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1. 发明申请

WO2008063809A8 THREE-DIMENSIONAL HOLOGRAPHIC RING TRAPS 审中-公开
标题翻译：三维全息环圈
公开(公告)号：WO2008063809A8
公开(公告)日：2008-07-10
申请号：PCT/US2007082418
申请日：2007-10-24
申请人： UNIV NEW YORK , ROICHMAN YOHAI , GRIER DAVID G
发明人： ROICHMAN YOHAI , GRIER DAVID G
CPC分类号： G03H1/0005 , G03H1/08 , G03H2001/0077 , G03H2001/085
摘要： A method and system for preparing and using three dimensional optical ring traps. The method and system includes applying a single phase hologram to be able to independently control shape and force profile of an optical trap but without employing orbital angular momentum for the control parameter of an optical ring trap to manipulate an object.
摘要翻译：制备和使用三维光环陷阱的方法和系统。该方法和系统包括应用单相全息图以能够独立地控制光学阱的形状和力分布，但不使用光环形阱的控制参数的轨道角动量来操纵物体。

2. 发明申请

WO2012061752A2 METHOD AND SYSTEM FOR MEASURING POROSITY OF PARTICLES 审中-公开
标题翻译：测量颗粒多孔性的方法和系统
公开(公告)号：WO2012061752A2
公开(公告)日：2012-05-10
申请号：PCT/US2011/059400
申请日：2011-11-04
申请人： NEW YORK UNIVERSITY , CHEONG, Fook Chiong , XIAO, Ke , PINE, David , GRIER, David, G.
发明人： CHEONG, Fook Chiong , XIAO, Ke , PINE, David , GRIER, David, G.
IPC分类号： G01N15/14 , G01N21/45 , G01N21/47
CPC分类号： G01N15/088 , G01N15/08 , G01N15/1463 , G01N21/4133 , G01N21/453 , G01N21/47 , G01N2015/0846 , G02B21/367
摘要： A method for analyzing porosity of a particle and a medium disposed in the porosity of the particle. A video-holographic microscope is provided to analyze interference patterns produced by providing a laser source to output a collimated beam, scattering the collimated beam off a particle and interacting with an unscattered beam to generate the interference pattern for analyzation to determine the refractive index of the particle and a medium disposed in the porosity of the particle to measure porosity and the medium.
摘要翻译：用于分析布置在颗粒的孔隙中的颗粒和介质的孔隙率的方法。提供视频全息显微镜以分析通过提供激光源输出准直光束产生的干涉图案，将准直光束散射离开颗粒并与未散射光束相互作用以产生用于分析的干涉图案以确定颗粒和放置在颗粒孔隙中的介质来测量孔隙率和介质。

3. 发明申请

WO2008076414A2 SELF-REPLICATING MATERIALS 审中-公开
标题翻译：自我更换材料
公开(公告)号：WO2008076414A2
公开(公告)日：2008-06-26
申请号：PCT/US2007/025749
申请日：2007-12-17
申请人： NEW YORK UNIVERSITY , SEEMAN, Nadrian , CHAIKIN, Paul Michael , PINE, David , GRIER, David G.
发明人： CHAIKIN, Paul Michael , PINE, David , GRIER, David G.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/682 , B82Y5/00 , B82Y20/00 , C12N15/10 , C12N15/1031 , C12N15/1068 , C12Q2563/155 , C12Q2565/113
摘要： The invention provides micron and sub-micron scale particles designed to recognize and selectively interact with each other by exploiting the recognition and specificity enabled by DNA-sequence-encoded coatings. Such materials possess sufficient information coded in their chemical and physical interactions to self assemble and self replicate. The invention further provides methods of using such materials to create self replicating and organizing materials. Replicated copies are permanently linked and then thermally detached, freeing them to act as templates for further growth. This new class of condensed matter systems, provides means to design and control the structure and function of materials and machines from the microscopic to life-size. In another aspect of the invention, depletion type forces and depletion zones can be utilized in the implementation of the self assembly and self replication of materials, including without limitation colloidal particles. The invention further provides novel means of synthesis and materials built by such synthesis, which may be used in a variety of applications, including microelectronics.
摘要翻译：本发明提供通过利用由DNA序列编码的涂层实现的识别和特异性来设计用于识别和选择性相互作用的微米级和亚微米级粒子。这样的材料具有足够的信息，以其化学和物理相互作用编码，以自组装和自我复制。本发明还提供了使用这种材料来创建自我复制和组织材料的方法。复制副本永久链接，然后热分离，释放它们作为进一步增长的模板。这种新型凝结物系统，提供了从微观到真实尺寸的材料和机器的结构和功能的设计和控制的手段。在本发明的另一方面，耗尽型力和耗尽区可以用于实现材料的自组装和自我复制，包括但不限于胶体颗粒。本发明还提供了新的合成方法和通过这种合成制备的材料，其可以用于包括微电子学在内的各种应用中。

4. 发明申请

WO2007084114A3 SYSTEM AND METHOD FOR PROCESSING NANOWIRES WITH HOLOGRAPHIC OPTICAL TWEEZERS 审中-公开
标题翻译：用全息光学镊子处理纳米线的系统和方法
公开(公告)号：WO2007084114A3
公开(公告)日：2007-12-13
申请号：PCT/US2006000946
申请日：2006-01-11
申请人： UNIV NEW YORK , UNIV HARVARD , GRIER DAVID G , AGARWAL RITESH , YU GUIHUA , LIEBER CHARLES M , LADAVAC KOSTA , ROICHMAN YAEL
发明人： GRIER DAVID G , AGARWAL RITESH , YU GUIHUA , LIEBER CHARLES M , LADAVAC KOSTA , ROICHMAN YAEL
IPC分类号： B82B3/00 , G03H1/08 , G21K1/00 , H05H3/04
CPC分类号： B82B3/00 , B82Y10/00 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C23C14/3407 , G03H1/2294 , G03H2001/0077 , G03H2210/30 , H01J37/3423 , H01L51/0002 , H01L51/0048 , H01L51/0052
摘要： A system and method for manipulating and processing nanowires in solution with arrays of holographic optical traps. The system and method of the present invention is capable of creating hundreds of individually controlled optical traps with the ability to manipulate objects in three dimensions. Individual nanowires with cross-sections as small as 20 nm and lengths exceeding 20 µm are capable of being isolated, translated, rotated and deposited onto a substrate with holographic optical trap arrays under conditions where single traps have no discernible influence. Spatially localized photothermal and photochemical processes induced by the well-focused traps can also be used to melt localized domains on individual nanowires and to fuse nanowire junctions.
摘要翻译：用全息光阱阵列处理和处理溶液中纳米线的系统和方法。本发明的系统和方法能够创建数百个单独控制的光阱，并具有三维操纵物体的能力。横截面小至20纳米且长度超过20微米的单个纳米线能够在单个陷阱没有可察觉的影响的情况下被隔离，平移，旋转并沉积到具有全息光阱阵列的基板上。由聚焦阱诱发的空间局部光热和光化学过程也可用于熔化单个纳米线上的局部区域并融合纳米线结。

5. 发明申请

WO2006078759A3 MODULATED OPTICAL TWEEZERS 审中-公开
标题翻译：调制光学仪器
公开(公告)号：WO2006078759A3
公开(公告)日：2006-12-21
申请号：PCT/US2006001806
申请日：2006-01-19
申请人： UNIV NEW YORK , GRIER DAVID G
发明人： GRIER DAVID G
IPC分类号： G21K1/00 , G03H1/08
CPC分类号： B01L3/502761 , B01L3/502715 , B01L2200/0636 , B01L2200/0647 , B01L2300/0864 , B01L2400/0454 , G01N30/00 , G01N30/02 , G01N2015/0288 , G03H1/0808 , G03H2001/0077 , G03H2001/0816 , G03H2210/30 , B01D2015/3895
摘要： A method and apparatus for selecting a specific fraction from a heterogeneous fluid-borne sample using optical gradient forces in a microfluidic or fluidic system are presented. Samples may range in size from a few nanometers to at least tens of micrometers, may be dispersed in any fluid medium transported from input channels (410) to output channels (430), and may be sorted on the basis of size, shape, optical characteristics, charge, and other physical properties. The selection process involves passive transport through optical intensity field - an array of optical traps or optical tweezers driven by flowing fluid, and so offers several advantages over competing techniques. These include continuous rather than batch-mode operation, continuous and dynamic tunability, operation over a wide range of samples, compactness, and low cost.
摘要翻译：提出了一种用于在微流体或流体系统中使用光学梯度力从异质流体样品中选择特定部分的方法和装置。样品的尺寸范围可以从几纳米到至少几十微米，可以分散在从输入通道（410）输送到输出通道（430）的任何流体介质中，并且可以基于尺寸，形状，光学特性，电荷等物理性质。选择过程包括通过光强度场的被动传输 - 由流动流体驱动的光学陷阱或光学镊子阵列，因此与竞争技术相比提供了几个优点。这些包括连续而不是批模式操作，连续和动态可调性，在各种样品中的操作，紧凑性和低成本。

6. 发明申请

WO2012061752A3 METHOD AND SYSTEM FOR MEASURING POROSITY OF PARTICLES 审中-公开
标题翻译：用于测量颗粒物质的方法和系统
公开(公告)号：WO2012061752A3
公开(公告)日：2012-07-26
申请号：PCT/US2011059400
申请日：2011-11-04
申请人： UNIV NEW YORK , CHEONG FOOK CHIONG , XIAO KE , PINE DAVID , GRIER DAVID G
发明人： CHEONG FOOK CHIONG , XIAO KE , PINE DAVID , GRIER DAVID G
IPC分类号： G01N15/14 , G01N21/45 , G01N21/47
CPC分类号： G01N15/088 , G01N15/08 , G01N15/1463 , G01N21/4133 , G01N21/453 , G01N21/47 , G01N2015/0846 , G02B21/367
摘要： A method for analyzing porosity of a particle and a medium disposed in the porosity of the particle. A video-holographic microscope is provided to analyze interference patterns produced by providing a laser source to output a collimated beam, scattering the collimated beam off a particle and interacting with an unscattered beam to generate the interference pattern for analyzation to determine the refractive index of the particle and a medium disposed in the porosity of the particle to measure porosity and the medium.
摘要翻译：用于分析颗粒的孔隙率的方法和设置在颗粒的孔隙中的介质。提供视频全息显微镜以分析通过提供激光源来输出准直光束产生的干涉图案，将准直光束从粒子散射并与未散射光束相互作用以产生用于分析的干涉图案，以确定折射率颗粒和设置在颗粒孔隙中的介质以测量孔隙度和介质。

7. 发明申请

WO2010101671A1 AUTOMATED REAL-TIME PARTICLE CHARACTERIZATION AND THREE-DIMENSIONAL VELOCIMETRY WITH HOLOGRAPHIC VIDEO MICROSCOPY 审中-公开
标题翻译：自动实时粒子特征和三维视频显微镜的三维视频
公开(公告)号：WO2010101671A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/021045
申请日：2010-01-14
申请人： NEW YORK UNIVERSITY , GRIER, David G. , CHEONG, Fook Chiong , XIAO, Ke
发明人： GRIER, David G. , CHEONG, Fook Chiong
IPC分类号： G01N15/10 , G06T1/00 , G02B21/34
CPC分类号： G01N15/1475 , G01N15/1429 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N2015/003 , G01N2015/0065 , G01N2015/1445 , G01N2015/1454 , G01N2015/1493 , G01N2015/1497 , G02B21/0056 , G02B21/0068 , G02B21/008 , G03H1/0005 , G03H2001/005
摘要： An in-line holographic microscope can be used to analyze on a frame by frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.
摘要翻译：可以使用在线全息显微镜逐帧分析视频流来跟踪单个胶体颗粒的三维运动。该系统和方法可以提供实时的纳米分辨率，同时测量粒径和折射率。通过结合使用Lorenz-Mie分析与选定的硬件和软件方法的组合，该分析可以近乎实时地进行。有效的粒子识别方法以足够的精度自动进行初始位置估计，以实现无人值守的全息跟踪和表征。

8. 发明申请

WO2008127410A3 HOLOGRAPHIC MICROFABRICATION AND CHARACTERIZATION SYSTEM FOR SOFT MATTER AND BIOLOGICAL SYSTEMS 审中-公开
标题翻译：软件和生物系统的全息微型化和特征化系统
公开(公告)号：WO2008127410A3
公开(公告)日：2009-08-20
申请号：PCT/US2007083823
申请日：2007-11-06
申请人： UNIV NEW YORK , GRIER DAVID G
发明人： GRIER DAVID G
IPC分类号： G21K1/00 , G02B21/32 , G03H1/18
CPC分类号： G02B21/32 , G02B5/001 , G02B5/32 , G03H1/08 , G03H1/2294 , G03H2001/0077
摘要： A method and system for micromanipulation of objects of any shape. The method and system creates various forms of holographic optical traps for a variety of commercial purposes. Some alternate forms of traps include a dark form of optical traps, optical vortices with different helical winding numbers and optical traps with variable phase profiles imprinted thereon.
摘要翻译：用于显微操作任何形状的物体的方法和系统。该方法和系统为各种商业目的创建各种形式的全息光学阱。陷阱的一些替代形式包括暗形式的光学陷阱，具有不同螺旋线圈数的光学旋涡和其上印刷有可变相位轮廓的光学陷阱。

9. 发明申请

WO2008092107B1 HOLOGRAPHIC MICROSCOPE SYSTEM AND METHOD FOR OPTICAL TRAPPING AND INSPECTION OF MATERIALS 审中-公开
标题翻译：全息显微镜系统及材料光学跟踪检测方法
公开(公告)号：WO2008092107B1
公开(公告)日：2008-11-06
申请号：PCT/US2008052098
申请日：2008-01-25
申请人： UNIV NEW YORK , LEE SANG-HYUK , GRIER DAVID G
发明人： LEE SANG-HYUK , GRIER DAVID G
IPC分类号： G21K1/00 , G01B9/021 , G02B21/32
CPC分类号： G03H1/0005 , G01B9/021 , G02B21/0088 , G02B21/32 , G03H1/0443 , G03H1/0866 , G03H1/2294 , G03H2001/0033 , G03H2001/0077 , G03H2001/0447 , Y10S359/902
摘要： A method and system for performing three-dimensional holographic microscopy of an optically trapped structure. The method and system use an inverted optical microscope, a laser source which generates a trapping laser beam wherein the laser beam is focused by an objective lens into a plurality of optical traps. The method and system also use a collimated laser at an imaging wavelength to illuminate the structure created by the optical traps. Imaging light scattered by the optically trapped structure forms holograms that are imaged by a video camera and analyzed by optical formalisms to determine light field to reconstruct 3-D images for analysis and evaluation.
摘要翻译：用于执行光学捕获结构的三维全息显微镜的方法和系统。该方法和系统使用倒置的光学显微镜，产生捕获激光束的激光源，其中激光束被物镜聚焦成多个光阱。该方法和系统还使用成像波长处的准直激光来照亮由光阱产生的结构。通过光学捕获结构散射的成像光形成由摄像机成像的全息图，并通过光学形式来分析以确定光场以重建用于分析和评估的3-D图像。

10. 发明申请

WO2011079139A3 SORTING COLLOIDAL PARTICLES INTO MULTIPLE CHANNELS WITH OPTICAL FORCES: PRISMATIC OPTICAL FRACTIONATION 审中-公开
标题翻译：用胶粘剂将胶体粒子分成多个通道：棱镜光学分离
公开(公告)号：WO2011079139A3
公开(公告)日：2011-10-20
申请号：PCT/US2010061617
申请日：2010-12-21
申请人： UNIV NEW YORK , GRIER DAVID G , XIAO KE
发明人： GRIER DAVID G , XIAO KE
IPC分类号： G01N15/14 , B01D17/00 , G01N1/10
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0454 , B01L2400/0487 , G01N15/1463 , G01N2015/1443 , G01N2015/1454 , G01N2015/149
摘要： A method and system for controlled fractionation of particles. A sample having a plurality of particles of different size distributions. A uniform array for the preparing of optical traps having a selected array lattice constant. The plurality of particles for inputting the plurality of particles to the uniform array of optical traps at a driving direction angle and the plurality of particles separating along different directions based on variable particle attributes.
摘要翻译：一种控制颗粒分级的方法和系统。具有多个不同尺寸分布的颗粒的样品。用于制备具有选定阵列晶格常数的光阱的均匀阵列。多个粒子用于以驱动方向角将多个粒子输入均匀的光阱阵列，并且多个粒子基于可变粒子属性沿着不同的方向分离。

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