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1. 发明申请

WO2012024785A1 HIGHLY BIOCOMPATIBLE DUAL THERMOGELLING CHITOSAN/GLUCOSAMINE SALT COMPOSITIONS 审中-公开
标题翻译：高度生物降解双重热凝胶壳聚糖/葡萄糖胺盐组合物
公开(公告)号：WO2012024785A1
公开(公告)日：2012-03-01
申请号：PCT/CA2011/000971
申请日：2011-08-26
申请人： OLIGO MEDIC INC. , CHENITE, Abdellatif , SELMANI, Amine
发明人： CHENITE, Abdellatif , SELMANI, Amine
IPC分类号： C08L5/08 , A61K47/36 , A61K9/10 , A61L27/44 , A61L31/12 , C08J3/075
CPC分类号： A61L27/44 , A61K9/06 , A61K47/26 , A61K47/36 , A61L27/20 , A61L27/50 , A61L27/52 , A61L27/54 , C08J3/075 , C08J2305/08 , C08L5/08
摘要： The present disclosure relates to a chitosan solution neutralized with amino-sugar carbonate buffering solution or amino-sugar phosphate buffering solution or phosphorylated aminosugar buffering solution. The resulting themogelling chitosan composition is highly biocompatible, isotonic and has the ability to rapidly turn into gel upon heating to the body temperature. It provides a novel chitosan-based composition to suitable for drug delivery, cell delivery and repair or regeneration of tissues and organs as well as other clinical treatment.
摘要翻译：本公开内容涉及用氨基糖碳酸盐缓冲溶液或氨基糖磷酸盐缓冲溶液或磷酸化氨基糖缓冲溶液中和的壳聚糖溶液。所得到的聚阴离子壳聚糖组合物是高度生物相容的，等渗的并且具有在加热至体温时迅速变成凝胶的能力。它提供了一种新的基于壳聚糖的组合物，适用于药物递送，细胞递送和组织和器官的修复或再生以及其他临床治疗。

2. 发明申请

WO2015189712A3 SILICONE-BASED BIOPHOTONIC COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：基于硅酮的生物组合物及其用途
公开(公告)号：WO2015189712A3
公开(公告)日：2016-04-07
申请号：PCT/IB2015001761
申请日：2015-06-09
申请人： KLOX TECHNOLOGIES INC , PIERGALLINI REMIGIO , LOUPIS NIKOLAOS , JAWORSKA JOANNA , DEVEMY EMMANUELLE , DESROSIERS ERIC , CHENITE ABDELLATIF
发明人： PIERGALLINI REMIGIO , LOUPIS NIKOLAOS , JAWORSKA JOANNA , DEVEMY EMMANUELLE , DESROSIERS ERIC , CHENITE ABDELLATIF
IPC分类号： A61K41/00 , A61P17/00 , A61Q19/08
CPC分类号： A61K31/80 , A61K8/416 , A61K8/463 , A61K8/498 , A61K8/731 , A61K8/86 , A61K8/891 , A61K8/895 , A61K8/90 , A61K9/0014 , A61K9/1075 , A61K9/7015 , A61K31/352 , A61K41/00 , A61K41/008 , A61K47/10 , A61K47/186 , A61K47/20 , A61K47/34 , A61K2800/434 , A61K2800/48 , A61K2800/52 , A61K2800/596 , A61K2800/81 , A61L26/0061 , A61L26/0095 , A61N5/0616 , A61N5/062 , A61N2005/0651 , A61N2005/0662 , A61Q19/00 , A61Q19/08 , C08L83/04 , C08L71/02
摘要： The present disclosure provides silicone-based biophotonic compositions and methods useful in phototherapy. In particular, the silicone-based biophotonic compositions of the present disclosure include a silicone phase and a surfactant phase, wherein the surfactant phase comprises at least one chromophore solubilized in a surfactant. The silicone-based biophotonic compositions and the methods of the present disclosure are useful for promoting wound healing and scarring, as well as various other skin disorders.
摘要翻译：本公开提供了基于有机硅的生物光子组合物和用于光疗法的方法。特别地，本公开的硅氧烷基生物光子组合物包括硅氧烷相和表面活性剂相，其中表面活性剂相包含溶解在表面活性剂中的至少一种生色团。硅氧烷基生物光子组合物和本公开的方法可用于促进伤口愈合和瘢痕形成以及各种其它皮肤病症。

3. 发明申请

WO2004006961A1 COMPOSITION FOR CYTOCOMPATIBLE, INJECTABLE, SELF-GELLING CHITOSAN SOLUTIONS FOR ENCAPSULATING AND DELIVERING LIVE CELLS OR BIOLOGICALLY ACTIVE FACTORS 审中-公开
标题翻译：用于包埋和递送活细胞或生物活性因子的可注射的，可注射的自体胶原蛋白溶液的组合物
公开(公告)号：WO2004006961A1
公开(公告)日：2004-01-22
申请号：PCT/CA2003/001069
申请日：2003-07-16
申请人： BIO SYNTECH CANADA INC. , CHENITE, Abdellatif , HOEMANN, Caroline , BUSCHMANN, Michael , SEREQI, Alessio , SUN, Jun
发明人： CHENITE, Abdellatif , HOEMANN, Caroline , BUSCHMANN, Michael , SEREQI, Alessio , SUN, Jun
IPC分类号： A61K47/36
CPC分类号： A61L27/3604 , A01N1/0205 , A01N1/021 , A01N1/0231 , A61K9/0024 , A61K31/717 , A61L27/20 , A61L27/3641 , A61L27/365 , A61L27/3654 , A61L27/3839 , A61L27/3847 , A61L27/3852 , A61L27/50 , A61L27/52 , C08L5/08
摘要： The present invention provides compositions and methods for tissue repair using a cytocompatible self-gelling cross-linked hydrogel. The composition comprises a biocompatible mixture of chitosan, bifunctional dialdehyde, and hydroxylated polymer, which can be used to immobilize or encapsulate viable cells, or bioactive substances. The method includes the process of mixing bioactive substances, live cells, and/or extracellular matrix components with a cross-linking solution comprising a bifunctional aldehyde-treated hydroxylated polymer such as hydroxyethyl cellulose. The cross-linking solution is then mixed homogenously with a neutral isotonic chitosan solution. The chitosan becomes cross-linked by the bifunctional aldehyde, while the cells are protected from potentially nocive effects of the aldehyde cross-linker by the hydroxylated polymer. The injectable solution retains cell viability and bioactivity, and immobilizes cells at the site of injection or delivery. Depending on the particular application, mixtures of chitosan and bifunctional dialdehyde may be employed. The injectable solution also liberates bioactive substances with controlled release kinetics from the site of injection.
摘要翻译：本发明提供使用细胞相容性自凝胶交联水凝胶进行组织修复的组合物和方法。组合物包含壳聚糖，双官能二醛和羟基化聚合物的生物相容性混合物，其可用于固定或包封活细胞或生物活性物质。该方法包括将生物活性物质，活细胞和/或细胞外基质组分与包含双功能醛处理的羟基化聚合物如羟乙基纤维素的交联溶液混合的方法。然后将交联溶液与中性等渗壳聚糖溶液均匀混合。壳聚糖通过双功能醛交联，同时保护细胞免受羟基化聚合物对醛交联剂的潜在的伤害作用。注射溶液保留细胞活力和生物活性，并将细胞固定在注射或递送部位。根据具体应用，可以使用壳聚糖和双官能二醛的混合物。注射溶液也释放出具有从注射部位释放动力学的生物活性物质。

4. 发明申请

WO0240072A3 FILLER COMPOSITION FOR SOFT TISSUE AUGMENTATION AND RECONSTRUCTIVE SURGERY 审中-公开
标题翻译：填充物组合物用于软组织增生和重建手术
公开(公告)号：WO0240072A3
公开(公告)日：2002-09-19
申请号：PCT/CA0101622
申请日：2001-11-15
申请人： BIOSYNTECH CANADA INC , DESROSIERS ERIC ANDRE , CHENITE ABDELLATIF , CHAPUT CYRIL , SHIVE MATTHEW
发明人： DESROSIERS ERIC ANDRE , CHENITE ABDELLATIF , CHAPUT CYRIL , SHIVE MATTHEW
IPC分类号： A61L24/08 , A61L26/00 , A61L27/20 , A61L27/24 , A61L27/50 , A61L27/52
CPC分类号： A61L27/52 , A61K8/60 , A61K8/65 , A61K8/736 , A61K2800/91 , A61L24/08 , A61L26/0023 , A61L27/20 , A61L27/24 , A61L27/50 , A61Q19/08 , C08L5/08
摘要： The present invention relates to a filler composition for soft-tissue augmentation and reconstructive surgery comprising an effective amount of an injectable thermo-gelling solution comprising 0.1 to 5.0 % by weight of chitosan or collagen or a derivative thereof; and 1.0 to 20 % by weight of a salt of polyol or sugar selected from the group consisting of mono-phosphate dibasic salt, mono-sulfate salt and a mono-carboxylic acid salt of polyol or sugar. The solution is stable and turns into a gel within a tem-perature range from 20 to 70 DEG C. The gel has a cosmetically acceptable consistency for providing a mechanical support to surrounding soft tissues once injected therein. The composition can thus be used as filler for soft tissue augmentation and reconstructive surgery.
摘要翻译：本发明涉及用于软组织增大和再造手术的填充剂组合物，其包含有效量的可注射热胶凝溶液，所述溶液包含0.1-5.0重量％的壳聚糖或胶原或其衍生物; 和1.0至20重量％的选自多元醇或糖的单磷酸二元盐，单硫酸盐和单羧酸盐的多元醇或糖的盐。该溶液是稳定的，并且在20-70℃的温度范围内变成凝胶。该凝胶具有美容上可接受的稠度，用于一旦注入其中就为周围的软组织提供机械支撑。因此该组合物可以用作软组织填充和重建手术的填充剂。

5. 发明申请

WO2002040070A3 METHOD FOR RESTORING A DAMAGED OR DEGENERATED INTERVERTEBRAL DISC 审中-公开
公开(公告)号：WO2002040070A3
公开(公告)日：2002-05-23
申请号：PCT/CA2001/001623
申请日：2001-11-15
申请人： BIO SYNTECH CANADA INC. , DESROSIERS, Eric, André , CHENITE, Abdellatif , BERRADA, Mohammed , CHAPUT, Cyril
发明人： DESROSIERS, Eric, André , CHENITE, Abdellatif , BERRADA, Mohammed , CHAPUT, Cyril
IPC分类号： A61F2/44
摘要： The present invention relates to a minimally-invasive method for restoring a damaged or degenerated intervertebral disc at an early stage. The method comprises the step of administering an injectable in situ setting formulation in the nucleus pulposus of the damaged or degenerated disc of a patient. The formulation once injected combines with nucleus matters and host cells, and becomes viscous or gels in situ within the annulus fibrosus of the disc for increasing the thickness and volume of the damaged or degenerated disc. The formulation is retained within the disc for providing restoration of the damaged or degenerated disc.

6. 发明申请

WO1998017710A1 METHOD FOR PREPARATION OF POLYMER MICROPARTICLES FREE OF ORGANIC SOLVENT TRACES 审中-公开
标题翻译：不含有机溶剂的聚合物微球的制备方法
公开(公告)号：WO1998017710A1
公开(公告)日：1998-04-30
申请号：PCT/CA1997000797
申请日：1997-10-24
申请人： BIO SYNTECH LTD. , CHENITE, Abdellatif , CHAPUT, Cyril , SELMANI, Amine
发明人： BIO SYNTECH LTD.
IPC分类号： C08J03/12
CPC分类号： C08J3/005 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1694 , A61K9/5031 , C08J3/12 , C08J2367/02 , Y10S514/963 , Y10T428/2982 , Y10T428/2989
摘要： The present invention relates to a new method for the production of polymer microparticles. The method is carried out in the absence of organic solvent, and consists in the steps of (a) combining first and second polymers, the first and second polymers being incompatible or immiscible, (b) heating the combination obtained in step (a) so as to melt the first and second polymers; (c) shaking the melted polymers obtained in step (b) under conditions effective to produce a biphasic system, the biphasic system comprising a dispersed phase and a matrix continuous phase, the dispersed phase consisting of a dispersion of the first polymer, the matrix continuous phase comprising the second polymer, the dispersed phase containing microparticles of the first polymer dispersed in the matrix continuous phase; (d) solidifying the biphasic system obtained in step (c) so as to keep the microparticles of the first polymer dispersed in the matrix continuous phase; and (e) separating and isolating the microparticles of the first polymer from the matrix continuous phase, wherein the first polymer in said dispersed phase is water-insoluble, while the second polymer forming the continuous phase is water-soluble.
摘要翻译：本发明涉及一种生产聚合物微粒的新方法。该方法在不存在有机溶剂的情况下进行，并且包括以下步骤：（a）将第一和第二聚合物混合，第一和第二聚合物不相容或不混溶，（b）将步骤（a）中获得的组合加热以熔化第一和第二聚合物; （c）在有效产生双相系统的条件下振荡步骤（b）中获得的熔融聚合物，所述双相系统包含分散相和基质连续相，所述分散相由第一聚合物的分散体，基体连续包含第二聚合物的相，所述分散相含有分散在基体连续相中的第一聚合物的微粒; （d）固化步骤（c）中获得的双相体系，以使第一聚合物的微粒分散在基质连续相中; 和（e）从基质连续相分离和分离第一聚合物的微粒，其中所述分散相中的第一聚合物是水不溶性的，而形成连续相的第二聚合物是水溶性的。

7. 发明申请

WO2015189712A2 SILICONE-BASED BIOPHOTONIC COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：基于硅酮的生物组合物及其用途
公开(公告)号：WO2015189712A2
公开(公告)日：2015-12-17
申请号：PCT/IB2015/001761
申请日：2015-06-09
申请人： KLOX TECHNOLOGIES INC. , PIERGALLINI, Remigio , LOUPIS, Nikolaos , JAWORSKA, Joanna , DEVEMY, Emmanuelle , DESROSIERS, Eric , CHENITE, Abdellatif
发明人： PIERGALLINI, Remigio , LOUPIS, Nikolaos , JAWORSKA, Joanna , DEVEMY, Emmanuelle , DESROSIERS, Eric , CHENITE, Abdellatif
IPC分类号： A61K41/00
CPC分类号： A61K31/80 , A61K8/416 , A61K8/463 , A61K8/498 , A61K8/731 , A61K8/86 , A61K8/891 , A61K8/895 , A61K8/90 , A61K9/0014 , A61K9/1075 , A61K9/7015 , A61K31/352 , A61K41/00 , A61K41/008 , A61K47/10 , A61K47/186 , A61K47/20 , A61K47/34 , A61K2800/434 , A61K2800/48 , A61K2800/52 , A61K2800/596 , A61K2800/81 , A61L26/0061 , A61L26/0095 , A61N5/0616 , A61N5/062 , A61N2005/0651 , A61N2005/0662 , A61Q19/00 , A61Q19/08 , C08L83/04 , C08L71/02
摘要： The present disclosure provides silicone-based biophotonic compositions and methods useful in phototherapy. In particular, the silicone-based biophotonic compositions of the present disclosure include a silicone phase and a surfactant phase, wherein the surfactant phase comprises at least one chromophore solubilized in a surfactant. The silicone-based biophotonic compositions and the methods of the present disclosure are useful for promoting wound healing and scarring, as well as various other skin disorders.
摘要翻译：本公开提供了基于有机硅的生物光子组合物和用于光疗法的方法。特别地，本公开的硅氧烷基生物光子组合物包括硅氧烷相和表面活性剂相，其中表面活性剂相包含溶解在表面活性剂中的至少一种生色团。硅氧烷基生物光子组合物和本公开的方法可用于促进伤口愈合和瘢痕形成以及各种其它皮肤病症。

8. 发明申请

WO2004050100A1 METHOD FOR TREATING A TUMOR USING A THERMO-GELLING CHITOSAN COMPOSITION 审中-公开
标题翻译：使用热凝胶壳聚糖组合物治疗肿瘤的方法
公开(公告)号：WO2004050100A1
公开(公告)日：2004-06-17
申请号：PCT/CA2003/001880
申请日：2003-12-03
申请人： BIO SYNTECH CANADA INC. , BERRADA, Mohammed , GUPTA, Ajay , CHENITE, Abdellatif
发明人： BERRADA, Mohammed , GUPTA, Ajay , CHENITE, Abdellatif
IPC分类号： A61K31/722
CPC分类号： A61K9/0024 , A61K9/0019 , A61K31/337 , A61K31/4745 , A61K31/722 , A61K33/24 , A61K47/02 , A61K47/36 , C08L5/08 , A61K2300/00
摘要： The present invention relates to a new method for treating tumor using as an active ingredient a thermo-gelling chitosan composition. The thermo-gelling chitosan composition preferably comprises i) 0.1 to 5.0% by weight of chitosan or a chitosan derivative; and ii) 1.0 to 20% by weight of a salt of polyol or sugar selected from the group consisting of mono-phosphate dibasic salt, mono-sulfate salt and a mono-carboxylic acid salt of polyol or sugar, wherein said composition has a final pH ranging from 5.8 and 7.4, and forms a stable, biocompatible, biodegradable gel under physiological conditions gels within a temperature range from 20 to 70°C, said composition reducing the growth of the tumor in said patient.
摘要翻译：本发明涉及使用热凝胶壳聚糖组合物作为活性成分治疗肿瘤的新方法。热胶凝壳聚糖组合物优选包含i）0.1至5.0重量％的壳聚糖或壳聚糖衍生物; 和ii）1.0至20重量％的选自单磷酸二盐，单硫酸盐和多元醇或糖的单羧酸盐的多元醇或糖的盐，其中所述组合物具有最终的 pH在5.8和7.4之间，并且在生理条件下在20至70℃的温度范围内形成稳定的，生物相容的可生物降解的凝胶，所述组合物降低了所述患者的肿瘤生长。

9. 发明申请

WO2003042250A1 COMPOSITION AND METHOD TO HOMOGENEOUSLY MODIFY OR CROSS-LINK CHITOSAN UNDER NEUTRAL CONDITIONS 审中-公开
标题翻译：在中性条件下均质地修饰或交叉链接的组合物和方法
公开(公告)号：WO2003042250A1
公开(公告)日：2003-05-22
申请号：PCT/CA2002/001756
申请日：2002-11-15
申请人： BIOSYNTECH CANADA INC. , CHENITE, Abdellatif , BERRADA, Mohammed , CHAPUT, Cyril , DABBARH, Fouad , SELMANI, Amine
发明人： CHENITE, Abdellatif , BERRADA, Mohammed , CHAPUT, Cyril , DABBARH, Fouad , SELMANI, Amine
IPC分类号： C08B37/08
CPC分类号： A61K9/0024 , A61L27/46 , A61L27/52 , C08B37/003 , C08L5/08
摘要： In accordance with the present invention there is provided a new composition and method for chemically modifying chitosan, including N-substituting or N-cross-linking, under homogeneous conditions by providing neutral aqueous chitosan solutions with enhanced reactivity. The method comprises the steps of i) preparing a clear aqueous solution of chitosan, said solution comprising 0.1 to 10% by weight of a chitosan, and 0.1 to 20% by weight of at least one buffering agent having a pKa between 6.0 and 7.6, said solution having a pH ranging from 6.8 to 7.2; and ii) dissolving homogeneously at least one reagent into the solution of step a), said reagent being reactive toward amine groups of chitosan; and said reagent being at a concentration from 0.01 to 10% by weight. The chitosan in the aqueous solution is chemically modified or cross-linked by a selective substitution on the amino group of chitosan
摘要翻译：根据本发明，提供了通过提供具有增强反应性的中性水性壳聚糖溶液在均相条件下化学改性壳聚糖（包括N-取代或N-交联）的新组合物和方法。该方法包括以下步骤：i）制备透明的壳聚糖水溶液，所述溶液包含0.1至10重量％的壳聚糖和0.1至20重量％的至少一种pKa在6.0和7.6之间的缓冲剂，所述溶液具有6.8-7.2的pH; 和ii）均匀地将至少一种试剂均匀地溶解到步骤a）的溶液中，所述试剂对壳聚糖的胺基具有反应性; 并且所述试剂的浓度为0.01至10重量％。水溶液中的壳聚糖通过壳聚糖氨基上的选择性取代被化学修饰或交联

10. 发明申请

WO0240070A2 METHOD FOR RESTORING A DAMAGED OR DEGENERATED INTERVERTEBRAL DISC 审中-公开
标题翻译：恢复损伤或变性的椎间盘的方法
公开(公告)号：WO0240070A2
公开(公告)日：2002-05-23
申请号：PCT/CA0101623
申请日：2001-11-15
申请人： BIOSYNTECH CANADA INC , DESROSIERS ERIC ANDRE , CHENITE ABDELLATIF , BERRADA MOHAMMED , CHAPUT CYRIL
发明人： DESROSIERS ERIC ANDRE , CHENITE ABDELLATIF , BERRADA MOHAMMED , CHAPUT CYRIL
IPC分类号： A61F2/30 , A61F2/44 , A61K31/722 , A61K31/728 , A61K31/737 , A61K31/765 , A61K45/06 , A61L27/00
CPC分类号： A61L27/20 , A61F2002/30677 , A61F2002/444 , A61F2002/4445 , A61F2002/445 , A61K9/0024 , A61K31/722 , A61K31/728 , A61K31/737 , A61K31/765 , A61K45/06 , A61L27/38 , A61L27/52 , A61L27/54 , A61L2300/64 , A61L2430/38 , A61K2300/00
摘要： The present invention relates to a minimally-invasive method for restoring a damaged or degenerated intervertebral disc at an early stage. The method comprises the step of administering an injectable in situ setting formulation in the nucleus pulposus of the damaged or degenerated disc of a patient. The formulation once injected combines with nucleus matters and host cells, and becomes viscous or gels in situ within the annulus fibrosus of the disc for increasing the thickness and volume of the damaged or degenerated disc. The formulation is retained within the disc for providing restoration of the damaged or degenerated disc.
摘要翻译：本发明涉及一种用于在早期阶段恢复受损或退化的椎间盘的微创方法。该方法包括在患者的损伤或退化的椎间盘的髓核髓质中施用可注射的原位置换制剂的步骤。一次注射的制剂与细胞核和宿主细胞结合，并且在椎间盘纤维环内原位粘稠或凝胶，以增加损伤或损伤的纤维的厚度和体积退化椎间盘制剂保留在盘内，以提供损坏或退化的椎间盘的恢复。

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