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1. 发明申请

WO2006074665A2 A METHOD OF PRODUCING A MICROFLUIDIC DEVICE AND MICROFLUIDIC DEVICES 审中-公开
标题翻译：一种制造微流体装置和微流体装置的方法
公开(公告)号：WO2006074665A2
公开(公告)日：2006-07-20
申请号：PCT/DK2006050002
申请日：2006-01-11
申请人： SCANDINAVIAN MICRO BIODEVICES , BARHOLM-HANSEN CLAUS , JONSMANN JACQUES , BAEKMARK THOMAS ROSLEFF , OVERBY BENT , BERENDSEN CHRISTIAN , BOUAIDAT SALIM , BAU-MADSEN NIELS KRISTIAN
发明人： BARHOLM-HANSEN CLAUS , JONSMANN JACQUES , BAEKMARK THOMAS ROSLEFF , OVERBY BENT , BERENDSEN CHRISTIAN , BOUAIDAT SALIM , BAU-MADSEN NIELS KRISTIAN
CPC分类号： F16K99/0017 , B01L3/502738 , B01L3/502746 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2300/089 , B01L2300/165 , B01L2400/0406 , B01L2400/0688 , F16K99/0001 , F16K2099/0078
摘要： The present invention relates to a method of producing a microfluidic device with a flow path optionally comprising one or more chambers, e.g. reaction chambers. The method comprises the steps: (i) providing a base substrate with a first surface and a top substrate with a second surface, the substrates e.g. being of polymer material, (ii) hydrophilically treating at least one of the first and the second surfaces to provide a surface layer with a higher surface tension, such as about 60 mN/m or higher, than the surface tension prior to the hydrophilic treatment, (iii) partly or totally removing the surface layer with a higher surface tension in a selected pattern of the hydrophilically treated first and/or second surfaces, e.g. using laser, to thereby provide the selected pattern with a lower surface tension than prior to the partly or totally removal of the surface layer with a higher surface tension in said selected pattern of the hydrophilic treated first and/or second surfaces, and (iv) joining said base substrate and top substrate to each other to provide a flow path between said first and second surfaces. The selected pattern can be shaped with a variety of shapes to obtain the desired hydrophilic/hydrophobic character of the flow path, e.g. a micro- pattern in the form of one or more segments with at least one dimension less than 25 µm, a micro-dotted pattern, a pattern in the form of one or more straight or rounded lines e.g. extending totally or partly across the flow path. The invention also relates to a microfluidic device obtainable by the method.
摘要翻译：本发明涉及一种生产微流体装置的方法，该流体装置具有可选地包括一个或多个室的流路，例如，反应室。该方法包括以下步骤：（i）提供具有第一表面的基底基底和具有第二表面的顶部基底，作为聚合物材料，（ii）亲水处理第一和第二表面中的至少一个，以提供具有比亲水处理之前的表面张力更高的表面张力（例如约60mN / m或更高）的表面层，（iii）在亲水处理的第一和/或第二表面的选定图案中部分或完全地去除具有较高表面张力的表面层，例如使用激光，从而使得所选择的图案具有比在所述亲水处理的第一和/或第二表面的所述选择图案中具有更高表面张力部分地或完全去除表面层之前的较低表面张力，以及（iv）将所述基底基底和顶部基底彼此接合以提供所述第一和第二表面之间的流动路径。所选择的图案可以用各种形状成形，以获得所需的流动路径的亲水/疏水特征，例如，具有至少一个尺寸小于25μm的一个或多个片段形式的微图案，微点图案，一个或多个直线或圆形线形式的图案，例如，全部或部分穿过流路延伸。本发明还涉及通过该方法可获得的微流体装置。

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