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    • 2. 发明申请
    • Fibrin Contained Semi-Solid Osteoblast Composition for Curing Bone Fracture and Method for Producing the Same
    • 用于固化骨折的纤维蛋白含有半固体成骨细胞组合物及其制备方法
    • US20080213229A1
    • 2008-09-04
    • US11885943
    • 2005-08-03
    • Hyun-Shin ParkJae-Deog JangCheong-Ho ChangSoo-Jin JungSae-Bom LeeChang-Kwon Ko
    • Hyun-Shin ParkJae-Deog JangCheong-Ho ChangSoo-Jin JungSae-Bom LeeChang-Kwon Ko
    • A61K35/12
    • A61K35/32A61K38/363A61K38/4833A61K2300/00
    • A method for producing the fibrin contained semi-solid osteoblast composition has developed for treating the bone fracture. The method is comprised of: isolating osteoblasts from a bone tissue and culturing/proliferating the isolated osteoblasts in Dulbecco's Modified Eagle's Medium (DMEM) or Minimum Essential Medium, Alpha Modification (α-MEM) to prepare an osteoblast suspension. Then, mixing the resulting osteoblast suspension with a coagulation factor to prepare an osteoblast therapeutic agent. Accordingly, the fibrin contained semi-solid osteoblast composition of the present invention has capability to achieve the bone grafting for performing bone union without the clinical graft rejection. It is possible to uniformly distribute the fibrin mixed semi-solid osteoblast composition into the affected area of the bone fracture via injection. Therefore, the fibrin contained semi-solid osteoblast composition is effectively and rapidly cure the bone fracture via constant injection of into the affected area.
    • 已经开发了用于生产含有纤维蛋白的半固体成骨细胞组合物的方法用于治疗骨折。 该方法包括:从骨组织中分离成骨细胞并在Dulbecco's Modified Eagle's Medium(DMEM)或Minimum Essential Medium,Alpha Modification(α-MEM))中培养/增殖分离的成骨细胞以制备成骨细胞悬浮液。 然后,将得到的成骨细胞悬浮液与凝血因子混合,制备成骨细胞治疗剂。 因此,本发明的纤维蛋白含有半固体成骨细胞组合物具有实现骨移植以进行骨结合而没有临床移植排斥的能力。 可以通过注射将纤维蛋白混合的半固体成骨细胞组合物均匀地分布到骨折的受影响区域中。 因此,含有纤维蛋白的半固体成骨细胞组合物通过持续注射进入受影响的区域,有效快速地治愈了骨折。