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1. 发明授权

US07227132B2 Apparatus and method for adjustment of ion separation resolution in FAIMS 失效
标题翻译：用于调整FAIMS中离子分离分辨率的装置和方法
公开(公告)号：US07227132B2
公开(公告)日：2007-06-05
申请号：US11285153
申请日：2005-11-23
申请人： Maria Guervremont, legal representative , James T. Kapron
发明人： Roger Guevremont, legally incapacitated
IPC分类号： H01J49/40
CPC分类号： G01N27/624
摘要： An apparatus for controllably varying specificity of a FAIMS-based ion separation includes a first electrode surface portion defining an ion inlet within a portion thereof and a second electrode surface portion defining an ion outlet within a portion thereof. The second electrode surface portion is spaced-apart from the first electrode surface portion along a first direction and disposed in a facing relationship relative to the first electrode surface portion so as to define a FAIMS analyzer region therebetween. An intermediate electrode is disposed between the first electrode surface portion and the second electrode surface portion, the intermediate electrode for defining a transition point of an average ion flow path between the ion inlet and the ion outlet. An actuator is provided for controllably moving the intermediate electrode relative to each of the first electrode surface portion and the second electrode surface portion, for translating the transition point so as to controllably vary the length of the average ion flow path.
摘要翻译：用于可控地改变基于FAIMS的离子分离的特异性的装置包括限定其一部分内的离子入口的第一电极表面部分和在其一部分内限定离子出口的第二电极表面部分。第二电极表面部分沿着第一方向与第一电极表面部分间隔开，并且相对于第一电极表面部分以相对的关系设置，以便在它们之间限定FAIMS分析器区域。中间电极设置在第一电极表面部分和第二电极表面部分之间，中间电极用于限定离子入口和离子出口之间的平均离子流动路径的转变点。提供致动器用于相对于第一电极表面部分和第二电极表面部分中的每一个可控地移动中间电极，用于平移过渡点以便可控地改变平均离子流动路径的长度。

2. 发明授权

US07265347B2 Multiple nano-spray delivery system for FAIMS 有权
标题翻译：用于FAIMS的多种纳米喷雾输送系统
公开(公告)号：US07265347B2
公开(公告)日：2007-09-04
申请号：US11130124
申请日：2005-05-17
申请人： Roger Guevremont , Govindanunny Thekkadath , James T. Kapron
发明人： Roger Guevremont , Govindanunny Thekkadath , James T. Kapron
IPC分类号： B01D59/44
CPC分类号： H01J49/0018 , G01N27/624 , H01J49/167
摘要： An apparatus for multiple nano-spray delivery of a sample to FAIMS analyzer includes a micro-machined ionization source having a plurality of discrete nozzles. At least some of the discrete nozzles of the plurality are aligned one each with an ion inlet of a plurality of discrete ion inlets of the FAIMS, so that ions produced at different discrete nozzles are introduced into different portions of the FAIMS analyzer region. The ions that are introduced via each ion inlet are at least partly separated prior to adding/mixing with the ions introduced via other ion inlets. This reduces the problems of ion-ion electric repulsions that occur when ion density is high.
摘要翻译：将样品多次纳米喷射输送到FAIMS分析仪的装置包括具有多个分立喷嘴的微加工电离源。多个离散喷嘴中的至少一些分立喷嘴与FAIMS的多个离散入口的离子入口对齐，使得在不同离散喷嘴处产生的离子被引入FAIMS分析器区域的不同部分。在通过其他离子入口引入的离子添加/混合之前，经由每个离子入口引入的离子至少部分地分离。这减少了当离子密度高时发生的离子离子电排斥的问题。

3. 发明授权

US07417225B2 Apparatus and method for adjustment of ion separation resolution in FAIMS 有权
标题翻译：用于调整FAIMS中离子分离分辨率的装置和方法
公开(公告)号：US07417225B2
公开(公告)日：2008-08-26
申请号：US11285162
申请日：2005-11-23
申请人： Roger Guevremont , Maria Guevremont , James T. Kapron , Govindanunny Thekkadath , Greg Skotnicki
发明人： Roger Guevremont , Maria Guevremont , James T. Kapron , Govindanunny Thekkadath , Greg Skotnicki
IPC分类号： B01D59/44
CPC分类号： G01N27/624
摘要： An apparatus for separating ions includes a FAIMS analyzer region having a first ion inlet for introducing ions into the FAIMS analyzer region. An ion outlet from the FAIMS analyzer region is provided for extracting a subset of the ions that is selectively transmitted along an average ion flow path defined through the FAIMS analyzer region. The apparatus also includes an actuator for controllably varying a length of the average ion flow path through the FAIMS analyzer region.
摘要翻译：用于分离离子的装置包括具有用于将离子引入FAIMS分析器区域的第一离子入口的FAIMS分析器区域。提供来自FAIMS分析器区域的离子出口，用于提取沿着通过FAIMS分析器区域限定的平均离子流路选择性地传输的离子子集。该装置还包括致动器，用于可控地改变通过FAIMS分析器区域的平均离子流动路径的长度。

4. 发明授权

US07274014B2 Apparatus and method for adjustment of ion separation resolution in FAIMS 有权
标题翻译：用于调整FAIMS中离子分离分辨率的装置和方法
公开(公告)号：US07274014B2
公开(公告)日：2007-09-25
申请号：US11285148
申请日：2005-11-23
申请人： Maria Guevremont, legal representative , James T. Kapron
发明人： Roger Guevremont
IPC分类号： H01J49/40
CPC分类号： G01N27/624
摘要： An apparatus for controllably varying specificity of a FAIMS-based ion separation includes a FAIMS analyzer region defined between a first electrode surface and a second other electrode surface. The FAIMS analyzer region is in communication with an ionization source for providing a flow of ions including a known ion, and with an ion outlet for extracting ions including the known ion from the FAIMS analyzer region. The first and second electrode surfaces are for having an asymmetric waveform voltage applied thereacross for defining an average ion flow path for the known ion traversing therebetween. An actuator is provided for controllably moving the first electrode surface relative to the second electrode surface for controllably varying the length of the average ion flow path.
摘要翻译：用于可控地改变基于FAIMS的离子分离的特异性的装置包括在第一电极表面和第二另外的电极表面之间限定的FAIMS分析器区域。 FAIMS分析器区域与电离源连通，用于提供包括已知离子的离子流，以及用于从FAIMS分析器区域提取包括已知离子的离子的离子出口。第一和第二电极表面用于在其上施加不对称波形电压，以限定用于其间已知离子的平均离子流动路径。提供致动器用于可控地移动第一电极表面相对于第二电极表面，以可控地改变平均离子流动路径的长度。

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