会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 7. 发明申请
    • PHARMACEUTICAL COMPOSITION FOR INHIBITING ABNORMAL PROLIFERATION OF CELLS
    • 用于抑制细胞异常增殖的药物组合物
    • WO2011096756A3
    • 2011-12-15
    • PCT/KR2011000768
    • 2011-02-07
    • UNIV EWHA IND COLLABORATIONKANG SANG WONLEE SOO YOUNG
    • KANG SANG WONLEE SOO YOUNG
    • A61K38/16A61P35/00C12N15/11G01N33/15
    • C12N15/1135A61K39/00C12N2310/11
    • The present invention relates to a pharmaceutical composition for preventing or treating diseases related to abnormal proliferation of cells, comprising a cytoplasmic heat shock protein (Hsp)60 kDa inhibitor as an active ingredient, and to a screening method and a kit using the composition. According to the present invention, substances which inhibit expression of cytoplasmic Hsp 60 genes or inhibit activity of cytoplasmic Hsp 60 or inhibit binding between cytoplasmic Hsp 60 and IKK protein prevent interaction between cytoplasmic Hsp 60 and IKK complexes to make NF- ?B path inactive, and thus induce apoptosis. Therefore, the substances can be valuably used in preventing or treating diseases related to abnormal proliferation of cells, such as cancer, inflammatory diseases or hyperproliferative vascular diseases.
    • 本发明涉及用于预防或治疗与细胞异常增殖有关的疾病的药物组合物,其包含细胞质热休克蛋白(Hsp)60kDa抑制剂作为活性成分,以及使用该组合物的筛选方法和试剂盒。 根据本发明,抑制细胞质Hsp 60基因表达或抑制细胞质Hsp60活性或抑制细胞质Hsp60与IKK蛋白之间结合的物质可防止细胞质Hsp60与IKK复合体之间的相互作用,使NF-κB通路无活性, 从而诱导凋亡。 因此,这些物质可以有效地用于预防或治疗与癌症,炎性疾病或过度增生性血管疾病等细胞的异常增殖有关的疾病。
    • 8. 发明申请
    • PHARMACEUTICAL COMPOSITION FOR INHIBITING ABNORMAL PROLIFERATION OF CELLS
    • 用于抑制细胞异常增殖的药物组合物
    • WO2011096756A2
    • 2011-08-11
    • PCT/KR2011000768
    • 2011-02-07
    • UNIV EWHA IND COLLABORATIONKANG SANG WONLEE SOO YOUNG
    • KANG SANG WONLEE SOO YOUNG
    • A61K38/16A61P35/00C12N15/11G01N33/15
    • C12N15/1135A61K39/00C12N2310/11
    • The present invention relates to a pharmaceutical composition for preventing or treating diseases related to abnormal proliferation of cells, comprising a cytoplasmic heat shock protein (Hsp)60 kDa inhibitor as an active ingredient, and to a screening method and a kit using the composition. According to the present invention, substances which inhibit expression of cytoplasmic Hsp 60 genes or inhibit activity of cytoplasmic Hsp 60 or inhibit binding between cytoplasmic Hsp 60 and IKK protein prevent interaction between cytoplasmic Hsp 60 and IKK complexes to make NF- ?B path inactive, and thus induce apoptosis. Therefore, the substances can be valuably used in preventing or treating diseases related to abnormal proliferation of cells, such as cancer, inflammatory diseases or hyperproliferative vascular diseases.
    • 本发明涉及用于预防或治疗与细胞异常增殖有关的疾病的药物组合物,其包含作为活性成分的细胞质热休克蛋白(Hsp)60kDa抑制剂,以及使用该组合物的筛选方法和试剂盒。 根据本发明,抑制细胞质热休克蛋白60基因表达或抑制细胞质热休克蛋白60活性或抑制细胞质热休克蛋白60和IKK蛋白之间结合的物质防止细胞质热休克蛋白60和IKK复合物之间的相互作用,使NF-κB途径失活, 并由此诱导细胞凋亡。 因此,这些物质可以有价值地用于预防或治疗与细胞异常增殖相关的疾病,例如癌症,炎性疾病或过度增殖性血管疾病。