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1. 发明授权

US07812309B2 Apparatus and method for an electro-acoustic ion transmittor 失效
标题翻译：电声离子发射器的装置和方法
公开(公告)号：US07812309B2
公开(公告)日：2010-10-12
申请号：US11815761
申请日：2006-02-09
申请人： Roger Guevremont , Govindanunny Thekkadath , Maria Guevremont
发明人： Roger Guevremont , Govindanunny Thekkadath , Maria Guevremont
IPC分类号： H01J49/22 , H01J49/06
CPC分类号： G01N27/624
摘要： A method of transmitting ions along an analyzer region between closely spaced electrodes is disclosed. The method includes providing an analyzer region for transmitting ions, the analyzer region in fluid communication with an ionization source and with an ion detecting device. The method further includes affecting a pressure within at least one portion of the analyzer region, to differ from the pressure within another part of the analyzer region, and providing an electric field that is synchronized with the pressure differences to focus the ions.
摘要翻译：公开了沿着紧密间隔的电极之间的分析器区域传输离子的方法。该方法包括提供用于传输离子的分析器区域，与电离源流体连通的分析器区域和离子检测装置。该方法还包括影响分析器区域的至少一部分内的压力，以与分析器区域的另一部分内的压力不同，并且提供与压力差同步的电场以聚焦离子。

2. 发明授权

US07714282B2 Apparatus and method for forming a gas composition gradient between FAIMS electrodes 有权
标题翻译：在FAIMS电极之间形成气体组成梯度的装置和方法
公开(公告)号：US07714282B2
公开(公告)日：2010-05-11
申请号：US11816380
申请日：2006-02-17
申请人： Roger Guevremont , Govindanunny Thekkadath
发明人： Roger Guevremont , Govindanunny Thekkadath
IPC分类号： H01J49/42 , H01J49/20 , H01J49/22 , H01J49/26
CPC分类号： H01J49/42
摘要： A method of separating ions includes providing a FAIMS analyzer region for separating ions, the FAIMS analyzer region in fluid communication with an ionization source and with an ion detecting device. The method further includes affecting a gas composition within a first portion of the FAIMS analyzer region to be different from a gas composition within a second portion of the FAIMS analyzer region. The establishment of a gas composition gradient within the FAIMS analyzer region enhances ion focusing and ion transport efficiency.
摘要翻译：分离离子的方法包括提供用于分离离子的FAIMS分析器区域，与电离源流体连通的FAIMS分析器区域和离子检测装置。该方法还包括影响FAIMS分析仪区域的第一部分内的气体组成与FAIMS分析仪区域的第二部分内的气体组成不同。在FAIMS分析仪区域内建立气体组分梯度增强了离子聚焦和离子传输效率。

3. 发明授权

US07265347B2 Multiple nano-spray delivery system for FAIMS 有权
标题翻译：用于FAIMS的多种纳米喷雾输送系统
公开(公告)号：US07265347B2
公开(公告)日：2007-09-04
申请号：US11130124
申请日：2005-05-17
申请人： Roger Guevremont , Govindanunny Thekkadath , James T. Kapron
发明人： Roger Guevremont , Govindanunny Thekkadath , James T. Kapron
IPC分类号： B01D59/44
CPC分类号： H01J49/0018 , G01N27/624 , H01J49/167
摘要： An apparatus for multiple nano-spray delivery of a sample to FAIMS analyzer includes a micro-machined ionization source having a plurality of discrete nozzles. At least some of the discrete nozzles of the plurality are aligned one each with an ion inlet of a plurality of discrete ion inlets of the FAIMS, so that ions produced at different discrete nozzles are introduced into different portions of the FAIMS analyzer region. The ions that are introduced via each ion inlet are at least partly separated prior to adding/mixing with the ions introduced via other ion inlets. This reduces the problems of ion-ion electric repulsions that occur when ion density is high.
摘要翻译：将样品多次纳米喷射输送到FAIMS分析仪的装置包括具有多个分立喷嘴的微加工电离源。多个离散喷嘴中的至少一些分立喷嘴与FAIMS的多个离散入口的离子入口对齐，使得在不同离散喷嘴处产生的离子被引入FAIMS分析器区域的不同部分。在通过其他离子入口引入的离子添加/混合之前，经由每个离子入口引入的离子至少部分地分离。这减少了当离子密度高时发生的离子离子电排斥的问题。

4. 发明授权

US07112788B2 Apparatus and method for controllably affecting the temperature of FAIMS components 有权
标题翻译：可控制地影响FAIMS部件温度的装置和方法
公开(公告)号：US07112788B2
公开(公告)日：2006-09-26
申请号：US11038166
申请日：2005-01-21
申请人： Roger Guevremont , Govindanunny Thekkadath , Edward Masionis , Randy Purves
发明人： Roger Guevremont , Govindanunny Thekkadath , Edward Masionis , Randy Purves
IPC分类号： H01J49/28
CPC分类号： G01N27/624
摘要： An apparatus for separating ions includes providing a FAIMS analyzer region defined by a space between a first electrode surface and a second electrode surface and extending between an ion inlet end and an ion outlet end. An asymmetric waveform is applied to the first electrode surface and a compensation voltage difference is applied between the first and second electrode surfaces. An output signal is provided from a temperature sensor, the output signal relating to a temperature within the FAIMS analyzer region. In dependence upon the output signal, the temperature within the FAIMS analyzer region is controllably affected. The apparatus supports operation of FAIMS at temperatures different from the temperature of other components in a tandem multi-stage system, and supports the stable operation of FAIMS at different temperatures which increases the separation capability of FAIMS.
摘要翻译：用于分离离子的装置包括提供由第一电极表面和第二电极表面之间的空间限定的FAIMS分析器区域，并且在离子入口端和离子出口端之间延伸。对第一电极表面施加非对称波形，并且在第一和第二电极表面之间施加补偿电压差。从温度传感器提供输出信号，该输出信号与FAIMS分析仪区域内的温度有关。根据输出信号，FAIMS分析仪区域内的温度受到可控制的影响。该装置支持在串联多级系统中与其他部件温度不同的FAIMS操作，支持FAIMS在不同温度下的稳定运行，增加了FAIMS的分离能力。

5. 发明申请

US20060151694A1 Apparatus and method for adjustment of ion separation resolution in FAIMS 有权
标题翻译：用于调整FAIMS中离子分离分辨率的装置和方法
公开(公告)号：US20060151694A1
公开(公告)日：2006-07-13
申请号：US11285162
申请日：2005-11-23
申请人： Roger Guevremont , Maria Guevremont , James Kapron , Govindanunny Thekkadath , Greg Skotnicki
发明人： Roger Guevremont , Maria Guevremont , James Kapron , Govindanunny Thekkadath , Greg Skotnicki
IPC分类号： B01D59/44
CPC分类号： G01N27/624
摘要： An apparatus for separating ions includes a FAIMS analyzer region having a first ion inlet for introducing ions into the FAIMS analyzer region. An ion outlet from the FAIMS analyzer region is provided for extracting a subset of the ions that is selectively transmitted along an average ion flow path defined through the FAIMS analyzer region. The apparatus also includes an actuator for controllably varying a length of the average ion flow path through the FAIMS analyzer region.
摘要翻译：用于分离离子的装置包括具有用于将离子引入FAIMS分析器区域的第一离子入口的FAIMS分析器区域。提供来自FAIMS分析器区域的离子出口，用于提取沿着通过FAIMS分析器区域限定的平均离子流路选择性地传输的离子子集。该装置还包括致动器，用于可控地改变通过FAIMS分析器区域的平均离子流动路径的长度。

6. 发明申请

US20050167587A1 Apparatus and method for controllably affecting the temperature of FAIMS components 有权
标题翻译：可控制地影响FAIMS部件温度的装置和方法
公开(公告)号：US20050167587A1
公开(公告)日：2005-08-04
申请号：US11038166
申请日：2005-01-21
申请人： Roger Guevremont , Govindanunny Thekkadath , Edward Masionis , Randy Purves
发明人： Roger Guevremont , Govindanunny Thekkadath , Edward Masionis , Randy Purves
IPC分类号： B01D59/44 , G01N27/64 , H01J49/28 , H01J49/40 , H01J49/42
CPC分类号： G01N27/624
摘要： An apparatus for separating ions includes providing a FAIMS analyzer region defined by a space between a first electrode surface and a second electrode surface and extending between an ion inlet end and an ion outlet end. An asymmetric waveform is applied to the first electrode surface and a compensation voltage difference is applied between the first and second electrode surfaces. An output signal is provided from a temperature sensor, the output signal relating to a temperature within the FAIMS analyzer region. In dependence upon the output signal, the temperature within the FAIMS analyzer region is controllably affected. The apparatus supports operation of FAIMS at temperatures different from the temperature of other components in a tandem multi-stage system, and supports the stable operation of FAIMS at different temperatures which increases the separation capability of FAIMS.
摘要翻译：用于分离离子的装置包括提供由第一电极表面和第二电极表面之间的空间限定的FAIMS分析器区域，并且在离子入口端和离子出口端之间延伸。对第一电极表面施加非对称波形，并且在第一和第二电极表面之间施加补偿电压差。从温度传感器提供输出信号，该输出信号与FAIMS分析仪区域内的温度有关。根据输出信号，FAIMS分析仪区域内的温度受到可控制的影响。该装置支持在串联多级系统中与其他部件温度不同的FAIMS操作，支持FAIMS在不同温度下的稳定运行，增加了FAIMS的分离能力。

7. 发明授权

US07223971B2 Method and apparatus for selecting inlets of a multiple inlet FAIMS 失效
标题翻译：用于选择多入口FAIMS的入口的方法和装置
公开(公告)号：US07223971B2
公开(公告)日：2007-05-29
申请号：US11068767
申请日：2005-03-02
申请人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
发明人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
IPC分类号： B01D59/44
CPC分类号： G01N27/624 , H01J49/067
摘要： An ion introduction system for selecting ions from one of two separate ionization sources of ions is provided. The system includes a plate having a hole formed therethrough, the plate for being disposed adjacent an ion introduction region of a gas phase ion analyzer such that the hole is selectively movable between a first location in which the hole is adjacent to a first ionization source of ions for supporting introduction of ions from the first ionization source of ions into the gas phase ion analyzer, and a second location in which the hole is adjacent to a second ionization source of ions for supporting introduction of ions from the second ionization source of ions into the gas phase ion analyzer. The system also includes a drive mechanism for driving the plate between a first position in which the hole is at the first location and a second position in which the hole is at the second location.
摘要翻译：提供了一种离子引入系统，用于从两个分离的离子离子源中选择一个离子。该系统包括具有穿过其形成的孔的板，该板用于邻近气相离子分析仪的离子引入区域设置，使得该孔可选择性地在第一位置与第一离子源离子，用于支持将离子从第一离子源离子引入气相离子分析器，以及第二位置，其中孔邻近离子的第二离子源，用于支持将离子从第二离子源离子引入到气相离子分析仪。该系统还包括用于在第一位置和第二位置之间驱动板的驱动机构，其中孔位于第一位置处的第一位置和第二位置。

8. 发明申请

US20050194532A1 Method and apparatus for selecting inlets of a multiple inlet FAIMS 失效
公开(公告)号：US20050194532A1
公开(公告)日：2005-09-08
申请号：US11068767
申请日：2005-03-02
申请人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
发明人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
IPC分类号： G01N27/64 , H01J49/04 , H01J49/16 , H01J49/28 , H01J49/40 , H01J49/42
CPC分类号： G01N27/624 , H01J49/067
摘要： An ion introduction system for selecting ions from one of two separate ionization sources of ions is provided. The system includes a plate having a hole formed therethrough, the plate for being disposed adjacent an ion introduction region of a gas phase ion analyzer such that the hole is selectively movable between a first location in which the hole is adjacent to a first ionization source of ions for supporting introduction of ions from the first ionization source of ions into the gas phase ion analyzer, and a second location in which the hole is adjacent to a second ionization source of ions for supporting introduction of ions from the second ionization source of ions into the gas phase ion analyzer. The system also includes a drive mechanism for driving the plate between a first position in which the hole is at the first location and a second position in which the hole is at the second location.

9. 发明申请

US20050194527A1 Method and apparatus for selecting inlets of a multiple inlet FAIMS 失效
标题翻译：用于选择多入口FAIMS的入口的方法和装置
公开(公告)号：US20050194527A1
公开(公告)日：2005-09-08
申请号：US11068764
申请日：2005-03-02
申请人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
发明人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
IPC分类号： G01N27/64 , H01J49/04 , H01J49/16 , H01J49/28 , H01J49/40 , H01J49/42
CPC分类号： G01N27/624 , H01J49/067
摘要： An ion introduction system for selecting ions from one of two separate ionization sources of ions is provided. The system includes a plate having a hole formed therethrough, the plate for being disposed adjacent an ion introduction region of a gas phase ion analyzer such that the hole is selectively movable between a first location in which the hole is adjacent to a first ionization source of ions for supporting introduction of ions from the first ionization source of ions into the gas phase ion analyzer, and a second location in which the hole is adjacent to a second ionization source of ions for supporting introduction of ions from the second ionization source of ions into the gas phase ion analyzer. The system also includes a drive mechanism for driving the plate between a first position in which the hole is at the first location and a second position in which the hole is at the second location.
摘要翻译：提供了一种离子引入系统，用于从两个分离的离子离子源中选择一个离子。该系统包括具有穿过其形成的孔的板，该板用于邻近气相离子分析仪的离子引入区域设置，使得该孔可选择性地在第一位置与第一离子源离子，用于支持将离子从第一离子源离子引入气相离子分析器;以及第二位置，其中孔邻近离子的第二电离源，用于支持将离子从第二离子源离子引入到气相离子分析仪。该系统还包括用于在第一位置和第二位置之间驱动板的驱动机构，其中孔位于第一位置处的第一位置和第二位置。

10. 发明申请

US20050127284A1 Method of separating ions 失效
标题翻译：分离离子的方法
公开(公告)号：US20050127284A1
公开(公告)日：2005-06-16
申请号：US10875291
申请日：2004-06-25
申请人： Roger Guevremont , Govindanunny Thekkadath
发明人： Roger Guevremont , Govindanunny Thekkadath
IPC分类号： B01J19/08 , G01N27/62 , H01J49/00 , H01J49/16
CPC分类号： H01J49/0031
摘要： A method of separating ions, including a first species of ion and a second species of ion that are transmitted through an analyzer region under substantially identical electrical field conditions, is provided. The method includes separating ions within an analyzer region according to the FAIMS principle, such that the first species of ion and the second species of ion are selectively transmitted along a time-averaged first direction through a portion of the analyzer region between the ion origin end and the ion detection end. Subsequently, the first species of ion and the second species of ion within the analyzer region are separated according to a difference in low field ion mobility values, such that relatively more of one of the first species of ion and the second species of ion is transmitted to an ion detection end than is transmitted absent separating the first species of ion and the second species of ion within the analyzer region according to a difference in their low field ion mobility values. The ions are transmitted through the remainder of the analyzer region under normal FAIMS operating conditions.
摘要翻译：提供了一种分离离子的方法，包括在基本上相同的电场条件下透射通过分析器区域的第一离子类型和第二离子种类。该方法包括根据FAIMS原理分离分析器区域内的离子，使得第一种离子和第二离子种类沿着时间平均的第一方向选择性地通过离子源端之间的分析器区域的一部分和离子检测端。随后，根据低场离子迁移率值的差异分离分析器区域内的第一离子种类和第二离子种类，使得离子和第二离子种类中的一种离子相对更多地被传输相对于离子检测端而言，不是根据其低场离子迁移率值的差异而将分离器区域内的第一种离子和第二离子种分离而不发生。在正常的FAIMS操作条件下，离子通过分析仪区域的其余部分传输。

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