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1. 发明申请

WO2008076414A2 SELF-REPLICATING MATERIALS 审中-公开
标题翻译：自我更换材料
公开(公告)号：WO2008076414A2
公开(公告)日：2008-06-26
申请号：PCT/US2007/025749
申请日：2007-12-17
申请人： NEW YORK UNIVERSITY , SEEMAN, Nadrian , CHAIKIN, Paul Michael , PINE, David , GRIER, David G.
发明人： CHAIKIN, Paul Michael , PINE, David , GRIER, David G.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/682 , B82Y5/00 , B82Y20/00 , C12N15/10 , C12N15/1031 , C12N15/1068 , C12Q2563/155 , C12Q2565/113
摘要： The invention provides micron and sub-micron scale particles designed to recognize and selectively interact with each other by exploiting the recognition and specificity enabled by DNA-sequence-encoded coatings. Such materials possess sufficient information coded in their chemical and physical interactions to self assemble and self replicate. The invention further provides methods of using such materials to create self replicating and organizing materials. Replicated copies are permanently linked and then thermally detached, freeing them to act as templates for further growth. This new class of condensed matter systems, provides means to design and control the structure and function of materials and machines from the microscopic to life-size. In another aspect of the invention, depletion type forces and depletion zones can be utilized in the implementation of the self assembly and self replication of materials, including without limitation colloidal particles. The invention further provides novel means of synthesis and materials built by such synthesis, which may be used in a variety of applications, including microelectronics.
摘要翻译：本发明提供通过利用由DNA序列编码的涂层实现的识别和特异性来设计用于识别和选择性相互作用的微米级和亚微米级粒子。这样的材料具有足够的信息，以其化学和物理相互作用编码，以自组装和自我复制。本发明还提供了使用这种材料来创建自我复制和组织材料的方法。复制副本永久链接，然后热分离，释放它们作为进一步增长的模板。这种新型凝结物系统，提供了从微观到真实尺寸的材料和机器的结构和功能的设计和控制的手段。在本发明的另一方面，耗尽型力和耗尽区可以用于实现材料的自组装和自我复制，包括但不限于胶体颗粒。本发明还提供了新的合成方法和通过这种合成制备的材料，其可以用于包括微电子学在内的各种应用中。

2. 发明申请

WO2007009046A2 ASSEMBLY OF QUASICRYSTALLINE PHOTONIC HETEROSTRUCTURES 审中-公开
标题翻译：等离子体光子体系的组装
公开(公告)号：WO2007009046A2
公开(公告)日：2007-01-18
申请号：PCT/US2006/027224
申请日：2006-07-07
申请人： NEW YORK UNIVERSITY , THE TRUSTEES OF PRINCETON UNIVERSITY , GRIER, David G. , ROICHMAN, Yael , MAN, Weining , CHAIKIN, Paul Michael , STEINHARDT, Paul Joseph
发明人： GRIER, David G. , ROICHMAN, Yael , MAN, Weining , CHAIKIN, Paul Michael , STEINHARDT, Paul Joseph
CPC分类号： B82Y20/00 , G02B6/1225
摘要： A method and system for assembling a quasicrystalline heterostructure. A plurality of particles is provided with desirable predetermined character. The particles are suspended in a medium, and holographic optical traps are used to position the particles in a way to achieve an arrangement which provides a desired property.
摘要翻译：一种用于组装准晶体异质结构的方法和系统。多个颗粒具有期望的预定特性。将颗粒悬浮在介质中，并且全息光学陷阱用于以实现提供所需性质的布置的方式来定位颗粒。

3. 发明申请

WO2010101671A1 AUTOMATED REAL-TIME PARTICLE CHARACTERIZATION AND THREE-DIMENSIONAL VELOCIMETRY WITH HOLOGRAPHIC VIDEO MICROSCOPY 审中-公开
标题翻译：自动实时粒子特征和三维视频显微镜的三维视频
公开(公告)号：WO2010101671A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/021045
申请日：2010-01-14
申请人： NEW YORK UNIVERSITY , GRIER, David G. , CHEONG, Fook Chiong , XIAO, Ke
发明人： GRIER, David G. , CHEONG, Fook Chiong
IPC分类号： G01N15/10 , G06T1/00 , G02B21/34
CPC分类号： G01N15/1475 , G01N15/1429 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N2015/003 , G01N2015/0065 , G01N2015/1445 , G01N2015/1454 , G01N2015/1493 , G01N2015/1497 , G02B21/0056 , G02B21/0068 , G02B21/008 , G03H1/0005 , G03H2001/005
摘要： An in-line holographic microscope can be used to analyze on a frame by frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.
摘要翻译：可以使用在线全息显微镜逐帧分析视频流来跟踪单个胶体颗粒的三维运动。该系统和方法可以提供实时的纳米分辨率，同时测量粒径和折射率。通过结合使用Lorenz-Mie分析与选定的硬件和软件方法的组合，该分析可以近乎实时地进行。有效的粒子识别方法以足够的精度自动进行初始位置估计，以实现无人值守的全息跟踪和表征。

4. 发明申请

WO2008063809A3 THREE-DIMENSIONAL HOLOGRAPHIC RING TRAPS 审中-公开
公开(公告)号：WO2008063809A3
公开(公告)日：2008-05-29
申请号：PCT/US2007/082418
申请日：2007-10-24
申请人： NEW YORK UNIVERSITY , ROICHMAN, Yohai , GRIER, David G.
发明人： ROICHMAN, Yohai , GRIER, David G.
IPC分类号： G21K1/00
摘要： A method and system for preparing and using three dimensional optical ring traps. The method and system includes applying a single phase hologram to be able to independently control shape and force profile of an optical trap but without employing orbital angular momentum for the control parameter of an optical ring trap to manipulate an object.

5. 发明申请

WO2006078759A2 MODULATED OPTICAL TWEEZERS 审中-公开
标题翻译：调制光学仪器
公开(公告)号：WO2006078759A2
公开(公告)日：2006-07-27
申请号：PCT/US2006/001806
申请日：2006-01-19
申请人： NEW YORK UNIVERSITY , GRIER, David G.
发明人： GRIER, David G.
IPC分类号： G21K1/00
CPC分类号： B01L3/502761 , B01L3/502715 , B01L2200/0636 , B01L2200/0647 , B01L2300/0864 , B01L2400/0454 , G01N30/00 , G01N30/02 , G01N2015/0288 , G03H1/0808 , G03H2001/0077 , G03H2001/0816 , G03H2210/30 , B01D2015/3895
摘要： A method and apparatus for selecting a specific fraction from a heterogeneous fluid-borne sample using optical gradient forces in a microfluidic or fluidic system are presented. Samples may range in size from a few nanometers to at least tens of micrometers, may be dispersed in any fluid medium, and may be sorted on the basis of size, shape, optical characteristics, charge, and other physical properties. The selection process involves passive transport through optical intensity field driven by flowing fluid, and so offers several advantages over competing techniques. These include continuous rather than batch-mode operation, continuous and dynamic tunability, operation over a wide range of samples, compactness, and low cost.
摘要翻译：提出了一种用于在微流体或流体系统中使用光学梯度力从异质流体样品中选择特定部分的方法和装置。样品的尺寸可以从几纳米至至少几十微米，可以分散在任何流体介质中，并且可以基于尺寸，形状，光学特性，电荷和其它物理性质进行分类。选择过程涉及通过由流动流体驱动的光强度场的被动传输，因此提供了优于竞争技术的几个优点。这些包括连续而不是批模式操作，连续和动态可调性，在各种样品中的操作，紧凑性和低成本。

6. 发明申请

WO2011079139A2 SORTING COLLOIDAL PARTICLES INTO MULTIPLE CHANNELS WITH OPTICAL FORCES: PRISMATIC OPTICAL FRACTIONATION 审中-公开
标题翻译：将胶体颗粒分解成具有光学力的多个通道：真实的光学分离
公开(公告)号：WO2011079139A2
公开(公告)日：2011-06-30
申请号：PCT/US2010/061617
申请日：2010-12-21
申请人： NEW YORK UNIVERSITY , GRIER, David G. , XIAO, Ke
发明人： GRIER, David G. , XIAO, Ke
IPC分类号： G01N15/14 , G01N1/10 , B01D17/00
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0454 , B01L2400/0487 , G01N15/1463 , G01N2015/1443 , G01N2015/1454 , G01N2015/149
摘要： A method and system for controlled fractionation of particles. A sample having a plurality of particles of different size distributions. A uniform array for the preparing of optical traps having a selected array lattice constant. The plurality of particles for inputting the plurality of particles to the uniform array of optical traps at a driving direction angle and the plurality of particles separating along different directions based on variable particle attributes.
摘要翻译：用于粒子控制分馏的方法和系统。具有不同尺寸分布的多个颗粒的样品。用于制备具有选定阵列晶格常数的光阱的均匀阵列。多个粒子，用于以驱动方向角将多个粒子输入到光阱的均匀阵列，并且多个粒子基于可变粒子属性沿着不同方向分离。

7. 发明申请

WO2004104551A2 OPTICAL FRACTIONATION METHODS AND APPARATUS 审中-公开
标题翻译：光分解方法和装置
公开(公告)号：WO2004104551A2
公开(公告)日：2004-12-02
申请号：PCT/US2004/015327
申请日：2004-05-14
申请人： UNIVERSITY OF CHICAGO , GRIER, David G.
发明人： GRIER, David G.
IPC分类号： G01N
CPC分类号： H05H3/04 , G01N15/1484 , G01N2015/0288 , G01N2015/1075 , G01N2015/149 , G01N2015/1493 , G03H2001/0077 , Y10S359/90
摘要： Static arrays of optical traps can be used to sort microscopic objects with exponential sensitivity to size. Such optical fractionation relies on competition between an externally applied force and the moving objects' differing affinities for optical gradient traps. In a reverse fractionation method, objects that are more strongly influenced by the traps tend to become kinetically locked in to the array and are systematically deflected back into an input flow. In a thermal ratcheting method, patterns are spaced to allow particle diffusion, thus providing the opportunity for forward or reverse movement through the patterns. Unlike other sorting techniques, optical fractionation can operate continuously and can be continuously optimized. The exponential sensitivity arises quite generally from the particle size dependence of the potential wells' apparent widths.
摘要翻译：光阱的静态阵列可用于对具有指数敏感度的微观物体进行分类。这种光学分级依赖于外部施加的力与运动物体对光学梯度陷阱的不同亲和力之间的竞争。在反向分馏方法中，受陷阱更强烈影响的物体趋向于动力学地锁定到阵列中并被系统地偏转回到输入流中。在热棘轮方法中，图案间隔开以允许颗粒扩散，从而提供通过图案的正向或反向移动的机会。与其他分选技术不同，光学分级可以连续工作，可以不断优化。指数敏感性通常来自潜在井的表观宽度的粒子尺寸依赖性。

8. 发明公开

EP2507615A2 SORTING COLLOIDAL PARTICLES INTO MULTIPLE CHANNELS WITH OPTICAL FORCES: PRISMATIC OPTICAL FRACTIONATION 审中-公开
标题翻译：分拣及光FORCES多通道胶体颗粒：光学PRISMAFRAKTIONIERUNG
公开(公告)号：EP2507615A2
公开(公告)日：2012-10-10
申请号：EP10840080.5
申请日：2010-12-21
申请人： New York University
发明人： GRIER, David G. , XIAO, Ke
IPC分类号： G01N15/14 , G01N1/10 , B01D17/00
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0454 , B01L2400/0487 , G01N15/1463 , G01N2015/1443 , G01N2015/1454 , G01N2015/149
摘要： A method and system for controlled fractionation of particles. A sample having a plurality of particles of different size distributions. A uniform array for the preparing of optical traps having a selected array lattice constant. The plurality of particles for inputting the plurality of particles to the uniform array of optical traps at a driving direction angle and the plurality of particles separating along different directions based on variable particle attributes.

9. 发明公开

EP1902335A2 ASSEMBLY OF QUASICRYSTALLINE PHOTONIC HETEROSTRUCTURES 审中-公开
标题翻译：准晶光子异质结构的组装
公开(公告)号：EP1902335A2
公开(公告)日：2008-03-26
申请号：EP06787166.5
申请日：2006-07-07
申请人： NEW YORK UNIVERSITY , The trustees of Princeton University
发明人： GRIER, David G. , ROICHMAN, Yael , MAN, Weining , CHAIKIN, Paul Michael , STEINHARDT, Paul Joseph
IPC分类号： G02B6/122
CPC分类号： B82Y20/00 , G02B6/1225
摘要： A method and system for assembling a quasicrystalline heterostructure. A plurality of particles is provided with desirable predetermined character. The particles are suspended in a medium, and holographic optical traps are used to position the particles in a way to achieve an arrangement which provides a desired property.
摘要翻译：一种组装准晶异质结构的方法和系统。多个粒子具有期望的预定字符。将颗粒悬浮在介质中，并且使用全息光学陷阱来以某种方式定位颗粒，以实现提供期望性质的布置。

10. 发明申请

WO2017139279A3 HOLOGRAPHIC CHARACTERIZATION OF PROTEIN AGGREGATES 审中-公开
公开(公告)号：WO2017139279A3
公开(公告)日：2017-08-17
申请号：PCT/US2017/016857
申请日：2017-02-07
申请人： NEW YORK UNIVERSITY
发明人： GRIER, David G. , WARD, Michael D. , ZHONG, Xiao , WANG, Chen , PHILIPS, Laura A. , RUFFNER, David B. , CHEONG, Fook Chiong
IPC分类号： G01B9/02 , G03H1/08 , G01N15/02 , G01N15/10 , G01N21/41 , G01P5/20
摘要： Systems and methods for holographic characterization of protein aggregates. Size and refractive index of individual aggregates in a solution can be determined. Information regarding morphology and porosity can be extracted from holographic data.

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