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1. 发明专利

JP2003329677A Method of detecting biochemical sample and detection chip 有权
标题翻译：检测生物化学样品和检测芯片的方法
公开(公告)号：JP2003329677A
公开(公告)日：2003-11-19
申请号：JP2001401649
申请日：2001-12-28
申请人： Hiroaki Misawa , Sumitomo Precision Prod Co Ltd , 弘明三澤 , 住友精密工業株式会社
发明人： YAMAGUCHI HIROSHI , YABUBAYASHI TADAAKI , MISAWA HIROAKI , TANAKA MASAZUMI
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/58 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method of detecting a biochemical sample making it possible to simplify detection processes by use of a new label for detection, in a way assuring good reproducibility, while not requiring much skill on the part of a measurer, increasing the accuracy of detection, and consisting of simple processes; and a detection chip. SOLUTION: Probe DNAs are aligned on a thin film of gold formed on the surface of a glass substrate, in such a way that the probe DNAs together form a loop structure, with their open terminals located on the thin film so that, when there is a target gene, hybridization occurs, releasing the loop structure. Thus, only the hybridized DNA probes can be selectively modified with fine ceramic particles; a light scattering method is applied to these to detect the hybridization through the observation of the intensity of light scattered by the particles. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种检测生化样品的方法，使得可以通过使用用于检测的新标签来简化检测过程，以确保良好的再现性的方式，同时不需要很多技能测量，提高检测精度，并由简单的过程组成; 和检测芯片。解决方案：探针DNA在玻璃基底表面上形成的金薄膜上排列，使得探针DNA一起形成环结构，其开放末端位于薄膜上，当有靶基因时，发生杂交，释放环结构。因此，只有杂交的DNA探针可以用精细的陶瓷颗粒选择性地修饰; 应用光散射法，通过观察由颗粒散射的光的强度来检测杂交。版权所有（C）2004，JPO

2. 发明专利

JP2003329676A Method of detecting biochemical sample and detection chip 审中-公开
标题翻译：检测生物化学样品和检测芯片的方法
公开(公告)号：JP2003329676A
公开(公告)日：2003-11-19
申请号：JP2001401638
申请日：2001-12-28
申请人： Hiroaki Misawa , Sumitomo Precision Prod Co Ltd , 弘明三澤 , 住友精密工業株式会社
发明人： YAMAGUCHI HIROSHI , YABUBAYASHI TADAAKI , MISAWA HIROAKI , TANAKA MASAZUMI
IPC分类号： G01N21/64 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/53 , G01N33/58 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method of detecting a biochemical sample making it possible to simplify detection processes in a manner assuring good reproducibility for the method of detecting fluorescently-modified double-helix DNA, while not requiring much skill on the part of a measurer, increasing the accuracy of detection, and consisting of simple processes; and a detection chip for fluoroscopy.
SOLUTION: Probe DNAs are aligned on a thin film of gold formed on a glass substrate, in such a manner that the probe DNAs together form a loop structure with their open terminals located on the thin film so that, when there is a target gene, hybridization occurs, releasing the loop structure. Thus when fluorescent labels are provided, fluorescence is emitted only from the hybridized probe DNAs. Alternatively, when the DNAs are modified after the hybridization, it is possible to fluorescently label only the target DNA, resulting in reduced background noise and higher accuracy of detection.
COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种检测生物化学样品的方法，使得可以以确保荧光改性双螺旋DNA检测方法的良好再现性的方式简化检测过程，同时不需要太多的技术测量者的一部分，提高检测的准确性，并由简单的过程组成; 以及用于荧光透视的检测芯片。解决方案：探针DNA在玻璃基底上形成的金薄膜上排列，使得探针DNA一起形成环状结构，其开放末端位于薄膜上，使得当存在靶基因，发生杂交，释放环结构。因此，当提供荧光标记时，仅从杂交的探针DNA发射荧光。或者，当杂交后修饰DNA时，可以仅对目标DNA进行荧光标记，导致背景噪声降低和检测精度更高。版权所有（C）2004，JPO

3. 发明专利

JP2005017233A Detection method for biochemical reactant, and biochip 审中-公开
标题翻译：生物化学反应物和生物化学检测方法
公开(公告)号：JP2005017233A
公开(公告)日：2005-01-20
申请号：JP2003185853
申请日：2003-06-27
申请人： Hiroaki Misawa , Sumitomo Precision Prod Co Ltd , 弘明三澤 , 住友精密工業株式会社
发明人： YABUBAYASHI TADAAKI , MISAWA HIROAKI
IPC分类号： G01N33/53 , C12M1/00 , C12Q1/68 , G01N33/543 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a detecting method of a biochemical reactant capable of simplifying a detection process with satisfactory reproducibility, without requiring excessive workmanship of a measuring person, capable of enhancing precisions of respective execution techniques and efficiencies in modification processes for hybridization and a label, and capable of enhancing finally detection precision of an objective specimen.
SOLUTION: A probe is fixed on a surface of a DNA (deoxyribonucleic acid) chip to be surface-treated thereafter with a hydrophobic surface treating agent, a substrate surface gets hydrophobic therein, the objective specimen gets thereby easy to react with the probe in the hybridization, modification probability of the label to the probe is also enhanced irrespectively before the hybridization and after the hybridization, and detection sensitivity is remarkably enhanced in any detection method.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供能够以令人满意的再现性简化检测过程的生物化学反应物的检测方法，而不需要测量人员过多的工艺，能够增强各种执行技术的精度和改进方法的效率杂交和标记，并且能够提高目标样品的最终检测精度。解决方案：探针固定在DNA（脱氧核糖核酸）芯片的表面上，然后用疏水性表面处理剂进行表面处理，底物表面在其中疏水，因此目标样品易于与在杂交中探针，杂交前和杂交后，标记对探针的修饰概率也增强，检测灵敏度在任何检测方法中显着增强。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2004268309A Method and apparatus for dividing sapphire substrate 有权
公开(公告)号：JP2004268309A
公开(公告)日：2004-09-30
申请号：JP2003059317
申请日：2003-03-06
申请人： Hiroaki Misawa , Tecdia Kk , テクダイヤ株式会社 , 弘明三澤
发明人： MISAWA HIROAKI , KOYAMA ETSUO
IPC分类号： B28D5/00 , B23K26/00 , B23K26/40 , B23K101/40 , C03B33/09 , C30B29/20 , C30B33/00 , H01L21/301
CPC分类号： Y02P40/57
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently dividing a sapphire substrate in a high yield at a low cost, and an apparatus therefor. SOLUTION: The method for dividing the sapphire substrate includes a first step for forming scribed grooves 11 to the first surface 10a of the sapphire substrate 10 and a second step for irradiating the positions 11' corresponding to the formed scribed grooves 11 with a laser beam 32 from the first surface 10a side or second surface 10b side of the sapphire substrate. The laser beam 32 has a wavelength enabling the sapphire substrate 10 to yield multiphoton absorption including two-photon absorption and the irradiation energy of the laser beam 32 is the breakdown energy of the sapphire substrate 10. COPYRIGHT: (C)2004,JPO&NCIPI

5. 发明申请

US20120103412A1 METHOD FOR FABRICATING A LASER-INDUCED SURFACE NANOARRAY STRUCTURE, AND DEVICE STRUCTURE FABRICATED USING SAID METHOD 审中-公开
标题翻译：用于制造激光诱导的表面纳米结构的方法和使用方法制造的器件结构
公开(公告)号：US20120103412A1
公开(公告)日：2012-05-03
申请号：US13322156
申请日：2010-05-25
申请人： Takahiko Kato , Seiichi Watanabe , Shigeo Yatsu , Satoshi Kayashima , Norihiko Nishiguchi , Hiroaki Misawa , Kiyotaka Asakura
发明人： Takahiko Kato , Seiichi Watanabe , Shigeo Yatsu , Satoshi Kayashima , Norihiko Nishiguchi , Hiroaki Misawa , Kiyotaka Asakura
IPC分类号： H01L31/0236 , B32B3/14 , C30B11/12 , B82Y40/00 , B82Y30/00
CPC分类号： H01L31/035218 , B23K26/0006 , B23K26/0624 , B23K26/354 , B23K26/355 , B23K2101/36 , B23K2103/50 , B23K2103/52 , B23K2103/56 , B81C1/00031 , Y10T428/24893
摘要： Provided is a method for manufacturing a two-dimensional pattern by simultaneously forming a plurality of quantum dots on a surface of a solid material and making the quantum dots a periodic structure by a laser irradiation, and a device structure and a device fabricated by the method. The method for fabricating a quantum dot-formed surface including the laser irradiation which irradiate at least one batch of laser onto a surface of a solid material to simultaneously form a plurality of quantum dots on the surface, arranging the plurality of quantum dots into periodic arrays.
摘要翻译：提供一种通过在固体材料的表面上同时形成多个量子点并通过激光照射使量子点成为周期性结构的二维图案的制造方法，以及通过该方法制造的器件结构和器件。一种包括激光照射的量子点形成表面的方法，其将至少一批激光照射到固体材料的表面上，以在表面上同时形成多个量子点，将多个量子点排列成周期性阵列。

6. 发明申请

US20080099444A1 Micro-Fabrication Method 审中-公开
标题翻译：微加工方法
公开(公告)号：US20080099444A1
公开(公告)日：2008-05-01
申请号：US10585845
申请日：2005-01-17
申请人： Hiroaki Misawa , Saulius Juodkazis
发明人： Hiroaki Misawa , Saulius Juodkazis
IPC分类号： B29C35/08
CPC分类号： B44C1/228 , B29C59/16 , B29C59/18 , B29C2791/009 , B29K2025/00 , B29L2007/008 , B29L2031/722 , B44C1/005 , B44C3/00
摘要： A micro-fabrication method characterized by comprising the steps of applying a pulse laser beam to a plastic material to be processed exhibiting a glass phase transition by heating and having a heat-shrinkage to form laser-processed patterns on the surface of or in the above plastic material to be processed, and then heat-treating the plastic material to be processed at a temperature not lower than a glass transition temperature Tg to fine the formed patterns by heat-shrinkage.
摘要翻译：一种微加工方法，其特征在于包括以下步骤：将脉冲激光束施加到待加工的塑料材料上，通过加热显示出玻璃相变，并具有热收缩率，以在上述表面上形成激光加工图案待处理的塑料材料，然后在不低于玻璃化转变温度Tg的温度下对待处理的塑料进行热处理，以通过热收缩对形成的图案进行精细化。

7. 发明授权

US5308976A Method for multi-beam manipulation of microparticles 失效
标题翻译：多光束操纵微粒的方法
公开(公告)号：US5308976A
公开(公告)日：1994-05-03
申请号：US891175
申请日：1992-05-29
申请人： Hiroaki Misawa , Keiji Sasaki , Nobura Kitamura
发明人： Hiroaki Misawa , Keiji Sasaki , Nobura Kitamura
IPC分类号： B01J19/12 , B22F1/00 , B23K26/00 , B23K26/06 , B23K26/073 , G21K1/00 , H05H3/04
CPC分类号： H05H3/04
摘要： Irradiating a plurality of laser beams onto different microparticles or different groups of microparticles, and trapping and/or manipulating these microparticles or groups of microparticles. This method permits manipulation of microparticles with a plurality of trapping laser beams not mutually interfering just as with two human hands. By coaxially introducing an excited laser beam, it is possible to induce chemical reactions for processing or assembling.
摘要翻译：将多个激光束照射到不同的微粒或不同的微粒组上，并捕获和/或操纵这些微粒或微粒组。该方法允许利用与两只人的手相同的多个捕获激光束来相互干扰的微粒的操作。通过同时引入激发的激光束，可以引起用于加工或组装的化学反应。

8. 发明授权

US09240286B2 Photoelectric conversion device, light detecting device, and light detecting method 有权
标题翻译：光电转换装置，光检测装置和光检测方法
公开(公告)号：US09240286B2
公开(公告)日：2016-01-19
申请号：US13394528
申请日：2010-09-02
申请人： Hiroaki Misawa , Yoshiaki Nishijima , Kosei Ueno , Kei Murakoshi
发明人： Hiroaki Misawa , Yoshiaki Nishijima , Kosei Ueno , Kei Murakoshi
IPC分类号： H01L31/0224 , H01L31/04 , H01L31/18 , H01L51/44 , H01L29/47 , H01G9/20
CPC分类号： H01G9/2031 , H01G9/2022 , H01L29/47 , H01L31/022425 , H01L31/18 , Y02E10/542 , Y02P70/521
摘要： The present invention has an object to provide a photoelectric conversion device which can be manufactured through a simple manufacturing process, achieve photoelectric conversion over a wide range of wavelength regions, and attain high photoelectric conversion efficiency even in the infrared wavelength region, a photodetection device, and a photodetection method. This photoelectric conversion device 1 includes a substrate 2 containing single crystalline titanium dioxide, adhesion layers 2c formed on a surface 2a of the substrate 2, metal microstructure bodies 3, each of which has a volume of 1,000 nm3 or more and 3,000,000 nm3 or less, arranged at predetermined intervals in a predetermined direction on surfaces of the adhesion layers 2c, a container 4 for containing an electrolyte solution L in an arrangement region of the metal microstructure bodies 3 on the surface 2a of the substrate 2, a conductive layer 7 formed on a rear surface 2b of the substrate 2, and a counter electrode 5 in contact with the electrolyte solution L in the container 4; and the metal microstructure bodies 3 adhere onto the substrate 2 through the adhesion layers 2c, a Schottky barrier is formed at an interface of the substrate 2 with the metal microstructure bodies 3, and photoelectric conversion is carried out for light in an infrared region by utilizing a plasmon resonance phenomenon.
摘要翻译：本发明的目的是提供一种能够通过简单的制造工艺制造的光电转换装置，在宽范围的波长区域上实现光电转换，并且即使在红外波长区域也获得高的光电转换效率，光电检测装置，和光电检测方法。该光电转换装置1包括含有单晶二氧化钛的基板2，形成在基板2的表面2a上的粘合层2c，金属微结构体3的体积为1000nm 3以上且3,000,000nm 3以下，在粘合层2c的表面上以预定方向以预定的方向排列，在基板2的表面2a上的金属微结构体3的配置区域中容纳电解液L的容器4，形成在基板2的表面2a上的导电层7 基板2的后表面2b和与容器4中的电解液L接触的对电极5; 并且金属微结构体3通过粘附层2c附着在基板2上，在基板2与金属微结构体3的界面形成肖特基势垒，利用红外线区域的光进行光电转换等离子体共振现象。

9. 发明授权

US08088484B2 Metallic structure and photodetector 有权
公开(公告)号：US08088484B2
公开(公告)日：2012-01-03
申请号：US12230622
申请日：2008-09-02
申请人： Kosei Ueno , Hiroaki Misawa , Dai Ohnishi , Takui Sakaguchi , Yoichi Mugino
发明人： Kosei Ueno , Hiroaki Misawa , Dai Ohnishi , Takui Sakaguchi , Yoichi Mugino
IPC分类号： B32B5/66
CPC分类号： G01J1/02 , B22F1/0018 , B22F1/0096 , B22F2001/0037 , B82Y30/00 , C22C5/02 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T428/2998
摘要： In a metallic structure including a metallic nano-chain with plasmon resonance absorption, a metallic nanoparticle forming the metallic nano-chain is formed in a circular, triangle, or rhomboid shape. The wavelength selectivity can be increased also by forming a closed region by mutually linking all of metallic nanoparticles that are mutually linked with bottlenecks. In a photodetector, a photodetection unit including a current detection probe, a nano-chain unit, and a current detection probe is arranged on a substrate. The nano-chain unit is a metallic structure with plasmon resonance absorption, where metallic nanoparticles are mutually linked with bottlenecks. Each current detection probe has a corner whose tip is formed with a predetermined angle, and this corner is arranged to face the tip of the nano-chain unit, i.e., a corner of the metallic nanoparticle. Photodetection with high wavelength selectivity is performed based on a change in the initial voltage of the current-voltage characteristic.

10. 发明申请

US20080049302A1 High-Luminance Quantum Correlation Photon Beam Generator 失效
标题翻译：高亮度量子相关光子束发生器
公开(公告)号：US20080049302A1
公开(公告)日：2008-02-28
申请号：US11664388
申请日：2005-09-30
申请人： Vygandas Jarutis , Vygantas Mizeikis , Saulius Juodkazis , Hiroaki Misawa
发明人： Vygandas Jarutis , Vygantas Mizeikis , Saulius Juodkazis , Hiroaki Misawa
IPC分类号： G02F1/39
CPC分类号： B82Y10/00 , G02F1/39 , G06N99/002
摘要： A high-luminance quantum correlation photon beam generator a photon beam of a quantum correlated pair characterized by includes: a laser light source (1) operable to emit a laser pumped light; a parametric crystal (2) operable to generate a pair of two photons of a signal photon and an idler photon on receiving the pumped light from the laser light source (1) to emit two photon beams along two non-concentric cones; a beam splitting means (5) operable to split a signal photon beam (6) from an idler photon beam (7); a mode inverter (10) operable to rotate one of the annular signal photon beam (6) and the idler photon beam (7) 180° around its geometric center; a phase adjusting means (8) operable to adjust phases of the signal photon beam (6) and the idler photon beam (7) based on an optical time delay; and a beam coupling means (14) operable to overlay the signal photon beam (6) with the idler photon beam (7) in a common-line polarized annular shape by the mode inverter (10) to bring them into a quantum correlated state.
摘要翻译：高亮度量子相关光子束发生器，量子相关对的光子束，其特征在于包括：激光源（1），其可操作以发射激光泵浦光; 参数晶体（2），用于在接收来自激光光源（1）的泵浦光以产生沿着两个非同心圆锥体发射两个光子束的信号光子和惰性光子的一对两个光子; 分束装置（5），其可操作以从惰轮光子束（7）分离信号光子束（6）; 模式逆变器（10），其可操作以围绕其几何中心旋转所述环形信号光子束（6）和所述惰轮光子束（7）中的一个180°; 相位调整装置（8），用于基于光学时间延迟来调节信号光子束（6）和惰轮光子束（7）的相位; 以及光束耦合装置（14），其可操作以通过所述模式反相器（10）将所述信号光子束（6）与所述惰性光子束（7）以共线偏振环形形状覆盖，以使其进入量子相关状态。

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