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    • 4. 发明申请
    • VINYL ALCOHOL CO-POLYMER CRYOGELS, VINYL ALCOHOL CO-POLYMERS, AND METHODS AND PRODUCTS THEREOF
    • 乙烯醇共聚物聚合物,乙烯醇共聚物及其制备方法
    • WO2010029517A1
    • 2010-03-18
    • PCT/IB2009/054012
    • 2009-09-14
    • STRÖMME, MariaMIHRANYAN, Albert
    • STRÖMME, MariaMIHRANYAN, Albert
    • C08F8/12C08F218/08A61K9/00
    • A61L27/16A61K9/0014A61K9/0024A61K9/0031A61K9/006A61K9/0065A61K9/06A61K9/19A61K9/7007A61K47/34A61L27/52C08F8/12C08F218/08C08F220/06C08F220/56C08J5/18C08L29/04
    • A cryogel-forming vinyl alcohol co-polymer is operable to form a cryogel, i.e., a hydrogel formed by crytropic gelation, in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier. In one embodiment, a vinyl alcohol co-polymer cryogel comprises at least about 75% by weight water and a vinyl alcohol co-polymer, wherein the vinyl alcohol co-polymer is operable to form a cryogel in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier. In another embodiment, a vinyl alcohol co-polymer cryogel comprises at least abut 75% by weight water and a vinyl alcohol co-polymer comprising a saponified product of a vinyl acetate co- polymer formed from at least about 80% by weight of vinyl acetate monomer, and (i) at least about 3% by weight of acrylamide monomer or a mixture of acrylamide monomer and acrylic acid monomer, or (ii) at least about 5% by weight acrylic acid monomer. The vinyl acetate co- polymer, vinyl alcohol co-polymer and vinyl alcohol co-polymer cryogel may be formed according to particular methods, and the vinyl alcohol co-polymer cryogels may be used in various applications including biomedical implants and thin films and for delivery of therapeutic or cosmetic agents.
    • 低温凝胶形成乙烯醇共聚物可操作以在不存在化学交联的情况下,以小于约10重量%的浓度在水溶液中形成冷冻凝胶,即通过热溶胶凝胶形成的水凝胶 并且在不存在乳化剂的情况下。 在一个实施方案中,乙烯醇共聚物冷冻凝胶包含至少约75重量%的水和乙烯醇共聚物,其中乙烯醇共聚物可操作以在浓度较低的水溶液中形成冷冻凝胶 在不存在化学交联剂的情况下和在不存在乳化剂的情况下。 在另一个实施方案中,乙烯醇共聚物冷冻凝胶包含至少约75重量%的水和包含由至少约80重量%的乙酸乙烯酯形成的乙酸乙烯酯共聚物的皂化产物的乙烯醇共聚物 单体,和(i)至少约3重量%的丙烯酰胺单体或丙烯酰胺单体和丙烯酸单体的混合物,或(ii)至少约5重量%的丙烯酸单体。 可以根据具体方法形成乙酸乙烯酯共聚物,乙烯醇共聚物和乙烯醇共聚物冷冻凝胶,并且乙烯醇共聚物冷冻凝胶可用于各种应用,包括生物医学植入物和薄膜并用于递送 的治疗或化妆品。