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1. 发明授权

US6361700B2 Method and partitioning blood using polyesters 有权
标题翻译：使用聚酯的方法和分配血液
公开(公告)号：US6361700B2
公开(公告)日：2002-03-26
申请号：US78896701
申请日：2001-02-20
申请人： COGNIS CORP
发明人： GATES JEFFREY A , SHARP MICHAEL S
IPC分类号： B01L3/14 , C08G63/21 , C08G63/48 , C08G63/52 , G01N33/49 , B01D33/15 , C08F20/00 , C08G63/54
CPC分类号： B01L3/5021 , C08G63/21 , C08G63/48 , C08G63/52 , G01N33/491
摘要： A polyester is provided which facilitates the separation of blood into light and heavy phases via centrifugation in a blood collection vessel. The polyester is useful as a component of a partitioning composition formulated to have appropriate specific gravity to be positioned intermediate the light and heavy blood phases during centrifugation. The polyester composition can be prepared with relative ease compared to prior art polyesters useful in blood partitioning compositions. The polyesters of this invention comprise a dicarboxylic acid member, a polymeric fatty acid, a diol member and a moiety having at least one polymerizable carbon-carbon double bond and at least one functional group capable of reacting with the ends of the polyester chain. The polyesters have a lower viscosity when synthesized and are later cured to increase their viscosity to the desired level.
摘要翻译：提供了一种聚酯，其有助于通过在采血容器中离心将血液分离成轻质和重质相。聚酯可用作分配组合物的组分，其配制成在离心过程中具有适当的比重位于轻和重的血液相之间。与可用于血液分配组合物的现有技术聚酯相比，可以相对容易地制备聚酯组合物。本发明的聚酯包括二羧酸构件，聚合脂肪酸，二醇构件和具有至少一个可聚合碳 - 碳双键的部分和至少一个能够与聚酯链端部反应的官能团。聚合物在合成时具有较低的粘度，并且随后固化以将其粘度增加到所需的水平。

2. 发明申请

WO2004022604A3 SOLVENT EXTRACTION PROCESS 审中-公开
标题翻译：溶剂萃取过程
公开(公告)号：WO2004022604A3
公开(公告)日：2004-12-09
申请号：PCT/US0324430
申请日：2003-08-06
申请人： COGNIS CORP
发明人： KORDOSKY GARY A , HEIN STEIGER HANS
IPC分类号： C22B3/04 , C08F20060101 , C08F2/00 , C22B3/02 , C22B3/26 , C22B15/00
CPC分类号： C22B3/02 , C22B3/0005 , C22B15/0084 , Y02P10/234 , Y02P10/236
摘要： A circuit configuration for a metal solvent extraction plant comprising: A) an extraction section for extracting metal ions from an aqueous leach solution containing the metal ions with an organic solvent solution containing at least one metal extraction reagent, wherein the extraction section consists of three countercurrent extraction stages; and B) a stripping section consisting of one stripping stage for stripping the metal ions from the metal extraction reagent.
摘要翻译：一种用于金属溶剂萃取设备的回路构造，其包括：A）萃取段，用于用含有至少一种金属萃取剂的有机溶剂溶液从含有金属离子的含水浸出溶液中萃取金属离子，其中萃取段由三个逆流提取阶段; 和B）由一个汽提阶段组成的汽提部分，用于从金属提取试剂中汽提金属离子。

3. 发明申请

WO2004033390A3 METHODS OF PREPARING TOCOPHEROL COMPOUND SALTS IN SUPERCRITICAL MEDIA 审中-公开
标题翻译：超临界介质中制备生育酚复方盐的方法
公开(公告)号：WO2004033390A3
公开(公告)日：2004-07-15
申请号：PCT/US0332114
申请日：2003-10-09
申请人： COGNIS CORP
发明人： MAO JIANHUA
IPC分类号： C07B20060101 , C07D311/72 , C07D311/74 , C07D311/76
CPC分类号： C07D311/72 , Y02P20/544
摘要： Methods for preparing salts of tocopherol dibasic acid hemiesters in supercritical media are described.
摘要翻译：描述了在超临界介质中制备生育酚二元酸半酯盐的方法。

4. 发明申请

WO2004016828A3 ANTIMISTING AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2004016828A3
公开(公告)日：2004-06-24
申请号：PCT/US0322733
申请日：2003-07-22
申请人： COGNIS CORP
发明人： WITSCHGER MARK , MAO JIANHUA , MATTISON PHILIP L , VIRNIG MICHAEL J , SAINT VICTOR MARIE-ESTHER
IPC分类号： C07C217/28 , C25C1/12 , C25D21/11 , C07C213/00
CPC分类号： C25D21/11 , C07C217/28 , C25C1/12
摘要： Alkoxylated compounds of formula (I) R((AO)nH)m Hp wherein each AO group is independently an alkyleneoxy group selected from ethyleneoxy, 1,2-propyleneoxy, 1,2-butyleneoxy, and styryleneoxy groups; n is an integer of from 2 to 100; m is an integer of from 1 to the total number of -OH plus -NH hydrogens in the R group prior to alkoxylation; the sum of m plus p equals the number of -OH plus -NH hydrogens in the R group prior to alkoxylation; and the R group is a group selected from the following formula (II): N(CH2CH2O)3; R N(CH2CH2O)2 where R is a C1-C24 alkyl, aryl, or aralkyl group formula (III); R N (CH2CH2O)3Y> where R has the above meaning and formula (IV) Y> is an anion, preferably an inorganic anion such as a halogen anion, a hydrogen sulfate anion, one-half of a sulfate anion, or one-third of a phosphate ion; NCH2CH2N formula (V); NCH2CH2NCH2CH2N formula (VI); CH3C(CH2O)3formula (VII); CH3CH2C(CH2O)3 formula (VIII); C(CH2O)4 formula (IX); and formula (X), where y is an integer of from 0 to 3, z is an integer of from 0 to 3, provided that the sum of y plus z is 2 or 3; and their use as anti-misting agents.
摘要翻译：式（I）R（（AO）nH）m Hp的烷氧基化化合物，其中每个AO基团独立地为选自乙烯氧基，1,2-亚丙氧基，1,2-亚丁基氧基和苯乙烯基的亚烷基氧基; n为2〜100的整数， m是在烷氧基化之前的R基团中的-OH与-NH氢的总数为1的整数; m加p的总和等于在烷氧基化之前的R基团中的-OH加上-NH氢的数目; 并且R基团是选自下式（II）的基团：N（CH 2 CH 2 O）3; R 1 N（CH 2 CH 2 O）2，其中R 1是C 1 -C 24烷基，芳基或芳烷基式（III）; R 1 N +（CH 2 CH 2 O）3 Y>其中R 1具有上述含义并且式（Ⅳ）Y>是阴离子，优选无机阴离子如卤素阴离子，硫酸氢根离子，一半的硫酸根阴离子，或三分之一的磷酸根离子; NCH2CH2N式（V）; NCH2CH2NCH2CH2N式（VI）; CH 3 C（CH 2 O）3配方（VII）; CH 3 CH 2 C（CH 2 O）3式（VIII）; C（CH 2 O）4式（IX）; 和式（X），其中y是0至3的整数，z是0至3的整数，条件是y加z的和为2或3; 并将其用作防雾剂。

5. 发明申请

WO0208413A3 CYTOCHROME B5 GENE AND PROTEIN OF CANDIDA TROPICALIS AND METHODS RELATING THERETO 审中-公开
标题翻译： CYTOCHROME B5基因和蛋白质的甘地热带菌及其相关方法
公开(公告)号：WO0208413A3
公开(公告)日：2002-11-14
申请号：PCT/US0123376
申请日：2001-07-25
申请人： COGNIS CORP
发明人： CRAFT DAVID L , MADDURI KRISHNA M , LOPER JOHN C
IPC分类号： C07K14/40 , C12N1/15 , C12N1/19 , C12N15/04 , C12N15/80 , C12P7/44
CPC分类号： C07K14/40
摘要： A gene has been isolated which encodes cytochrome b5 (CYTb5) protein of the omega-hydroxylase complex of C. tropicalids 20336. Vectors including this gene, and transformed host cells are provided. Methods of increasing the production of a CYTb5 protein are also provided which involve transforming a host cell with a gene encoding this protein and culturing the cells. Methods of increasing the production of a dicarboxylic acid are also provided which involve increasing in the host cell the number of genes encoding this protein.
摘要翻译：已经分离出一种编码C型嗜热链球菌的ω-羟化酶复合物的细胞色素b5（CYTb5）蛋白的基因20336.提供了包含该基因和转化的宿主细胞的载体。还提供了增加CYTb5蛋白产生的方法，其涉及用编码该蛋白的基因转化宿主细胞并培养细胞。还提供了增加二羧酸生产的方法，其涉及在宿主细胞中增加编码该蛋白质的基因的数量。

6. 发明申请

WO02056921A3 NONAQUEOUS COMPOSITIONS AND ADDITIVES THEREFOR 审中-公开
标题翻译：非特异性组合物及其添加剂
公开(公告)号：WO02056921A3
公开(公告)日：2002-10-24
申请号：PCT/US0148580
申请日：2001-10-30
申请人： COGNIS CORP
发明人： DONES MIGUEL A , NARAYAN RAMESH L
IPC分类号： C08F2/46 , C08G59/04 , C08G65/337 , C08K5/00 , C08L63/00 , C08L71/02 , C09D7/12 , C08K5/02 , C08K5/04 , C08K5/053 , C08K5/06
CPC分类号： C08L71/02 , C08G59/04 , C08G65/337 , C08G2650/06 , C08G2650/16 , C08K5/00 , C08L63/00 , C08L2205/05 , C09D7/63 , C08L2666/04 , C08L71/00
摘要： Nonaqueous compositions comprising at least one product of the reaction between (A) a linking agent of formula (I): R (Y)3 wherein each Y group is a halogen atom or one Y group is a halogen atom and two Y groups represent an epoxy oxygen atom, which is attached to two adjacent carbon atoms in the R4 group to form an epoxy group, and R4 is an alkanetriyl group containing from 3 to 10 carbon atoms; and (B) a compound of formula (II): R (EO)n(PO)m(BO)pX wherein R3 is substituted or unsubstituted, saturated or unsaturated, organic oxy or thio group having from 1 to 36 carbon atoms or a primary or secondary amino group having from 1 to 36 carbon atoms; n is a number of from 0 to 50; m is a number of from 0 to 50; p is a number of from 0 to 50; and X is hydrogen, or X can be mercapto group, an amino group, or a C1-C6 alkylamino group in place of a terminal -OH group, provided that when X is mercapto, amino or a C1-C6 alkylamino, the sum of n, m, and p must be at least 1; and the mole ratio of 1:11 is from about 0.1:1 to about 5:1.
摘要翻译：包含（A）式（I）的交联剂：R 4（Y）3之间的反应的至少一种产物的非水性组合物，其中每个Y基团是卤素原子或一个Y基团是卤素原子，两个Y 基团表示环氧氧原子，其与R 4基团中的两个相邻的碳原子连接以形成环氧基，并且R 4是含有3至10个碳原子的烷三基; 和（B）式（II）的化合物：R 3（EO）n（PO）m（BO）pX其中R 3是取代或未取代的饱和或不饱和的，具有1至36个碳的有机氧基或硫基原子或具有1至36个碳原子的伯或仲氨基; n为0〜50的数; m是从0到50的数字; p是从0到50的数字; X是氢，X可以是巯基，氨基或C1-C6烷基氨基代替末端-OH基团，条件是当X是巯基，氨基或C1-C6烷基氨基时，总和 n，m和p必须至少为1; 摩尔比为1:11为约0.1:1至约5:1。

7. 发明申请

WO2004096400A3 INTERLACED SERIES PARALLEL CONFIGURATION FOR METAL SOLVENT EXTRACTION PLANTS 审中-公开
标题翻译：用于金属溶剂萃取植物的相互连接的系列并行配置
公开(公告)号：WO2004096400A3
公开(公告)日：2005-12-29
申请号：PCT/US2004010706
申请日：2004-04-08
申请人： COGNIS CORP , HEIN HANS C , ARAYA GABRIEL
发明人： HEIN HANS C , ARAYA GABRIEL
IPC分类号： B01D20060101 , C22B3/02 , C22B3/08 , C22B3/26 , C22B3/30 , C22B15/00
CPC分类号： C22B3/0005 , C22B3/02 , C22B15/0063 , C22B23/04 , Y02P10/234 , Y02P10/236
摘要： An interlaced series parallel configuration for the extraction of metal values from an metal value containing aqueous is a special series parallel configuration wherein the stripped organic is first contacted in a second 5 extraction stage with the partially copper depleted aqueous stream exiting from a first extraction stage. This partially loaded organic then advances to a parallel extraction stage where it is contacted with a fresh volume of PLS and extracts additional copper. The organic then advances to the first extraction stage where it contacts a second stream of PLS. This approach 10 results in an overall higher recovery of copper than in the conventional modified series parallel configuration. An increase of 4% overall recovery of copper is achieved relative to that realized with the conventional series parallel. configuration.
摘要翻译：用于从含有金属含量的金属值提取金属值的隔行串联并行配置是特殊的串联并行配置，其中剥离的有机物在第二个萃取阶段首先与部分贫铜的含水流从第一提取阶段排出。然后将该部分负载的有机物前进到平行萃取阶段，其中其与新鲜体积的PLS接触并提取另外的铜。然后有机物前进到其接触第二个PLS流的第一提取阶段。这种方法10导致铜的总体回收率高于常规改进的串联配置。相对于传统的串联平行实现的，铜的总回收率增加了4％。组态。

8. 发明申请

WO2004106297A3 NONIONIC SURFACTANT COMPOSITIONS 审中-公开
标题翻译：非离子表面活性剂组合物
公开(公告)号：WO2004106297A3
公开(公告)日：2005-05-12
申请号：PCT/US2004017221
申请日：2004-05-28
申请人： COGNIS CORP , BROWN DAVID W , BREINDEL KENNETH , BROADBENT RONALD W , WIGGINS MICHAEL S
发明人： BROWN DAVID W , BREINDEL KENNETH , BROADBENT RONALD W , WIGGINS MICHAEL S
IPC分类号： A61K31/40 , C07D20060101
CPC分类号： A61K31/40 , C11D1/662 , C11D1/72 , C11D1/825
摘要： Surfactant concentrates containing the following components: I) at least one base-catalyzed reaction product of reactants comprising: A) at least one compound of formula I R (X)3 (I) wherein each X group is a halogen atom or one X group is a halogen atom and two X groups represent an epoxy oxygen atom, which is attached to two adjacent carbon atoms in the R group to form an epoxy group, and R is an alkanetriyl group containing from 3 to 10 carbon atoms; and B) at least one compound having the formula II R X(AO)nY (II) wherein R is a substituted or unsubstituted, saturated or unsaturated, organic group having from 1 to 36 carbon atoms; X is -0-, -S-, or -NR - where R is hydrogen or a C1-C18 alkyl group; each AO group is independently an ethyleneoxy, 1,2-propyleneoxy, or 1,2-buyleneoxy group, n is a number of from 0 to 200, preferably from 1 to 100, more preferably from 2 to 20; and Y is hydrogen, or Y can be a mercapto group or an amino group (amino or C i-C6 alkylamino group) in place of the terminal -OH group, provided that when Y is mercapto, amino, or a C1-C6 alkylamino group, n is at least 1; and II) at least one nonionic surfactant other than nonionic surfactants of component I).
摘要翻译：含有以下组分的表面活性剂浓缩物：I）反应物的至少一种碱催化反应产物，其包含：A）至少一种式IR 1（X）3（I）的化合物，其中每个X基团是卤素原子或一个 X基是卤素原子，两个X基团表示环氧氧原子，其与R 1基团中的两个相邻的碳原子连接以形成环氧基，R 1是含有3〜 10个碳原子; 和B）至少一种具有式II R 2 X（AO）n Y（II）的化合物，其中R 2是具有1至36个碳原子的取代或未取代的饱和或不饱和的有机基团; X是-O - ， - S-或-NR 3 - ，其中R 3是氢或C 1 -C 18烷基; 每个AO基团独立地为亚乙氧基，1,2-亚丙氧基或1,2-二烃基氧基，n为0至200，优选1至100，更优选2至20的数; Y是氢，Y可以是巯基或氨基（氨基或C 1 -C 6烷基氨基）代替末端-OH基团，条件是当Y是巯基，氨基或C 1 -C 6烷基氨基组，n至少为1; 和II）除了组分I）的非离子表面活性剂之外的至少一种非离子表面活性剂。

9. 发明申请

WO2004104238A3 METHOD FOR EXTRACTING COPPER FROM LEACH SOLUTIONS AT ELEVATED TEMPERATURES 审中-公开
标题翻译：从高温溶液中提取铜的方法
公开(公告)号：WO2004104238A3
公开(公告)日：2005-05-06
申请号：PCT/US2004012907
申请日：2004-04-27
申请人： COGNIS CORP , KORDOSKY GARY A , SUDDERTH R BRANTLEY , VIRNIG MICHAEL J
发明人： KORDOSKY GARY A , SUDDERTH R BRANTLEY , VIRNIG MICHAEL J
IPC分类号： C22B20060101 , C22B3/26 , C22B3/30 , C22B11/00 , C22B15/00
CPC分类号： C22B15/0063 , C22B3/0017 , C22B3/0032 , C22B15/0084 , Y02P10/234 , Y02P10/236
摘要： Copper is extracted from aqueous copper leach solutions wherein the leach solutions have a temperature of at least 30°C. The method comprises contacting the aqueous solution with an extraction reagent of the formula (I) : wherein R is a linear or branched C10-18 alkyl group and R1 is H or CH3. These extraction reagents do not undergo any significant degradation normally encountered with the use of conventional reagents in leach solutions having temperatures equal to or greater than 30°C.
摘要翻译：从浸出溶液中浸出溶液的温度至少为30℃的铜浸出溶液中提取铜。该方法包括使水溶液与式（I）的提取试剂接触：其中R是直链或支链C 10-18烷基，R 1是H或CH 3。这些提取试剂在温度等于或大于30℃的浸出溶液中使用常规试剂时通常不会遇到任何明显的降解。

10. 发明申请

WO2004065644A3 METHOD FOR CONTROLLING BIOOXIDATION REACTIONS 审中-公开
标题翻译：控制生物反应的方法
公开(公告)号：WO2004065644A3
公开(公告)日：2005-04-28
申请号：PCT/US2004000907
申请日：2004-01-14
申请人： COGNIS CORP , ANDERSON KEVIN W , WENZEL J DOUGLAS
发明人： ANDERSON KEVIN W , WENZEL J DOUGLAS
IPC分类号： C12P7/44 , C12P7/46 , C12P7/64 , C22B20060101
CPC分类号： C12P7/6409 , C12P7/44 , C12P7/46
摘要： Biooxidation reactions can be controlled by a method which comprises the steps of: (1) independently adding a substrate and a co-substrate at predetermined rates to a bioxidation reaction mixture comprised of a biocatalyst; (2) measuring the oxygen consumption rate and carbon dioxide evolution rate from the reaction mixture; (3) determining the instantaneous rates of substrate and cosubstrate consumption by solving simultaneous equations relating carbon dioxide evolution rate and oxygen consumption rate to the substrate oxidation stoichiometry, the cosubstrate combustion stoichiometry, and optionally the biomass formation stoichiometry; (4) simultaneously adjusting the substrate and cosubstrate addition rates to the rates of substrate oxidation and cosubstrate consumption in order to maximize the rate of product formation while simultaneously minimizing the rate of cosubstrate usage. The method provides a rapid means of controlling fed-batch biooxidation reactions which can employ in-line techniques and is broadly applicable for diverse oxidation reactions.
摘要翻译：生物氧化反应可以通过一种方法来控制，该方法包括以下步骤：（1）以包含生物催化剂的生物氧化反应混合物以预定速率独立地加入底物和共底物; （2）从反应混合物中测量氧气消耗速率和二氧化碳释放速率; （3）通过求解将二氧化碳进化速率和氧耗率相关联的联立方程与底物氧化化学计量，同位素燃烧化学计量学和任选的生物质形成化学计量来确定底物和辅助消耗的瞬时速率; （4）同时调整衬底并将衬底加入速率与底物氧化和辅助消耗的速率进行调和，以最大限度地提高产物形成速率，同时最大限度地降低衬底使用率。该方法提供了控制补料分批生物氧化反应的快速方法，其可以使用在线技术并且广泛适用于多种氧化反应。

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