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1. 发明公开

EP1981851A1 KINASE INHIBITORS AND METHODS OF USE THEREOF 有权转让
标题翻译：激酶抑制剂和使用方法
公开(公告)号：EP1981851A1
公开(公告)日：2008-10-22
申请号：EP07762713.1
申请日：2007-01-26
申请人： Array Biopharma, Inc. , Groneberg, Robert , Burgess, Laurence E. , Harvey, Darren , Laird, Ellen , Munson, Mark , Rizzi, James , Rodriguez, Martha , Eary, Charles Todd , Watson, Daniel
发明人： GRONEBERG, Robert , BURGESS, Laurence, E. , HARVEY, Darren , LAIRD, Ellen , MUNSON, Mark , RIZZI, James , RODRIGUEZ, Martha , EARY, Charles, Todd , WATSON, Daniel
IPC分类号： C07D231/40 , C07D231/56 , A61K31/416 , A61P29/00
CPC分类号： C07D231/40 , C07D231/56
摘要： The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.

2. 发明专利

IL183961D0 NOVEL PYRIDINE COMPOUNDS 未知
公开(公告)号：IL183961D0
公开(公告)日：2007-10-31
申请号：IL18396107
申请日：2007-06-14
申请人： ASTRAZENECA AB , BRICKMANN KAY , CHENG LEIFENG , BOSTROM JONAS , FABRIZIO GIORDANETTO , GRONEBERG ROBERT D , HARVEY DARREN MARTIN , SULLIVAN MICHAEL F O , ZETTERBERG FREDRIK , BACH PETER , OSTERLUND KRISTER
IPC分类号： C07D20100101
摘要： The present invention relates to certain novel pyridin compounds of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-thrombotic agents etc, and processes for their preparation, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

3. 发明专利

IL170527A INDAZOLES SUBSTITUTED AT 5-POSITION AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 未知
公开(公告)号：IL170527A
公开(公告)日：2011-11-30
申请号：IL17052705
申请日：2005-08-28
申请人： ARRAY BIOPHARMA INC , MUNSON MARK , MARESKA DAVID A , KIM YOUNGBOO , GRONEBERG ROBERT , RIZZI JAMES , RODRIGUEZ MARTHA , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN , KIM GANHYEOK
发明人： MUNSON MARK , MARESKA DAVID A , KIM YOUNGBOO , GRONEBERG ROBERT , RIZZI JAMES , RODRIGUEZ MARTHA , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN , KIM GANHYEOK
IPC分类号： A61K20060101 , A61K31/4745 , A61K31/503 , A61K31/675 , C07D20060101 , C07D231/56 , C07D261/20 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
摘要： Compounds having the Formula: wherein Y, A, W, B, U, V, X and Ar 1 have the meanings given in the specification, which compounds are useful in therapy as p38-inhibitors.

4. 发明专利

IL280182D0 Pyridin-2-one compounds useful as smarca2 antagonists 未知
公开(公告)号：IL280182D0
公开(公告)日：2021-03-01
申请号：IL28018221
申请日：2021-01-14
申请人： EPIZYME INC , HARVEY DARREN MARTIN , MORADEI OSCAR , LAMPE JOHN W , CAMPBELL JOHN EMMERSON , DUNCAN KENNETH WILLIAM , MUNCHHOF MICHAEL JOHN
发明人： HARVEY DARREN MARTIN , MORADEI OSCAR , LAMPE JOHN W , CAMPBELL JOHN EMMERSON , DUNCAN KENNETH WILLIAM , MUNCHHOF MICHAEL JOHN
IPC分类号： A61P35/00
摘要： This disclosure generally relates to pyridine-2-one compounds of formula (I) and methods of using them in the treatment of a disorder, such as cancer or a SMARCA2-associated disorder, including as antagonists (e.g., inhibitors) of SMARCA2. The present disclosure provides treatment modalities, e.g., strategies, treatment methods, patient stratification methods, compounds, combinations, and compositions that are useful for the treatment of disorders, e.g., proliferative disorders, such as certain cancers. Some aspects of this disclosure provide treatment modalities, methods, strategies, compounds, compositions, combinations, and dosage forms for the treatment of cell proliferative disorders, e.g., cancers with decreased activity or function, or loss of function, of SMARCA4 with a SMARCA2 antagonist.

5. 发明申请

WO2009027651A1 MANUALLY OPERATED SOLDERING APPARATUS 审中-公开
标题翻译：手动操作的焊接设备
公开(公告)号：WO2009027651A1
公开(公告)日：2009-03-05
申请号：PCT/GB2008/002869
申请日：2008-08-26
申请人： PILLARHOUSE INTERNATIONAL LIMITED , HARVEY, Darren
发明人： HARVEY, Darren
IPC分类号： B23K3/06 , B23K1/08 , B23K3/08 , H05K13/04
CPC分类号： B23K3/0653 , B23K1/085
摘要： A manually operable soldering apparatus comprising a solder bath having a nozzle (92) which is raised to solder a lead or PCB track positioned above the nozzle. A movable frame (28) carries the PCB (30) to be soldered and is mounted to be moved in a plane above the nozzle by manual operation of an operator. A reference board (36) is positioned above board (36) and laser beam (72a) is used to align the reference board, board (36) and nozzle (90) so that an operator works by positioning the board (36) under the beam (72a). A frame carrying the board is pivotable to a maintenance position and can also be held at an angle to the horizontal for a wave soldering operation.
摘要翻译：一种手动操作的焊接装置，其包括具有喷嘴（92）的焊料槽，所述喷嘴（92）被升高以焊接位于喷嘴上方的引线或PCB轨道。可移动框架（28）承载要焊接的PCB（30），并通过操作者的手动操作安装成在喷嘴上方的平面中移动。参考板（36）位于板（36）上方，并且激光束（72a）用于对准参考板，板（36）和喷嘴（90），使得操作者通过将板（36）定位在梁（72a）。承载板的框架可枢转到维护位置，并且也可以与水平面保持一定角度进行波峰焊接操作。

6. 发明申请

WO2007089646A1 KINASE INHIBITORS AND METHODS OF USE THEREOF 审中-公开
标题翻译：激酶抑制剂及其使用方法
公开(公告)号：WO2007089646A1
公开(公告)日：2007-08-09
申请号：PCT/US2007/002272
申请日：2007-01-26
申请人： ARRAY BIOPHARMA INC. , GRONEBERG, Robert , BURGESS, Laurence, E. , HARVEY, Darren , LAIRD, Ellen , MUNSON, Mark , RIZZI, James , RODRIGUEZ, Martha , EARY, Charles, Todd , WATSON, Daniel
发明人： GRONEBERG, Robert , BURGESS, Laurence, E. , HARVEY, Darren , LAIRD, Ellen , MUNSON, Mark , RIZZI, James , RODRIGUEZ, Martha , EARY, Charles, Todd , WATSON, Daniel
IPC分类号： C07D231/40 , C07D231/56 , A61K31/416 , A61P29/00
CPC分类号： C07D231/40 , C07D231/56
摘要： The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.
摘要翻译：式（I）化合物及其药学上可接受的盐和前药可用于治疗和预防由激酶介导的各种疾病。

7. 发明申请

WO2006073361A1 NOVEL PYRIDINE COMPOUNDS 审中-公开
标题翻译：新型吡啶化合物
公开(公告)号：WO2006073361A1
公开(公告)日：2006-07-13
申请号：PCT/SE2006/000010
申请日：2006-01-04
申请人： ASTRAZENECA AB , BACH, Peter , BOSTRÖM, Jonas , BRICKMANN, Kay , CHENG, Leifeng , GIORDANETTO, Fabrizio , GRONEBERG, Robert D. , HARVEY, Darren, Martin , O'SULLIVAN, Michael, F. , ZETTERBERG, Fredrik , ÖSTERLUND, Krister
发明人： BACH, Peter , BOSTRÖM, Jonas , BRICKMANN, Kay , CHENG, Leifeng , GIORDANETTO, Fabrizio , GRONEBERG, Robert D. , HARVEY, Darren, Martin , O'SULLIVAN, Michael, F. , ZETTERBERG, Fredrik , ÖSTERLUND, Krister
IPC分类号： C07D401/04 , A61K31/4427 , A61P7/02 , C07D213/78 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
CPC分类号： C07D413/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14
摘要： The present invention relates to certain novel pyridin compounds of Formula ( I ) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, and processes for their preparation, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的某些新颖的吡啶化合物，用于制备这些化合物的方法，以其作为P2Y12抑制剂和抗血栓形成剂等的用途及其制备方法，它们作为心血管疾病中的药物使用作为含有它们的药物组合物。

8. 发明申请

WO2004078116A3 P38 INHIBITORS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2004078116A3
公开(公告)日：2004-09-16
申请号：PCT/US2004/005693
申请日：2004-02-25
申请人： ARRAY BIOPHARMA, INC. , MUNSON, Mark , MARESKA, David, A. , KIM, Youngboo , GRONEBERG, Robert , RIZZI, James , RODRIGUEZ, Martha , KIM, Ganghyeok , VIGERS, Guy , RAO, Chang , BALACHARI, Devan , HARVEY, Darren
发明人： MUNSON, Mark , MARESKA, David, A. , KIM, Youngboo , GRONEBERG, Robert , RIZZI, James , RODRIGUEZ, Martha , KIM, Ganghyeok , VIGERS, Guy , RAO, Chang , BALACHARI, Devan , HARVEY, Darren
IPC分类号： A61K31/4745 , A61K31/503 , A61K31/675 , C07D401/14 , C07D471/02 , C07D487/02
摘要： This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.

9. 发明申请

WO2010080864A1 PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF 审中-公开
标题翻译：含哌啶化合物及其用途
公开(公告)号：WO2010080864A1
公开(公告)日：2010-07-15
申请号：PCT/US2010/020304
申请日：2010-01-07
申请人： ARRAY BIOPHARMA INC. , RODRIGUEZ, Martha, E. , MARESKA, David, A. , HANS, Jeremy, J. , HARVEY, Darren, M. , GRONEBERG, Robert, D. , O'SULLIVAN, Michael
发明人： RODRIGUEZ, Martha, E. , MARESKA, David, A. , HANS, Jeremy, J. , HARVEY, Darren, M. , GRONEBERG, Robert, D. , O'SULLIVAN, Michael
IPC分类号： A01N43/42
CPC分类号： C07D413/14 , A61K31/445 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/14 , C07D471/04
摘要： A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I) wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.
摘要翻译：一种预防和/或治疗代谢性疾病，脑血管疾病等的方法，其包括向哺乳动物施用有效量的式（I）化合物，其中所有符号具有与说明书中定义的相同的含义; 其盐，其N-氧化物，其溶剂合物或其前药。和式（I-1）的新化合物：其中所有符号具有与说明书中定义的相同的含义; 其盐，其N-氧化物，其溶剂化物或其前药具有抗糖尿病作用和神经保护作用。因此，式（I）的化合物和式（I-1）的化合物可用于预防和/或治疗诸如糖尿病，脑血管疾病如中风等的代谢疾病的方法。

10. 发明申请

WO2005115669A2 SELECTIVE SOLDERING APPARATUS WITH JET WAVE SOLDER JET AND NITROGEN PREHEAT 审中-公开
标题翻译：选择性焊接设备，喷射波峰喷射和氮气预处理
公开(公告)号：WO2005115669A2
公开(公告)日：2005-12-08
申请号：PCT/GB2005/002032
申请日：2005-05-24
申请人： PILLARHOUSE INTERNATIONAL LIMITED , CINIGLIO, Alexander, James , KENT, Charles , HARVEY, Darren , DRAIN, Colin
发明人： CINIGLIO, Alexander, James , KENT, Charles , HARVEY, Darren , DRAIN, Colin
IPC分类号： B23K1/08
CPC分类号： B23K3/0653 , B23K1/085
摘要： Solder is pumped through a nozzle to produce a jet (12) of solder and leads on a printed circuit board are passed through the jet to solder them to the board tracks. The nozzle (2) is mounted on a flange (16) held between slip rings (18, 20) so that the nozzle can be rotated to change the direction of the jet. A nitrogen conduit (68, 70) may be provided inline with the jet to provide a nitrogen atmosphere. A thin plate (92) downstream of the nozzle outlet to contact the jet and inhibit sideways fluctuations when leads are passed sideways through the jet. The apparatus may also include a tube (204, 212, 224) for delivering heated nitrogen gas to pre-heat a region to be soldered.
摘要翻译：焊料通过喷嘴泵送以产生焊料射流（12），印刷电路板上的引线通过喷射器将其焊接到板轨道。喷嘴（2）安装在保持在滑环（18,20）之间的凸缘（16）上，使得喷嘴可以旋转以改变射流的方向。氮气管道（68,70）可以与射流一体设置以提供氮气氛。在喷嘴出口下游的薄板（92）与喷嘴接触，并且当引线横过通过射流时通过侧向波动来抑制侧向波动。该装置还可以包括用于输送加热的氮气以预热待焊接的区域的管（204,212,224）。

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