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1. 发明申请

WO1996000110A1 IONTOPHORETIC SAMPLING DEVICE AND METHOD 审中-公开
标题翻译：独立取样装置及方法
公开(公告)号：WO1996000110A1
公开(公告)日：1996-01-04
申请号：PCT/US1995007692
申请日：1995-06-23
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： CYGNUS THERAPEUTIC SYSTEMS , TAMADA, Janet , AZIMI, Nooshin, T. , LEUNG, Lewis , LEE, Richard, K-T , PLANTE, Phillip, J. , BHAYANI, Bhaskar, V. , CAO, Michael , TIERNEY, Michael, J. , VIJAYAKUMAR, Prema
IPC分类号： A61N01/30
CPC分类号： A61B5/14532
摘要： An iontophoresis apparatus for the transdermal monitoring of a target substance comprising: first and second collection reservoirs, the first collection reservoir comprising a first ionically conductive medium (111) and the second collection reservoir comprising a second ionically conductive medium (113); a first iontophoresis electrode (162) in contact with the first conductive medium (111) and a second iontophoresis electrode (164) in contact with the second conductive medium (113); a sensor for detecting the target substance contained within at least one conductive medium (111, 113); and an iontophoretic power source (224). The conductive medium (111, 113) is either an ionically conductive hydrogel or a wicking material containing an ionically conductive medium. The invention also includes a collection reservoir for use with an iontophoresis apparatus for the transdermal monitoring of a target substance, the collection reservoir comprising an ionically conductive hydrogel having a pH in the range of from about 4.0 to about 10.0 and an enzyme reactive with the target substance. The invention also includes a method for using the transdermal monitoring apparatus. In particular, the invention is a method for continuous in vivo monitoring of the blood glucose level of a patient comprising the following steps: (a) placing a collection reservoir on a collection site on a tissue surface of the patient; (b) applying electrical energy to the collection site to move glucose or a glucose metabolite into the collection reservoir; (c) analyzing the collection reservoir for concentration of glucose or glucose metabolite; (d) correlating the concentration determined in step (c) with blood glucose level; and (e) performing steps (a)-(d) substantially continuously.
摘要翻译：一种用于透皮监测目标物质的离子电渗仪，包括：第一和第二收集容器，所述第一收集容器包括第一离子导电介质，所述第二收集容器包括第二离子导电介质; 与第一导电介质（111）接触的第一离子电渗电极（162）和与第二导电介质（113）接触的第二离子电渗电极（164）; 用于检测包含在至少一个导电介质（111,113）内的目标物质的传感器; 和离子电渗电源（224）。导电介质（111,113）是离子导电水凝胶或含有离子导电介质的芯吸材料。本发明还包括一种与用于透皮监测目标物质的离子电渗仪器一起使用的收集容器，所述收集容器包含pH范围为约4.0至约10.0的离子导电水凝胶和与目标物反应的酶物质。本发明还包括使用透皮监视装置的方法。特别地，本发明是用于连续体内监测患者的血糖水平的方法，包括以下步骤：（a）将收集容器放置在患者的组织表面上的收集部位上; （b）将电能施加到收集位置以将葡萄糖或葡萄糖代谢物移动到收集容器中; （c）分析收集库用于浓缩葡萄糖或葡萄糖代谢物; （d）将步骤（c）中确定的浓度与血糖水平相关; 和（e）基本连续地执行步骤（a） - （d）。

2. 发明申请

WO1996000109A1 DEVICE AND METHOD FOR SAMPLING OF SUBSTANCES USING ALTERNATING POLARITY 审中-公开
标题翻译：使用替代极性取样物质的装置和方法
公开(公告)号：WO1996000109A1
公开(公告)日：1996-01-04
申请号：PCT/US1995007579
申请日：1995-06-23
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： CYGNUS THERAPEUTIC SYSTEMS , TAMADA, Janet
IPC分类号： A61N01/30
CPC分类号： A61B5/6833 , A61B5/14532
摘要： A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the subject in a first direction in one or more sampling chambers that function alternatively as both an anode and cathode during the course of the method; reversing the polarity to cause direct current to flow in second direction opposite the first direction; and analyzing the sampling chamber or chambers for the concentration of a substance or a substance metabolite. There is also provided a device for sampling of a substance from an organism on continuously or intermittently using alternating polarity method based on the application of low intensity electric fields of alternating polarity across the skin (iontophoresis) to enhance the transport of a substance (such as glucose, lactic acid, pyruvic acid, and the like) from body tissues to a sampling chamber. The device comprises an electrical power supply; a transdermal system that contains one ro more sampling chambers that function as both anode and cathode during the course of sampling; a means to alternate or reverse the polarity during the iontophoretic sampling; and means for analyzing for the concentration of a substance or a substance metabolite.
摘要翻译：提供了一种用于从受试者取样物质的方法，其包括将一个或多个取样室放置在受试者的组织表面上的收集部位上; 在所述方法的过程中，在一个或多个采样室中以电流作为阳极和阴极的方式，将电流传导通过所述组织以从第一方向从所述受检者提取物质; 反转极性以使直流电流沿与第一方向相反的第二方向流动; 并分析用于物质或物质代谢物浓缩的取样室或室。还提供了一种基于通过皮肤交替极性的低强度电场（离子电渗疗法）的连续或间歇地使用交替极性方法从生物体中取样物质以增强物质（例如葡萄糖，乳酸，丙酮酸等）从身体组织到采样室。该装置包括电源; 经皮系统，其在采样过程中包含一个更多的采样室，起阳极和阴极的作用; 在离子电渗检测过程中交替或反转极性的方法; 以及用于分析物质或物质代谢物的浓度的方法。

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