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1. 发明专利

CA2676797C NOVEL MACROMOLECULE TRANSDUCTION DOMAINS AND METHODS FOR IDENTIFICATION AND USES THEREOF 未知
公开(公告)号：CA2676797C
公开(公告)日：2014-04-22
申请号：CA2676797
申请日：2008-01-29
申请人： JO DAE WOONG , KO JAE SUN , KIM JIN SOOK , PARK KYUNG MI , SONG JIN KYUNG , LIM JUNG HEE , DO THI THUY NGA , DO THI LAN PHUONG , DUONG MINH TAM
发明人： JO DAE WOONG , KO JAE SUN , KIM JIN SOOK , PARK KYUNG MI , SONG JIN KYUNG , LIM JUNG HEE , DO THI THUY NGA , DO THI LAN PHUONG , DUONG MINH TAM
IPC分类号： C07K7/04 , C07K7/06 , C07K7/08
摘要： The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.

2. 发明申请

WO2012050402A3 CELL-PERMEABLE RECOMBINANT PARKIN PROTEIN AND A PHARMACEUTICAL COMPOSITION FOR TREATING DEGENERATIVE BRAIN DISEASES CONTAINING THE SAME 审中-公开
标题翻译：细胞可透性重组蛋白和蛋白质组合物，用于治疗含有其的变应性脑疾病
公开(公告)号：WO2012050402A3
公开(公告)日：2012-07-26
申请号：PCT/KR2011007682
申请日：2011-10-14
申请人： PROCELL THERAPEUTICS INC , JO DAEWOONG , KIM CHANKI , LIM JUNG-HEE , CHOI YOORI , KIM HEE-HYUN
发明人： JO DAEWOONG , KIM CHANKI , LIM JUNG-HEE , CHOI YOORI , KIM HEE-HYUN
IPC分类号： C07K19/00 , A61K38/17 , A61P25/28 , C12N15/62 , C12N15/63
CPC分类号： C12N9/93 , C07K2319/10
摘要： The present invention relates to: a recombinant parkin protein having cell-permeable properties, wherein a macromolecule transduction domain (MTD) is fused to a degenerative-brain-disease therapeutic protein parkin; and a pharmaceutical composition or the like for treating degenerative brain diseases which contains the cell-permeable recombinant parkin protein as an active ingredient. For the recombinant parkin protein having cell-permeable properties of the present invention, a cell-permeable recombinant protein is produced in which a macromolecule transduction domain is fused to a parkin protein which is a dopamine neuron death suppression factor, and, because the same is endowed with the ability to be transmitted into cells, in use the protein is transmitted into dopamine neurons in in vitro or in vivo environments such that cell death is suppressed, or else there is a dopamine-secretion increasing effect whereby the protein can be used in studies which aim to treat Parkinson's disease, and the protein can be used to advantage as a therapeutic agent for human degenerative brain diseases.
摘要翻译：本发明涉及具有细胞渗透性质的重组帕金蛋白，其中高分子转导结构域（MTD）与退行性脑病治疗蛋白质parkin融合; 以及用于治疗退行性脑疾病的药物组合物等，其含有细胞可渗透重组帕金蛋白作为有效成分。对于具有本发明的具有细胞渗透性质的重组帕金蛋白，产生细胞可渗透的重组蛋白，其中大分子转导结构域与作为多巴胺神经元死亡抑制因子的帕金蛋白融合，并且因为同样是具有被传播到细胞中的能力，在使用中，蛋白质在体外或体内环境中被传播到多巴胺神经元中，使得细胞死亡被抑制，或者存在多巴胺分泌增加的作用，由此蛋白质可以用于旨在治疗帕金森病的研究，该蛋白质可用作人退行性脑疾病的治疗剂。

3. 发明申请

WO2010104357A3 ESTABLISHMENT OF INDUCED PLURIPOTENT STEM CELL USING CELL-PERMEABLE REPROGRAMMING TRANSCRIPTION FACTOR FOR CUSTOMIZED STEM CELL THERAPY 审中-公开
标题翻译：利用细胞渗透重复序列因子建立诱导性多功能干细胞定制干细胞治疗
公开(公告)号：WO2010104357A3
公开(公告)日：2011-03-03
申请号：PCT/KR2010001559
申请日：2010-03-12
申请人： PROCELL THERAPEUTICS INC , JO DAEWOONG , LIM JUNG-HEE , KIM JUNGEUN , JEONG SOOYOUNG , JUNG INHEE
发明人： JO DAEWOONG , LIM JUNG-HEE , KIM JUNGEUN , JEONG SOOYOUNG , JUNG INHEE
IPC分类号： C07K19/00 , C07K14/435 , C12N5/074 , C12N5/10 , C12N15/62 , C12N15/63
CPC分类号： C07K14/4702 , C07K2319/09 , C07K2319/10
摘要： The present invention relates to a reprogramming transfer factor recombinant protein in which a macromolecule transduction domain (MTD) is fused to a reprogramming transcription factor to obtain cell permeability. The present invention also relates to a polynucleotide for coding said reprogramming transfer factor recombinant protein, and to an expression vector of said cell-permeable reprogramming transfer factor recombinant protein. Treating a somatic cell with the cell-permeable reprogramming transfer factor recombinant protein induces the reprogramming of the stem cell-specific gene of the somatic cell, and thus can be effectively used in the establishment of an induced pluripotent stem cell (iPS cell) having characteristics similar to those of an embryonic stem cell in terms of morphology and genetics.
摘要翻译：本发明涉及重编程转移因子重组蛋白，其中大分子转导结构域（MTD）与重编程转录因子融合以获得细胞通透性。本发明还涉及用于编码所述重编程转移因子重组蛋白的多核苷酸，以及所述细胞可渗透重编程转移因子重组蛋白的表达载体。用可渗透细胞的重编程转移因子重组蛋白处理体细胞诱导体细胞干细胞特异性基因的重编程，因此可有效用于建立具有特征的诱导性多能干细胞（iPS细胞）在形态学和遗传学方面与胚胎干细胞相似。

4. 发明申请

WO2009031836A1 CELL PERMEABLE p18 RECOMBINANT PROTEINS, POLYNUCLEOTIDES ENCODING THE SAME, AND ANTICANCER COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：细胞渗透性p18重组蛋白，编码其的多核苷酸和包含其的抗体组合物
公开(公告)号：WO2009031836A1
公开(公告)日：2009-03-12
申请号：PCT/KR2008/005222
申请日：2008-09-04
申请人： INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY , JO, Daewoong , KIM, Seolhwa , LIM, Jung-Hee , PARK, Kisuk , KANG, Se-Eun
发明人： JO, Daewoong , KIM, Seolhwa , LIM, Jung-Hee , PARK, Kisuk , KANG, Se-Eun
IPC分类号： C12N15/62
CPC分类号： C07K14/4703 , C07K14/50 , C07K2319/033
摘要： The present invention discloses cell permeable p18 recombinant proteins where a macromolecule transduction domain (MTD) is fused to a tumor suppressor p18. Also disclosed are polynucleotides encoding the cell permeable p18 recombinant proteins, an expression vector containing the cell permeable p18 recombinant protein, and a pharmaceutical composition for treating p18 deficiency or failure which contains the cell permeable p18 recombinant protein as an effective ingredient. The cell permeable p18 recombinant proteins of the present invention are capable of efficiently introducing a haploinsufficient tumor suppressor p18 into a cell, and thus, can activate cell signaling mechanisms involved in the activation of ATM and p53 that induce cell cycle arrest and apoptosis in response to DNA damage or oncogenic signals. Therefore, the cell permeable p18 recombinant proteins of the present invention can be effectively used as an anticancer agent.
摘要翻译：本发明公开了一种细胞渗透性p18重组蛋白，其中大分子转导结构域（MTD）与肿瘤抑制基因p18融合。还公开了编码细胞可渗透性p18重组蛋白质的多核苷酸，含有细胞可渗透性p18重组蛋白质的表达载体和含有细胞可渗透性p18重组蛋白质作为有效成分的p18缺陷或失败的药物组合物。本发明的细胞可渗透性p18重组蛋白能够有效地将不充分的单倍体肿瘤抑制基因p18引入细胞，从而可以激活参与ATM和p53激活的细胞信号传导机制，诱导细胞周期停滞和凋亡，以响应于 DNA损伤或致癌信号。因此，本发明的细胞渗透性p18重组蛋白质可以有效地用作抗癌剂。

5. 发明申请

WO2010104357A4 ESTABLISHMENT OF INDUCED PLURIPOTENT STEM CELL USING CELL-PERMEABLE REPROGRAMMING TRANSCRIPTION FACTOR FOR CUSTOMIZED STEM CELL THERAPY 审中-公开
标题翻译：使用细胞渗透性重组转录因子建立诱导型细胞干细胞用于定制干细胞治疗
公开(公告)号：WO2010104357A4
公开(公告)日：2011-04-21
申请号：PCT/KR2010001559
申请日：2010-03-12
申请人： PROCELL THERAPEUTICS INC , JO DAEWOONG , LIM JUNG-HEE , KIM JUNGEUN , JEONG SOOYOUNG , JUNG INHEE
发明人： JO DAEWOONG , LIM JUNG-HEE , KIM JUNGEUN , JEONG SOOYOUNG , JUNG INHEE
IPC分类号： C07K19/00 , C07K14/435 , C12N5/074 , C12N5/10 , C12N15/62 , C12N15/63
CPC分类号： C07K14/4702 , C07K2319/09 , C07K2319/10
摘要： The present invention relates to a reprogramming transfer factor recombinant protein in which a macromolecule transduction domain (MTD) is fused to a reprogramming transcription factor to obtain cell permeability. The present invention also relates to a polynucleotide for coding said reprogramming transfer factor recombinant protein, and to an expression vector of said cell-permeable reprogramming transfer factor recombinant protein. Treating a somatic cell with the cell-permeable reprogramming transfer factor recombinant protein induces the reprogramming of the stem cell-specific gene of the somatic cell, and thus can be effectively used in the establishment of an induced pluripotent stem cell (iPS cell) having characteristics similar to those of an embryonic stem cell in terms of morphology and genetics.
摘要翻译：本发明涉及重编程转移因子重组蛋白，其中大分子转导结构域（MTD）与重编程转录因子融合以获得细胞通透性。本发明还涉及用于编码所述重编程转移因子重组蛋白的多核苷酸以及所述细胞可透过重编程转移因子重组蛋白的表达载体。用细胞可渗透的重编程转移因子重组蛋白处理体细胞诱导体细胞干细胞特异性基因的重新编程，因此可以有效地用于建立具有特征的诱导多能干细胞（iPS细胞）类似于胚胎干细胞在形态学和遗传学方面。

6. 发明申请

WO2009139599A2 CELL-PERMEABLE P27 RECOMBINANT PROTEIN, A POLYNUCLEOTIDE THAT CODES THE SAME AND AN ANTI-CANCER COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：细胞可透性P27重组蛋白，其相同的多核苷酸和包含其的抗癌组合物作为活性成分
公开(公告)号：WO2009139599A2
公开(公告)日：2009-11-19
申请号：PCT/KR2009002588
申请日：2009-05-15
申请人： PROCELL THERAPEUTICS INC , JO DAEWOONG , LIM JUNG-HEE
发明人： JO DAEWOONG , LIM JUNG-HEE
IPC分类号： C07K19/00 , A61K38/17 , A61P35/00 , C07K14/47 , C12N15/62
CPC分类号： C07K14/4738 , A61K38/00 , C07K2319/10
摘要： The present invention concerns a cell-permeable p27 recombinant protein with its macromolecule transduction domain (MTD) fused to tumour suppressor p27, a polynucleotide that codes the said cell-permeable p27 recombinant protein, the expression vector of the said cell-permeable p27 recombinant protein, and a pharmaceutical composition for anti-cancer drugs containing the said cell-permeable p27 recombinant protein as an active ingredient. The cell-permeable p27 recombinant protein according to the present invention transduces tumour suppressor p27 into the cell nucleus and suppresses the formation of cyclin-dependent kinase and cycline complex, effectively revitalising the signal transduction mechanism that participates in the inhibition of the cell cycle and induction of cell death, and thus a composition containing the same as an active ingredient can be used as an anti-cancer drug for the prevention and/or treatment of various cancers.
摘要翻译：本发明涉及具有与肿瘤抑制基因p27融合的大分子转导结构域（MTD）的细胞可渗透性p27重组蛋白，编码所述细胞可渗透性p27重组蛋白的多核苷酸，所述细胞可渗透性p27重组蛋白质的表达载体以及含有所述细胞可渗透性p27重组蛋白作为活性成分的抗癌药物用药物组合物。根据本发明的细胞可渗透性p27重组蛋白将肿瘤抑制基因p27转导入细胞核并抑制细胞周期蛋白依赖性激酶和细胞周期复合物的形成，有效振兴参与抑制细胞周期和诱导的信号转导机制的细胞死亡，因此含有与活性成分相同的组合物可以用作预防和/或治疗各种癌症的抗癌药物。

7. 发明申请

WO2009061130A2 CELL PERMEABLE RUNX3 RECOMBINANT PROTEINS, POLYNUCLEOTIDES ENCODING THE SAME, AND ANTICANCER COMPOSITIONS INCLUDING THE SAME 审中-公开
标题翻译：细胞渗透性RUNX3重组蛋白，编码多核苷酸的多核苷酸，以及包含相同物质的抗癌组合物
公开(公告)号：WO2009061130A2
公开(公告)日：2009-05-14
申请号：PCT/KR2008/006526
申请日：2008-11-06
申请人： PROCELL THERAPEUTICS INC. , JO, Daewoong , HONG, Eun Kyung , LIM, Jung-Hee , KANG, Se-Eun , CHE, Lihua
发明人： JO, Daewoong , HONG, Eun Kyung , LIM, Jung-Hee , KANG, Se-Eun , CHE, Lihua
IPC分类号： C12N15/00 , C12N15/12 , C07K14/52 , C07H21/04 , A61K48/00
CPC分类号： C07K14/4702 , C07K2319/09 , C07K2319/10 , C07K2319/21
摘要： The present invention discloses cell permeable RUNX3 recombinant proteins where a Macromolecule Transduction Domain (MTD) is fused to a tumor and metastasis suppressor RUNX3. Also disclosed are polynucleotides encoding the cell permeable RUNX3 recombinant proteins, an expression vector containing the cell permeable RUNX3 recombinant protein, and a pharmaceutical composition for preventing metastasis which contains the cell permeable RUNX3 recombinant protein as an effective ingredient. The cell permeable RUNX3 recombinant proteins of the present invention can induce the reactivation of TGF-β signal transduction pathway which causes cell cycle arrest by efficiently introducing a tumor and metastasis suppressor RUNX3 into a cell. Therefore, the cell permeable RUNX3 recombinant proteins of the present invention can be effectively used as an anticancer agent capable of preventing cancer growth and metastasis by suppressing the proliferation, differentiation, and migration of cancer cells.
摘要翻译：本发明公开了细胞渗透性RUNX3重组蛋白，其中大分子转导结构域（MTD）与肿瘤和转移抑制因子RUNX3融合。还公开了编码细胞透过性RUNX3重组蛋白质的多核苷酸，含有细胞透过性RUNX3重组蛋白质的表达载体，以及含有细胞透过性RUNX3重组蛋白质作为有效成分的用于防止转移的药物组合物。本发明的细胞渗透性RUNX3重组蛋白可以通过有效地将肿瘤和转移抑制因子RUNX3导入细胞中来诱导导致细胞周期停滞的TGF-β信号转导途径的再激活。因此，通过抑制癌细胞的增殖，分化和迁移，本发明的可透过细胞的RUNX3重组蛋白可以有效地用作能够预防癌症生长和转移的抗癌剂。

8. 发明申请

WO2008093982A1 NOVEL MACROMOLECULE TRANSDUCTION DOMAINS AND METHODS FOR IDENTIFICATION AND USES THEREOF 审中-公开
标题翻译：新型MACROMOLECULE传输域及其识别方法及其应用
公开(公告)号：WO2008093982A1
公开(公告)日：2008-08-07
申请号：PCT/KR2008/000525
申请日：2008-01-29
申请人： INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY , JO, Dae Woong , KO, Jae Sun , KIM, Jin Sook , PARK, Kyung Mi , SONG, Jin Kyung , LIM, Jung Hee , DO, Thi Thuy Nga , DO, Thi Lan Phuong , DUONG, Minh Tam
发明人： JO, Dae Woong , KO, Jae Sun , KIM, Jin Sook , PARK, Kyung Mi , SONG, Jin Kyung , LIM, Jung Hee , DO, Thi Thuy Nga , DO, Thi Lan Phuong , DUONG, Minh Tam
IPC分类号： C07K7/04 , C07K7/06 , C07K7/08
CPC分类号： A61K47/48246 , A61K39/39 , A61K48/0041 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/47
摘要： The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.
摘要翻译：本发明公开了促进细胞膜上生物活性分子穿越的新型大分子转导结构域（MTD）肽。还公开了编码MTD肽的多核苷酸，鉴定MTD肽的方法; 通过使用MTD肽将生物活性分子遗传工程化以具有细胞渗透性的方法，通过使用MTD肽将生物活性分子导入细胞的方法及其用途。

9. 发明申请

WO2009061130A3 CELL PERMEABLE RUNX3 RECOMBINANT PROTEINS, POLYNUCLEOTIDES ENCODING THE SAME, AND ANTICANCER COMPOSITIONS INCLUDING THE SAME 审中-公开
标题翻译：细胞渗透性RUNX3重组蛋白，编码它们的多核苷酸和包括其的抗体组合物
公开(公告)号：WO2009061130A3
公开(公告)日：2009-08-06
申请号：PCT/KR2008006526
申请日：2008-11-06
申请人： PROCELL THERAPEUTICS INC , JO DAEWOONG , HONG EUN KYUNG , LIM JUNG-HEE , KANG SE-EUN , CHE LIHUA
发明人： JO DAEWOONG , HONG EUN KYUNG , LIM JUNG-HEE , KANG SE-EUN , CHE LIHUA
IPC分类号： C12N15/00 , A61K48/00 , C07H21/04 , C07K14/525 , C12N15/12
CPC分类号： C07K14/4702 , C07K2319/09 , C07K2319/10 , C07K2319/21
摘要： The present invention discloses cell permeable RUNX3 recombinant proteins where a Macromolecule Transduction Domain (MTD) is fused to a tumor and metastasis suppressor RUNX3. Also disclosed are polynucleotides encoding the cell permeable RUNX3 recombinant proteins, an expression vector containing the cell permeable RUNX3 recombinant protein, and a pharmaceutical composition for preventing metastasis which contains the cell permeable RUNX3 recombinant protein as an effective ingredient. The cell permeable RUNX3 recombinant proteins of the present invention can induce the reactivation of TGF-ß signal transduction pathway which causes cell cycle arrest by efficiently introducing a tumor and metastasis suppressor RUNX3 into a cell. Therefore, the cell permeable RUNX3 recombinant proteins of the present invention can be effectively used as an anticancer agent capable of preventing cancer growth and metastasis by suppressing the proliferation, differentiation, and migration of cancer cells.
摘要翻译：本发明公开了细胞渗透性的RUNX3重组蛋白，其中大分子转导结构域（MTD）与肿瘤融合，转移抑制子RUNX3。还公开了编码细胞可渗透性RUNX3重组蛋白的多核苷酸，含有细胞可渗透性RUNX3重组蛋白的表达载体，以及含有可透过细胞的RUNX3重组蛋白作为有效成分的用于预防转移的药物组合物。本发明的细胞可渗透的RUNX3重组蛋白可以通过有效地将肿瘤和转移抑制子RUNX3引入细胞而诱导TGF-β信号转导途径的再活化，引起细胞周期停滞。因此，通过抑制癌细胞的增殖，分化和迁移，本发明的细胞可渗透的RUNX3重组蛋白可以有效地用作能够预防癌症生长和转移的抗癌剂。

10. 发明申请

WO2010064838A2 CELL PERMEABLE P53 RECOMBINANT PROTEIN, POLYNUCLEOTIDE ENCODING THE SAME, AND ANTI-CANCER COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译：细胞渗透性P53重组蛋白，编码多核苷酸的多核苷酸以及含有相同活性成分的抗癌组合物
公开(公告)号：WO2010064838A2
公开(公告)日：2010-06-10
申请号：PCT/KR2009007142
申请日：2009-12-02
申请人： PROCELL THERAPEUTICS INC , JO DAEWOONG , LIM JUNG-HEE , YANG KYUNGMI
发明人： JO DAEWOONG , LIM JUNG-HEE , YANG KYUNGMI
IPC分类号： C07K19/00 , A61K38/17 , A61P35/00 , C12N15/62 , C12N15/63
CPC分类号： C07K14/4746 , A61K38/00 , C07K2319/10
摘要： The present invention relates to: a p53 recombinant protein having cell permeability by fusion of a macromolecule transduction domain (MTD) with a tumor suppressor p53, a polynucleotide encoding the cell permeable p53 recombinant protein, an expression vector of the cell permeable p53 recombinant protein, and an anti-cancer pharmaceutical composition containing the cell permeable p53 recombinant protein as an active ingredient. According to the present invention, the cell permeable p53 recombinant protein effectively reactivates the mechanism of signal transduction relating to cell cycle suppression and apoptosis induction by transferring tumor suppressor p53 into the nucleus of a cell and suppressing formation of cyclin-dependent kinase and cyclin complex. Therefore, a composition containing the cell permeable p53 recombinant protein as an active ingredient can be used as an anti-cancer drug for preventing and/or treating various cancers.
摘要翻译：本发明涉及通过大分子转导结构域（MTD）与肿瘤抑制因子p53融合而具有细胞通透性的p53重组蛋白质，编码可透过细胞的p53重组蛋白质的多核苷酸，可透过细胞的p53重组蛋白质的表达载体，以及含有细胞透过性p53重组蛋白作为有效成分的抗癌药物组合物。根据本发明，通过将肿瘤抑制基因p53转移到细胞核中并抑制细胞周期蛋白依赖性激酶和细胞周期蛋白复合物的形成，可透过细胞的p53重组蛋白有效地重新激活与细胞周期抑制和凋亡诱导有关的信号转导机制。因此，含有透过细胞的p53重组蛋白作为有效成分的组合物可以用作预防和/或治疗各种癌症的抗癌药。

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