基本信息:
- 专利标题： Pyridin-2-one compounds useful as smarca2 antagonists
- 申请号：IL28018221 申请日：2021-01-14
- 公开(公告)号：IL280182D0 公开(公告)日：2021-03-01
- 发明人： HARVEY DARREN MARTIN , MORADEI OSCAR , LAMPE JOHN W , CAMPBELL JOHN EMMERSON , DUNCAN KENNETH WILLIAM , MUNCHHOF MICHAEL JOHN
- 申请人： EPIZYME INC , HARVEY DARREN MARTIN , MORADEI OSCAR , LAMPE JOHN W , CAMPBELL JOHN EMMERSON , DUNCAN KENNETH WILLIAM , MUNCHHOF MICHAEL JOHN
- 专利权人： EPIZYME INC,HARVEY DARREN MARTIN,MORADEI OSCAR,LAMPE JOHN W,CAMPBELL JOHN EMMERSON,DUNCAN KENNETH WILLIAM,MUNCHHOF MICHAEL JOHN
- 当前专利权人： EPIZYME INC,HARVEY DARREN MARTIN,MORADEI OSCAR,LAMPE JOHN W,CAMPBELL JOHN EMMERSON,DUNCAN KENNETH WILLIAM,MUNCHHOF MICHAEL JOHN
- 优先权： US201862702481 2018-07-24; US201962815208 2019-03-07
- 主分类号： A61P35/00
- IPC分类号： A61P35/00
摘要：
This disclosure generally relates to pyridine-2-one compounds of formula (I) and methods of using them in the treatment of a disorder, such as cancer or a SMARCA2-associated disorder, including as antagonists (e.g., inhibitors) of SMARCA2. The present disclosure provides treatment modalities, e.g., strategies, treatment methods, patient stratification methods, compounds, combinations, and compositions that are useful for the treatment of disorders, e.g., proliferative disorders, such as certain cancers. Some aspects of this disclosure provide treatment modalities, methods, strategies, compounds, compositions, combinations, and dosage forms for the treatment of cell proliferative disorders, e.g., cancers with decreased activity or function, or loss of function, of SMARCA4 with a SMARCA2 antagonist.
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61P | 化合物或药物制剂的治疗活性 |
| ------A61P35/00 | 抗肿瘤药 |