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1. 发明授权

US5101673A Ultra low sample liquid analysis apparatus and method 失效
标题翻译：超低样品液体分析仪器及方法
公开(公告)号：US5101673A
公开(公告)日：1992-04-07
申请号：US763484
申请日：1991-09-23
申请人： Kenneth F. Uffenheimer , Nicholas F. Di Domenico , Stephen L. Weitz
发明人： Kenneth F. Uffenheimer , Nicholas F. Di Domenico , Stephen L. Weitz
IPC分类号： G01N1/00 , G01N35/10
CPC分类号： G01N35/1004 , G01N35/1095
摘要： The sample liquids analysis system includes a probe which is automatically operable to successively aspirate sample liquids and reagent and/or other sample liquids processing liquids and to dispense the same in turn into sample liquids analysis apparatus for automatic, successive sample liquids analyses. Isolation liquid supply apparatus are operatively associated with the sample liquids aspirating and dispensing probe and operate to introduce an isolation liquid which is immiscible with the sample liquids and which selectively wets the probe to the substantial exclusion of the sample liquids, to the probe to, in combination with operatively associated rinse liquid supply apparatus which operate to fill the probe with a rinse liquid between successive sample liquids aspirations, reduce sample liquids carryover to ultra low levels. The sample liquids aspirating and dispensing probe are operated by the rinse liquid supply apparatus; and comprise a probe body member, and an active probe component operatively connected thereto by a readily disconnectable connector, thus making possible the ready and convenient replacement of the active probe component without adverse effect upon the essential configuration and/or operational characteristics of the rinse liquid supply apparatus, and thereby upon the overall performance of the sample liquids analysis system. The configuration of the probe operates to reduce sample liquids flow velocity in the active probe component, thereby further reducing sample liquids carryover.
摘要翻译：样品液体分析系统包括可以自动操作以连续吸取样品液体和试剂和/或其它样品液体处理液体的探针，并将其分配到用于自动连续样品液体分析的样品液体分析装置中。隔离液体供应装置与抽吸和分配探针的样品液体可操作地相关联，并且操作以引入与样品液体不混溶的分离液体，并且选择性地润湿探针以将样品液体基本上排除在探针之外与操作相关联的冲洗液体供应装置组合，其操作以在连续的样品液体期望之间用漂洗液填充探针，将样品液体携带到超低水平。样品液体抽吸和分配探针由冲洗液体供应装置操作; 并且包括探针主体构件和通过易于拆卸的连接器可操作地连接到其上的主动探头组件，从而使得有效探针组件的即时和方便的更换成为可能，而不会对冲洗液的基本构造和/或操作特性产生不利影响供应装置，从而达到样品液体分析系统的整体性能。探头的结构可以减少样品液体在活性探针组分中的流速，从而进一步减少样品液体携带。

2. 发明授权

US5133218A Sample liquid aspirating and dispensing probe 失效
标题翻译：样本液体吸入和分配探针
公开(公告)号：US5133218A
公开(公告)日：1992-07-28
申请号：US685983
申请日：1991-04-15
申请人： Kenneth F. Uffenhiemer , Nicholas F. Di Domenico
发明人： Kenneth F. Uffenhiemer , Nicholas F. Di Domenico
IPC分类号： G01N1/14 , G01N1/00 , G01N35/08
CPC分类号： G01N35/1095 , G01N35/08
摘要： The sample liquids analysis system includes a probe which is automatically operable to successively aspirate sample liquids and reagent and/or other sample liquids processing liquids and to dispense the same in turn into sample liquids analysis apparatus for automatic, successive sample liquids analyses. Isolation liquid supply apparatus are operatively associated with the sample liquids aspirating the dispensing probe and operate to introduce an isolation liquid which is immiscible with the sample liquids and which selectively wets the probe to the substantial exclusion of the sample liquids, to the probe to, in combination with operatively associated rinse liquid supply apparatus which operate to fill the probe with a rinse liquid between successive sample liquids aspirations, reduce sample liquids carryover to ultra low levels. The sample liquids aspirating and dispensing probe are operated by the rinse liquid supply apparatus; and comprise a probe body member, and an active probe component operatively connected thereto by a readily disconnectable connector, thus making possible the ready and convenient replacement of the active probe component without adverse effect upon the essential configuration and/or operational characteristics of the rinse liquid supply apparatus, and thereby upon the overall performance of the sample liquids analysis system. The configuration of the probe operates to reduce sample liquids flow velocity in the active probe component, thereby further reducing sample liquids carryover.
摘要翻译：样品液体分析系统包括可以自动操作以连续吸取样品液体和试剂和/或其它样品液体处理液体的探针，并将其分配到用于自动连续样品液体分析的样品液体分析装置中。隔离液体供应装置与抽吸分配探针的样品液体可操作地相关联，并且操作以引入与样品液体不混溶的分离液体，并且将分离液体选择性地润湿探针以将样品液体基本排除到探针与操作相关联的冲洗液体供应装置组合，其操作以在连续的样品液体期望之间用漂洗液填充探针，将样品液体携带到超低水平。样品液体抽吸和分配探针由冲洗液体供应装置操作; 并且包括探针主体构件和通过易于拆卸的连接器可操作地连接到其上的主动探头组件，从而使得有效探针组件的即时和方便的更换成为可能，而不会对冲洗液的基本构造和/或操作特性产生不利影响供应装置，从而达到样品液体分析系统的整体性能。探头的结构可以减少样品液体在活性探针组分中的流速，从而进一步减少样品液体携带。

3. 发明授权

US4984475A Ultra low carryover sample liquid analysis apparatus and method 失效
标题翻译：超低残留样品液体分析仪器及方法
公开(公告)号：US4984475A
公开(公告)日：1991-01-15
申请号：US384742
申请日：1989-07-24
申请人： Kenneth F. Uffenheimer , Nicholas F. Di Domenico , Stephen L. Weitz
发明人： Kenneth F. Uffenheimer , Nicholas F. Di Domenico , Stephen L. Weitz
IPC分类号： G01N1/00 , G01N35/10
CPC分类号： G01N35/1004 , G01N35/1095
摘要： The sample liquids analysis system includes a probe which is automatically operable to successively aspirate sample liquids and reagent and/or other sample liquids processing liquids and to dispense the same in turn into sample liquids analysis apparatus for automatic, successive sample liquids analyses. Isolation liquid supply apparatus are operatively associated with the sample liquids aspirating and dispensing probe and operate to introduce an isolation liquid which is immiscible with the sample liquids and which selectively wets the probe to the substantial exclusion of the sample liquids, to the probe to, in combination with operatively associated rinse liquid supply apparatus which operate to fill the probe with a rinse liquid between successive sample liquids aspirations, reduce sample liquids carryover to ultra low levels. The sample liquids aspirating and dispensing probe are operated by the rinse liquid supply apparatus; and comprise a probe body member, and an active probe component operatively connected thereto by a readily disconnectable connector, thus making possible the ready and convenient replacement of the active probe component without adverse effect upon the essential configuration and/or operational characteristics of the rinse liquid supply apparatus, and thereby upon the overall performance of the sample liquids analysis system. The configuration of the probe operates to reduce sample liquids flow velocity in the active probe component, thereby further reducing sample liquids carryover.
摘要翻译：样品液体分析系统包括可以自动操作以连续吸取样品液体和试剂和/或其它样品液体处理液体的探针，并将其分配到用于自动连续样品液体分析的样品液体分析装置中。隔离液体供应装置与抽吸和分配探针的样品液体可操作地相关联，并且操作以引入与样品液体不混溶的分离液体，并且选择性地润湿探针以将样品液体基本上排除在探针之外与操作相关联的冲洗液体供应装置组合，其操作以在连续的样品液体期望之间用漂洗液填充探针，将样品液体携带到超低水平。样品液体抽吸和分配探针由冲洗液体供应装置操作; 并且包括探针主体构件和通过易于拆卸的连接器可操作地连接到其上的主动探头组件，从而使得有效探针组件的即时和方便的更换成为可能，而不会对冲洗液的基本构造和/或操作特性产生不利影响供应装置，从而达到样品液体分析系统的整体性能。探头的结构可以减少样品液体在活性探针组分中的流速，从而进一步减少样品液体携带。

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