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1. 发明申请

WO2006061026A3 A MICRO FLUIDIC DEVICE AND METHODS FOR PRODUCING A MICRO FLUIDIC DEVICE 审中-公开
标题翻译：一种用于生产微流体装置的微流体装置和方法
公开(公告)号：WO2006061026A3
公开(公告)日：2007-05-24
申请号：PCT/DK2005050009
申请日：2005-12-07
申请人： INVERNESS MEDICAL SWITZERLAND , BAU-MADSEN NIELS KRISTIAN , BARHOLM-HANSEN CLAUS , JONSMANN JACQUES , OVERBY BENT
发明人： BAU-MADSEN NIELS KRISTIAN , BARHOLM-HANSEN CLAUS , JONSMANN JACQUES , OVERBY BENT
IPC分类号： B01L3/00
CPC分类号： B01L3/502746 , B81B2203/0323
摘要： The invention relates to a micro fluidic device comprising a flow channel with an interface between a cartridge base and a lid, as well as methods of producing it. The cartridge base comprises a channel shaped depression and the lid is bonded to said cartridge base to form the flow channel: The interface between the cartridge base and the lid, adjacent to and along with the flow channel comprises at least two, such as three or more capillary gap sections in the form of a gap between the Ii and the cartridge base, separated by a flow break section, which flow break section provides a barrier for a capillary flow of liquid along adjoining capillary gap sections. In one embodiment the surface of at least one of the cartridge base and the lid in the interface between the cartridge base and the lid in the flow break sections, adjacent to and along with the flow channel, is less hydrophilic than one or both of the surfaces of the cartridge base and the lid in said capillary gap sections. In one embodiment the bonding material has at least partly penetrated into the flow channel.
摘要翻译：本发明涉及一种微流体装置，其包括具有在盒基座和盖子之间的界面的流动通道，以及其制造方法。墨盒底座包括通道形凹陷部分，并且盖子结合到所述墨盒底座以形成流动通道：墨盒基座和盖子之间的与流动通道相邻并与流动通道一起的界面包括至少两个，例如三个或更多的毛细孔隙部分以Ii和药筒基座之间的间隙的形式形成，由流动断裂部分分开，该流动断裂部分为沿着相邻的毛细管间隙部分的液体的毛细管流动提供了屏障。在一个实施例中，与底部和盖子之间的界面中的至少一个的位于流动断裂部分中的与流动通道相邻并与流动通道相邻的表面的表面的亲水性比其中一个或两个所述毛细管间隙部分中的药筒基座和盖子的表面。在一个实施例中，接合材料至少部分地穿透到流动通道中。

2. 发明申请

WO2006074665A2 A METHOD OF PRODUCING A MICROFLUIDIC DEVICE AND MICROFLUIDIC DEVICES 审中-公开
标题翻译：一种制造微流体装置和微流体装置的方法
公开(公告)号：WO2006074665A2
公开(公告)日：2006-07-20
申请号：PCT/DK2006050002
申请日：2006-01-11
申请人： SCANDINAVIAN MICRO BIODEVICES , BARHOLM-HANSEN CLAUS , JONSMANN JACQUES , BAEKMARK THOMAS ROSLEFF , OVERBY BENT , BERENDSEN CHRISTIAN , BOUAIDAT SALIM , BAU-MADSEN NIELS KRISTIAN
发明人： BARHOLM-HANSEN CLAUS , JONSMANN JACQUES , BAEKMARK THOMAS ROSLEFF , OVERBY BENT , BERENDSEN CHRISTIAN , BOUAIDAT SALIM , BAU-MADSEN NIELS KRISTIAN
CPC分类号： F16K99/0017 , B01L3/502738 , B01L3/502746 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2300/089 , B01L2300/165 , B01L2400/0406 , B01L2400/0688 , F16K99/0001 , F16K2099/0078
摘要： The present invention relates to a method of producing a microfluidic device with a flow path optionally comprising one or more chambers, e.g. reaction chambers. The method comprises the steps: (i) providing a base substrate with a first surface and a top substrate with a second surface, the substrates e.g. being of polymer material, (ii) hydrophilically treating at least one of the first and the second surfaces to provide a surface layer with a higher surface tension, such as about 60 mN/m or higher, than the surface tension prior to the hydrophilic treatment, (iii) partly or totally removing the surface layer with a higher surface tension in a selected pattern of the hydrophilically treated first and/or second surfaces, e.g. using laser, to thereby provide the selected pattern with a lower surface tension than prior to the partly or totally removal of the surface layer with a higher surface tension in said selected pattern of the hydrophilic treated first and/or second surfaces, and (iv) joining said base substrate and top substrate to each other to provide a flow path between said first and second surfaces. The selected pattern can be shaped with a variety of shapes to obtain the desired hydrophilic/hydrophobic character of the flow path, e.g. a micro- pattern in the form of one or more segments with at least one dimension less than 25 µm, a micro-dotted pattern, a pattern in the form of one or more straight or rounded lines e.g. extending totally or partly across the flow path. The invention also relates to a microfluidic device obtainable by the method.
摘要翻译：本发明涉及一种生产微流体装置的方法，该流体装置具有可选地包括一个或多个室的流路，例如，反应室。该方法包括以下步骤：（i）提供具有第一表面的基底基底和具有第二表面的顶部基底，作为聚合物材料，（ii）亲水处理第一和第二表面中的至少一个，以提供具有比亲水处理之前的表面张力更高的表面张力（例如约60mN / m或更高）的表面层，（iii）在亲水处理的第一和/或第二表面的选定图案中部分或完全地去除具有较高表面张力的表面层，例如使用激光，从而使得所选择的图案具有比在所述亲水处理的第一和/或第二表面的所述选择图案中具有更高表面张力部分地或完全去除表面层之前的较低表面张力，以及（iv）将所述基底基底和顶部基底彼此接合以提供所述第一和第二表面之间的流动路径。所选择的图案可以用各种形状成形，以获得所需的流动路径的亲水/疏水特征，例如，具有至少一个尺寸小于25μm的一个或多个片段形式的微图案，微点图案，一个或多个直线或圆形线形式的图案，例如，全部或部分穿过流路延伸。本发明还涉及通过该方法可获得的微流体装置。

3. 发明公开

EP2307141A1 A MICROFLUIDIC DEVICE 有权转让
标题翻译：微流体装置
公开(公告)号：EP2307141A1
公开(公告)日：2011-04-13
申请号：EP09802439.1
申请日：2009-07-29
申请人： Jonsmann, Jacques , Bau-Madsen, Niels Kristian
发明人： Jonsmann, Jacques , Bau-Madsen, Niels Kristian
IPC分类号： B01L3/00
CPC分类号： B01L3/502746 , B01L3/502723 , B01L2200/0684 , B01L2300/0816 , B01L2300/0883 , B01L2400/0406 , B01L2400/084 , Y10T436/2575
摘要： A microfluidic device comprising a flow channel with an inlet and a gas escape opening is described. The flow channel comprises a liquid flow channel section and a flow controlling section downstream to the liquid flow channel section and upstream to or coinciding with the gas escape opening. The flow controlling section provides a flow resistance to gas, which is sufficiently high to reduce velocity of a capillary flow of a liquid in the liquid flow channel section. The microfluidic device with the flow controlling section provides a device in which the velocity of the flow can be reduced to a desired level. Also is described a method of performing a test using the microfluidic device.

4. 发明申请

WO2008113361A1 A FLOW THROUGH SYSTEM, FLOW THROUGH DEVICE AND A METHOD OF PERFORMING A TEST 审中-公开
标题翻译：流动通过系统，通过设备流动和执行测试的方法
公开(公告)号：WO2008113361A1
公开(公告)日：2008-09-25
申请号：PCT/DK2008/050066
申请日：2008-03-17
申请人： SCANDINAVIAN MICRO BIODEVICES ApS , JONSMANN, Jacques
发明人： JONSMANN, Jacques
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/558 , B01L3/5027 , B01L2300/0636 , B01L2300/0877 , B01L2400/0406 , G01N33/54366
摘要： The invention relates to a flow through system for quantifying a target component in a liquid. The flow through system comprises a flow-through device comprising a flow path comprising a marker section, a capture section downstream to said marker section, and at least two quantification sections. The marker section comprises a non-immobilized marker. The capture section comprises a capture zone with an immobilized capture agent, and the at least two quantification sections comprise a pre-capture quantification section placed downstream to the marker section and up stream to the capture section, and a post-capture quantification section placed downstream to the capture section. The system further comprises a quantification unit for each of said quantification sections. The quantification unit(s) being arranged to quantify marker containing components and/or particles passing through said respective quantification sections. The invention also relates to a flow through device for such flow through system and a method of determining the amount of target component in a liquid using a flow through system.
摘要翻译：本发明涉及一种用于量化液体中的目标成分的流通系统。流过系统包括流通装置，其包括流路，该流路包括标记部分，所述标记部分下游的捕获部分和至少两个定量部分。标记部分包括非固定化标记。捕获部分包括具有固定的捕获剂的捕获区，并且所述至少两个定量部分包含放置在标记部分下游的捕获前定量部分和向捕获部分的上游，以及放置在下游的捕获后定量部分到捕获部分。该系统还包括用于每个所述定量部分的量化单元。定量单元被布置成量化通过所述各个量化部分的含有标记物的组分和/或颗粒。本发明还涉及用于这种流通系统的流通装置和使用流通系统确定液体中的目标成分的量的方法。

5. 发明申请

WO2008086809A1 A MICROFLUIDIC DEVICE AND A KIT FOR PERFORMING A TEST 审中-公开
标题翻译：微型设备和用于执行测试的工具包
公开(公告)号：WO2008086809A1
公开(公告)日：2008-07-24
申请号：PCT/DK2008/050002
申请日：2008-01-04
申请人： SCANDINAVIAN MICRO BIODEVICES ApS , KRING, Ole , JONSMANN, Jacques , BAU-MADSEN, Niels Kristian
发明人： KRING, Ole , JONSMANN, Jacques , BAU-MADSEN, Niels Kristian
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： B01L3/502746 , B01L2300/0636 , B01L2300/0825 , B01L2300/089 , B01L2300/165 , B01L2400/0406 , B01L2400/0688 , B01L2400/088
摘要： The invention relates to a microfluidic device comprising a flow path with a first and a second opposite solid flow path surfaces (1) and a liquid inlet for said flow path. In the microfluid device at least one solid side wall free section (2) of the flow path (1) is provided by the first and the second opposite solid flow path surfaces in at least said one solid side wall free section (2) and a pair of borderlines (3, 31) defines the edges of the side wall free section (2) of said flow path (1). The pair of borderlines is placed on the first surface of a first and a second opposite surfaces to define the flow path surfaces of said first and second opposite surfaces. The pair of borderlines (3, 31) is defined by an abrupt change of the first and/or the second surface, e.g. in the form of an abrupt change of surface tension and/or an abrupt change of distance between the first and second surfaces beyond and adjacent to the borderlines (3, 31). For example the borderlines (3, 31) may be arranged with a sharp edge with an angle between a flow path surface in the side wall free flow path section and the respective surfaces beyond and, adjacent to the borderlines which is less than 135 degrees, such as about 90 degrees. The flow path comprises an immobilized capture reagent (7) downstream from or in said solid side wall free flow path section (2), said immobilized capture reagent (7) preferably being immobilized onto at least one of said first and second opposite solid flow path surfaces.
摘要翻译：本发明涉及一种微流体装置，其包括具有第一和第二相对的固体流动路径表面（1）的流动路径和用于所述流动路径的液体入口。在微流体装置中，流路（1）的至少一个固体侧壁自由部分（2）由至少所述一个实心侧壁自由部分（2）中的第一和第二相对的固体流动通道表面提供，并且一对边界线（3,31）限定了所述流动路径（1）的侧壁自由部分（2）的边缘。一对边界线放置在第一和第二相对表面的第一表面上，以限定所述第一和第二相对表面的流动路径表面。一对边界线（3,31）由第一和/或第二表面的突然变化限定，例如，其形式是表面张力的突然变化和/或第一和第二表面之间的距离和边界线（3,31）之间的距离的突然变化。例如，边界线（3,31）可以布置成具有在侧壁自由流动路径部分中的流动路径表面与超过小于135度的边界线的相邻表面之间的角度的尖锐边缘，如约90度。流动路径包括在所述固体侧壁自由流动路段部分（2）中或所述固体侧壁自由流动路段部分（2）下游的固定的捕获试剂（7），所述固定化捕获试剂（7）优选固定在所述第一和第二相对固体流动路径中的至少一个表面。

6. 发明申请

WO2002095497A3 METHOD OF LIFT-OFF MICROSTRUCTURING DEPOSITION MATERIAL ON A SUBSTRATE, SUBSTRATES OBTAINABLE BY THE METHOD, AND USE THEREOF 审中-公开
公开(公告)号：WO2002095497A3
公开(公告)日：2002-11-28
申请号：PCT/DK2002/000274
申请日：2002-04-25
申请人： SCANDINAVIAN MICRO BIODEVICES A/S , BOUAIDAT, Salim , JONSMANN, Jacques , WINTHER-JENSEN, Bjørn , CHRISTENSEN, Søren, Flygenring
发明人： BOUAIDAT, Salim , JONSMANN, Jacques , WINTHER-JENSEN, Bjørn , CHRISTENSEN, Søren, Flygenring
IPC分类号： G03F7/00
摘要： Methods and apparatus for lift-off microstructuring deposition material, here alternate hydrophilic (601) and hydrophobic (602) letters, on a substrate; a method comprising deposition of polymeric material by plasma polymerisation deposition of monomers of substituted benzenes, (halo)aliphatic compounds, or a combination thereof; another method comprising deposition of polymeric material by plasma polymerisation deposition of monomers of vinyls, substituted vinyls, acrylics, silanes, and phosphites, or a combination thereof; still another method comprising deposition of polymeric material by plasma polymerisation deposition of monomers wherein said plasma is generated by a multiple phase AC supply, or DC supply; and substrates and devices prepared by lift-off microstructuring using plasma polymerisation deposition of monomers according to such methods. Scale A indicates about 100 μ.

7. 发明申请

WO2009112038A3 A MICROFLUIDIC SYSTEM AND A METHOD OF PERFORMING A TEST 审中-公开
标题翻译：微流控系统及其测试方法
公开(公告)号：WO2009112038A3
公开(公告)日：2009-12-17
申请号：PCT/DK2009050058
申请日：2009-03-13
申请人： SCANDINAVIAN MICRO BIODEVICES , BAU-MADSEN NIELS KRISTIAN , JONSMANN JACQUES , OVERBY BENT , BERENDSEN CHRISTIANUS
发明人： BAU-MADSEN NIELS KRISTIAN , JONSMANN JACQUES , OVERBY BENT , BERENDSEN CHRISTIANUS
IPC分类号： G01N33/49 , B01L3/00 , G01N33/86
CPC分类号： G01N33/4905 , B01L3/5027 , B01L2200/0684 , B01L2200/148 , B01L2300/0654 , B01L2300/0883 , B01L2300/18 , B01L2400/0406 , B01L2400/0487 , G01N33/5304 , G01N33/86
摘要： The invention relates to a microfluidic system comprising a microfluidic device (1) having a first and a second opposite surfaces, an optical detector (3a, 3b) a flow channel with a detection channel section having a length of at least about lmm, at least one aperture section (2) comprising at least a part of said detection channel section and a transparent window into said detection channel section. The optical detector (3a, 3b) is in optical communication with said aperture section (2) for determining at least one optical property of said aperture section as a function of time. The flow channel may have capillary dimensions and/or it may wholly or fully be arranged to drive a fluid flow by applying external forces. The optical detector (3a, 3b) is arranged to transmit light onto the aperture section (2) and to detect a light transmission from the aperture section. The microfluid device (1) may be used to determine various properties of a sample fluid, for example it may be used to determine a samples coagulation properties and/or reactions of one or more components in a blood sample as a function of time.
摘要翻译：本发明涉及一种微流体系统，其包括具有第一和第二相对表面的微流体装置（1），光学检测器（3a，3b），具有至少约1mm长度的检测通道部分的流动通道，至少一个孔径部分（2）包括所述检测通道部分的至少一部分和透明窗口进入所述检测通道部分。光学检测器（3a，3b）与所述孔径部分（2）光学连通，用于确定所述孔径部分的至少一个光学特性作为时间的函数。流动通道可以具有毛细管尺寸和/或其可以完全或完全地布置成通过施加外力来驱动流体流动。光检测器（3a，3b）被布置成将光传送到孔部（2）上并检测来自孔部的光透射。微流体装置（1）可以用于确定样品流体的各种性质，例如其可用于确定样品凝血性质和/或作为时间的函数的血液样品中的一种或多种组分的反应。

8. 发明申请

WO2007006315A2 A METHOD OF PERFORMING A TEST, A SUPPORT INSTRUMENT AND A MICROLIQUID SYSTEM COMPRISING SUCH SUPPORT INSTRUMENT 审中-公开
标题翻译：执行测试的方法，支持仪器和包含这种支持仪器的微型系统
公开(公告)号：WO2007006315A2
公开(公告)日：2007-01-18
申请号：PCT/DK2006050026
申请日：2006-06-28
申请人： INVERNESS MEDICAL SWITZERLAND , JONSMANN JACQUES , BAY JESPER
发明人： JONSMANN JACQUES , BAY JESPER
CPC分类号： B01L3/502746 , B01L3/50273 , Y10T137/0753
摘要： The invention relates to a method of performing a test of a liquid sample using a microfluidic device with one or more flow paths , a support instrument for use in performing a test as well as a microfluidic system comprising such support instrument. The method of performing the test comprising the steps of introducing the liquid sample into the flow path and subjecting the microfluidic device to at least one linear motion with an acceleration sufficiently high to affect the flow of the liquid sample in the flow path. The flow path e.g. comprises a capillary stop junction, and the method comprises subjecting the microfluidic device to at least one linear motion with an acceleration sufficiently high to force the flow front of said liquid sample to flow over the capillary stop junction. The support instrument for use in supporting a microfluidic device comprises a sustaining arrangement capable of sustaining a microfluidic device, and a motion arrangement capable of subjecting a sustained microfluidic device to at least one linear motion e.g. by subjecting the microfluidic device to a force of at least 0.1 mN. The microfluidic system comprises a microfluidic device and a support instrument.
摘要翻译：本发明涉及使用具有一个或多个流动路径的微流体装置进行液体样品的测试的方法，用于进行测试的支撑仪器以及包含该支撑仪器的微流体系统。执行测试的方法包括以下步骤：将液体样品引入流路并使微流体装置以足够高的加速度进行至少一个直线运动，以影响液体样品在流动路径中的流动。流路例如包括毛细管停止接头，并且所述方法包括使所述微流体装置以足够高的加速度进行至少一个线性运动，以迫使所述液体样品的流动前沿流过所述毛细管停止连接点。用于支持微流体装置的支撑仪器包括能够维持微流体装置的维持装置和能够使持续微流体装置进行至少一个线性运动的运动装置，例如，通过对微流体装置施加至少0.1mN的力。微流体系统包括微流体装置和支撑装置。

9. 发明申请

WO2006074665A3 A METHOD OF PRODUCING A MICROFLUIDIC DEVICE AND MICROFLUIDIC DEVICES 审中-公开
公开(公告)号：WO2006074665A3
公开(公告)日：2006-07-20
申请号：PCT/DK2006/050002
申请日：2006-01-11
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , BARHOLM-HANSEN, Claus , JONSMANN, Jacques , BÆKMARK, Thomas, Rosleff , OVERBY, Bent , BERENDSEN, Christian , BOUAIDAT, Salim , BAU-MADSEN, Niels, Kristian
发明人： BARHOLM-HANSEN, Claus , JONSMANN, Jacques , BÆKMARK, Thomas, Rosleff , OVERBY, Bent , BERENDSEN, Christian , BOUAIDAT, Salim , BAU-MADSEN, Niels, Kristian
IPC分类号： B01L3/00 , B01J19/00 , B81B1/00
摘要： The present invention relates to a method of producing a microfluidic device with a flow path optionally comprising one or more chambers, e.g. reaction chambers. The method comprises the steps: (i) providing a base substrate with a first surface and a top substrate with a second surface, the substrates e.g. being of polymer material, (ii) hydrophilically treating at least one of the first and the second surfaces to provide a surface layer with a higher surface tension, such as about 60 mN/m or higher, than the surface tension prior to the hydrophilic treatment, (iii) partly or totally removing the surface layer with a higher surface tension in a selected pattern of the hydrophilically treated first and/or second surfaces, e.g. using laser, to thereby provide the selected pattern with a lower surface tension than prior to the partly or totally removal of the surface layer with a higher surface tension in said selected pattern of the hydrophilic treated first and/or second surfaces, and (iv) joining said base substrate and top substrate to each other to provide a flow path between said first and second surfaces. The selected pattern can be shaped with a variety of shapes to obtain the desired hydrophilic/hydrophobic character of the flow path, e.g. a micro- pattern in the form of one or more segments with at least one dimension less than 25 µm, a micro-dotted pattern, a pattern in the form of one or more straight or rounded lines e.g. extending totally or partly across the flow path. The invention also relates to a microfluidic device obtainable by the method.

10. 发明申请

WO2008083687A1 A MICROFLUIDIC DEVICE AND A MICROFLUIDIC SYSTEM AND A METHOD OF PERFORMING A TEST 审中-公开
标题翻译：微流体装置和微流体系统及其执行方法
公开(公告)号：WO2008083687A1
公开(公告)日：2008-07-17
申请号：PCT/DK2008/050001
申请日：2008-01-04
申请人： SCANDINAVIAN MICRO BIODEVICES ApS , BAU-MADSEN, Niels Kristian , JONSMANN, Jacques , LARSEN, Søren
发明人： BAU-MADSEN, Niels Kristian , JONSMANN, Jacques , LARSEN, Søren
IPC分类号： B01L3/00 , G01N33/49
CPC分类号： B01L3/50273 , B01L3/502738 , B01L3/502769 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0688 , Y10T436/143333
摘要： The invention relates to a microfluidic device comprising at least one test channel (2) comprising an upper test channel section (6) with an upstream end and a sampling region (4) at its upstream end and at least one reference channel (12) comprising an upper reference channel section (16) with an upstream end and a sampling region (4) at its upstream end. The test channel and the reference channel have a merging region (7) downstream to said upper test channel section and a common downstream channel section (8). The merging region (7) and the common downstream channel section (8) are arranged such that a reference liquid flowing from the upper reference channel section into the merging region will block a test liquid flow in the upper test channel section when said test liquid flow has not yet reached the merging section. The microfluid device may preferably be used for detecting change of flow properties e.g. due to agglomeration, agglutination rpr viscosity change in a liquid preferably selected from the group of water, urine, blood, and blood plasma.
摘要翻译：本发明涉及一种微流体装置，其包括至少一个测试通道（2），其包括具有上游端的上测试通道部分（6）和在其上游端的采样区域（4）和至少一个参考通道（12），所述参考通道包括具有上游端的上参考通道部分（16）和在其上游端的采样区域（4）。测试信道和参考信道具有在所述上测试信道部分和公共下行信道部分（8）的下游的合并区域（7）。合并区域（7）和公共下游通道部分（8）被布置成使得当所述测试液体流动时，从上部参考通道部分流入合并区域的参考液体将阻挡上部测试通道部分中的测试液体流动尚未达到合并部分。微流体装置可以优选地用于检测流动特性的变化，例如，由于聚集，优选选自水，尿，血液和血浆的液体中的凝集rpr粘度变化。

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