" is C.sub.1-4 -alkyl.The compounds of the invention have catabolic activity and can be used for the treatment of obesity and of diabetes mellitus or of conditions which are associated with an increased protein breakdown, or as feed additives for fattening animals.
摘要翻译：本发明涉及具有下式的苯乙醇胺衍生物及其药学上相容的盐，其中n是数1或2; L 1和L 2是氢，C 1-3 - （烷基）羰基或C 1-3（烷氧基）羰基; T是氢或甲基; X 1和X 2是苯基或在m-位被Br，Cl，F，CF 3和NO 2单取代的苯基; Y是 - （CH 2）1-6 -O-G， - （CH 2）1-6 -CH = CH-C（O）-Z，-C（O）-Z或-CH（COOR“ G是C 1-4 - 烷基，C 1-4 - 烷氧基-C 1-4 - 烷基或 - （CH 2）1-4-Q; Q是苯氧基，苯基，对氟苯基或对苯氧基苯基; Z是-OR或-N（R，R'）; R和R'是氢或C 1-4 - 烷基或R和R'与它们所连接的N-原子一起形成5-或6-元饱和环，其任选地含有O-原子或另外的N- 原子; 和R“是C 1-4 - 烷基。本发明的化合物具有分解代谢活性并且可用于治疗肥胖症和糖尿病或与增加的蛋白质分解有关的病症，或用作育肥动物的饲料添加剂。

9. 发明授权

US4285880A D-Homopregnanes 失效
公开(公告)号：US4285880A
公开(公告)日：1981-08-25
申请号：US82269
申请日：1979-10-05
申请人： Andor Furst , Peter Keller , Marcel Muller
发明人： Andor Furst , Peter Keller , Marcel Muller
IPC分类号： A61K31/20 , A61K31/575 , A61K31/585 , A61P7/10 , C07D307/94 , C07J63/00
CPC分类号： C07J63/008 , Y10S514/869 , Y10S514/96 , Y10S514/962
摘要： D-Homopregnanes of the formula ##STR1## wherein X is hydrogen, Y is hydroxy or X and Y taken together denote an oxygen to carbon bond; R.sup.6 is hydrogen, R.sup.7 is hydrogen, lower alkanoylthio or aroylthio, or R.sup.6 and R.sup.7 taken together denote a carbon to carbon bond and the dotted line in the 1,2-position of the A-ring together with the corresponding solid line denotes a single or double carbon to carbon bond or a pharmaceutically acceptable basic addition salt thereof when Y is hydroxy having diuretic activity are disclosed.
摘要翻译：其中X是氢，Y是羟基或X和Y一起表示氧碳键的式I- R6是氢，R7是氢，低级烷酰硫基或芳酰硫基，或R6和R7一起表示碳 - 碳键，A环的1,2位虚线与相应的实线一起表示单或双碳 - 碳键或其药学上可接受的碱加成盐时，其中Y为具有利尿活性的羟基。

10. 发明授权

US4272630A D-Homosteroids 失效
标题翻译： D-类固醇
公开(公告)号：US4272630A
公开(公告)日：1981-06-09
申请号：US111424
申请日：1980-01-11
申请人： Leo Alig , Andor Furst , Marcel Muller , Ulrich Kerb , Klaus Kieslich , Rudolf Wiechert
发明人： Leo Alig , Andor Furst , Marcel Muller , Ulrich Kerb , Klaus Kieslich , Rudolf Wiechert
IPC分类号： C07J63/00 , C12P33/02 , C12P33/08 , C07C69/75
CPC分类号： C07J63/008 , C12P33/02 , C12P33/08
摘要： The present invention is directed to 3-oxo, 6,9-hydro or halo, 11-oxo or (.alpha.--H,.beta.--OH), 17a-alkanoyloxy, 17a.beta.-carboxylate D-homosteroids which are useful as antiinflammatory agents.
摘要翻译：本发明涉及可用作抗炎剂的3-氧代，6,9-氢或卤素，11-氧代或（α-H，β-OH），17a-烷酰氧基，17β-羧酸酯D-类固醇激素。

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