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1. 发明申请

WO0217210A3 FORMULATION AND MANIPULATION OF DATABASES OF ANALYTE AND ASSOCIATED VALUES 审中-公开
标题翻译：分析数据库和相关值数据库的配置和操作
公开(公告)号：WO0217210A3
公开(公告)日：2003-03-27
申请号：PCT/US0125154
申请日：2001-08-10
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： FORD RUSSELL , LESHO MATTHEW J , POTTS RUSSELL O , TIERNEY MICHAEL J , WEI CHARLES W
IPC分类号： G06F19/00
CPC分类号： G16H10/40 , G06F19/3456 , G16H10/60 , G16H40/63 , Y10S707/99945 , Y10S707/99948
摘要： The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.
摘要翻译：本发明涉及配制分析物数据数据库的方法，数据库本身及其操作方法。一方面，本发明包括分析物数据点，派生数据和数据属性数据库的配方，其包括使用能够频繁地监测分析物浓度或量的分析物监测装置收集的数据点。这样的数据点可以包括获取的数据（例如，对应于由所述分析物监测装置测量的分析物浓度或量的值）。然后将这些数据点与一个或多个相关数据属性相关联。可以操纵生成的数据库以确定数据库的组件之间的关系。

2. 发明申请

WO0018289A9 METHOD AND DEVICE FOR PREDICTING PHYSIOLOGICAL VALUES 审中-公开
标题翻译：用于预测生理学值的方法和装置
公开(公告)号：WO0018289A9
公开(公告)日：2000-08-31
申请号：PCT/US9922294
申请日：1999-09-27
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： DUNN TIMOTHY C , JAYALAKSHMI YALIA , KURNIK RONALD T , LESHO MATTHEW J , OLIVER JONATHAN JAMES , POTTS RUSSELL O , TAMADA JANET A , WATERHOUSE STEVEN RICHARD , WEI CHARLES W
IPC分类号： G01N33/48 , A61B5/00 , A61B5/103 , A61B5/145 , A61B5/1477 , G01N1/28
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/441 , Y10S435/808 , Y10S435/817 , Y10S436/805 , Y10S436/806 , Y10S436/815 , Y10T436/115831
摘要： The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.
摘要翻译：本发明一般涉及使用从监测系统和专家混合物（MOE）算法获得的一系列测量结果来测量生物系统中存在的目标分析物浓度的方法，系统和设备。在一个实施方案中，本发明描述了用于测量受试者的血糖的方法。

3. 发明申请

WO03082098A2 IMPROVING PERFORMANCE OF AN ANALYTE MONITORING DEVICE 审中-公开
标题翻译：改进分析监测装置的性能
公开(公告)号：WO03082098A2
公开(公告)日：2003-10-09
申请号：PCT/US0308914
申请日：2003-03-21
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： BARTKOWIAK MIROSLAW , HARPER WESLEY S , KULCU ERAY , LESHO MATTHEW J , TAMADA JANET A
IPC分类号： G01N27/26 , A61B5/00 , A61B5/053 , A61B5/145 , A61B5/1477 , G01N27/28 , G01N27/327 , G01N27/416 , G01N33/487
CPC分类号： A61B5/681 , A61B5/0531 , A61B5/14532 , A61B5/7242 , G01N27/3271 , Y10T436/144444
摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.
摘要翻译：本发明包括一个或多个微处理器，其被编程为执行用于通过利用预测的较慢时间常数（1 / k2）来改善受试者的葡萄糖水平的预测来提高分析物监测装置的性能的方法。在本发明的另一方面，预指数项（1 / c2）可以用于提供信号衰减的校正（例如增益因子）。在其他方面，本发明涉及一种或多种微处理器，其包括编程以控制（i）用于条件筛选数据点以减少跳过的测量的方法的执行，（ii）用于限定插值/外推分析物测量值的方法，（iii）获得分析物相关信号的最大积分的各种集成方法，以及包括这种微处理器的分析物监测装置。此外，本发明涉及用于改进需要优化可调参数的预测模型中使用的参数优化的算法。

4. 发明申请

WO03000127A2 METHOD FOR IMPROVING THE PERFORMANCE OF AN ANALYTE MONITORING SYSTEM 审中-公开
标题翻译：改进分析监测系统性能的方法
公开(公告)号：WO03000127A2
公开(公告)日：2003-01-03
申请号：PCT/US0219693
申请日：2002-06-21
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： DESAI SHASHI , DUNN TIMOTHY C , LESHO MATTHEW J , POTTS RUSSELL O , TAMADA JANET A , WEI CHARLES W
IPC分类号： A61B5/00 , A61N1/30
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/1477 , A61N1/30
摘要： The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a "rolling" value based on the two or more signals can be employed. In another aspect, interpolation and/or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and/or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds. The invention includes the above-described methods, one or more microprocessors programmed to execute the methods, one or more microprocessors programmed to execute the methods and control at least one sensing and/or sampling device, and monitoring systems employing the methods described herein.
摘要翻译：本发明涉及增加用于提供分析物测量值的分析物相关信号的数量的方法，例如当使用两个或更多个与分析物相关的信号来获得单个分析物测量值时，基于两个分析物相关信号的“滚动”值或更多的信号。在另一方面，内插和/或外插方法用于估计不可用，缺失或与误差相关的分析物相关信号。此外，在本发明的另一方面，采用了内插和外推值来减少校准失败的事件。此外，本发明涉及采用梯度和/或预测算法来提供与超过预定阈值的分析物值相关的警报的方法。本发明包括上述方法，被编程为执行方法的一个或多个微处理器，被编程为执行方法和控制至少一个感测和/或采样装置的一个或多个微处理器，以及采用本文描述的方法的监视系统。

5. 发明专利

CA2346055C METHOD AND DEVICE FOR PREDICTING PHYSIOLOGICAL VALUES 未知
公开(公告)号：CA2346055C
公开(公告)日：2004-06-29
申请号：CA2346055
申请日：1999-09-27
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： POTTS RUSSELL O , KURNIK RONALD T , OLIVER JONATHAN JAMES , LESHO MATTHEW J , DUNN TIMOTHY C , TAMADA JANET A , JAYALAKSHMI YALIA , WATERHOUSE STEVEN RICHARD , WEI CHARLES W
IPC分类号： G01N33/48 , A61B5/00 , A61B5/103 , A61B5/145 , A61B5/1477 , G01N1/28
摘要： The invention relates generally to methods, systems, and devices for measuri ng the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.

6. 发明专利

CA2480550A1 IMPROVING PERFORMANCE OF AN ANALYTE MONITORING DEVICE 未知
公开(公告)号：CA2480550A1
公开(公告)日：2003-10-09
申请号：CA2480550
申请日：2003-03-21
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： TAMADA JANET A , LESHO MATTHEW J , HARPER WESLEY S , KULCU ERAY , BARTKOWIAK MIROSLAW
IPC分类号： G01N27/26 , A61B5/00 , A61B5/053 , A61B5/145 , A61B5/1477 , G01N27/28 , G01N27/327 , G01N27/416 , G01N33/487
摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring devic e including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre- exponential terms (1/c2) can be used to provide a correction for signal deca y (e.g., a Gain Factor). In other aspects, the present invention relates to on e or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.

7. 发明专利

DK1102559T3 未知
公开(公告)号：DK1102559T3
公开(公告)日：2003-09-29
申请号：DK99949883
申请日：1999-09-27
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： DUNN TIMOTHY C , JAYALAKSHMI YALIA , KURNIK RONALD T , LESHO MATTHEW J , POTTS RUSSELL O , TAMADA JANET A , WATERHOUSE STEVEN RICHARD , WEI CHARLES W , OLIVER JONATHAN JAMES
IPC分类号： G01N33/48 , A61B5/00 , A61B5/103 , A61B5/145 , A61B5/1477 , G01N1/28

8. 发明专利

ES2200557T3 未知
公开(公告)号：ES2200557T3
公开(公告)日：2004-03-01
申请号：ES99949883
申请日：1999-09-27
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： DUNN TIMOTHY C , JAYALAKSHMI YALIA , KURNIK RONALD T , LESHO MATTHEW J , OLIVER JONATHAN JAMES , POTTS RUSSELL O
IPC分类号： G01N33/48 , A61B5/00 , A61B5/103 , A61B5/145 , A61B5/1477 , G01N1/28

9. 发明专利

PT1102559E 未知
公开(公告)号：PT1102559E
公开(公告)日：2003-10-31
申请号：PT99949883
申请日：1999-09-27
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： KURNIK RONALD T , POTTS RUSSELL O , TAMADA JANET A , DUNN TIMOTHY C , JAYALAKSHMI YALIA , LESHO MATTHEW J , OLIVER JONATHAN JAMES , WATERHOUSE STEVEN RICHARD , WEI CHARLES W
IPC分类号： G01N33/48 , A61B5/00 , A61B5/103 , A61B5/145 , A61B5/1477 , G01N1/28

10. 发明专利

CA2480550C IMPROVING PERFORMANCE OF AN ANALYTE MONITORING DEVICE 未知
公开(公告)号：CA2480550C
公开(公告)日：2011-07-12
申请号：CA2480550
申请日：2003-03-21
申请人： CYGNUS THERAPEUTIC SYSTEMS
发明人： BARTKOWIAK MIROSLAW , HARPER WESLEY S , KULCU ERAY , LESHO MATTHEW J , TAMADA JANET A
IPC分类号： A61B5/00 , G01N27/26 , A61B5/053 , A61B5/145 , A61B5/1477 , G01N27/28 , G01N27/327 , G01N27/416 , G01N33/48 , G01N33/487 , G01N33/66
摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.

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