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    • 7. 发明申请
    • 1-(2-CHLOROETHYL)-3-ACYL-3-ALKYLTRIAZENES
    • 1-(2-氯乙基)-3 - 酰基-3- ALKYLTRIAZENES
    • WO1989009207A1
    • 1989-10-05
    • PCT/US1989001178
    • 1989-03-27
    • BIONETICS RESEARCH, INC.
    • BIONETICS RESEARCH, INC.MICHEJDA, Christopher, J.SMITH, Richard, H., Jr.
    • C07C107/00
    • C07C245/24C07C281/02C07C281/06C07C333/12C07F7/1804C07F9/2491
    • A substituted 1-(2-chloroethyl)-3-acyl-3-alkyltriazene of the formula: in which R1 is 1-oxoalkyl containing from two to eight carbon atoms, fluorinated 1-oxoalkyls containing from two to eight carbon atoms and substituted with up to three fluorine atoms, benzoyl, phenylacetyl, carboalkoxy containing from two to eight carbon atoms, fluorinated carboalkyl containing from two to eight carbon atoms and up to three fluorine atoms, carbophenoxy, N-phenyl aminocarbonyl, N-alkyl aminocarbonyl containing from two to eight carbon atoms, thiocarbamoyl, N-alkylthiocarbamoyls with from two to eight carbon atoms, N-phenylthiocarbamoyl, dialkylphosphonates in which the alkyl groups can be the same or different and each contains from one to seven carbon atoms, phenylsulfonyl, and meta or para-substituted phenylsulfonyl in which the meta or para substituent is methyl, ethyl, methoxy, ethoxy, fluoro and chloro; and R2 is indepedently alkyl containing from one to seven carbon atoms, fluoroalkyl containing from two to seven carbon atoms and from one to three fluorine atoms in which the alpha carbon of the fluoroalkyl group is not substituted with fluorine, benzyl, meta or para-substituted benzyl in which the meta or para substituent is chloro, fluoro, and alkoxy with from one to three carbon atoms, alkenyl containing from two to seven carbon atoms, and alkynyl containing from two to seven carbon atoms, useful as antitumor agents.