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1. 发明授权

US09408975B2 Apparatus for operating syringe piston 有权
标题翻译：用于操作注射器活塞的装置
公开(公告)号：US09408975B2
公开(公告)日：2016-08-09
申请号：US14019657
申请日：2013-09-06
申请人： Seok-Jung Kim , Cheong-Ho Chang , Jae-Deog Jang , Hyun-Shin Park , Sae-Bom Lee , Kyoung-Phil Byun
发明人： Seok-Jung Kim , Cheong-Ho Chang , Jae-Deog Jang , Hyun-Shin Park , Sae-Bom Lee , Kyoung-Phil Byun
IPC分类号： A61M5/31 , A61M5/315 , A61M5/48 , A61M5/20
CPC分类号： A61M5/31511 , A61M5/20 , A61M5/31 , A61M5/31565 , A61M5/484 , A61M2005/2026
摘要： An apparatus for operating a syringe has developed comprising: an upper semi-cylindrical tube section, semi-circular shaped locking groove and lower semi-cylindrical tube section. The upper semi-cylindrical tube section is integrally formed an upper head part with a threaded hole for axial movement. The lower semi-cylindrical tube section forms a top portion, intermediate portion and end portion. A diameter (Dc) at the intermediate portion larger than the diameter (Dtip) at end portion is gradually reduced from intermediate to end portion. The length of the tapered portion is same as that portion of the constant diameter. A tip portion has formed an opened semi-circular shape to simply overlap the syringe over the cartridge for easily snapping-in and out. The syringe piston moves downward with no reverse action when the piston press-unit is rotated, thus it is possible to inject the precise amount of medicine to a patient with constant pressure.
摘要翻译：已经开发了一种用于操作注射器的装置，其包括：上半圆筒管部分，半圆形锁定槽和下半圆筒管部分。上部半圆柱形管部分一体地形成有具有用于轴向移动的螺纹孔的上部头部。下半圆柱形管部分形成顶部，中间部分和端部。在中间部分处的直径（Dc）大于端部部分处的直径（Dtip）的直径（Dc）从中间部分逐渐减小。锥形部分的长度与恒定直径的那部分相同。尖端部分形成为开放的半圆形形状，以使得注射器在盒上简单地重叠，以便容易地进入和退出。当活塞压力单元旋转时，注射器活塞向下移动而没有反向作用，因此可以将恒定压力的精确量的药剂注射到患者身上。

2. 发明申请

US20090254065A1 Simple method of transplanting injectable chordrocyte for autologous chondrocyte transplantation 审中-公开
标题翻译：移植注射性软骨细胞用于自体软骨细胞移植的简单方法
公开(公告)号：US20090254065A1
公开(公告)日：2009-10-08
申请号：US11988924
申请日：2005-09-23
申请人： Chang-Kwon Ko , Eun-Young Lee , Jeong-Yong Choi , Jae-Deog Jang , Cheong-Ho Chang , Pyoung-Min Kim
发明人： Chang-Kwon Ko , Eun-Young Lee , Jeong-Yong Choi , Jae-Deog Jang , Cheong-Ho Chang , Pyoung-Min Kim
IPC分类号： A61M37/00
CPC分类号： A61K38/363 , A61K38/39 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L2430/06 , A61K2300/00
摘要： A method of transplanting an injectable chondrocyte is developed for autologous chondrocyte transplantation, comprising mixing matrices including fibrin, hyaluronic acid and collagen, which are the main ingredients of animal cartilage, and injecting the resulting mixture into a damaged cartilage region. One 1 ml syringe is prepared by mixing 1 ml of a chondrocyte culture with white or light-yellow lyophilized powder (fibrinogen). A second 1 ml syringe is prepared by mixing 1 ml of chondrocyte culture with white lyophilized powder (thrombin), adding 0.1 cc of that mixture to the entire contents of two vials containing chondrocyte suspension, and mixing well. The two syringes are then mounted on a syringe stand, and a mixing tip is mounted to their tips. The contents are mixed in the mixing tip while injecting the resulting mixture into a damaged cartilage region of an animal.
摘要翻译：开发了用于自体软骨细胞移植的移植注射软骨细胞的方法，包括混合作为动物软骨的主要成分的纤维蛋白，透明质酸和胶原的基质，并将所得混合物注入损伤的软骨区域。通过将1ml软骨细胞培养物与白色或浅黄色冻干粉末（纤维蛋白原）混合来制备1ml注射器。通过将1ml软骨细胞培养物与白色冻干粉末（凝血酶）混合，将0.1cc该混合物加入到含有软骨细胞悬液的两个小瓶的全部内容物中并混合，制备第二个1ml注射器。然后将两个注射器安装在注射器支架上，并将混合头安装到其尖端。将内容物混合在混合尖端中，同时将所得混合物注入动物的损伤的软骨区域。

3. 发明申请

US20070087032A1 Composition of cartilage therapeutic agents and its application 审中-公开
标题翻译：软骨治疗剂的组成及其应用
公开(公告)号：US20070087032A1
公开(公告)日：2007-04-19
申请号：US10578719
申请日：2004-12-07
申请人： Cheong-Ho Chang , Chang-Kwon Ko , Jae-Deog Jang , Eun-Young Lee , Jeong-Yong Choi
发明人： Cheong-Ho Chang , Chang-Kwon Ko , Jae-Deog Jang , Eun-Young Lee , Jeong-Yong Choi
IPC分类号： A61F2/00
CPC分类号： A61K35/32 , A61F2/30756 , A61K35/36 , A61K35/39 , A61L27/225 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61K2300/00
摘要： A cartilage therapeutic composition is developed for clinical transplantation into articulatio genu (knee joints) or ankle joints. It has clinical significance for symptomatic cartilage defects of the femoral condyle (medial, lateral, or trochlear) and bone cartilage defects of the talus (anklebone) in human or animal hosts, The cartilage therapeutic composition comprises a mixture of components of chondrocytes isolated and expanded or differentiated from a host such as a human or animal, and thrombin and a fibrinogen matrix containing fibrinogen. An application of the cartilage therapeutic composition is that a mixture of thrombin, chondrocyte components and a fibrinogen matrix is injected into a cartilage defect region followed by solidification therein. It provides rapid healing and effective regeneration of cartilage without surgical operation. It has the merits of safety and simplicity by allowing the use of an arthroscope for transplantation.
摘要翻译：软骨治疗组合物被开发用于临床移植到关节（膝关节）或踝关节。对于人或动物宿主中的距骨（踝骨）的股骨髁（内侧，外侧或滑车）和骨软骨缺损的症状性软骨缺损具有临床意义。软骨治疗组合物包含分离和扩大的软骨细胞成分的混合物或与宿主如人或动物分化，以及含有纤维蛋白原的凝血酶和纤维蛋白原基质。软骨治疗组合物的应用是将凝血酶，软骨细胞成分和纤维蛋白原基质的混合物注射到软骨缺损区域中，随后在其中固化。它可以快速愈合，有效地再生软骨，无需外科手术。通过允许使用关节镜进行移植，具有安全和简单的优点。

4. 发明授权

US09011929B2 Composition for inducing tissue regeneration by activating platelet-rich plasma (PRP) 有权
标题翻译：通过激活富血小板血浆（PRP）诱导组织再生的组合物
公开(公告)号：US09011929B2
公开(公告)日：2015-04-21
申请号：US13502116
申请日：2009-11-17
申请人： Hyun-Shin Park , Ji-Chul Yu , Ju-Hee Park , Jang-Hoon Kim , Hun Kim , Sae-Bom Lee , Jae-Deog Jang , Cheong-Ho Jang
发明人： Hyun-Shin Park , Ji-Chul Yu , Ju-Hee Park , Jang-Hoon Kim , Hun Kim , Sae-Bom Lee , Jae-Deog Jang , Cheong-Ho Jang
IPC分类号： A61K35/16 , A61K38/39 , A61L27/36 , A61L27/24 , A61L27/38
CPC分类号： A61L27/3616 , A61K35/16 , A61K38/39 , A61L27/24 , A61L27/38 , A61K2300/00
摘要： The present invention relates to a composition for cartilaginous tissue repair and to a production method therefor. The present invention comprises the steps of: (a) dissolving freeze-dried fibrinogen in an aprotinin solution; (b) dissolving freeze-dried thrombin in a stabilizing solution; (c) mixing an enriched collagen solution with thrombin and the stabilizing solution; and installing the fibrinogen solution (a) to one side of a dual kit and the solution (c) containing the collagen to the other side, and then mixing and injecting into damaged cartilaginous tissue. In the present invention, which is constituted as described above, biomaterials such as collagen and fibrin are mixed so as to allow damaged cartilaginous tissue to be repaired to a state allowing transplantation onto the tissue, and efficient regeneration is induced, thereby making it possible to reduce surgery-related stress on people and animals while inducing relatively rapid and efficient cartilage repair and regeneration.
摘要翻译：本发明涉及一种用于软骨组织修复的组合物及其制备方法。本发明包括以下步骤：（a）将冷冻干燥的纤维蛋白原溶解在抑肽酶溶液中; （b）将冻干凝血酶溶解在稳定溶液中; （c）将富集的胶原溶液与凝血酶和稳定溶液混合; 并将纤维蛋白原溶液（a）安装在双重试剂盒的一侧和将胶原蛋白溶液（c）另一侧，然后混合并注入损伤的软骨组织中。在如上所述构成的本发明中，混合了诸如胶原和纤维蛋白等生物材料，以便使损伤的软骨组织被修复到允许移植到组织上的状态，从而可以有效地再生，减少对人和动物的手术相关压力，同时诱导相对快速和有效的软骨修复和再生。

5. 发明申请

US20120207736A1 COMPOSITION FOR CARTILAGINOUS TISSUE REPAIR AND A PRODUCTION METHOD THEREFOR 审中-公开
标题翻译：用于组织织物修复的组合物及其生产方法
公开(公告)号：US20120207736A1
公开(公告)日：2012-08-16
申请号：US13503228
申请日：2009-12-03
申请人： Cheong-Ho Jang , Ji-Chul Yu , Sae-Bom Lee , Hyun-Shin Park , Hyun-Jo Kim , Jae-Deog Jang , Se-Ken Yeo , Ju-Hee Park , Seok-Jung Kim
发明人： Cheong-Ho Jang , Ji-Chul Yu , Sae-Bom Lee , Hyun-Shin Park , Hyun-Jo Kim , Jae-Deog Jang , Se-Ken Yeo , Ju-Hee Park , Seok-Jung Kim
IPC分类号： A61K38/48 , A61P19/00
CPC分类号： A61L27/26 , A61F2002/30766 , A61L2400/06 , A61L2430/06 , C08L89/06
摘要： The present invention relates to a composition for cartilaginous tissue repair and to a production method therefor. The present invention comprises the steps of: (a) dissolving freeze-dried fibrinogen in an aprotinin solution; (b) dissolving freeze-dried thrombin in a stabilizing solution; (c) mixing an enriched collagen solution with thrombin and the stabilizing solution; and installing the fibrinogen solution (a) to one side of a dual kit and the solution (c) containing the collagen to the other side, and then mixing and injecting into damaged cartilaginous tissue. In the present invention, which is constituted as described above, biomaterials such as collagen and fibrin are mixed so as to allow damaged cartilaginous tissue to be repaired to a state allowing transplantation onto the tissue, and efficient regeneration is induced, thereby making it possible to reduce surgery-related stress on people and animals while inducing relatively rapid and efficient cartilage repair and regeneration.
摘要翻译：本发明涉及一种用于软骨组织修复的组合物及其制备方法。本发明包括以下步骤：（a）将冷冻干燥的纤维蛋白原溶解在抑肽酶溶液中; （b）将冻干凝血酶溶解在稳定溶液中; （c）将富集的胶原溶液与凝血酶和稳定溶液混合; 并将纤维蛋白原溶液（a）安装在双重试剂盒的一侧和将胶原蛋白溶液（c）另一侧，然后混合并注入损伤的软骨组织中。在如上所述构成的本发明中，混合了诸如胶原和纤维蛋白等生物材料，以便将损伤的软骨组织修复到允许移植到组织上的状态，从而可以有效地再生，减少对人和动物的手术相关压力，同时诱导相对快速和有效的软骨修复和再生。

6. 发明申请

US20100034783A1 Medical kit and using method thereof 审中-公开
标题翻译：医疗套件及其使用方法
公开(公告)号：US20100034783A1
公开(公告)日：2010-02-11
申请号：US12311783
申请日：2006-11-03
申请人： Hyun-Mi Son , Cheong-Ho Chang , Jae-Deog Jang
发明人： Hyun-Mi Son , Cheong-Ho Chang , Jae-Deog Jang
IPC分类号： A61K35/12 , A61B10/00 , B65D81/18 , B65B7/28 , A61B5/15 , C12N5/02 , A01N1/02
CPC分类号： A61L27/3847 , A61F2/28 , A61F2/30756 , A61L27/3817 , A61L27/3821 , A61L27/3834 , A61L27/3852
摘要： An aseptic/sterile medical kits are comprising a cartilage regeneration kit, a bone regeneration kit or an umbilical cord blood storage kit in a configuration that each process performs according to functionally-specialized kit sets for each step, via division of overall processes into corresponding steps for isolation, culture, collection and storage of cells, and implantation of desired cells into target sites of the body. The cartilage is regenerated by cartilage tissue collection; chondrocyte isolation; chondrocyte medium change and subculture; preparation of chondrocyte therapy product; media for isolation/culture/preparation/cryopreservation of cells; and media for isolation/culture/cryopreservation of cells, using the cartilage regeneration kit. The bone is regenerated by bone marrow collection; osteoblast isolation; osteoblast medium change and subculture; and preparation of osteoblast therapy product, using the bone regeneration kit. Additionally, the umbilical cord blood is stored by umbilical cord blood collection; hematopoietic stem cell isolation; and cryopreservation of hematopoietic stem cells, using the umbilical cord blood storage kit.
摘要翻译：无菌/无菌医疗试剂盒包括软骨再生试剂盒，骨再生试剂盒或脐带血液存储试剂盒，其配置为每个过程根据功能上专门用于每一步骤的试剂盒进行，通过将整个过程分为对应步骤用于细胞的分离，培养，收集和储存，以及将期望的细胞植入人体的靶位点。软骨通过软骨组织收集再生; 软骨细胞分离; 软骨细胞培养基变化和亚文化; 软骨细胞治疗产品的制备; 介质用于分离/培养/制备/冷冻保存细胞; 和培养基用于细胞的分离/培养/冷冻保存，使用软骨再生试剂盒。骨骼通过骨髓采集再生; 成骨细胞分离; 成骨细胞介质变化和亚文化; 并使用骨再生试剂盒制备成骨细胞治疗产品。另外，脐带血通过脐带血采集储存; 造血干细胞分离; 并使用脐带血液储存试剂盒对造血干细胞进行冷冻保存。

7. 发明申请

US20090137965A1 Apparatus for Operating Syringe Piston 审中-公开
标题翻译：用于操作注射器活塞的装置
公开(公告)号：US20090137965A1
公开(公告)日：2009-05-28
申请号：US12226316
申请日：2006-06-02
申请人： Seok-Jung Kim , Cheong-Ho Chang , Jae-Deog Jang , Hyun-Shin Park , Sae-Bom Lee , Kyoung-Phil Byun
发明人： Seok-Jung Kim , Cheong-Ho Chang , Jae-Deog Jang , Hyun-Shin Park , Sae-Bom Lee , Kyoung-Phil Byun
IPC分类号： A61M5/315
CPC分类号： A61B17/8822 , A61M5/315
摘要： An apparatus for operating a syringe piston is developed, which is comprised of: a syringe mounting section for fixedly holding a syringe, a thread hole formed at an upper head part of the syringe mounting section, and a piston press unit having a threaded rod, which is inserted into the thread hole so that the syringe piston press unit can move up and down along the thread hole, a locking slot for fixedly inserting and retaining the medicine filled syringe, a semi-cylindrical tube to assemble with the syringe mounting section. The syringe filled with medical cement is attached to the syringe mounting section and the syringe piston is moved downward with no reverse movement when the piston press unit is rotated, so the medical cement contained in the syringe is injected with a constant pressure, so that a predetermined amount of medical cement is precisely injected into a patient's body.
摘要翻译：开发了一种用于操作注射器活塞的装置，其包括：用于固定地保持注射器的注射器安装部分，形成在注射器安装部分的上头部的螺纹孔和具有螺杆的活塞压力单元，其插入到螺纹孔中，使得注射器活塞压力单元可以沿着螺纹孔上下移动，用于固定地插入和保持药液填充的注射器的锁定槽，与注射器安装部分组装的半圆柱形管。填充有医用水泥的注射器被安装在注射器安装部上，当活塞压力单元旋转时，注射器活塞不会反向移动，所以注射器中所含的医用胶水被注入一定的压力，将预定量的医用水泥精确地注入患者体内。

8. 发明授权

US07781158B2 Method of separating collagen from the various animal tissues for producing collagen solution and product using the same 失效
标题翻译：从各种动物组织分离胶原蛋白以产生胶原蛋白溶液的方法和使用其的产品的方法
公开(公告)号：US07781158B2
公开(公告)日：2010-08-24
申请号：US11885386
申请日：2006-03-09
申请人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
发明人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
IPC分类号： A01N1/00 , C12P21/04 , C12P21/06 , A61K38/00 , A61K38/39 , C07K14/00
CPC分类号： C07K14/78
摘要： A method for separation the collagen from the various animal tissues is disclosed for preparing collagen solution and product using the same. The porcine tissues are processed to have proper form and size for acid-treatment. The acid-treatment is repeated with pepsin to separate type I or II collagens. The separated collagen is salt-treated for fractionation and ethanol-treated for obtaining 5˜10% of collagen from the initial tissue weight. The prepared tissues are processed for separating collagen through the collagen separating process. The separated collagen is processed for preparing product. The method for preparing product is comprised: treating a collagen solution having a predetermined concentration under a neutral condition at a low temperature, followed by overnight treatment at a temperature of 30 to 35° C.; concentrating collagen by centrifugation; and dissolving the thus-concentrated collagen in refrigerated weakly-acidic solvent or phosphate buffered saline (PBS), thereby preparing collagen having a concentration of 1 to 5 mg/mL.
摘要翻译：公开了从各种动物组织分离胶原蛋白的方法，用于制备胶原蛋白溶液和使用其的产品。将猪组织加工成具有适当的形式和尺寸以进行酸处理。用胃蛋白酶重复酸处理以分离I型或II型胶原蛋白。分离的胶原蛋白进行盐分处理以进行分级和乙醇处理，从初始组织重量获得5〜10％的胶原蛋白。处理所制备的组织通过胶原分离过程分离胶原。处理分离的胶原蛋白以制备产品。制备产品的方法包括：在低温下在中性条件下处理具有预定浓度的胶原溶液，然后在30至35℃的温度下进行过夜处理; 通过离心浓缩胶原蛋白; 将如此浓缩的胶原蛋白溶解在冷冻的弱酸性溶剂或磷酸盐缓冲盐水（PBS）中，由此制备浓度为1〜5mg / mL的胶原。

9. 发明申请

US20080118947A1 Method of Separating Collagen From the Various Animal Tissues for Producing Collagen Solution and Product Using the Same 失效
标题翻译：从各种动物组织分离胶原蛋白的方法，用于生产胶原蛋白溶液和使用其的产品
公开(公告)号：US20080118947A1
公开(公告)日：2008-05-22
申请号：US11885386
申请日：2006-03-09
申请人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
发明人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
IPC分类号： C12P21/06 , C07K14/78 , A61K38/40
CPC分类号： C07K14/78
摘要： A method for separation the collagen from the various animal tissues is disclosed for preparing collagen solution and product using the same. The porcine tissues are processed to have proper form and size for acid-treatment. The acid-treatment is repeated with pepsin to separate type I or II collagens. The separated collagen is salt-treated for fractionation and ethanol-treated for obtaining 5˜10% of collagen from the initial tissue weight. The prepared tissues are processed for separating collagen through the collagen separating process. The separated collagen is processed for preparing product. The method for preparing product is comprised: treating a collagen solution having a predetermined concentration under a neutral condition at a low temperature, followed by overnight treatment at a temperature of 30 to 35° C.; concentrating collagen by centrifugation; and dissolving the thus-concentrated collagen in refrigerated weakly-acidic solvent or phosphate buffered saline (PBS), thereby preparing collagen having a concentration of 1 to 5 mg/mL.
摘要翻译：公开了从各种动物组织分离胶原蛋白的方法，用于制备胶原蛋白溶液和使用其的产品。将猪组织加工成具有适当的形式和尺寸用于酸处理。用胃蛋白酶重复酸处理以分离I型或II型胶原蛋白。分离的胶原蛋白进行盐分处理以进行分级和乙醇处理，从初始组织重量获得5〜10％的胶原蛋白。处理所制备的组织以通过胶原分离过程分离胶原。处理分离的胶原蛋白以制备产品。制备产品的方法包括：在低温下在中性条件下处理具有预定浓度的胶原溶液，然后在30至35℃的温度下进行过夜处理; 通过离心浓缩胶原蛋白; 将如此浓缩的胶原蛋白溶解在冷冻的弱酸性溶剂或磷酸盐缓冲盐水（PBS）中，由此制备浓度为1〜5mg / mL的胶原。

10. 发明申请

US20150073351A1 Apparatus for Operating Syringe Piston 审中-公开
标题翻译：用于操作注射器活塞的装置
公开(公告)号：US20150073351A1
公开(公告)日：2015-03-12
申请号：US14019657
申请日：2013-09-06
申请人： Seok-Jung KIM , Cheong-Ho CHANG , Jae-Deog JANG , Hyun-Shin PARK , Sae-Bom LEE , Kyoung-Phil BYUN
发明人： Seok-Jung KIM , Cheong-Ho CHANG , Jae-Deog JANG , Hyun-Shin PARK , Sae-Bom LEE , Kyoung-Phil BYUN
IPC分类号： A61M5/315 , A61M5/31
CPC分类号： A61M5/31511 , A61M5/20 , A61M5/31 , A61M5/31565 , A61M5/484 , A61M2005/2026
摘要： An apparatus for operating a syringe has developed comprising that: an upper semi-cylindrical tube section, semi-circular groove shaped locking slot and lower semi-cylindrical tube section. The upper semi-cylindrical tube section is integrally formed an upper head part with a threaded hole for axial movement. The lower semi-cylindrical tube section forms a top portion, intermediate portion and end portion. A diameter (Dc) at the intermediate portion is larger than the diameter (Dtip) at end portion, which is gradually reduced from intermediate to end portion. The length of tapered portion is same as that of the constant diameter portion. A tip portion has formed an opened semi-circular shape to simply overlap the syringe over the syringe mounting device for easily snapping-in and out. The syringe piston moves downward with no reverse action when the piston press unit is rotated, so that it is possible to inject the precise amount of medical to a patient with constant pressure.
摘要翻译：已经开发了一种用于操作注射器的装置，其包括：上半圆筒管部分，半圆形槽形锁定槽和下半圆筒管部分。上部半圆柱形管部分一体地形成有具有用于轴向移动的螺纹孔的上部头部。下半圆柱形管部分形成顶部，中间部分和端部。中间部分处的直径（Dc）大于从中间部分逐渐减小的端部处的直径（Dtip）。锥形部分的长度与恒定直径部分的长度相同。尖端部分形成为开放的半圆形形状，以便在注射器安装装置上简单地将注射器重叠，以便容易地进入和退出。当活塞压力单元旋转时，注射器活塞向下移动而不反作用，从而可以将恒定压力的精确量的医疗注射给患者。

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