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1. 发明申请

WO1996025910A1 WATER-SOLUBLE PRESSURE-SENSITIVE MUCOADHESIVE 审中-公开
标题翻译：水溶性感压敏感
公开(公告)号：WO1996025910A1
公开(公告)日：1996-08-29
申请号：PCT/US1996002666
申请日：1996-02-23
申请人： CYGNUS THERAPEUTIC SYSTEMS , BIEGAJSKI, James, E. , VENKATRAMAN, Subbu, S. , ABRAHAM, William
发明人： CYGNUS THERAPEUTIC SYSTEMS
IPC分类号： A61K06/00
CPC分类号： C08L1/284 , A61K9/006 , C08L39/06 , C08L2666/02 , C09J101/284 , A61K6/0026 , C08L33/08 , C08L29/04 , C08L1/286 , C08L33/10 , C08L1/12
摘要： Water-soluble pressure-sensitive adhesives include a water-soluble polymer that is made tacky at room temperature by addition of a water-soluble plasticizer that is miscible with the polymer. Suitable polymers are solid at room temperature and have a hydrophilicity as measured by water uptake greater than about 25 %. Suitable plasticizers are liquid at room temperature and having a boiling point higher than about 80 DEG C. The adhesives according to the invention may conveniently be provided in dry film form. Preferred water-soluble pressure-sensitive adhesives of the invention adhere both to mucosal surfaces and to a variety of materials that may constitute a part of a device or prosthesis to be held in a body cavity that has a mucosal lining, and adhesive films of the invention are useful as denture adhesives. For use in the oral cavity preferred adhesives of the invention are made of GRAS- or NF-certified materials.
摘要翻译：水溶性压敏粘合剂包括通过加入可与聚合物混溶的水溶性增塑剂在室温下变粘的水溶性聚合物。合适的聚合物在室温下为固体，并且具有通过吸水率大于约25％测量的亲水性。合适的增塑剂在室温下为液体，沸点高于约80℃。根据本发明的粘合剂可以方便地以干膜形式提供。本发明优选的水溶性压敏粘合剂既粘附于粘膜表面，也可以粘附到可以构成待保持在具有粘膜衬里的体腔中的装置或假体的一部分的各种材料，以及粘膜本发明可用作义齿粘合剂。为了在口腔中使用，本发明优选的粘合剂由GRAS或NF认证的材料制成。

2. 发明申请

WO9505416A3 WATER-SOLUBLE PRESSURE-SENSITIVE MUCOADHESIVE AND DEVICES PROVIDED THEREWITH FOR EMPLACEMENT IN A MUCOSA-LINED BODY CAVITY 审中-公开
标题翻译：水溶性压敏敏感剂及其在MUCOSA-LINED BODY CAVITY中的应用提供的设备
公开(公告)号：WO9505416A3
公开(公告)日：1995-03-23
申请号：PCT/US9409305
申请日：1994-08-19
申请人： CYGNUS THERAPEUTIC SYSTEMS , BIEGAJSKI JAMES E , VENKATRAMAN SUBBU S , SCOTT ANN M
发明人： BIEGAJSKI JAMES E , VENKATRAMAN SUBBU S , SCOTT ANN M
IPC分类号： A61K9/70 , A61F6/06 , A61F13/00 , A61F13/02 , A61K6/00 , A61K9/00 , C08K5/10 , C09J9/00 , C09J101/08 , C09J103/00 , C09J103/02 , C09J105/00 , C09J107/00 , C09J129/04 , C09J133/02 , C09J137/00 , C09J139/06 , C09J171/00 , C09J171/02 , C09J189/00 , C09J193/00 , C09J201/00 , C08L1/26 , C08K5/11
CPC分类号： C09J139/06 , A61F6/06 , A61F13/023 , A61F13/0253 , A61F2013/00642 , A61F2013/00685 , A61F2013/0071 , A61F2013/00714 , A61F2013/00906 , A61F2013/0091 , A61F2013/00914 , A61K9/006 , C08K5/10 , C08L2666/28 , C08L2666/34 , C09J201/00 , C09J2201/606 , C08L39/06 , A61K6/0026 , C08L1/284 , C08L1/286 , C08L29/04 , C08L71/02 , C08L33/08
摘要： PCT No. PCT/US94/09305 Sec. 371 Date Aug. 3, 1995 Sec. 102(e) Date Aug. 3, 1995 PCT Filed Aug. 19, 1994 PCT Pub. No. WO95/05416 PCT Pub. Date Feb. 23, 1995Water-soluble pressure-sensitive adhesives include a water-soluble polymer that is made tacky at room temperature by addition of a water-soluble plasticizer that is miscible with the polymer. Suitable polymers are solid at room temperature; and have a hydrophilicity as measured by water uptake greater than about 25%; they are liquid at room temperature and have a boiling point higher than about 80 DEG C. The adhesives according to the invention may conveniently be provided in dry film form. Preferred water-soluble pressure-sensitive adhesives of the invention adhere both to mucosal surfaces and to a variety of materials that may constitute a part of a device or prosthesis to be held in a body cavity that has a mucosal lining. Also, a laminated device for the controlled release of a substance within a mucosa-lined body cavity includes the substance dissolved or dispersed in either or both of a water-soluble pressure-sensitive adhesive layer and optionally one or more water-soluble polymer layers. Also, devices for administering a substance over an extended time for relief of sore throat or cough, or for administering a breath freshening agent, particularly a mint odorant, include a water soluble polymer film layer containing the active ingredient, and a water soluble pressure sensitive mucoadhesive layer.

3. 发明申请

WO2008002353A1 TWO-PHASE MUCOADHESIVE COMPOSITION 审中-公开
标题翻译：两相MUCOADHESIVE组合物
公开(公告)号：WO2008002353A1
公开(公告)日：2008-01-03
申请号：PCT/US2007/011095
申请日：2007-05-08
申请人： DOW PHARMACEUTICAL SCIENCES , BIEGAJSKI, James, E.
发明人： BIEGAJSKI, James, E.
IPC分类号： A61K9/14
CPC分类号： A61K9/0014 , A61K9/006 , A61K9/7015
摘要： A novel two-phase, film-forming, mucoadhesive gel composition has been developed. The composition contains an anhydrous non-aqueous solvent, a water-insoluble polymer that is dissolved in the non-aqueous solvent, and a water- soluble polymer that is dispersed in the non-aqueous solvent. The composition adheres to water-bearing surfaces, such as to moistened skin or mucosal surfaces, and can be used to provide extended, local delivery of pharmaceutically active agents from the composition to skin or a mucosal surface. The composition may be solvent-cast to form a mucoadhesive film, which may contain a polymeric backing layer. The mucoadhesive film may further contain a pharmaceutically active agent and may be used to administer the pharmaceutically active agent to skin or mucosal surfaces.
摘要翻译：已经开发了一种新型的两相，成膜，粘膜粘附凝胶组合物。该组合物包含无水非水溶剂，溶于非水溶剂中的水不溶性聚合物和分散在非水溶剂中的水溶性聚合物。组合物粘附到含水表面，例如润湿的皮肤或粘膜表面，并且可用于将药物活性剂从组合物延伸，局部递送到皮肤或粘膜表面。可以将组合物溶剂浇铸以形成粘膜粘附膜，其可以含有聚合物背衬层。粘膜粘附膜还可以含有药物活性剂，并可用于将药物活性剂施用于皮肤或粘膜表面。

4. 发明申请

WO1995005416A2 WATER-SOLUBLE PRESSURE-SENSITIVE MUCOADHESIVE AND DEVICES PROVIDED THEREWITH FOR EMPLACEMENT IN A MUCOSA-LINED BODY CAVITY 审中-公开
标题翻译：水溶性压敏敏感剂及其在MUCOSA-LINED BODY CAVITY中的应用提供的设备
公开(公告)号：WO1995005416A2
公开(公告)日：1995-02-23
申请号：PCT/US1994009305
申请日：1994-08-19
申请人： CYGNUS THERAPEUTIC SYSTEMS , BIEGAJSKI, James, E. , VENKATRAMAN, Subbu, S. , SCOTT, Ann, M.
发明人： CYGNUS THERAPEUTIC SYSTEMS
IPC分类号： C08L01/26
CPC分类号： C09J139/06 , A61F6/06 , A61F13/023 , A61F13/0253 , A61F2013/00642 , A61F2013/00685 , A61F2013/0071 , A61F2013/00714 , A61F2013/00906 , A61F2013/0091 , A61F2013/00914 , A61K9/006 , C08K5/10 , C08L2666/28 , C08L2666/34 , C09J201/00 , C09J2201/606 , C08L39/06 , A61K6/0026 , C08L1/284 , C08L1/286 , C08L29/04 , C08L71/02 , C08L33/08
摘要： Water-soluble pressure-sensitive adhesives include a water-soluble polymer that is made tacky at room temperature by addition of a water-soluble plasticizer that is miscible with the polymer. Suitable polymers are solid at room temperature; and have a hydrophilicity as measured by water uptake greater than about 25 %; they are liquid at room temperature and have a boiling point higher than about 80 DEG C. The adhesives according to the invention may conveniently be provided in dry film form. Preferred water-soluble pressure-sensitive adhesives of the invention adhere both to mucosal surfaces and to a variety of materials that may constitute a part of a device or prosthesis to be held in a body cavity that has a mucosal lining. Also, a laminated device for the controlled release of a substance within a mucosa-lined body cavity includes the substance dissolved or dispersed in either or both of a water-soluble pressure-sensitive adhesive layer and optionally one or more water-soluble polymer layers. Also, devices for administering a substance over an extended time for relief of sore throat or cough, or for administering a breath freshening agent, particularly a mint odorant, include a water soluble polymer film layer containing the active ingredient, and a water soluble pressure sensitive mucoadhesive layer.
摘要翻译：水溶性压敏粘合剂包括水溶性聚合物，其通过加入可与聚合物混溶的水溶性增塑剂在室温下变粘。合适的聚合物在室温下为固体; 并且具有通过吸水率大于约25％测量的亲水性; 它们在室温下为液体，沸点高于约80℃。根据本发明的粘合剂可以方便地以干膜形式提供。本发明优选的水溶性压敏粘合剂既粘附到粘膜表面，也可以粘附到可以构成待保持在具有粘膜衬里的体腔中的装置或假体的一部分的各种材料。而且，用于在粘膜内衬的体腔中控制释放物质的层压装置包括溶解或分散在水溶性压敏粘合剂层和任选的一种或多种水溶性聚合物层之一或两者中的物质。此外，用于长时间施用物质以缓解喉咙痛或咳嗽或用于施用呼吸清新剂，特别是薄荷味剂的装置包括含有活性成分的水溶性聚合物膜层和水溶性压敏粘膜粘附层。

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