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1. 发明授权

US07112788B2 Apparatus and method for controllably affecting the temperature of FAIMS components 有权
标题翻译：可控制地影响FAIMS部件温度的装置和方法
公开(公告)号：US07112788B2
公开(公告)日：2006-09-26
申请号：US11038166
申请日：2005-01-21
申请人： Roger Guevremont , Govindanunny Thekkadath , Edward Masionis , Randy Purves
发明人： Roger Guevremont , Govindanunny Thekkadath , Edward Masionis , Randy Purves
IPC分类号： H01J49/28
CPC分类号： G01N27/624
摘要： An apparatus for separating ions includes providing a FAIMS analyzer region defined by a space between a first electrode surface and a second electrode surface and extending between an ion inlet end and an ion outlet end. An asymmetric waveform is applied to the first electrode surface and a compensation voltage difference is applied between the first and second electrode surfaces. An output signal is provided from a temperature sensor, the output signal relating to a temperature within the FAIMS analyzer region. In dependence upon the output signal, the temperature within the FAIMS analyzer region is controllably affected. The apparatus supports operation of FAIMS at temperatures different from the temperature of other components in a tandem multi-stage system, and supports the stable operation of FAIMS at different temperatures which increases the separation capability of FAIMS.
摘要翻译：用于分离离子的装置包括提供由第一电极表面和第二电极表面之间的空间限定的FAIMS分析器区域，并且在离子入口端和离子出口端之间延伸。对第一电极表面施加非对称波形，并且在第一和第二电极表面之间施加补偿电压差。从温度传感器提供输出信号，该输出信号与FAIMS分析仪区域内的温度有关。根据输出信号，FAIMS分析仪区域内的温度受到可控制的影响。该装置支持在串联多级系统中与其他部件温度不同的FAIMS操作，支持FAIMS在不同温度下的稳定运行，增加了FAIMS的分离能力。

2. 发明申请

US20050167587A1 Apparatus and method for controllably affecting the temperature of FAIMS components 有权
标题翻译：可控制地影响FAIMS部件温度的装置和方法
公开(公告)号：US20050167587A1
公开(公告)日：2005-08-04
申请号：US11038166
申请日：2005-01-21
申请人： Roger Guevremont , Govindanunny Thekkadath , Edward Masionis , Randy Purves
发明人： Roger Guevremont , Govindanunny Thekkadath , Edward Masionis , Randy Purves
IPC分类号： B01D59/44 , G01N27/64 , H01J49/28 , H01J49/40 , H01J49/42
CPC分类号： G01N27/624
摘要： An apparatus for separating ions includes providing a FAIMS analyzer region defined by a space between a first electrode surface and a second electrode surface and extending between an ion inlet end and an ion outlet end. An asymmetric waveform is applied to the first electrode surface and a compensation voltage difference is applied between the first and second electrode surfaces. An output signal is provided from a temperature sensor, the output signal relating to a temperature within the FAIMS analyzer region. In dependence upon the output signal, the temperature within the FAIMS analyzer region is controllably affected. The apparatus supports operation of FAIMS at temperatures different from the temperature of other components in a tandem multi-stage system, and supports the stable operation of FAIMS at different temperatures which increases the separation capability of FAIMS.
摘要翻译：用于分离离子的装置包括提供由第一电极表面和第二电极表面之间的空间限定的FAIMS分析器区域，并且在离子入口端和离子出口端之间延伸。对第一电极表面施加非对称波形，并且在第一和第二电极表面之间施加补偿电压差。从温度传感器提供输出信号，该输出信号与FAIMS分析仪区域内的温度有关。根据输出信号，FAIMS分析仪区域内的温度受到可控制的影响。该装置支持在串联多级系统中与其他部件温度不同的FAIMS操作，支持FAIMS在不同温度下的稳定运行，增加了FAIMS的分离能力。

3. 发明申请

US20060060773A1 Side-to-side faims appartus having an analyzer region with non-uniform spacing and method therefore 失效
标题翻译：具有具有不均匀间隔的分析器区域和方法的侧对侧faims appartus
公开(公告)号：US20060060773A1
公开(公告)日：2006-03-23
申请号：US10503656
申请日：2003-02-07
申请人： Roger Guevremont , Randy Purves , David Barnett , Mark Weir
发明人： Roger Guevremont , Randy Purves , David Barnett , Mark Weir
IPC分类号： B01D59/44
CPC分类号： H01J49/42
摘要： Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) having a side-to-side electrode geometry. The FAIMS includes an inner electrode (102) having a length and an outer surface that is curved in a direction transverse to the length. The FAIMS also includes an outer electrode (104) having a length, a channel extending therethrough along at least a portion of the length, and a curved inner surface, a portion of the length of the outer electrode overlapping a portion of the length of the inner electrode so as to provide an analyzer region therebetween. The outer electrode has an ion inlet (114) for introducing ions from a source of ions into the analyzer region and an ion outlet (112) for extracting ions from the analyzer region, the ion inlet and the ion outlet being disposed on opposing sides of the outer electrode. The FAIMS is characterized in that at least one of the inner and outer electrodes is shaped such that a width of the analyzer region in the vicinity of the ion outlet is other than a width of the analyzer region in at least one other region.
摘要翻译：公开了具有侧对电极几何形状的高场非对称波形离子迁移谱仪（FAIMS）。 FAIMS包括内部电极（102），其具有在与该长度方向横向的方向上弯曲的长度和外表面。 FAIMS还包括具有长度的外部电极（104），沿其长度的至少一部分延伸穿过的通道和弯曲的内表面，外部电极的长度的一部分与所述外部电极的长度的一部分重叠内部电极，以便在其间提供分析器区域。外部电极具有用于将离子从离子源引入分析器区域的离子入口（114）和用于从分析器区域提取离子的离子出口（112），离子入口和离子出口设置在离子入口外电极。 FAIMS的特征在于，内电极和外电极中的至少一个被成形为使得离子出口附近的分析器区域的宽度不同于至少另一个区域中的分析器区域的宽度。

4. 发明授权

US06799355B2 Apparatus and method for tandem ICP/FAIMS/MS 有权
标题翻译：串联ICP / FAIMS / MS的装置和方法
公开(公告)号：US06799355B2
公开(公告)日：2004-10-05
申请号：US10221479
申请日：2002-09-13
申请人： Roger Guevremont , Randy Purves , David Barnett , Gholamreza Javahery , William Ronald Stott
发明人： Roger Guevremont , Randy Purves , David Barnett , Gholamreza Javahery , William Ronald Stott
IPC分类号： H01J4940
CPC分类号： H01J49/004 , G01N27/624
摘要： A method and an apparatus for selectively transmitting ions produced by an inductively coupled plasma ionization technique is disclosed. Ions produced within the plasma source are provided to a FAIMS analyzer within a low pressure chamber of a mass spectrometer and in fluid communication with the plasma source for receiving ions therefrom. The ions are separated in FAIMS and at least some of the ions are provided to the mass spectrometer after separation.
摘要翻译：公开了一种用于选择性地传输由电感耦合等离子体电离技术产生的离子的方法和装置。在等离子体源内产生的离子被提供给质谱仪的低压室内的FAIMS分析仪，并与等离子体源流体连通以接收离子。离子在FAIMS中分离，分离后至少有一些离子被提供给质谱仪。

5. 发明授权

US06713758B2 Spherical side-to-side FAIMS 有权
标题翻译：球面侧向FAIMS
公开(公告)号：US06713758B2
公开(公告)日：2004-03-30
申请号：US10359644
申请日：2003-02-07
申请人： Roger Guevremont , Randy Purves , David Barnett
发明人： Roger Guevremont , Randy Purves , David Barnett
IPC分类号： H01J4900
CPC分类号： H01J49/00 , B01D59/46 , B01D59/48 , G01N21/3504 , G01N27/624
摘要： A high field asymmetric waveform ion mobility spectrometer (FAIMS) having spherical electrode geometry is disclosed. The spherical FAIMS includes an inner generally spherical electrode supported in a spaced-apart arrangement relative to an outer electrode. The outer electrode has a curved inner surface that maintains an approximately uniform spacing to the inner electrode. The space between the inner and outer electrodes defines an analyzer region, where an electric field is established by the application of an asymmetric waveform voltage and a direct current compensation voltage to at least one of the inner and outer electrodes. An ion inlet and an ion outlet are disposed within the curved inner surface of the outer electrode such that the shortest distance between the inlet and the outlet in any direction around the inner electrode is approximately a same distance.
摘要翻译：公开了具有球形电极几何形状的高场非对称波形离子迁移谱仪（FAIMS）。球形FAIMS包括相对于外部电极以间隔布置的方式支撑的内部大体上球形的电极。外电极具有弯曲的内表面，其保持与内电极大致均匀的间隔。内电极和外电极之间的空间限定分析器区域，其中通过对内电极和外电极中的至少一个施加非对称波形电压和直流补偿电压来建立电场。离子入口和离子出口设置在外电极的弯曲内表面内，使得入口和出口之间在内电极周围的任何方向上的最短距离大致相同的距离。

6. 发明授权

US07034289B2 Segmented side-to-side FAIMS 失效
标题翻译：分段的侧向FAIMS
公开(公告)号：US07034289B2
公开(公告)日：2006-04-25
申请号：US10503714
申请日：2003-02-07
申请人： Roger Guevremont , Randy Purves , David Barnett
发明人： Roger Guevremont , Randy Purves , David Barnett
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： G01N27/624 , G01N21/03 , G01N21/35 , G01N21/3504 , G01N21/65 , Y10T436/105831 , Y10T436/24
摘要： Provided is a side-to-side high field asymmetric waveform ion mobility spectrometer (FAIMS) including a generally cylindrically-shaped inner electrode having a length. Encircling the inner electrode is a generally cylindrically-shaped outer electrode assembly comprising at least first and second and third outer electrode segments. Each of the outer electrode segments has a channel extending therethrough and open at opposite ends thereof. In an assembled condition, the second outer electrode segment is disposed intermediate the first and third outer electrode segments in an end-to-end arrangement, each one of the first and second and third electrode segments overlapping a different portion of the length of the inner electrode. An electrical contact is provided on at least one of the inner electrode and the second outer electrode segment for receiving a first direct current voltage between the inner electrode and the second outer electrode segment, and for applying an asymmetric waveform voltage to the at least one of the inner electrode and the second outer electrode segment. The second outer electrode segment is maintained at a different potential relative to the first and third outer electrode segments, such that a potential gradient is formed in a direction along the length of the inner electrode.
摘要翻译：提供了一种包括具有长度的大致圆柱形的内部电极的侧对侧高场非对称波形离子迁移谱仪（FAIMS）。围绕内部电极是大致圆柱形的外部电极组件，其包括至少第一和第二和第三外部电极段。每个外部电极段具有穿过其延伸并在其相对端处开口的通道。在组装状态下，第二外部电极段以端对端布置设置在第一和第三外部电极段的中间，第一和第二和第三电极段中的每一个与内部电极段的长度的不同部分重叠电极。在内部电极和第二外部电极段中的至少一个上提供电接触，用于接收内部电极和第二外部电极段之间的第一直流电压，并且将不对称波形电压施加到至少一个内电极和第二外电极段。第二外部电极段相对于第一和第三外部电极段保持在不同的电势，使得在沿着内部电极的长度的方向上形成电位梯度。

7. 发明授权

US06806466B2 Parallel plate geometry FAIMS apparatus and method 失效
标题翻译：平行板几何FAIMS装置及方法
公开(公告)号：US06806466B2
公开(公告)日：2004-10-19
申请号：US10221480
申请日：2002-09-13
申请人： Roger Guevremont , Randy Purves
发明人： Roger Guevremont , Randy Purves
IPC分类号： H01J4900
CPC分类号： G01N27/624
摘要： A method and an apparatus is disclosed for selectively transmitting ions in which the ions are subjected to a focusing effect such that the overall efficiency of ion transmission is increased. The method relies on a FAIMS analyzer having at least an electrode disposed approximately between two other electrode surfaces for producing an electric field that is symmetric on opposing sides of the at least an electrode. An ion exiting from between the electrodes experiences a balanced electric field, such that impact with one of the electrodes is prevented.
摘要翻译：公开了一种用于选择性地透射离子的方法和装置，其中离子受到聚焦效应，使得离子透射的总体效率增加。该方法依赖于FAIMS分析器，其至少具有设置在两个其它电极表面之间的电极，用于产生在至少一个电极的相对侧上对称的电场。从电极之间离开的离子经历平衡的电场，从而防止与其中一个电极的冲击。

8. 发明授权

US06621077B1 Apparatus and method for atmospheric pressure-3-dimensional ion trapping 失效
标题翻译：大气压力三维离子捕获的装置和方法
公开(公告)号：US06621077B1
公开(公告)日：2003-09-16
申请号：US09762237
申请日：2001-04-12
申请人： Roger Guevremont , Randy Purves
发明人： Roger Guevremont , Randy Purves
IPC分类号： H01J4940
CPC分类号： G01N27/624
摘要： The present invention provides an apparatus for selectively transmitting ions and trapping the ions within a defined 3-dimensional space at atmospheric pressure. The invention is based on the ion focussing principles of high field asymmetric wave-form ion mobility spectrometry in which an analyzer region is defined by a space between first and second spaced apart electrodes, the analyzer region having a gas inlet and a gas outlet for providing a flow of gas through the analyzer region. Ions which are introduced into the analyzer region are carried by a gas flow towards a gas outlet. At least one of the electrodes has a curved surface terminus located near the gas outlet and the gas flow is adjusted so that ions are trapped in a defined 3-dimensional space located near the tip of the terminus. Trapping of ions in a defined 3-dimensional space allows a more concentrated flow of desired ions.
摘要翻译：本发明提供一种用于选择性地传输离子并将离子捕获在大气压力的限定的三维空间内的装置。本发明基于高场非对称波形离子迁移谱的离子聚焦原理，其中分析器区域由第一和第二间隔开的电极之间的空间限定，分析器区域具有气体入口和气体出口，用于提供通过分析器区域的气体流。引入分析器区域的离子通过气体流向气体出口承载。电极中的至少一个具有位于气体出口附近的弯曲表面终端，并且调节气流，使得离子被捕获在位于末端末端附近的限定的三维空间中。在限定的三维空间中捕获离子允许更集中的所需离子流。

9. 发明授权

US07223967B2 Side-to-side FAIMS apparatus having an analyzer region with non-uniform spacing and method therefore 失效
标题翻译：具有具有不均匀间隔的分析器区域和方法的侧对侧FAIMS装置
公开(公告)号：US07223967B2
公开(公告)日：2007-05-29
申请号：US10503656
申请日：2003-02-07
申请人： Roger Guevremont , Randy Purves , David Barnett , Mark Weir
发明人： Roger Guevremont , Randy Purves , David Barnett , Mark Weir
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/42
摘要： Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) having a side-to-side electrode geometry. The FAIMS includes an inner electrode (102) having a length and an outer surface that is curved in a direction transverse to the length. The FAIMS also includes an outer electrode (104) having a length, a channel extending therethrough along at least a portion of the length, and a curved inner surface, a portion of the length of the outer electrode overlapping a portion of the length of the inner electrode so as to provide an analyzer region therebetween. The outer electrode has an ion inlet (114) for introducing ions from a source of ions into the analyzer region and an ion outlet (112) for extracting ions from the analyzer region, the ion inlet and the ion outlet being disposed on opposing sides of the outer electrode. The FAIMS is characterized in that at least one of the inner and outer electrodes is shaped such that a width of the analyzer region in the vicinity of the ion outlet is other than a width of the analyzer region in at least one other region.
摘要翻译：公开了具有侧对电极几何形状的高场非对称波形离子迁移谱仪（FAIMS）。 FAIMS包括内部电极（102），其具有在与该长度方向横向的方向上弯曲的长度和外表面。 FAIMS还包括具有长度的外部电极（104），沿其长度的至少一部分延伸穿过的通道和弯曲的内表面，外部电极的长度的一部分与所述外部电极的长度的一部分重叠内部电极，以便在其间提供分析器区域。外部电极具有用于将离子从离子源引入分析器区域的离子入口（114）和用于从分析器区域提取离子的离子出口（112），离子入口和离子出口设置在离子入口外电极。 FAIMS的特征在于，内电极和外电极中的至少一个被成形为使得离子出口附近的分析器区域的宽度不同于至少另一个区域中的分析器区域的宽度。

10. 发明授权

US07026612B2 FAIMS apparatus and method using carrier gases that contain a trace amount of a dopant species 有权
标题翻译：使用含有微量掺杂剂种类的载气的FAIMS装置和方法
公开(公告)号：US07026612B2
公开(公告)日：2006-04-11
申请号：US10503713
申请日：2003-02-07
申请人： Roger Guevremont , Randy Purves , David Barnett , Barbara Ells
发明人： Roger Guevremont , Randy Purves , David Barnett , Barbara Ells
IPC分类号： H01J49/40
CPC分类号： G01N27/624 , H01J49/04
摘要： Disclosed is a method and apparatus for improving at least one of a peak separation and a signal intensity relating to an ion of interest being transmitted through an analyzer region of a FAIMS apparatus. A method according to the instant invention includes a step of introducing ions including an ion of interest into an analyzer region of a FAIMS. A flow of a doped carrier gas other than air is also provided through the analyzer region. The doped carrier gas includes a carrier gas and a trace amount of a predetermined dopant gas, the predetermined dopant gas selected for improving at least one of a peak separation and a signal intensity relating to the ion of interest relative to the peak separation and the signal intensity relating to the ion of interest in the presence of the carrier gas only. The ion of interest is selectively transmitted through the analyzer region in the presence of the doped carrier gas, and detected at a detector.
摘要翻译：公开了一种用于改善通过FAIMS装置的分析器区域传输的与感兴趣的离子相关的峰值分离和信号强度中的至少一个的方法和装置。根据本发明的方法包括将包含感兴趣的离子的离子引入到FAIMS的分析器区域中的步骤。除了空气之外的掺杂载气的流动也通过分析器区域提供。掺杂的载气包括载气和痕量的预定掺杂气体，所选择的预定掺杂剂气体相对于峰值分离和信号来改善峰值分离和与感兴趣的离子相关的信号强度中的至少一个仅在载气存在下与感兴趣的离子有关的强度。感兴趣的离子在掺杂的载气的存在下选择性地透过分析器区域，并在检测器处检测。

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