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1. 发明申请

WO2008061261A3 PREPARATION AND USE OF CELL-SYNTHESIZED THREADS 审中-公开
标题翻译：细胞合成线的制备和使用
公开(公告)号：WO2008061261A3
公开(公告)日：2008-11-20
申请号：PCT/US2007085148
申请日：2007-11-19
申请人： CYTOGRAFT TISSUE ENGINEERING I , L HEUREUX NICOLAS , MCALLISTER TODD N
发明人： L HEUREUX NICOLAS , MCALLISTER TODD N
IPC分类号： C12N5/00
CPC分类号： A61L27/3895
摘要： The present technology provides for a cell-synthesized biological thread, processes for making a cell-synthesized thread, and an apparatus for carrying out a process used to engineer the cell-synthesized thread. The thread is produced from living cells in culture and can be grown around the outer surface of a cylindrical bioreactor. The tissue comprising the thread has mechanical and biological properties achieved by altering the climactic conditions, stresses and strains on the tissue and chemical composition that prove beneficial in the medical industry. This process results in a biological thread that has high mechanical strength, decreased immunogenic effect and decreased thrombogenic effect when combined with other tissue. It also results in a product which can be used to create more complex constructs that otherwise could not have been generated. The threads can be used to make sutures, patches, and tubes, for example.
摘要翻译：本技术提供细胞合成生物细胞线，制备细胞合成细胞线的过程以及用于执行用于细胞合成细胞线工程化的过程的装置。线由培养的活细胞产生，可以在圆柱形生物反应器的外表面周围生长。包含线的组织具有通过改变组织中的高潮条件，应力和应变以及在医疗行业中证明有益的化学组成而获得的机械和生物特性。该过程产生具有高机械强度，降低的免疫原性效应和与其他组织结合时降低的血栓形成效应的生物线。它还会产生一种产品，可用于创建更复杂的结构，否则这些结构可能无法生成。例如，线可用于制作缝合线，贴片和管。

2. 发明专利

CA2209211A1 PRODUCTION OF A CONTRACTILE SMOOTH MUSCLE 未知
公开(公告)号：CA2209211A1
公开(公告)日：1996-07-11
申请号：CA2209211
申请日：1995-12-29
申请人： HEUREUX NICOLAS L , GERMAIN LUCIE , UNIV LAVAL , AUGER FRANCOIS A
发明人： L HEUREUX NICOLAS , GERMAIN LUCIE , AUGER FRANCOIS A
IPC分类号： A61L27/00 , C12N5/071 , C12N5/08
摘要： A contractile smooth muscle cell construct and a method for preparing the smooth muscle cell construct are described. The smooth muscle cell construct is comprised of (i) smooth muscle cells that have been cultured in vitro under conditions to allow the formation of a sheet of smooth muscle cells and (ii) an endogenous fibrous matrix formed by the smooth muscle cells, wherein the smooth muscle cell construct retains the ability to contract in response to vasoactive agonists. The smooth muscle cell construct may be prepared in planar or tubular form and can be used to study or evaluate the contractile responses of smooth muscle cells.

3. 发明申请

WO2010102673A1 HELLEBRIN AND HELLEBRIGENIN DERIVATIVES 审中-公开
标题翻译： HELLEBRIN和HELLEBRIGENIN衍生物
公开(公告)号：WO2010102673A1
公开(公告)日：2010-09-16
申请号：PCT/EP2009/052985
申请日：2009-03-13
申请人： Unibioscreen S.A. , DEWELLE, Janique , EL YAZIDI, Mohamed , VAN QUAQUEBEKE, Eric , DE NEVE, Nancy , MIJATOVIC, Tatjana , INGRASSIA, Laurent , KISS, Robert , VAN VYNCKT, Frank , HEUREUX, Nicolas
发明人： DEWELLE, Janique , EL YAZIDI, Mohamed , VAN QUAQUEBEKE, Eric , DE NEVE, Nancy , MIJATOVIC, Tatjana , INGRASSIA, Laurent , KISS, Robert , VAN VYNCKT, Frank , HEUREUX, Nicolas
IPC分类号： C07J19/00 , C07J41/00 , C07J43/00 , A61K31/58 , A61P35/00
CPC分类号： C07J19/00 , C07J19/005 , C07J41/0055 , C07J43/003
摘要： The present invention relates to new cardiotonic Steroid Compounds of Formula (I) or (II) wherein X 1 , X 2 , X 3 , L, R 1 , R 2 , R 3 , R 4 , and R 5 have the same meaning as that defined in the Claims. The invention also relates to the use of said Compounds as medicaments, in particular in the treatment of Cancer.
摘要翻译：本发明涉及式（I）或（II）的新的强心型类固醇化合物，其中X 1，X 2，X 3，L，R 1，R 2，R 3，R 4和R 5具有与权利要求中所定义相同的含义。本发明还涉及所述化合物作为药物，特别是用于治疗癌症的用途。

4. 发明申请

WO0137884A3 IMPROVED TISSUE ENGINEERED BLOOD VESSELS AND METHODS AND APPARATUS FOR THEIR MANUFACTURE 审中-公开
标题翻译：改进的组织工程血液容器及其制造方法和装置
公开(公告)号：WO0137884A3
公开(公告)日：2002-01-03
申请号：PCT/US0042239
申请日：2000-11-22
申请人： CYTOGRAFT TISSUE ENGINEERING I , MCALLISTER TODD N , HEUREUX NICOLAS L
发明人： MCALLISTER TODD N , L HEUREUX NICOLAS
IPC分类号： A61F2/06 , A61K35/12 , A61L27/36 , A61L27/38 , A61L27/50 , C12N5/071
CPC分类号： A61L27/3886 , A61F2/06 , A61K35/12 , A61L27/3804 , A61L27/3808 , A61L27/507 , C12M21/08 , C12M23/06 , C12M27/12 , C12N5/0691 , C12N2502/1323 , Y10S623/916
摘要： The invention is a tissue engineered blood vessel (TEBV) made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood pressure without the inclusion of smooth muscle cells or synthetic scaffolding. The TEBV is made in a bioreactor (40) having an enclosed chamber (25), a sheet growth module, a rollable mandrel and a clamp for holding the sheet to the mandrel for rolling.
摘要翻译：本发明是由培养的成纤维细胞片制成的组织工程化血管（TEBV），其被卷成多层容器，其具有足够的破裂强度以抵抗生理血压而不包括平滑肌细胞或合成脚手架。 TEBV在具有封闭腔室（25）的生物反应器（40）中制造，片材生长模块，可滚动心轴和用于将片材保持在心轴上用于滚动的夹具。

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