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1. 发明申请

WO2006073361A1 NOVEL PYRIDINE COMPOUNDS 审中-公开
标题翻译：新型吡啶化合物
公开(公告)号：WO2006073361A1
公开(公告)日：2006-07-13
申请号：PCT/SE2006/000010
申请日：2006-01-04
申请人： ASTRAZENECA AB , BACH, Peter , BOSTRÖM, Jonas , BRICKMANN, Kay , CHENG, Leifeng , GIORDANETTO, Fabrizio , GRONEBERG, Robert D. , HARVEY, Darren, Martin , O'SULLIVAN, Michael, F. , ZETTERBERG, Fredrik , ÖSTERLUND, Krister
发明人： BACH, Peter , BOSTRÖM, Jonas , BRICKMANN, Kay , CHENG, Leifeng , GIORDANETTO, Fabrizio , GRONEBERG, Robert D. , HARVEY, Darren, Martin , O'SULLIVAN, Michael, F. , ZETTERBERG, Fredrik , ÖSTERLUND, Krister
IPC分类号： C07D401/04 , A61K31/4427 , A61P7/02 , C07D213/78 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
CPC分类号： C07D413/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14
摘要： The present invention relates to certain novel pyridin compounds of Formula ( I ) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, and processes for their preparation, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的某些新颖的吡啶化合物，用于制备这些化合物的方法，以其作为P2Y12抑制剂和抗血栓形成剂等的用途及其制备方法，它们作为心血管疾病中的药物使用作为含有它们的药物组合物。

2. 发明申请

WO2010117323A1 METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE 审中-公开
标题翻译：生产热能和二氧化碳的方法和装置
公开(公告)号：WO2010117323A1
公开(公告)日：2010-10-14
申请号：PCT/SE2010/050375
申请日：2010-04-06
申请人： ASTRAZENECA AB , BOSTRÖM, Jonas , CHENG, Leifeng , FEX, Tomas , KARLE, Michael , PETTERSEN, Daniel , SCHELL, Peter
发明人： BOSTRÖM, Jonas , CHENG, Leifeng , FEX, Tomas , KARLE, Michael , PETTERSEN, Daniel , SCHELL, Peter
IPC分类号： C07D413/04 , A61K31/4523 , A61P7/04
CPC分类号： C07D413/04
摘要： Formula I or a pharmaceutically suitable salt thereof, wherein, R1 and R2 independently are hydrogen, deuterium, aryl, hetero aryl, C1-C8 alkyl, optionally being substituted with one or more substituents independently being R3, R3 is an aryl, hetero aryl, fluorine(s), a C1-C6 alkyl containing one or more fluorine, a C1-C6 alkyl containing one or more deuterium, a C1-C6 alkyl containing hydroxy, the aryl and heteroaryl optionally being substituted with one or more halogen, a fluorinated alkoxy, a fluorinated alkyl, a sulfonyl, one or more deuterium, a C1-6 alkyl, a C1-6 alkoxy, a nitrile, or R3 is a C1-6 alkyl optionally substituted with one or more of the following groups: COOR4, OCOR4, CONR5R6, NR5COR6, OR4; wherein, R4 is a C1-10 alkyl optionally substituted with one or more fluorine, deuterium, alkoxy, arylcarboxylate, alkyl carboxylate; R5 and R6 are independently selected from hydrogen, alkyl or they may together form a 4-8 membered carbon ring; or R1 and R2 form a 3-10 membered carbon ring optionally comprising O or N and optionally substituted with a C1-10 alkyl or aryl, hetero aryl optionally substituted with R3.
摘要翻译：式I或其药学上合适的盐，其中R 1和R 2独立地是氢，氘，芳基，杂芳基，任选被一个或多个取代基独立地被R 3取代的C 1 -C 8烷基，R 3是芳基，杂芳基，氟，含有一个或多个氟的C 1 -C 6烷基，含有一个或多个氘的C 1 -C 6烷基，含羟基的C 1 -C 6烷基，任选被一个或多个卤素取代的芳基和杂芳基，氟化烷氧基，氟化烷基，磺酰基，一个或多个氘，C 1-6烷基，C 1-6烷氧基，腈或R 3是任选被一个或多个下列基团取代的C 1-6烷基：COOR 4， OCOR4，CONR5R6，NR5COR6，OR4; 其中，R4为任选被一个或多个氟，氘，烷氧基，芳基羧酸酯，羧酸烷基酯取代的C 1-10烷基; R 5和R 6独立地选自氢，烷基或它们可以一起形成4-8元碳环; 或R 1和R 2形成任选地包含O或N并任选被C 1-10烷基或芳基取代的3-10元碳环，任选被R 3取代的杂芳基。

3. 发明申请

WO2009041904A1 QUINOLINE COMPOUNDS HAVING AN ACTIVITY AGAINST THE GABAB RECEPTOR 审中-公开
标题翻译：具有抗GABAB受体活性的喹啉化合物
公开(公告)号：WO2009041904A1
公开(公告)日：2009-04-02
申请号：PCT/SE2008/051077
申请日：2008-09-26
申请人： ASTRAZENECA AB , CHENG, Leifeng , KARLE, Michael
发明人： CHENG, Leifeng , KARLE, Michael
IPC分类号： C07D215/38 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61P1/04 , A61P1/10 , A61P1/12 , C07D215/18 , C07D401/06 , C07D401/12
CPC分类号： C07D215/18 , C07D215/38 , C07D215/54 , C07D401/06 , C07D401/12
摘要： 62 Abstract The present invention relates to novel compounds of the general formula (I) N R1 R4 R5 X 5 (I) wherein R1, R4, R5 and X are as defined, having a positive allosteric GABA Breceptor (GBR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABA Bagonist, for the inhibition of transient lower esophageal sphincter relaxations, 10 for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS).
摘要翻译： 62摘要本发明涉及通式（I）的新化合物，其中R 1，R 4，R 5和X如上所定义，具有正的变构GABA受体（GBR）调节剂效应，方法用于制备所述化合物及其用途，任选地与GABA Bagonist组合用于抑制短暂食管下括约肌松弛，10用于治疗胃食管反流疾病，以及治疗功能性胃肠道疾病和易激惹肠综合征（IBS）。

4. 发明申请

WO2006067443A1 THERAPEUTIC AGENTS 审中-公开
标题翻译：治疗药剂
公开(公告)号：WO2006067443A1
公开(公告)日：2006-06-29
申请号：PCT/GB2005/004977
申请日：2005-12-21
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , CHENG, Leifeng
发明人： CHENG, Leifeng
IPC分类号： C07D231/22 , C07D231/24 , A61K31/415 , A61P25/00
CPC分类号： C07D231/14 , C07D401/12
摘要： The present invention relates to 1,5-diphenylpyrazole compounds of formula I (A chemical formula should be inserted here - please see paper copy enclosed herewith) and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及式I的1,5-二苯基吡唑化合物（这里应插入一种化学式，请参见随附的纸质复制品）及其制备方法，用于治疗肥胖症，精神病和神经障碍，其治疗用途的方法和含有它们的药物组合物。

5. 发明申请

WO2008120000A1 THERAPEUTIC AGENTS 审中-公开
标题翻译：治疗药剂
公开(公告)号：WO2008120000A1
公开(公告)日：2008-10-09
申请号：PCT/GB2008/001165
申请日：2008-04-02
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , CHENG, Leifeng , HELGESSON, Sara, Annelie , JUDKINS, Robert, Andrew , LINDHAGEN, Marika, Jenny, Susanna , PONTÉN, John, Fritiof
发明人： CHENG, Leifeng , HELGESSON, Sara, Annelie , JUDKINS, Robert, Andrew , LINDHAGEN, Marika, Jenny, Susanna , PONTÉN, John, Fritiof
IPC分类号： C07D471/04 , A61K31/437 , A61P3/04
CPC分类号： C07D471/04
摘要： Certain 4, 5, 6, 7 -tetrahydropyrrolo[3,2-c]pyridin-4-one and 4, 5 -dihydropyrrolo[3,2- c ]pyridin-4-one compounds of formula (I), processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, methods for their therapeutic use and pharmaceutical compositions containing them are described.
摘要翻译：一些式（I）的4,5,6,7-四氢吡咯并[3,2-c]吡啶-4-酮和4,5,5-二氢吡咯并[3,2-c]吡啶-4-酮化合物，制备描述了这些化合物，它们在治疗肥胖症，精神病学和神经病学障碍中的用途，其治疗用途的方法和含有它们的药物组合物。

6. 发明申请

WO2007031721A1 MIDAZOLE-4-CARBOXAMIDE DERIVATIVES FOR USE AS CB MODULATORS 审中-公开
标题翻译：用作CB调节剂的中间体4-羧酰胺衍生物
公开(公告)号：WO2007031721A1
公开(公告)日：2007-03-22
申请号：PCT/GB2006/003358
申请日：2006-09-12
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , CHENG, Leifeng
发明人： CHENG, Leifeng
IPC分类号： C07D401/12 , C07D233/90 , A61K31/55 , A61K31/417 , A61P3/04
CPC分类号： C07D233/90 , C07D401/12
摘要： The present invention relates to substituted 1,2-diphenylimidazol-4-carboxamide compounds of formula (I) to processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的取代的1,2-二苯基咪唑-4-甲酰胺化合物，其用于制备这些化合物，它们在治疗肥胖，精神和神经障碍中的用途，用于治疗用途的方法和药物含有它们的组合物。

7. 发明申请

WO2007031720A1 1,2-DIARYLIMIDAZOLES FOR USE AS CBI MODULATORS 审中-公开
标题翻译：用作CBI调节剂的1,2-二胺基咪唑
公开(公告)号：WO2007031720A1
公开(公告)日：2007-03-22
申请号：PCT/GB2006/003356
申请日：2006-09-12
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , AHLQVIST, Matti , CHENG, Leifeng , LUNDQVIST, Robert , SÖRENSEN, Henrik
发明人： AHLQVIST, Matti , CHENG, Leifeng , LUNDQVIST, Robert , SÖRENSEN, Henrik
IPC分类号： C07D233/90 , C07D401/12 , C07D409/12 , A61K31/4178 , A61P25/00
CPC分类号： C07D233/90 , C07D401/12 , C07D409/12
摘要： Salts of 1,2-diarylimidazole-4-carboxamides and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译： 1,2-二芳基咪唑-4-甲酰胺的盐和制备这些化合物的方法，它们在治疗肥胖症，精神病学和神经障碍中的用途，其治疗用途的方法和含有它们的药物组合物。

8. 发明申请

WO2007010222A2 THERAPEUTIC AGENTS 审中-公开
标题翻译：治疗剂
公开(公告)号：WO2007010222A2
公开(公告)日：2007-01-25
申请号：PCT/GB2006/002638
申请日：2006-07-17
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , BOSTROM, Jonas , CHENG, Leifeng , OLSSON, Roine
发明人： BOSTROM, Jonas , CHENG, Leifeng , OLSSON, Roine
IPC分类号： C07D231/14 , C07D233/90 , C07D207/34 , C07D277/56
CPC分类号： C07D213/83 , C07D207/34 , C07D231/14 , C07D233/90 , C07D239/28 , C07D277/56
摘要： The present invention relates to compounds of formula (I) and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）化合物及其制备方法，其在治疗肥胖症，精神病和神经疾病中的用途，治疗用途的方法和含有它们。

9. 发明申请

WO2005095354A1 THERAPEUTIC AGENTS 审中-公开
标题翻译：治疗药剂
公开(公告)号：WO2005095354A1
公开(公告)日：2005-10-13
申请号：PCT/GB2005/001153
申请日：2005-03-30
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , CHENG, Leifeng , LINDSTEDT-ALSTERMARK, Eva-Lotte , BOIJE, Anna, Maria, Persdotter
发明人： CHENG, Leifeng , LINDSTEDT-ALSTERMARK, Eva-Lotte , BOIJE, Anna, Maria, Persdotter
IPC分类号： C07D233/54
CPC分类号： C07D233/64 , C07D233/66 , C07D401/12 , C07D409/12
摘要： The present invention relates to compounds of formula (I) and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）化合物及其制备方法，它们在治疗肥胖症，精神病学和神经障碍学中的用途及其治疗用途的方法以及含有它们的药物组合物。

10. 发明申请

WO2004111039A1 2,3-SUBSTITUTED 5,6-DIARYL-PYRAZINE DERIVATIVES AS CB1 MODULATORS 审中-公开
标题翻译：作为CB1调节剂的2,3-取代的5,6-二氨基吡啶衍生物
公开(公告)号：WO2004111039A1
公开(公告)日：2004-12-23
申请号：PCT/SE2004/000968
申请日：2004-06-16
申请人： ASTRAZENECA AB , CHENG, Leifeng , WILSTERMANN, Michael
发明人： CHENG, Leifeng , WILSTERMANN, Michael
IPC分类号： C07D401/14
CPC分类号： C07D241/24 , C07D209/54 , C07D413/04 , C07D413/06
摘要： The present invention relates to 2,3-substituted 5,6-diaryl-pyrazine derivatives, e.g. 5,6-diaryl-3-heterocyclylpyrazine-2-ester derivatives of formula (I) and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them. The compounds are cannabinoid receptor 1 (CB1) modulators.
摘要翻译：本发明涉及2,3-取代的5,6-二芳基 - 吡嗪衍生物，例如式（I）的5,6-二芳基-3-杂环基吡嗪-2-酯衍生物及其制备方法，其用于治疗肥胖症，精神病学和神经障碍的用途及其治疗用途的方法和含有他们。这些化合物是大麻素受体1（CB1）调节剂。

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