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1. 发明申请

US20060151694A1 Apparatus and method for adjustment of ion separation resolution in FAIMS 有权
标题翻译：用于调整FAIMS中离子分离分辨率的装置和方法
公开(公告)号：US20060151694A1
公开(公告)日：2006-07-13
申请号：US11285162
申请日：2005-11-23
申请人： Roger Guevremont , Maria Guevremont , James Kapron , Govindanunny Thekkadath , Greg Skotnicki
发明人： Roger Guevremont , Maria Guevremont , James Kapron , Govindanunny Thekkadath , Greg Skotnicki
IPC分类号： B01D59/44
CPC分类号： G01N27/624
摘要： An apparatus for separating ions includes a FAIMS analyzer region having a first ion inlet for introducing ions into the FAIMS analyzer region. An ion outlet from the FAIMS analyzer region is provided for extracting a subset of the ions that is selectively transmitted along an average ion flow path defined through the FAIMS analyzer region. The apparatus also includes an actuator for controllably varying a length of the average ion flow path through the FAIMS analyzer region.
摘要翻译：用于分离离子的装置包括具有用于将离子引入FAIMS分析器区域的第一离子入口的FAIMS分析器区域。提供来自FAIMS分析器区域的离子出口，用于提取沿着通过FAIMS分析器区域限定的平均离子流路选择性地传输的离子子集。该装置还包括致动器，用于可控地改变通过FAIMS分析器区域的平均离子流动路径的长度。

2. 发明授权

US07417225B2 Apparatus and method for adjustment of ion separation resolution in FAIMS 有权
标题翻译：用于调整FAIMS中离子分离分辨率的装置和方法
公开(公告)号：US07417225B2
公开(公告)日：2008-08-26
申请号：US11285162
申请日：2005-11-23
申请人： Roger Guevremont , Maria Guevremont , James T. Kapron , Govindanunny Thekkadath , Greg Skotnicki
发明人： Roger Guevremont , Maria Guevremont , James T. Kapron , Govindanunny Thekkadath , Greg Skotnicki
IPC分类号： B01D59/44
CPC分类号： G01N27/624
摘要： An apparatus for separating ions includes a FAIMS analyzer region having a first ion inlet for introducing ions into the FAIMS analyzer region. An ion outlet from the FAIMS analyzer region is provided for extracting a subset of the ions that is selectively transmitted along an average ion flow path defined through the FAIMS analyzer region. The apparatus also includes an actuator for controllably varying a length of the average ion flow path through the FAIMS analyzer region.
摘要翻译：用于分离离子的装置包括具有用于将离子引入FAIMS分析器区域的第一离子入口的FAIMS分析器区域。提供来自FAIMS分析器区域的离子出口，用于提取沿着通过FAIMS分析器区域限定的平均离子流路选择性地传输的离子子集。该装置还包括致动器，用于可控地改变通过FAIMS分析器区域的平均离子流动路径的长度。

3. 发明授权

US07812309B2 Apparatus and method for an electro-acoustic ion transmittor 失效
标题翻译：电声离子发射器的装置和方法
公开(公告)号：US07812309B2
公开(公告)日：2010-10-12
申请号：US11815761
申请日：2006-02-09
申请人： Roger Guevremont , Govindanunny Thekkadath , Maria Guevremont
发明人： Roger Guevremont , Govindanunny Thekkadath , Maria Guevremont
IPC分类号： H01J49/22 , H01J49/06
CPC分类号： G01N27/624
摘要： A method of transmitting ions along an analyzer region between closely spaced electrodes is disclosed. The method includes providing an analyzer region for transmitting ions, the analyzer region in fluid communication with an ionization source and with an ion detecting device. The method further includes affecting a pressure within at least one portion of the analyzer region, to differ from the pressure within another part of the analyzer region, and providing an electric field that is synchronized with the pressure differences to focus the ions.
摘要翻译：公开了沿着紧密间隔的电极之间的分析器区域传输离子的方法。该方法包括提供用于传输离子的分析器区域，与电离源流体连通的分析器区域和离子检测装置。该方法还包括影响分析器区域的至少一部分内的压力，以与分析器区域的另一部分内的压力不同，并且提供与压力差同步的电场以聚焦离子。

4. 发明授权

US07041969B2 Method and apparatus for selecting inlets of a multiple inlet FAIMS 失效
标题翻译：用于选择多入口FAIMS的入口的方法和装置
公开(公告)号：US07041969B2
公开(公告)日：2006-05-09
申请号：US11068764
申请日：2005-03-02
申请人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
发明人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
IPC分类号： H01J49/04
CPC分类号： G01N27/624 , H01J49/067
摘要： An ion introduction system for selecting ions from one of two separate ionization sources of ions is provided. The system includes a plate having a hole formed therethrough, the plate for being disposed adjacent an ion introduction region of a gas phase ion analyzer such that the hole is selectively movable between a first location in which the hole is adjacent to a first ionization source of ions for supporting introduction of ions from the first ionization source of ions into the gas phase ion analyzer, and a second location in which the hole is adjacent to a second ionization source of ions for supporting introduction of ions from the second ionization source of ions into the gas phase ion analyzer. The system also includes a drive mechanism for driving the plate between a first position in which the hole is at the first location and a second position in which the hole is at the second location.
摘要翻译：提供了一种离子引入系统，用于从两个分离的离子离子源中选择一个离子。该系统包括具有穿过其形成的孔的板，该板用于邻近气相离子分析仪的离子引入区域设置，使得该孔可选择性地在第一位置与第一离子源离子，用于支持将离子从第一离子源离子引入气相离子分析器，以及第二位置，其中孔邻近离子的第二离子源，用于支持将离子从第二离子源离子引入到气相离子分析仪。该系统还包括用于在第一位置和第二位置之间驱动板的驱动机构，其中孔位于第一位置处的第一位置和第二位置。

5. 发明授权

US07223971B2 Method and apparatus for selecting inlets of a multiple inlet FAIMS 失效
标题翻译：用于选择多入口FAIMS的入口的方法和装置
公开(公告)号：US07223971B2
公开(公告)日：2007-05-29
申请号：US11068767
申请日：2005-03-02
申请人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
发明人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
IPC分类号： B01D59/44
CPC分类号： G01N27/624 , H01J49/067
摘要： An ion introduction system for selecting ions from one of two separate ionization sources of ions is provided. The system includes a plate having a hole formed therethrough, the plate for being disposed adjacent an ion introduction region of a gas phase ion analyzer such that the hole is selectively movable between a first location in which the hole is adjacent to a first ionization source of ions for supporting introduction of ions from the first ionization source of ions into the gas phase ion analyzer, and a second location in which the hole is adjacent to a second ionization source of ions for supporting introduction of ions from the second ionization source of ions into the gas phase ion analyzer. The system also includes a drive mechanism for driving the plate between a first position in which the hole is at the first location and a second position in which the hole is at the second location.
摘要翻译：提供了一种离子引入系统，用于从两个分离的离子离子源中选择一个离子。该系统包括具有穿过其形成的孔的板，该板用于邻近气相离子分析仪的离子引入区域设置，使得该孔可选择性地在第一位置与第一离子源离子，用于支持将离子从第一离子源离子引入气相离子分析器，以及第二位置，其中孔邻近离子的第二离子源，用于支持将离子从第二离子源离子引入到气相离子分析仪。该系统还包括用于在第一位置和第二位置之间驱动板的驱动机构，其中孔位于第一位置处的第一位置和第二位置。

6. 发明申请

US20050194532A1 Method and apparatus for selecting inlets of a multiple inlet FAIMS 失效
公开(公告)号：US20050194532A1
公开(公告)日：2005-09-08
申请号：US11068767
申请日：2005-03-02
申请人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
发明人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
IPC分类号： G01N27/64 , H01J49/04 , H01J49/16 , H01J49/28 , H01J49/40 , H01J49/42
CPC分类号： G01N27/624 , H01J49/067
摘要： An ion introduction system for selecting ions from one of two separate ionization sources of ions is provided. The system includes a plate having a hole formed therethrough, the plate for being disposed adjacent an ion introduction region of a gas phase ion analyzer such that the hole is selectively movable between a first location in which the hole is adjacent to a first ionization source of ions for supporting introduction of ions from the first ionization source of ions into the gas phase ion analyzer, and a second location in which the hole is adjacent to a second ionization source of ions for supporting introduction of ions from the second ionization source of ions into the gas phase ion analyzer. The system also includes a drive mechanism for driving the plate between a first position in which the hole is at the first location and a second position in which the hole is at the second location.

7. 发明申请

US20050194527A1 Method and apparatus for selecting inlets of a multiple inlet FAIMS 失效
标题翻译：用于选择多入口FAIMS的入口的方法和装置
公开(公告)号：US20050194527A1
公开(公告)日：2005-09-08
申请号：US11068764
申请日：2005-03-02
申请人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
发明人： Roger Guevremont , Govindanunny Thekkadath , Greg Skotnicki
IPC分类号： G01N27/64 , H01J49/04 , H01J49/16 , H01J49/28 , H01J49/40 , H01J49/42
CPC分类号： G01N27/624 , H01J49/067
摘要： An ion introduction system for selecting ions from one of two separate ionization sources of ions is provided. The system includes a plate having a hole formed therethrough, the plate for being disposed adjacent an ion introduction region of a gas phase ion analyzer such that the hole is selectively movable between a first location in which the hole is adjacent to a first ionization source of ions for supporting introduction of ions from the first ionization source of ions into the gas phase ion analyzer, and a second location in which the hole is adjacent to a second ionization source of ions for supporting introduction of ions from the second ionization source of ions into the gas phase ion analyzer. The system also includes a drive mechanism for driving the plate between a first position in which the hole is at the first location and a second position in which the hole is at the second location.
摘要翻译：提供了一种离子引入系统，用于从两个分离的离子离子源中选择一个离子。该系统包括具有穿过其形成的孔的板，该板用于邻近气相离子分析仪的离子引入区域设置，使得该孔可选择性地在第一位置与第一离子源离子，用于支持将离子从第一离子源离子引入气相离子分析器;以及第二位置，其中孔邻近离子的第二电离源，用于支持将离子从第二离子源离子引入到气相离子分析仪。该系统还包括用于在第一位置和第二位置之间驱动板的驱动机构，其中孔位于第一位置处的第一位置和第二位置。

8. 发明申请

US20090127457A1 APPARATUS AND METHOD FOR AN ELECTRO-ACOUSTIC ION TRANSMITTOR 失效
标题翻译：电声离子发射机的装置和方法
公开(公告)号：US20090127457A1
公开(公告)日：2009-05-21
申请号：US11815761
申请日：2006-02-09
申请人： Roger Guevremont , Govindanunny Thekkadath , Maria Guevremont
发明人： Roger Guevremont , Govindanunny Thekkadath , Maria Guevremont
IPC分类号： H01J49/34
CPC分类号： G01N27/624
摘要： A method of transmitting ions along an analyzer region between closely spaced electrodes is disclosed. The method includes providing an analyzer region for transmitting ions, the analyzer region in fluid communication with an ionization source and with an ion detecting device. The method further includes affecting a pressure within at least one portion of the analyzer region, to differ from the pressure within another part of the analyzer region, and providing an electric field that is synchronized with the pressure differences to focus the ions.
摘要翻译：公开了沿着紧密间隔的电极之间的分析器区域传输离子的方法。该方法包括提供用于传输离子的分析器区域，与电离源流体连通的分析器区域和离子检测装置。该方法还包括影响分析器区域的至少一部分内的压力，以与分析器区域的另一部分内的压力不同，并且提供与压力差同步的电场以聚焦离子。

9. 发明申请

US20050258359A1 Multiple nano-spray delivery system for FAIMS 有权
标题翻译：用于FAIMS的多种纳米喷雾输送系统
公开(公告)号：US20050258359A1
公开(公告)日：2005-11-24
申请号：US11130124
申请日：2005-05-17
申请人： Roger Guevremont , Govindanunny Thekkadath , James Kapron
发明人： Roger Guevremont , Govindanunny Thekkadath , James Kapron
IPC分类号： G01N27/68 , H01J49/04 , H01J49/40 , H01J49/42
CPC分类号： H01J49/0018 , G01N27/624 , H01J49/167
摘要： An apparatus for multiple nano-spray delivery of a sample to FAIMS analyzer includes a micro-machined ionization source having a plurality of discrete nozzles. At least some of the discrete nozzles of the plurality are aligned one each with an ion inlet of a plurality of discrete ion inlets of the FAIMS, so that ions produced at different discrete nozzles are introduced into different portions of the FAIMS analyzer region. The ions that are introduced via each ion inlet are at least partly separated prior to adding/mixing with the ions introduced via other ion inlets. This reduces the problems of ion-ion electric repulsions that occur when ion density is high.
摘要翻译：将样品多次纳米喷射输送到FAIMS分析仪的装置包括具有多个分立喷嘴的微加工电离源。多个离散喷嘴中的至少一些分立喷嘴与FAIMS的多个离散入口的离子入口对齐，使得在不同离散喷嘴处产生的离子被引入FAIMS分析器区域的不同部分。在通过其他离子入口引入的离子添加/混合之前，经由每个离子入口引入的离子至少部分地分离。这减少了当离子密度高时发生的离子离子电排斥的问题。

10. 发明申请

US20060237643A1 Apparatus and method for adjustment of ion separation resolution in FAIMS 有权
标题翻译：用于调整FAIMS中离子分离分辨率的装置和方法
公开(公告)号：US20060237643A1
公开(公告)日：2006-10-26
申请号：US11285148
申请日：2005-11-23
申请人： Roger Guevremont , Maria Guevremont , James Kapron
发明人： Roger Guevremont , Maria Guevremont , James Kapron
IPC分类号： H01J49/00
CPC分类号： G01N27/624
摘要： An apparatus for controllably varying specificity of a FAIMS-based ion separation includes a FAIMS analyzer region defined between a first electrode surface and a second other electrode surface. The FAIMS analyzer region is in communication with an ionization source for providing a flow of ions including a known ion, and with an ion outlet for extracting ions including the known ion from the FAIMS analyzer region. The first and second electrode surfaces are for having an asymmetric waveform voltage applied thereacross for defining an average ion flow path for the known ion traversing therebetween. An actuator is provided for controllably moving the first electrode surface relative to the second electrode surface for controllably varying the length of the average ion flow path.
摘要翻译：用于可控地改变基于FAIMS的离子分离的特异性的装置包括在第一电极表面和第二另外的电极表面之间限定的FAIMS分析器区域。 FAIMS分析器区域与电离源连通，用于提供包括已知离子的离子流，以及用于从FAIMS分析器区域提取包括已知离子的离子的离子出口。第一和第二电极表面用于在其上施加不对称波形电压，以限定用于其间已知离子的平均离子流动路径。提供致动器用于可控地移动第一电极表面相对于第二电极表面，用于可控地改变平均离子流动路径的长度。

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