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1. 发明申请

US20150073351A1 Apparatus for Operating Syringe Piston 审中-公开
标题翻译：用于操作注射器活塞的装置
公开(公告)号：US20150073351A1
公开(公告)日：2015-03-12
申请号：US14019657
申请日：2013-09-06
申请人： Seok-Jung KIM , Cheong-Ho CHANG , Jae-Deog JANG , Hyun-Shin PARK , Sae-Bom LEE , Kyoung-Phil BYUN
发明人： Seok-Jung KIM , Cheong-Ho CHANG , Jae-Deog JANG , Hyun-Shin PARK , Sae-Bom LEE , Kyoung-Phil BYUN
IPC分类号： A61M5/315 , A61M5/31
CPC分类号： A61M5/31511 , A61M5/20 , A61M5/31 , A61M5/31565 , A61M5/484 , A61M2005/2026
摘要： An apparatus for operating a syringe has developed comprising that: an upper semi-cylindrical tube section, semi-circular groove shaped locking slot and lower semi-cylindrical tube section. The upper semi-cylindrical tube section is integrally formed an upper head part with a threaded hole for axial movement. The lower semi-cylindrical tube section forms a top portion, intermediate portion and end portion. A diameter (Dc) at the intermediate portion is larger than the diameter (Dtip) at end portion, which is gradually reduced from intermediate to end portion. The length of tapered portion is same as that of the constant diameter portion. A tip portion has formed an opened semi-circular shape to simply overlap the syringe over the syringe mounting device for easily snapping-in and out. The syringe piston moves downward with no reverse action when the piston press unit is rotated, so that it is possible to inject the precise amount of medical to a patient with constant pressure.
摘要翻译：已经开发了一种用于操作注射器的装置，其包括：上半圆筒管部分，半圆形槽形锁定槽和下半圆筒管部分。上部半圆柱形管部分一体地形成有具有用于轴向移动的螺纹孔的上部头部。下半圆柱形管部分形成顶部，中间部分和端部。中间部分处的直径（Dc）大于从中间部分逐渐减小的端部处的直径（Dtip）。锥形部分的长度与恒定直径部分的长度相同。尖端部分形成为开放的半圆形形状，以便在注射器安装装置上简单地将注射器重叠，以便容易地进入和退出。当活塞压力单元旋转时，注射器活塞向下移动而不反作用，从而可以将恒定压力的精确量的医疗注射给患者。

2. 发明申请

US20140370600A1 METHOD OF PREPARING MESENCHYMAL STEM CELL BASIC CULTURING MEDIUM, MAKING OF CELLULAR THERAPY PRODUCT WITH MESENCHYMAL STEM CELL BASIC CULTURING MEDIUM, AND THE DIFFERENTIATED ONE BY USING THE MEDIUM 有权
标题翻译：制备中胚层干细胞基础培养液的方法，用细胞培养基制备细胞干细胞基质培养基的细胞治疗产物，使用中等化合物制备差异化物质
公开(公告)号：US20140370600A1
公开(公告)日：2014-12-18
申请号：US14241393
申请日：2011-09-06
申请人： Dong-Sam Suh , Jun Keun Lee , Dong Il Chang , Min Jung Choi , Jang Hoon Kim , Ga Ram Kim , Cheong Ho Chang
发明人： Dong-Sam Suh , Jun Keun Lee , Dong Il Chang , Min Jung Choi , Jang Hoon Kim , Ga Ram Kim , Cheong Ho Chang
IPC分类号： C12N5/0775
CPC分类号： C12N5/0667 , C12N5/0663 , C12N2500/32 , C12N2500/34 , C12N2500/38
摘要： Disclosed is a basic culture medium for mesenchymal stem cells, and a cell therapeutic agent cultured and differentiated using same. The basic culture medium reduces the time taken from collection to mass culturing by increasing the proliferation rate of undifferentiated mesenchymal stem cells derived from an adult tissue such as human marrow and adipose tissue, and also is capable of various differentiations into treating agents for bone-forming cells, for cartilage cells, or for fat cells.
摘要翻译：公开了间充质干细胞的基础培养基和使用其培养和分化的细胞治疗剂。碱性培养基通过增加源于成人组织如人骨髓和脂肪组织的未分化的间充质干细胞的增殖速率而减少从收集到大量培养所需的时间，并且还能够各种分化成骨形成治疗剂细胞，软骨细胞，或脂肪细胞。

3. 发明申请

US20090311220A1 Bone forming compound composed of a mixture of osteoblast and biomatrix and method for producing the same 审中-公开
标题翻译：由成骨细胞和生物基质的混合物组成的骨形成化合物及其制造方法
公开(公告)号：US20090311220A1
公开(公告)日：2009-12-17
申请号：US11921217
申请日：2005-06-27
申请人： Jae-Deog Jang , Hyun-Shin Park , Cheong-Ho Chang , Soo-Jin Jung , Sae-Bom Lee , Chang-Kwon Ko
发明人： Jae-Deog Jang , Hyun-Shin Park , Cheong-Ho Chang , Soo-Jin Jung , Sae-Bom Lee , Chang-Kwon Ko
IPC分类号： A61K35/32 , A61P19/00
CPC分类号： A61K35/32 , A61K35/12 , A61K38/4833 , A61L27/3821 , A61L27/3847 , A61L27/3895 , A61L2430/02 , C12N5/0654 , C12N2533/56
摘要： A compound for bone forming and a method for producing the same are provided using a mixture of an osteoblast and a bio-matrix. The method comprises: isolating osteoblasts from bone tissue and culturing the isolated osteoblasts to prepare an osteoblast suspension; and mixing the resulting osteoblast suspension with a bio-matrix to prepare an osteoblast therapeutic agent. A bone formation method is provided that results in no clinical graft rejection, and is capable of achieving effective and rapid bone formation via injection of a compound which has been pre-shaped to a certain extent, so as to alleviate problems associated with bone tissue formation in unwanted regions resulting from escape of injected osteoblasts from the targeted site for bone formation and then propagation thereof to other sites via the blood stream, which are caused by injection of an osteoblast suspension.
摘要翻译：使用成骨细胞和生物基质的混合物提供骨形成用化合物及其制造方法。该方法包括：从骨组织中分离成骨细胞并培养分离的成骨细胞以制备成骨细胞悬液; 并将所得的成骨细胞悬浮液与生物基质混合以制备成骨细胞治疗剂。提供了一种骨形成方法，其导致没有临床移植物排斥反应，并且能够通过注射预先形成一定程度的化合物来实现有效和快速的骨形成，以便减轻与骨组织形成相关的问题在由注射的成骨细胞从目标部位排出骨形成而导致的不需要的区域中，然后通过注射成骨细胞悬浮液引起的血流将其传播到其它部位。

4. 发明申请

US20090111087A1 Separation method of Nucleated Cells Derived from Bone Marrow for Bone Formation 审中-公开
标题翻译：来自骨髓的成骨细胞分离方法用于骨形成
公开(公告)号：US20090111087A1
公开(公告)日：2009-04-30
申请号：US12226472
申请日：2006-06-23
申请人： Hyun-Shin Park , Jae-Deog Jang , Sae-Bom Lee , Cheong-Ho Chang
发明人： Hyun-Shin Park , Jae-Deog Jang , Sae-Bom Lee , Cheong-Ho Chang
IPC分类号： A01N1/02
CPC分类号： C12N5/0654 , A61K35/28
摘要： The present invention relates to a method for separating bone marrow-derived nucleated cells for bone formation. The method comprises: the steps of: washing bone marrow; lysing red blood cells in the bone marrow; neutralizing the bone marrow lysate; purifying nucleated cells from the neutralized bone marrow; and mixing the nucleated cells with a maintenance buffer for bone formation. According to the invention, bone marrow-derived nucleated cells, which can be grafted into a site in need of bone formation or bone defect treatment, can be separated in a rapid and convenient manner. As a result, bone formation in emergency patients or patients, who require repeated surgical operations, can be effectively achieved by separating the nucleated cells for bone formation in surgical locations in a convenient and rapid manner and injecting the separated cells into the patients.
摘要翻译：本发明涉及用于分离用于骨形成的骨髓衍生的有核细胞的方法。该方法包括：洗涤骨髓; 裂解骨髓中的红细胞; 中和骨髓裂解物; 从中和骨髓中纯化有核细胞; 并将有核细胞与用于骨形成的维持缓冲液混合。根据本发明，可以以快速方便的方式分离可以移植到需要骨形成或骨缺损处理的部位的骨髓衍生的有核细胞。结果，需要重复外科手术的急诊患者或患者的骨形成可以通过以方便和快速的方式分离外科手术位置中的骨形成核细胞并将分离的细胞注射入患者中来有效地实现。

5. 发明申请

US20090099548A1 Device for Regenerating Adipose Tissue and Method for Utilizing Thereof 审中-公开
标题翻译：用于再生脂肪组织的装置及其使用方法
公开(公告)号：US20090099548A1
公开(公告)日：2009-04-16
申请号：US12224738
申请日：2006-03-15
申请人： Hyun-Mi Son , Jae-Deog Jang , Cheong-Ho Chang
发明人： Hyun-Mi Son , Jae-Deog Jang , Cheong-Ho Chang
IPC分类号： A61K35/12 , A61M5/31
CPC分类号： A61K35/35 , A61B50/31 , A61B2050/3008 , A61B2050/3011 , A61M39/10
摘要： A device and method for regenerating adipose tissue has developed comprising: a washing container filled with an sterile solution for washing the adipose tissues; a syringe container holding syringes for washing and separating adipose tissues; injecting the wash solution and mixing the Bio-Gel, respectively; a second syringe container containing Bio-Gel syringes filled with materials to induce adipogenesis; and connector containers holding connectors for injection of the wash solution, and mixing of washed tissues and Bio-Gel. These containers are restrained in the kit by grooves in the bottom of the box. The box top holds needle containers for transplantation needles; and a protocol for fat transplantation, restrained by grooves. The kit minimizes risk of infection in fat transplantations using the patient's own tissues. It enables stable tissue transplantation as well as adipose tissue regeneration via use of aseptic/sterile implements, and a protocol for fat transplantation, solving the problems associated with conventional adipose tissue transplantation.
摘要翻译：开发了用于再生脂肪组织的装置和方法，其包括：填充有用于洗涤脂肪组织的无菌溶液的洗涤容器; 注射器容器，其容纳用于洗涤和分离脂肪组织的注射器; 注入洗涤溶液并分别混合Bio-Gel; 包含填充有诱导脂肪形成的材料的生物凝胶注射器的第二注射器容器; 和用于注入洗涤溶液的连接器的连接器容器，以及洗涤的组织和Bio-Gel的混合。这些容器通过盒底部的槽限制在套件中。盒顶装有移植针针头容器; 和脂肪移植方案，由槽限制。该套件使用患者自己的组织将脂肪移植中的感染风险降至最低。它通过使用无菌/无菌器具实现稳定的组织移植和脂肪组织再生，以及用于脂肪移植的方案，解决与常规脂肪组织移植相关的问题。

6. 发明申请

US20080213229A1 Fibrin Contained Semi-Solid Osteoblast Composition for Curing Bone Fracture and Method for Producing the Same 审中-公开
标题翻译：用于固化骨折的纤维蛋白含有半固体成骨细胞组合物及其制备方法
公开(公告)号：US20080213229A1
公开(公告)日：2008-09-04
申请号：US11885943
申请日：2005-08-03
申请人： Hyun-Shin Park , Jae-Deog Jang , Cheong-Ho Chang , Soo-Jin Jung , Sae-Bom Lee , Chang-Kwon Ko
发明人： Hyun-Shin Park , Jae-Deog Jang , Cheong-Ho Chang , Soo-Jin Jung , Sae-Bom Lee , Chang-Kwon Ko
IPC分类号： A61K35/12
CPC分类号： A61K35/32 , A61K38/363 , A61K38/4833 , A61K2300/00
摘要： A method for producing the fibrin contained semi-solid osteoblast composition has developed for treating the bone fracture. The method is comprised of: isolating osteoblasts from a bone tissue and culturing/proliferating the isolated osteoblasts in Dulbecco's Modified Eagle's Medium (DMEM) or Minimum Essential Medium, Alpha Modification (α-MEM) to prepare an osteoblast suspension. Then, mixing the resulting osteoblast suspension with a coagulation factor to prepare an osteoblast therapeutic agent. Accordingly, the fibrin contained semi-solid osteoblast composition of the present invention has capability to achieve the bone grafting for performing bone union without the clinical graft rejection. It is possible to uniformly distribute the fibrin mixed semi-solid osteoblast composition into the affected area of the bone fracture via injection. Therefore, the fibrin contained semi-solid osteoblast composition is effectively and rapidly cure the bone fracture via constant injection of into the affected area.
摘要翻译：已经开发了用于生产含有纤维蛋白的半固体成骨细胞组合物的方法用于治疗骨折。该方法包括：从骨组织中分离成骨细胞并在Dulbecco's Modified Eagle's Medium（DMEM）或Minimum Essential Medium，Alpha Modification（α-MEM））中培养/增殖分离的成骨细胞以制备成骨细胞悬浮液。然后，将得到的成骨细胞悬浮液与凝血因子混合，制备成骨细胞治疗剂。因此，本发明的纤维蛋白含有半固体成骨细胞组合物具有实现骨移植以进行骨结合而没有临床移植排斥的能力。可以通过注射将纤维蛋白混合的半固体成骨细胞组合物均匀地分布到骨折的受影响区域中。因此，含有纤维蛋白的半固体成骨细胞组合物通过持续注射进入受影响的区域，有效快速地治愈了骨折。

7. 发明授权

US09879226B2 Mesenchymal stem cell basic culturing medium 有权
公开(公告)号：US09879226B2
公开(公告)日：2018-01-30
申请号：US14241393
申请日：2011-09-06
申请人： Dong-Sam Suh , Jun Keun Lee , Dong Il Chang , Min Jung Choi , Jang Hoon Kim , Ga Ram Kim , Cheong Ho Chang
发明人： Dong-Sam Suh , Jun Keun Lee , Dong Il Chang , Min Jung Choi , Jang Hoon Kim , Ga Ram Kim , Cheong Ho Chang
IPC分类号： C12N5/0775
CPC分类号： C12N5/0667 , C12N5/0663 , C12N2500/32 , C12N2500/34 , C12N2500/38
摘要： Disclosed is a basic culture medium for mesenchymal stem cells, and a cell therapeutic agent cultured and differentiated using same. The basic culture medium reduces the time taken from collection to mass culturing by increasing the proliferation rate of undifferentiated mesenchymal stem cells derived from an adult tissue such as human marrow and adipose tissue, and also is capable of various differentiations into treating agents for bone-forming cells, for cartilage cells, or for fat cells.

8. 发明授权

US09408975B2 Apparatus for operating syringe piston 有权
标题翻译：用于操作注射器活塞的装置
公开(公告)号：US09408975B2
公开(公告)日：2016-08-09
申请号：US14019657
申请日：2013-09-06
申请人： Seok-Jung Kim , Cheong-Ho Chang , Jae-Deog Jang , Hyun-Shin Park , Sae-Bom Lee , Kyoung-Phil Byun
发明人： Seok-Jung Kim , Cheong-Ho Chang , Jae-Deog Jang , Hyun-Shin Park , Sae-Bom Lee , Kyoung-Phil Byun
IPC分类号： A61M5/31 , A61M5/315 , A61M5/48 , A61M5/20
CPC分类号： A61M5/31511 , A61M5/20 , A61M5/31 , A61M5/31565 , A61M5/484 , A61M2005/2026
摘要： An apparatus for operating a syringe has developed comprising: an upper semi-cylindrical tube section, semi-circular shaped locking groove and lower semi-cylindrical tube section. The upper semi-cylindrical tube section is integrally formed an upper head part with a threaded hole for axial movement. The lower semi-cylindrical tube section forms a top portion, intermediate portion and end portion. A diameter (Dc) at the intermediate portion larger than the diameter (Dtip) at end portion is gradually reduced from intermediate to end portion. The length of the tapered portion is same as that portion of the constant diameter. A tip portion has formed an opened semi-circular shape to simply overlap the syringe over the cartridge for easily snapping-in and out. The syringe piston moves downward with no reverse action when the piston press-unit is rotated, thus it is possible to inject the precise amount of medicine to a patient with constant pressure.
摘要翻译：已经开发了一种用于操作注射器的装置，其包括：上半圆筒管部分，半圆形锁定槽和下半圆筒管部分。上部半圆柱形管部分一体地形成有具有用于轴向移动的螺纹孔的上部头部。下半圆柱形管部分形成顶部，中间部分和端部。在中间部分处的直径（Dc）大于端部部分处的直径（Dtip）的直径（Dc）从中间部分逐渐减小。锥形部分的长度与恒定直径的那部分相同。尖端部分形成为开放的半圆形形状，以使得注射器在盒上简单地重叠，以便容易地进入和退出。当活塞压力单元旋转时，注射器活塞向下移动而没有反向作用，因此可以将恒定压力的精确量的药剂注射到患者身上。

9. 发明申请

US20090254065A1 Simple method of transplanting injectable chordrocyte for autologous chondrocyte transplantation 审中-公开
标题翻译：移植注射性软骨细胞用于自体软骨细胞移植的简单方法
公开(公告)号：US20090254065A1
公开(公告)日：2009-10-08
申请号：US11988924
申请日：2005-09-23
申请人： Chang-Kwon Ko , Eun-Young Lee , Jeong-Yong Choi , Jae-Deog Jang , Cheong-Ho Chang , Pyoung-Min Kim
发明人： Chang-Kwon Ko , Eun-Young Lee , Jeong-Yong Choi , Jae-Deog Jang , Cheong-Ho Chang , Pyoung-Min Kim
IPC分类号： A61M37/00
CPC分类号： A61K38/363 , A61K38/39 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L2430/06 , A61K2300/00
摘要： A method of transplanting an injectable chondrocyte is developed for autologous chondrocyte transplantation, comprising mixing matrices including fibrin, hyaluronic acid and collagen, which are the main ingredients of animal cartilage, and injecting the resulting mixture into a damaged cartilage region. One 1 ml syringe is prepared by mixing 1 ml of a chondrocyte culture with white or light-yellow lyophilized powder (fibrinogen). A second 1 ml syringe is prepared by mixing 1 ml of chondrocyte culture with white lyophilized powder (thrombin), adding 0.1 cc of that mixture to the entire contents of two vials containing chondrocyte suspension, and mixing well. The two syringes are then mounted on a syringe stand, and a mixing tip is mounted to their tips. The contents are mixed in the mixing tip while injecting the resulting mixture into a damaged cartilage region of an animal.
摘要翻译：开发了用于自体软骨细胞移植的移植注射软骨细胞的方法，包括混合作为动物软骨的主要成分的纤维蛋白，透明质酸和胶原的基质，并将所得混合物注入损伤的软骨区域。通过将1ml软骨细胞培养物与白色或浅黄色冻干粉末（纤维蛋白原）混合来制备1ml注射器。通过将1ml软骨细胞培养物与白色冻干粉末（凝血酶）混合，将0.1cc该混合物加入到含有软骨细胞悬液的两个小瓶的全部内容物中并混合，制备第二个1ml注射器。然后将两个注射器安装在注射器支架上，并将混合头安装到其尖端。将内容物混合在混合尖端中，同时将所得混合物注入动物的损伤的软骨区域。

10. 发明申请

US20090018868A1 Method for Utilizing Cell Therapy Product Facility and Network-Based Business Model Using the Same 审中-公开
标题翻译：使用细胞疗法产品设施和基于网络的商业模式的使用方法
公开(公告)号：US20090018868A1
公开(公告)日：2009-01-15
申请号：US12224949
申请日：2006-03-16
申请人： Jae-Deog Chang , Cheong-Ho Chang , Dong-Sam Suh , Chang-Kwon Ko , Seung-Ju Ryu , Hee-Chul Ko , Sae-Bom Lee
发明人： Jae-Deog Chang , Cheong-Ho Chang , Dong-Sam Suh , Chang-Kwon Ko , Seung-Ju Ryu , Hee-Chul Ko , Sae-Bom Lee
IPC分类号： G06Q50/00 , C12N5/00 , G06Q30/00
CPC分类号： G06Q50/22
摘要： A method is provided for utilizing a cell therapy product facility and an internet franchise market business comprising: producing a cell therapy product by a CT (Cell Therapy)-module (1) of prefabricated units having specific functions, and; storing of hematopoietic stem cells, bone marrow cells and other cells, by a BC (Banking of Cell and Tissue)-module (2) of prefabricated units having specific functions. Both modules eliminate contamination and maximize efficiency. It provides an operating method and a use method and business method for the above cell therapy product facility. The invention enables easy, low cost production of a product having sufficient quality to be transplanted into patients and put into clinical application within a short period of time. The facility module of the invention can be installed and used wherever adequate space is available. The invention provides improved quality and reliability of cell therapy products.
摘要翻译：提供了一种利用细胞疗法产品设备和网络营销市场业务的方法，包括：通过具有特定功能的预制单元的CT（Cell Therapy）模块（1）产生细胞治疗产品; 通过具有特定功能的预制单元的BC（Cell of Cell and Tissue）模块（2）存储造血干细胞，骨髓细胞和其它细胞。两个模块都能消除污染并最大限度地提高效率。它提供了上述细胞治疗产品设施的操作方法和使用方法和商业方法。本发明能够容易，低成本地生产具有足够质量的产品移植到患者中并在短时间内投入临床应用。本发明的设施模块可以在有足够空间的地方安装和使用。本发明提供了改善细胞治疗产品的质量和可靠性。

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