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1. 发明专利

JPH09100227A SOLID MATRIX SYSTEM FOR PERCUTANEOUS DRUG DELIVERY 失效
公开(公告)号：JPH09100227A
公开(公告)日：1997-04-15
申请号：JP19501396
申请日：1996-07-24
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： CHIAAMIN CHIYAN , RENII AN TENZERU
IPC分类号： A61K9/70 , A61K31/56 , A61K31/565 , A61K31/57 , A61K47/32 , C07J1/00 , C07J7/00
摘要： PROBLEM TO BE SOLVED: To obtain a medicinal matrix structure which can administer an effective does of the medicine in no need of skin penetration accelerator. SOLUTION: The medicine is dispersed in a matrix containing a pressure- sensitively adhering acrylate copolymer (for example, vinyl acetate-acrylate copolymer). The medicine is selected from the group consisting of androgen, progestogen, estrogen, estradiol, norethindrone, norethindrone acetate, progesterone, estrogen, estradiol and a mixture of progestogen and estrogen and the amount is 0.5-25wt.%. The medicine is incorporated into the matrix and sent to the patient in no need of a skin penetration accelerator. The medicine is prepared in a form of the percutaneous drug delivery system. The system is prepared in a laminated form comprising the backing layer along the surface of the drug-impermeable synthetic material and the bottom layer containing the matrix layer containing the medicine. The matrix preferably contains a water-soluble polymer.

2. 发明专利

JP2000026284A SOLID MATRIX SYSTEM FOR PERCUTANEOUS DRUG DELIVERY 失效
公开(公告)号：JP2000026284A
公开(公告)日：2000-01-25
申请号：JP17034699
申请日：1999-06-16
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： CHIANG CHIA-MING , TENZEL RENEE A
IPC分类号： A61K9/70 , A61K31/56 , A61K31/565 , A61K31/57 , A61K47/32 , C07J1/00 , C07J7/00
摘要： PROBLEM TO BE SOLVED: To administer estrogen at a high rate without adding a permeation promoting agent by integrating estrogen in a matrix containing a pressure- sensitive tacky adhesive copolymer such as vinyl acetate-acrylate copolymer and delivering the estrogen from the matrix into blood flow. SOLUTION: A drug such as estrogen is dispersed in a pressure-sensitive tacky adhesive copolymer containing e.g. 2-ethylhexyl acrylate and a comonomer selected from vinyl acetate, acrylic acid and methyl acrylate and the dispersion is used as a drug-containing matrix for a percutaneous drug delivery device. The matrix of the above device preferably further contains a hydrophilic polymer, e.g. a water-soluble polymer such as polyvinyl alcohol or polyvinylpyrrolidone. The thickness of the matrix is preferably about 10-250 μm.

3. 发明专利

JP2000000227A BIOSENSOR, ION PERMEATION SAMPLING SYSTEM AND ITS USE 失效
公开(公告)号：JP2000000227A
公开(公告)日：2000-01-07
申请号：JP6743199
申请日：1999-03-12
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： KIM LYNN , PARRIS NORMAN A , POTTS RUSSELL O , JANET A TAMADA , TIERNEY MICHAEL J
IPC分类号： A61B5/00 , A61B5/0408 , A61B5/145 , A61B5/1477 , A61N1/30 , G01N27/28 , G01N27/30 , G01N27/416 , G01N33/487 , G01N33/66
摘要： PROBLEM TO BE SOLVED: To provide a device for noninvasively and exactly measure the concn. of a small amt. of a target article to be analyzed existing in a biological system at a low cost and a measurement method therefor. SOLUTION: The sampling system for monitoring the concn. of the article to be analyzed existing in the biological system has a reservoir which contains an ion conductive medium and an enzyme capable of forming hydrogen peroxide by reacting with the article to be analyzed, a sampling means which extracts the article to be analyzed into the reservoir from the biological system forms the hydrogen peroxide by reacting with the enzyme in the reservoir and obtains the article to be analyzed of the concn. below millimol, which sampling systems comes into contact operatively with the reservoir, and a sensor element which comes into contact operatively with the reservoir.

4. 发明专利

JP2002191582A INSTRUMENT AND METHOD FOR ION INDUCTION SAMPLING 审中-公开
公开(公告)号：JP2002191582A
公开(公告)日：2002-07-09
申请号：JP2001338791
申请日：2001-11-02
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： TAMADA JANET , AZIMI NOOSHIN T , LEUNG LEWIS , LEE RICHARD K T , PLANTE PHILLIP J , BHAYANI BHASKAR V , CAO MICHAEL , TIERNEY MICHAEL J , VIJAYAKUMAR PREMA
IPC分类号： G01N33/483 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1459 , A61B5/1473 , A61B5/1477 , A61B5/1495 , A61N1/30 , G01N27/04 , G01N27/416 , G01N27/42 , G01N30/88 , G01N33/66
摘要： PROBLEM TO BE SOLVED: To improve a percutaneous monitor method and an instrument therefor using a preceding technique by providing an ion induction sampling instrument having an integrated sensor for monitoring the blood concentration of a target substance or of a configuration element in terms of non-invasion. SOLUTION: The ion induction instrument is the instrument for percutaneous monitoring and is provided with a first collection reserver having a first ion conductive medium (111), a second collection reserver having a second ion conductive medium (113), a first ion induction electrode (162) being brought into contact with the first conductive medium (111), a second ion induction electrode (164) being brought into contact with the second conductive medium (113), a sensor for detecting the target substance which is comprised in at least one of the conductive media (111 and 113), and an ion induction power source (224).

5. 发明专利

JPH0881364A PRINTED SKIN-PERMEABLE DRUG ADMINISTRATION TOOL 失效
公开(公告)号：JPH0881364A
公开(公告)日：1996-03-26
申请号：JP17650195
申请日：1995-07-12
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： JIIZASU MIRANDA , GEERII DABURIYU KUREARII
IPC分类号： A61F13/02 , A61F20060101 , A61K9/70
摘要： PROBLEM TO BE SOLVED: To provide a transdermal drug delivery device for the administration of a drug to the skin or the mucosa at a controllable and therapeutically effective rate. SOLUTION: This device is provided with a synthesized laminate composed of the following layers (a) to (e). (a) A backing layer scarcely permeable to drug and defining the upper surface of the delivery device, (b) a fixed adhesive layer placed adjacent to the face opposite to the backing layer and laminated to the face, (c) a pressure-sensitive adhesive layer made of a drug-permeable material, defining the base surface of the delivery device, bonded in contact with the skin in the case of using the delivery device and meeting the pharmaceutical standards, (d) an adsorptive porous layer placed in contact with and between the layers (b) and (c), and (e) a drug dispersed in the pressure-sensitive adhesive layer and the fixed adhesive layer and optionally in the layer (b) and the above part of the layer (b). The device is preferably provided further with a releasable liner layer covering the lower surface defined by the pressure- sensitive adhesive layer and the liner is provided with a layer which is removed from the delivery device before use for exposing the lower surface of the pressure-sensitive adhesive layer.

6. 发明专利

JPH0840937A PHARMACEUTICAL COMPOSITION FOR PERCUTANEOUS DOSAGE, CONTAINING FATTY ACID ESTER/ETHER OF ALKANE DIOL 失效
公开(公告)号：JPH0840937A
公开(公告)日：1996-02-13
申请号：JP20122895
申请日：1995-08-07
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： GEIRII DABURIYU KURIARII
IPC分类号： A61K9/00 , A61K9/70 , A61K31/445 , A61K47/14
摘要： PROBLEM TO BE SOLVED: To obtain a pharmaceutical composition for transdermal administration, containing a specific nonaqueous mixture of a polymer with a drug and a prescribed amount of a 2-4C fatty acid ester or a fatty alcohol ether of a 2-4C alkanediol and capable of increasing the solubility of the drug into the polymer and excellent in dermal permeability. SOLUTION: This pharmaceutical composition in the form of a solid transdermal drug-delivery device 11 containing a nonaqueous mixture of (A) a polymer such as a polyether block amide copolymer with (B) a drug such as a steroid, an estradiol or fentanil (analog) and (C) a permeation enhancing amount of a fatty acid ester or a fatty alcohol ether of a 2-4C alkanediol (the fatty acid or fatty alcohol portion is preferably of 8-22 carbon atoms). The device 11 is preferably a laminated composite of a holding layer and a pressure- sensitive adhesive layer 17.

7. 发明申请

WO0217210A3 FORMULATION AND MANIPULATION OF DATABASES OF ANALYTE AND ASSOCIATED VALUES 审中-公开
标题翻译：分析数据库和相关值数据库的配置和操作
公开(公告)号：WO0217210A3
公开(公告)日：2003-03-27
申请号：PCT/US0125154
申请日：2001-08-10
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： FORD RUSSELL , LESHO MATTHEW J , POTTS RUSSELL O , TIERNEY MICHAEL J , WEI CHARLES W
IPC分类号： G06F19/00
CPC分类号： G16H10/40 , G06F19/3456 , G16H10/60 , G16H40/63 , Y10S707/99945 , Y10S707/99948
摘要： The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.
摘要翻译：本发明涉及配制分析物数据数据库的方法，数据库本身及其操作方法。一方面，本发明包括分析物数据点，派生数据和数据属性数据库的配方，其包括使用能够频繁地监测分析物浓度或量的分析物监测装置收集的数据点。这样的数据点可以包括获取的数据（例如，对应于由所述分析物监测装置测量的分析物浓度或量的值）。然后将这些数据点与一个或多个相关数据属性相关联。可以操纵生成的数据库以确定数据库的组件之间的关系。

8. 发明申请

WO1996000110A1 IONTOPHORETIC SAMPLING DEVICE AND METHOD 审中-公开
标题翻译：独立取样装置及方法
公开(公告)号：WO1996000110A1
公开(公告)日：1996-01-04
申请号：PCT/US1995007692
申请日：1995-06-23
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： CYGNUS THERAPEUTIC SYSTEMS , TAMADA, Janet , AZIMI, Nooshin, T. , LEUNG, Lewis , LEE, Richard, K-T , PLANTE, Phillip, J. , BHAYANI, Bhaskar, V. , CAO, Michael , TIERNEY, Michael, J. , VIJAYAKUMAR, Prema
IPC分类号： A61N01/30
CPC分类号： A61B5/14532
摘要： An iontophoresis apparatus for the transdermal monitoring of a target substance comprising: first and second collection reservoirs, the first collection reservoir comprising a first ionically conductive medium (111) and the second collection reservoir comprising a second ionically conductive medium (113); a first iontophoresis electrode (162) in contact with the first conductive medium (111) and a second iontophoresis electrode (164) in contact with the second conductive medium (113); a sensor for detecting the target substance contained within at least one conductive medium (111, 113); and an iontophoretic power source (224). The conductive medium (111, 113) is either an ionically conductive hydrogel or a wicking material containing an ionically conductive medium. The invention also includes a collection reservoir for use with an iontophoresis apparatus for the transdermal monitoring of a target substance, the collection reservoir comprising an ionically conductive hydrogel having a pH in the range of from about 4.0 to about 10.0 and an enzyme reactive with the target substance. The invention also includes a method for using the transdermal monitoring apparatus. In particular, the invention is a method for continuous in vivo monitoring of the blood glucose level of a patient comprising the following steps: (a) placing a collection reservoir on a collection site on a tissue surface of the patient; (b) applying electrical energy to the collection site to move glucose or a glucose metabolite into the collection reservoir; (c) analyzing the collection reservoir for concentration of glucose or glucose metabolite; (d) correlating the concentration determined in step (c) with blood glucose level; and (e) performing steps (a)-(d) substantially continuously.
摘要翻译：一种用于透皮监测目标物质的离子电渗仪，包括：第一和第二收集容器，所述第一收集容器包括第一离子导电介质，所述第二收集容器包括第二离子导电介质; 与第一导电介质（111）接触的第一离子电渗电极（162）和与第二导电介质（113）接触的第二离子电渗电极（164）; 用于检测包含在至少一个导电介质（111,113）内的目标物质的传感器; 和离子电渗电源（224）。导电介质（111,113）是离子导电水凝胶或含有离子导电介质的芯吸材料。本发明还包括一种与用于透皮监测目标物质的离子电渗仪器一起使用的收集容器，所述收集容器包含pH范围为约4.0至约10.0的离子导电水凝胶和与目标物反应的酶物质。本发明还包括使用透皮监视装置的方法。特别地，本发明是用于连续体内监测患者的血糖水平的方法，包括以下步骤：（a）将收集容器放置在患者的组织表面上的收集部位上; （b）将电能施加到收集位置以将葡萄糖或葡萄糖代谢物移动到收集容器中; （c）分析收集库用于浓缩葡萄糖或葡萄糖代谢物; （d）将步骤（c）中确定的浓度与血糖水平相关; 和（e）基本连续地执行步骤（a） - （d）。

9. 发明申请

WO9505416A3 WATER-SOLUBLE PRESSURE-SENSITIVE MUCOADHESIVE AND DEVICES PROVIDED THEREWITH FOR EMPLACEMENT IN A MUCOSA-LINED BODY CAVITY 审中-公开
标题翻译：水溶性压敏敏感剂及其在MUCOSA-LINED BODY CAVITY中的应用提供的设备
公开(公告)号：WO9505416A3
公开(公告)日：1995-03-23
申请号：PCT/US9409305
申请日：1994-08-19
申请人： CYGNUS THERAPEUTIC SYSTEMS , BIEGAJSKI JAMES E , VENKATRAMAN SUBBU S , SCOTT ANN M
发明人： BIEGAJSKI JAMES E , VENKATRAMAN SUBBU S , SCOTT ANN M
IPC分类号： A61K9/70 , A61F6/06 , A61F13/00 , A61F13/02 , A61K6/00 , A61K9/00 , C08K5/10 , C09J9/00 , C09J101/08 , C09J103/00 , C09J103/02 , C09J105/00 , C09J107/00 , C09J129/04 , C09J133/02 , C09J137/00 , C09J139/06 , C09J171/00 , C09J171/02 , C09J189/00 , C09J193/00 , C09J201/00 , C08L1/26 , C08K5/11
CPC分类号： C09J139/06 , A61F6/06 , A61F13/023 , A61F13/0253 , A61F2013/00642 , A61F2013/00685 , A61F2013/0071 , A61F2013/00714 , A61F2013/00906 , A61F2013/0091 , A61F2013/00914 , A61K9/006 , C08K5/10 , C08L2666/28 , C08L2666/34 , C09J201/00 , C09J2201/606 , C08L39/06 , A61K6/0026 , C08L1/284 , C08L1/286 , C08L29/04 , C08L71/02 , C08L33/08
摘要： PCT No. PCT/US94/09305 Sec. 371 Date Aug. 3, 1995 Sec. 102(e) Date Aug. 3, 1995 PCT Filed Aug. 19, 1994 PCT Pub. No. WO95/05416 PCT Pub. Date Feb. 23, 1995Water-soluble pressure-sensitive adhesives include a water-soluble polymer that is made tacky at room temperature by addition of a water-soluble plasticizer that is miscible with the polymer. Suitable polymers are solid at room temperature; and have a hydrophilicity as measured by water uptake greater than about 25%; they are liquid at room temperature and have a boiling point higher than about 80 DEG C. The adhesives according to the invention may conveniently be provided in dry film form. Preferred water-soluble pressure-sensitive adhesives of the invention adhere both to mucosal surfaces and to a variety of materials that may constitute a part of a device or prosthesis to be held in a body cavity that has a mucosal lining. Also, a laminated device for the controlled release of a substance within a mucosa-lined body cavity includes the substance dissolved or dispersed in either or both of a water-soluble pressure-sensitive adhesive layer and optionally one or more water-soluble polymer layers. Also, devices for administering a substance over an extended time for relief of sore throat or cough, or for administering a breath freshening agent, particularly a mint odorant, include a water soluble polymer film layer containing the active ingredient, and a water soluble pressure sensitive mucoadhesive layer.

10. 发明申请

WO1994004109A1 PRINTED TRANSDERMAL DRUG DELIVERY DEVICE 审中-公开
标题翻译：印刷转印药物递送装置
公开(公告)号：WO1994004109A1
公开(公告)日：1994-03-03
申请号：PCT/US1992010672
申请日：1992-12-10
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： CYGNUS THERAPEUTIC SYSTEMS , MIRANDA, Jesus , CLEARY, Gary, W.
IPC分类号： A61F13/00
CPC分类号： A61K9/703 , A61K9/7084 , A61K31/465
摘要： A transdermal drug delivery device (10) which can be worn by a human patient for 24 hours while continuously delivering a drug to the patient for approximately 16 hours is produced by a particular method of manufacture. The device (10) is particularly useful with respect to the delivery of drugs which, if delivered for 24 hours, result in problems such as drug tolerance (e.g., nitroglycerin) or sleep disorders (e.g., nicotine). The drug is loaded into the device (10) in a concentration such that the drug becomes depleted from the device after approximately 16 hours to the extent that the rate of delivery of the drug to the patient is slowed to such an extent that the pharmacological effect of the drug on the patient becomes substantially nonexistent. The device (10) is in the form of a laminated composite that is adpated to be adhered to a predetermined area of unbroken skin or mucosal tissue. The individual layers of the device include an upper backing or "outer skin" layer (11), an anchor adhesive layer (12), a source layer (13) onto which the drug and/or vehicles are deposited initially, a contact adhesive (14) which is adapted to adhere to the skin or mucosa, and a release liner (15).
摘要翻译：通过特定的制造方法生产可由人类患者佩戴24小时，同时向药物持续输送药物约16小时的透皮药物输送装置（10）。装置（10）对于递送药物而言是特别有用的，如果在24小时内递送，则导致药物耐受性（例如硝酸甘油）或睡眠障碍（例如尼古丁）等问题。将药物以如下浓度装载到装置（10）中，使得药物在大约16小时后从装置中耗尽到药物递送到患者的速度降低到药理作用的程度的药物基本上不存在。装置（10）是层叠复合材料的形式，其被贴合以粘附到未破裂的皮肤或粘膜组织的预定区域。装置的各个层包括上背衬或“外皮”层（11），锚固粘合剂层（12），最初沉积药物和/或载体的源层（13），接触粘合剂 14），其适于粘附到皮肤或粘膜上，以及释放衬垫（15）。

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