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1. 发明授权

US4984475A Ultra low carryover sample liquid analysis apparatus and method 失效
标题翻译：超低残留样品液体分析仪器及方法
公开(公告)号：US4984475A
公开(公告)日：1991-01-15
申请号：US384742
申请日：1989-07-24
申请人： Kenneth F. Uffenheimer , Nicholas F. Di Domenico , Stephen L. Weitz
发明人： Kenneth F. Uffenheimer , Nicholas F. Di Domenico , Stephen L. Weitz
IPC分类号： G01N1/00 , G01N35/10
CPC分类号： G01N35/1004 , G01N35/1095
摘要： The sample liquids analysis system includes a probe which is automatically operable to successively aspirate sample liquids and reagent and/or other sample liquids processing liquids and to dispense the same in turn into sample liquids analysis apparatus for automatic, successive sample liquids analyses. Isolation liquid supply apparatus are operatively associated with the sample liquids aspirating and dispensing probe and operate to introduce an isolation liquid which is immiscible with the sample liquids and which selectively wets the probe to the substantial exclusion of the sample liquids, to the probe to, in combination with operatively associated rinse liquid supply apparatus which operate to fill the probe with a rinse liquid between successive sample liquids aspirations, reduce sample liquids carryover to ultra low levels. The sample liquids aspirating and dispensing probe are operated by the rinse liquid supply apparatus; and comprise a probe body member, and an active probe component operatively connected thereto by a readily disconnectable connector, thus making possible the ready and convenient replacement of the active probe component without adverse effect upon the essential configuration and/or operational characteristics of the rinse liquid supply apparatus, and thereby upon the overall performance of the sample liquids analysis system. The configuration of the probe operates to reduce sample liquids flow velocity in the active probe component, thereby further reducing sample liquids carryover.
摘要翻译：样品液体分析系统包括可以自动操作以连续吸取样品液体和试剂和/或其它样品液体处理液体的探针，并将其分配到用于自动连续样品液体分析的样品液体分析装置中。隔离液体供应装置与抽吸和分配探针的样品液体可操作地相关联，并且操作以引入与样品液体不混溶的分离液体，并且选择性地润湿探针以将样品液体基本上排除在探针之外与操作相关联的冲洗液体供应装置组合，其操作以在连续的样品液体期望之间用漂洗液填充探针，将样品液体携带到超低水平。样品液体抽吸和分配探针由冲洗液体供应装置操作; 并且包括探针主体构件和通过易于拆卸的连接器可操作地连接到其上的主动探头组件，从而使得有效探针组件的即时和方便的更换成为可能，而不会对冲洗液的基本构造和/或操作特性产生不利影响供应装置，从而达到样品液体分析系统的整体性能。探头的结构可以减少样品液体在活性探针组分中的流速，从而进一步减少样品液体携带。

2. 发明授权

US4799393A Combined closed and open tube sampling apparatus and method 失效
标题翻译：组合式封闭式开管取样装置及方法
公开(公告)号：US4799393A
公开(公告)日：1989-01-24
申请号：US124352
申请日：1987-11-20
申请人： Kenneth F. Uffenheimer
发明人： Kenneth F. Uffenheimer
IPC分类号： G01N1/00 , G01N35/10 , B01L3/02
CPC分类号： G01N35/1097 , G01N35/1004
摘要： Sampler apparatus and method are provided and include both closed and open tube samplers, and selector valve operable to select therebetween for sample supply to automated sample analysis apparatus. A shear valve divides the samples into separate sample quantities for independent sample quantity analysis by multi-channel sample analysis apparatus. A pressure equilibration chamber prevents vacuum build-up in the closed tube sampler to insure the supply of consistent sample quantities therefrom. A source of a pressurized rinse solution is provided; and is operatively connected to the sampler apparatus in such manner as to insure the particularly thorough rinsing and cleansing of all relevant sampler components to remove sample residue therefrom between sampling operations, thereby reducing sample carryover to levels below those of clinical significance.
摘要翻译：提供了采样器装置和方法，包括封闭和开放管取样器，以及可操作以在其间选择供自动化样品分析装置供样的选择阀。剪切阀将样品分成不同的样品量，用于通过多通道样品分析仪器进行独立样品量分析。压力平衡室防止密闭管取样器中的真空积聚，以确保从中提供一致的样品量。提供加压冲洗溶液的来源; 并且以这样的方式可操作地连接到采样器装置，以确保在采样操作之间特别彻底地冲洗和清洁所有相关采样器组件以从其中去除样品残余物，从而将样品携带量降低到低于临床意义的水平。

3. 发明申请

US20080283773A1 Particle or Cell Analyzer and Method 有权
标题翻译：粒子或细胞分析仪和方法
公开(公告)号：US20080283773A1
公开(公告)日：2008-11-20
申请号：US12183301
申请日：2008-07-31
申请人： Philippe J. Goix , Paul J. Lingane , Janette T. Phi-Wilson , Kenneth F. Uffenheimer
发明人： Philippe J. Goix , Paul J. Lingane , Janette T. Phi-Wilson , Kenneth F. Uffenheimer
IPC分类号： G01J1/58 , C12M1/34
CPC分类号： G01N15/1404 , G01N21/64
摘要： A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles.
摘要翻译：其中待分析的标记颗粒通过毛细管中的预定体积被照亮的悬浮毛细管吸取的颗粒分析仪。由所述颗粒散射的照明由检测器检测以计数所有颗粒。检测由标记的颗粒发射的荧光照明，并且处理来自荧光检测器和散射检测器的输出信号以提供颗粒的分析。

4. 发明授权

US07410809B2 Particle or cell analyzer and method 有权
标题翻译：粒子或细胞分析仪和方法
公开(公告)号：US07410809B2
公开(公告)日：2008-08-12
申请号：US10410230
申请日：2003-04-08
申请人： Philippe J. Goix , Paul J. Lingane , Janette T. Phi-Wilson , Kenneth F. Uffenheimer
发明人： Philippe J. Goix , Paul J. Lingane , Janette T. Phi-Wilson , Kenneth F. Uffenheimer
IPC分类号： G01N33/543
CPC分类号： G01N15/1404 , G01N21/64
摘要： A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles.
摘要翻译：其中待分析的标记颗粒通过毛细管中的预定体积被照亮的悬浮毛细管吸取的颗粒分析仪。由所述颗粒散射的照明由检测器检测以计数所有颗粒。检测由标记的颗粒发射的荧光照明，并且处理来自荧光检测器和散射检测器的输出信号以提供颗粒的分析。

5. 发明授权

US5101673A Ultra low sample liquid analysis apparatus and method 失效
标题翻译：超低样品液体分析仪器及方法
公开(公告)号：US5101673A
公开(公告)日：1992-04-07
申请号：US763484
申请日：1991-09-23
申请人： Kenneth F. Uffenheimer , Nicholas F. Di Domenico , Stephen L. Weitz
发明人： Kenneth F. Uffenheimer , Nicholas F. Di Domenico , Stephen L. Weitz
IPC分类号： G01N1/00 , G01N35/10
CPC分类号： G01N35/1004 , G01N35/1095
摘要： The sample liquids analysis system includes a probe which is automatically operable to successively aspirate sample liquids and reagent and/or other sample liquids processing liquids and to dispense the same in turn into sample liquids analysis apparatus for automatic, successive sample liquids analyses. Isolation liquid supply apparatus are operatively associated with the sample liquids aspirating and dispensing probe and operate to introduce an isolation liquid which is immiscible with the sample liquids and which selectively wets the probe to the substantial exclusion of the sample liquids, to the probe to, in combination with operatively associated rinse liquid supply apparatus which operate to fill the probe with a rinse liquid between successive sample liquids aspirations, reduce sample liquids carryover to ultra low levels. The sample liquids aspirating and dispensing probe are operated by the rinse liquid supply apparatus; and comprise a probe body member, and an active probe component operatively connected thereto by a readily disconnectable connector, thus making possible the ready and convenient replacement of the active probe component without adverse effect upon the essential configuration and/or operational characteristics of the rinse liquid supply apparatus, and thereby upon the overall performance of the sample liquids analysis system. The configuration of the probe operates to reduce sample liquids flow velocity in the active probe component, thereby further reducing sample liquids carryover.
摘要翻译：样品液体分析系统包括可以自动操作以连续吸取样品液体和试剂和/或其它样品液体处理液体的探针，并将其分配到用于自动连续样品液体分析的样品液体分析装置中。隔离液体供应装置与抽吸和分配探针的样品液体可操作地相关联，并且操作以引入与样品液体不混溶的分离液体，并且选择性地润湿探针以将样品液体基本上排除在探针之外与操作相关联的冲洗液体供应装置组合，其操作以在连续的样品液体期望之间用漂洗液填充探针，将样品液体携带到超低水平。样品液体抽吸和分配探针由冲洗液体供应装置操作; 并且包括探针主体构件和通过易于拆卸的连接器可操作地连接到其上的主动探头组件，从而使得有效探针组件的即时和方便的更换成为可能，而不会对冲洗液的基本构造和/或操作特性产生不利影响供应装置，从而达到样品液体分析系统的整体性能。探头的结构可以减少样品液体在活性探针组分中的流速，从而进一步减少样品液体携带。

6. 发明授权

US4683212A Random access single channel sheath stream apparatus 失效
标题翻译：随机接入单通道鞘流装置
公开(公告)号：US4683212A
公开(公告)日：1987-07-28
申请号：US431639
申请日：1982-09-30
申请人： Kenneth F. Uffenheimer
发明人： Kenneth F. Uffenheimer
IPC分类号： G01N35/08 , G01N1/00 , G01N15/14 , G01N21/05
CPC分类号： G01N15/1404 , Y10T137/86187 , Y10T436/117497
摘要： An apparatus and method are provided for the precisely controlled and coordinated, concomitant supply at optimal flow rates, by differential pumping, of selected sample and sheath liquids from respective pluralities of different sources thereof, to the same sheath stream flow cell for successive different types of sample analyses, thereby maximizing sample analysis accuracy and reproducibility, and reducing apparatus complexity and costs. The apparatus and method are particularly useful in high-speed automated biomedical analytical systems.
摘要翻译：提供了一种装置和方法，用于通过将选定的样品和鞘液从相应的多个不同的来源差分泵送到相同的鞘流流动池，用于连续不同类型的装置和方法，用于以最佳流速进行精确控制和协调的供应样品分析，从而最大限度地提高样品分析的准确性和可重复性，并降低仪器的复杂性和成本。该装置和方法在高速自动生物医学分析系统中特别有用。

7. 外观设计

USD277891S Cuvette tray 失效
公开(公告)号：USD277891S
公开(公告)日：1985-03-05
申请号：US416804
申请日：1982-09-13
申请人： Kenneth F. Uffenheimer , Dario Svenjak , Herman G. Diebler , William J. C. McCandless , Rand E. Herron , Stephen Saros
设计人： Kenneth F. Uffenheimer , Dario Svenjak , Herman G. Diebler , William J. C. McCandless , Rand E. Herron , Stephen Saros

8. 发明授权

US4357301A Reaction cuvette 失效
标题翻译：反应试管
公开(公告)号：US4357301A
公开(公告)日：1982-11-02
申请号：US284845
申请日：1981-07-20
申请人： Michael M. Cassaday , Herman G. Diebler , Dario Svenjak , Kenneth F. Uffenheimer
发明人： Michael M. Cassaday , Herman G. Diebler , Dario Svenjak , Kenneth F. Uffenheimer
IPC分类号： G01N33/48 , G01N21/03 , G01N21/25 , G01N35/02 , G01N21/13
CPC分类号： G01N21/253
摘要： The reaction cuvette adapted to receive a liquid dispensing probe and having at least one surface of hydrophilic material which is treated or formed to have inwardly extending projections against which the liquid is dispensed.
摘要翻译：反应试管适于接收液体分配探针并具有至少一个亲水材料表面，其被处理或形成为具有向内延伸的突起，液体被分配到其上。

9. 发明授权

US07939017B2 Automated fluid handling system and method 有权
标题翻译：自动流体处理系统和方法
公开(公告)号：US07939017B2
公开(公告)日：2011-05-10
申请号：US11679289
申请日：2007-02-27
申请人： Kenneth F. Uffenheimer , Arthur Hunt
发明人： Kenneth F. Uffenheimer , Arthur Hunt
IPC分类号： G01N21/00 , G01N1/14
CPC分类号： G01N35/1002 , G01N15/1404 , G01N35/109 , G01N2001/383 , G01N2015/1409 , G01N2015/1411 , G01N2015/149 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/119163 , Y10T436/2575
摘要： An automated fluid handling system configured to prepare fluid samples and to introduce them into an analytical instrument, such as a particle analyzer, flow cytometer or sorter flow cell, and that is capable of analyzing both accurately and quickly.
摘要翻译：一种自动化流体处理系统，其被配置为制备流体样品并将其引入分析仪器，例如粒子分析仪，流式细胞仪或分选器流动池，并且能够准确且快速地分析。

10. 发明授权

US6110427A Flow regulator to maintain controllable volumetric flow rate 有权
标题翻译：流量调节器保持可控的体积流量
公开(公告)号：US6110427A
公开(公告)日：2000-08-29
申请号：US133845
申请日：1998-08-14
申请人： Kenneth F. Uffenheimer
发明人： Kenneth F. Uffenheimer
IPC分类号： G05D7/01
CPC分类号： G05D7/0133 , Y10T137/7788 , Y10T137/7792 , Y10T436/117497 , Y10T436/2575
摘要： A flow regulator is provided which comprises a housing defining a chamber therein and including inlet and outlet ports that are adaptable to allow fluid to flow into and out of the chamber. A piston assembly, including an orifice defining member in which is formed an orifice, is movably disposed in the chamber and is capable of moving in directions toward and away from the outlet port. An urging device, such as a spring, magnetic or electromagnetic device, urges the piston assembly away from the outlet port. As fluid flows into the flow regulator, the fluid flows through the orifice. The clearance between a control surface of the piston assembly and the outlet port automatically adjusts so that an equilibrium condition occurs in the flow regulator in which the difference between the pressure of the fluid upstream of the orifice and the pressure of the fluid downstream of the orifice is maintained essentially constant. This results in the fluid flowing through the orifice, and in turn through the clearance between the control surface of the piston and the outlet port, and subsequently out of the flow regulator, at a flow rate which is relatively unaffected by a change in supply pressure, downstream pressure, and the temperature of the fluid which affects the viscosity of the fluid.
摘要翻译：提供了一种流量调节器，其包括在其中限定腔室的壳体，并且包括适于允许流体流入和流出腔室的入口和出口。包括形成孔口的孔口限定构件的活塞组件可移动地设置在腔室中并且能够在朝向和远离出口的方向上移动。诸如弹簧，磁性或电磁装置的推动装置促使活塞组件远离出口。当流体流入流量调节器时，流体流过孔口。活塞组件的控制表面和出口之间的间隙自动调节，使得在流量调节器中发生平衡状态，其中孔口上游的流体的压力与孔口下游的流体的压力之间的差异维持基本恒定。这导致流体流过孔口，并且依次通过活塞的控制表面和出口之间的间隙，并随后流出流量调节器，流量相对不受供应压力变化的影响，下游压力以及影响流体粘度的流体温度。

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