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1. 发明申请

WO2004006961A1 COMPOSITION FOR CYTOCOMPATIBLE, INJECTABLE, SELF-GELLING CHITOSAN SOLUTIONS FOR ENCAPSULATING AND DELIVERING LIVE CELLS OR BIOLOGICALLY ACTIVE FACTORS 审中-公开
标题翻译：用于包埋和递送活细胞或生物活性因子的可注射的，可注射的自体胶原蛋白溶液的组合物
公开(公告)号：WO2004006961A1
公开(公告)日：2004-01-22
申请号：PCT/CA2003/001069
申请日：2003-07-16
申请人： BIO SYNTECH CANADA INC. , CHENITE, Abdellatif , HOEMANN, Caroline , BUSCHMANN, Michael , SEREQI, Alessio , SUN, Jun
发明人： CHENITE, Abdellatif , HOEMANN, Caroline , BUSCHMANN, Michael , SEREQI, Alessio , SUN, Jun
IPC分类号： A61K47/36
CPC分类号： A61L27/3604 , A01N1/0205 , A01N1/021 , A01N1/0231 , A61K9/0024 , A61K31/717 , A61L27/20 , A61L27/3641 , A61L27/365 , A61L27/3654 , A61L27/3839 , A61L27/3847 , A61L27/3852 , A61L27/50 , A61L27/52 , C08L5/08
摘要： The present invention provides compositions and methods for tissue repair using a cytocompatible self-gelling cross-linked hydrogel. The composition comprises a biocompatible mixture of chitosan, bifunctional dialdehyde, and hydroxylated polymer, which can be used to immobilize or encapsulate viable cells, or bioactive substances. The method includes the process of mixing bioactive substances, live cells, and/or extracellular matrix components with a cross-linking solution comprising a bifunctional aldehyde-treated hydroxylated polymer such as hydroxyethyl cellulose. The cross-linking solution is then mixed homogenously with a neutral isotonic chitosan solution. The chitosan becomes cross-linked by the bifunctional aldehyde, while the cells are protected from potentially nocive effects of the aldehyde cross-linker by the hydroxylated polymer. The injectable solution retains cell viability and bioactivity, and immobilizes cells at the site of injection or delivery. Depending on the particular application, mixtures of chitosan and bifunctional dialdehyde may be employed. The injectable solution also liberates bioactive substances with controlled release kinetics from the site of injection.
摘要翻译：本发明提供使用细胞相容性自凝胶交联水凝胶进行组织修复的组合物和方法。组合物包含壳聚糖，双官能二醛和羟基化聚合物的生物相容性混合物，其可用于固定或包封活细胞或生物活性物质。该方法包括将生物活性物质，活细胞和/或细胞外基质组分与包含双功能醛处理的羟基化聚合物如羟乙基纤维素的交联溶液混合的方法。然后将交联溶液与中性等渗壳聚糖溶液均匀混合。壳聚糖通过双功能醛交联，同时保护细胞免受羟基化聚合物对醛交联剂的潜在的伤害作用。注射溶液保留细胞活力和生物活性，并将细胞固定在注射或递送部位。根据具体应用，可以使用壳聚糖和双官能二醛的混合物。注射溶液也释放出具有从注射部位释放动力学的生物活性物质。

2. 发明申请

WO2011060554A1 PRESOLIDIFIED COMPOSITION AND METHOD FOR IN SITU DELIVERY OF BROAD MOLECULAR WEIGHT RANGE OF CHITOSAN IMPLANTS WITH OR WITHOUT THERAPEUTICS FOR REGENERATIVE MEDICINE AND CARTILAGE REPAIR APPLICATIONS 审中-公开
标题翻译：预处理组合物和方法，用于在带有或没有用于再生医学和治疗维持应用的治疗剂的情况下提供具有或不带有治疗药物的CHITOSAN植入物的广泛分子量范围
公开(公告)号：WO2011060554A1
公开(公告)日：2011-05-26
申请号：PCT/CA2010/001857
申请日：2010-11-19
申请人： CORPORATION DE L'ECOLE POLYTECHNIQUE DE MONTREAL , HOEMANN, Caroline , SUN, Jun , HURTIG, Mark , GUZMAN-MORALES, Jessica , HUBERT-LAFANTAISIE, Charles
发明人： HOEMANN, Caroline , SUN, Jun , HURTIG, Mark , GUZMAN-MORALES, Jessica , HUBERT-LAFANTAISIE, Charles
IPC分类号： A61L27/44 , A61L27/20 , A61L27/38 , A61L27/54 , A61L33/00 , A61L33/12
CPC分类号： A61L27/3654 , A61L27/3616 , A61L27/44 , A61L2430/06 , C08L5/08
摘要： The present description relates to a presolidified implant composition, a method for its preparation, and a use of said implant composition for repairing tissue of a patient wherein the implant comprises a blood component, a salt and a polymer which are solidified in a glass or plastic recipient prior to being administered to the patient. The implants are preferably prepared using chitosan as the polymer and may further comprise therapeutics for in vivo release. The presolidified implants are useful for regenerate e medicine and cartilage repair applications.
摘要翻译：本说明书涉及预先固定的植入物组合物，其制备方法，以及所述植入物组合物用于修复患者组织的用途，其中所述植入物包括在玻璃或塑料中固化的血液成分，盐和聚合物在给予患者之前的接受者。植入物优选使用壳聚糖作为聚合物制备，并且还可以包含用于体内释放的治疗剂。预固结的植入物可用于再生e药和软骨修复应用。

3. 发明申请

WO2011060553A1 FORMULATION AND METHOD FOR RAPID PREPARATION OF ISOTONIC AND CYTOCOMPATIBLE CHITOSAN SOLUTIONS WITHOUT INDUCING CHITOSAN PRECIPITATION 审中-公开
标题翻译：在不诱导CHITOSAN降解的情况下快速制备同位素和CYCOCOMPATIBLE CHITOSAN解决方案的配方和方法
公开(公告)号：WO2011060553A1
公开(公告)日：2011-05-26
申请号：PCT/CA2010/001856
申请日：2010-11-19
申请人： CORPORATION DE L'ECOLE POLYTECHNIQUE DE MONTREAL , HOEMANN, Caroline , SUN, Jun
发明人： HOEMANN, Caroline , SUN, Jun
IPC分类号： A61K31/722 , A61K35/14 , A61K35/28 , A61K9/00 , A61P19/00
CPC分类号： A61K31/722 , A61L27/20 , A61L27/54 , A61L2300/00 , C08L5/08
摘要： The present disclosure is directed to a two-part cytocompatible system for preparing a cytocompatible composition for use in repairing tissue of a subject. The system comprises an admixture of a first-part liquid solution of a polysaccharide, such as chitosan and a second-part liquid solution of a salt, such as glycerol phosphate. When the chitosan and glycerol phosphate solutions are combined, a cytocompatible composition is produced which is free of polymer precipitation at room temperature. The composition also promotes non-covalent complex formation between chitosan and therapeutic anionic proteins with a pl
摘要翻译：本公开涉及用于制备用于修复受试者组织的细胞相容性组合物的两部分细胞相容性系统。该系统包括多糖的第一部分液体溶液如壳聚糖和第二部分盐的液体溶液如磷酸甘油的混合物。当壳聚糖和磷酸甘油酯溶液组合时，产生在室温下不含聚合物沉淀的细胞相容性组合物。组合物还促进壳聚糖与治疗性阴离子蛋白质之间的非共价复合体形成，其中p <6 78。

4. 发明公开

EP1536837A1 COMPOSITION FOR CYTOCOMPATIBLE, INJECTABLE, SELF-GELLING CHITOSAN SOLUTIONS FOR ENCAPSULATING AND DELIVERING LIVE CELLS OR BIOLOGICALLY ACTIVE FACTORS 有权
标题翻译：组成生产细胞相容，注射，SELBSTGELIERENDER壳聚糖溶液封装并添加活细胞或生物活性因子
公开(公告)号：EP1536837A1
公开(公告)日：2005-06-08
申请号：EP03763548.9
申请日：2003-07-16
申请人： Bio Syntech Canada Inc.
发明人： HOEMANN, Caroline , CHENITE, Abdellatif , BUSCHMANN, Michael , SERRIQUI, Alessio , SUN, Jun
IPC分类号： A61K47/36 , A61K47/38 , A61L27/20 , A61L27/38 , A61P19/02
CPC分类号： A61L27/3604 , A01N1/0205 , A01N1/021 , A01N1/0231 , A61K9/0024 , A61K31/717 , A61L27/20 , A61L27/3641 , A61L27/365 , A61L27/3654 , A61L27/3839 , A61L27/3847 , A61L27/3852 , A61L27/50 , A61L27/52 , C08L5/08
摘要： The present invention provides compositions and methods for tissue repair using a cytocompatible self-gelling cross-linked hydrogel. The composition comprises a biocompatible mixture of chitosan, bifunctional dialdehyde, and hydroxylated polymer, which can be used to immobilize or encapsulate viable cells, or bioactive substances. The method includes the process of mixing bioactive substances, live cells, and/or extracellular matrix components with a cross-linking solution comprising a bifunctional aldehyde-treated hydroxylated polymer such as hydroxyethyl cellulose. The cross-linking solution is then mixed homogenously with a neutral isotonic chitosan solution. The chitosan becomes cross-linked by the bifunctional aldehyde, while the cells are protected from potentially nocive effects of the aldehyde cross-linker by the hydroxylated polymer. The injectable solution retains cell viability and bioactivity, and immobilizes cells at the site of injection or delivery. Depending on the particular application, mixtures of chitosan and bifunctional dialdehyde may be employed. The injectable solution also liberates bioactive substances with controlled release kinetics from the site of injection.

5. 发明授权

EP1536837B1 COMPOSITION FOR CYTOCOMPATIBLE, INJECTABLE, SELF-GELLING CHITOSAN SOLUTIONS FOR ENCAPSULATING AND DELIVERING LIVE CELLS OR BIOLOGICALLY ACTIVE FACTORS 有权
标题翻译：组成生产细胞相容，注射，SELBSTGELIERENDER壳聚糖溶液封装并添加活细胞或生物活性因子
公开(公告)号：EP1536837B1
公开(公告)日：2010-09-15
申请号：EP03763548.9
申请日：2003-07-16
申请人： Bio Syntech Canada Inc.
发明人： HOEMANN, Caroline , CHENITE, Abdellatif , BUSCHMANN, Michael , SERRIQI, Alessio , SUN, Jun
IPC分类号： A61K47/36 , A61K47/38 , A61L27/20 , A61L27/38 , A61P19/02
CPC分类号： A61L27/3604 , A01N1/0205 , A01N1/021 , A01N1/0231 , A61K9/0024 , A61K31/717 , A61L27/20 , A61L27/3641 , A61L27/365 , A61L27/3654 , A61L27/3839 , A61L27/3847 , A61L27/3852 , A61L27/50 , A61L27/52 , C08L5/08
摘要： The present invention provides compositions and methods for tissue repair using a cytocompatible self-gelling cross-linked hydrogel. The composition comprises a biocompatible mixture of chitosan, bifunctional dialdehyde, and hydroxylated polymer, which can be used to immobilize or encapsulate viable cells, or bioactive substances. The method includes the process of mixing bioactive substances, live cells, and/or extracellular matrix components with a cross-linking solution comprising a bifunctional aldehyde-treated hydroxylated polymer such as hydroxyethyl cellulose. The cross-linking solution is then mixed homogenously with a neutral isotonic chitosan solution. The chitosan becomes cross-linked by the bifunctional aldehyde, while the cells are protected from potentially nocive effects of the aldehyde cross-linker by the hydroxylated polymer. The injectable solution retains cell viability and bioactivity, and immobilizes cells at the site of injection or delivery. Depending on the particular application, mixtures of chitosan and bifunctional dialdehyde may be employed. The injectable solution also liberates bioactive substances with controlled release kinetics from the site of injection.

6. 发明申请

WO2013104322A1 OBJECT RECOGNIZING METHOD AND OBJECT RECOGNIZING DEVICE 审中-公开
标题翻译：对象识别方法和对象识别装置
公开(公告)号：WO2013104322A1
公开(公告)日：2013-07-18
申请号：PCT/CN2013/070312
申请日：2013-01-10
申请人： FUJITSU LIMITED , FAN, Wei , AKIHIRO, Minagawa , SUN, Jun , YOSHINOBU, Hotta , SATOSHI, Naoi
发明人： FAN, Wei , AKIHIRO, Minagawa , SUN, Jun , YOSHINOBU, Hotta , SATOSHI, Naoi
IPC分类号： G06K9/46
CPC分类号： G06K9/00382 , G06K9/4652
摘要： The present invention discloses an object recognizing method and an object recognizing device. The object recognizing method according to the invention is used for recognizing an object with a specific color distribution characteristic and a specific contour characteristic. The method includes the steps of: extracting a contour in an input image according to the color distribution characteristic thereof; determining a scan window using the extracted contour according to the contour characteristic and the color distribution characteristic; and classifying a part of the image corresponding to the determined scan window and determining whether the part of the image contains the object.
摘要翻译：本发明公开了一种物体识别方法和物体识别装置。根据本发明的物体识别方法用于识别具有特定颜色分布特性和特定轮廓特征的物体。该方法包括以下步骤：根据其颜色分布特征提取输入图像中的轮廓; 根据轮廓特征和颜色分布特征，使用所提取的轮廓确定扫描窗口; 以及对与确定的扫描窗口相对应的图像的一部分进行分类，并确定图像的一部分是否包含对象。

7. 发明申请

WO2013012975A1 METHODS FOR INCREASING PRODUCT YIELDS 审中-公开
标题翻译：增加产品线的方法
公开(公告)号：WO2013012975A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/047278
申请日：2012-07-19
申请人： GENOMATICA, INC. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
发明人： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
IPC分类号： C12P1/04 , C12N1/21
CPC分类号： C12P7/04 , C12N15/52 , C12P7/18 , C12P7/42
摘要： A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a precursor. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product.
摘要翻译：非天然存在的微生物体包括具有还原性TCA或Wood-Ljungdahl途径的微生物生物体，其中至少一种编码这些途径酶的外源核酸以足够的量表达以增强通过乙酰辅酶A的碳通量。通过乙酰辅酶A增强碳通量的方法包括在条件和足够的时间内培养这些非天然存在的微生物，以产生具有乙酰辅酶A作为前体的产物。另一种非天然存在的微生物生物体包括至少一种编码以足够量表达的酶的外源核酸，以增强在一氧化碳或氢气存在下还原当量的可用性，从而通过碳水化合物 - 碳原料。在一氧化碳或氢气存在下增强还原当量的可用性的方法包括在足够的时间内培养该生物体以产生产物。

8. 发明申请

WO2012177710A1 MICROORGANISMS FOR PRODUCING BUTADIENE AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产二苯乙烯的微生物及其相关方法
公开(公告)号：WO2012177710A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043270
申请日：2012-06-20
申请人： GENOMATICA, INC. , BURK, Mark, J. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
发明人： BURK, Mark, J. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
IPC分类号： C07C29/00 , C12N1/20 , C12N1/00 , C12P7/16
CPC分类号： C12P7/04 , C12N15/52 , C12N15/70 , C12P5/026 , C12P7/16
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene or crotyl alcohol pathway. The invention additionally provides methods of using such organisms to produce butadiene or crotyl alcohol.
摘要翻译：本发明提供具有丁二烯或巴豆醇途径的非天然存在的微生物。本发明另外提供了使用这种生物体来生产丁二烯或巴豆醇的方法。

9. 发明申请

WO2007131326A1 A SYSTEM AND A METHOD FOR DETECTING A DAMAGED OR MISSING MACHINE PART 审中-公开
标题翻译：一种用于检测损坏或损坏机器的系统和方法
公开(公告)号：WO2007131326A1
公开(公告)日：2007-11-22
申请号：PCT/CA2007/000776
申请日：2007-05-04
申请人： ALBERTA RESEARCH COUNCIL INC. , RIDLEY, Rodney, K. , KAZMIERCZAK, Tadeusz , CAI, Linsong , JOHNSTON, Paul, Charles , PINTO, Helen , SUN, Jun , PROVENCHER, Marc , WOOLLEY, John, Harry , CARDINAL, Garry
发明人： RIDLEY, Rodney, K. , KAZMIERCZAK, Tadeusz , CAI, Linsong , JOHNSTON, Paul, Charles , PINTO, Helen , SUN, Jun , PROVENCHER, Marc , WOOLLEY, John, Harry , CARDINAL, Garry
IPC分类号： G01N21/892 , G06T7/00
CPC分类号： G06T7/0008 , E02F9/267 , E02F9/2808
摘要： A system and a method for detecting a damaged or missing machine part. The system includes an image capturing device for capturing images of the machine and a processor for processing the captured images. The system may further include a sensible output for providing an indication of a damaged or missing machine part. The method includes capturing images of the machine against a background which moves relative to the machine over time, selecting a pair of time-separated images from the captured images, generating a displacement image from the pair of images, comparing the machine from the displacement image with a machine model, and identifying a damaged or missing machine part from the comparison of the displacement image with the machine model. The method may further include providing a sensible output which indicates a damaged or missing machine part.
摘要翻译：用于检测损坏或缺少机器部件的系统和方法。该系统包括用于捕获机器的图像的图像捕获装置和用于处理所捕获的图像的处理器。系统还可以包括用于提供损坏或缺失的机器部件的指示的敏感输出。该方法包括：随着时间的推移相对于机器移动的背景拍摄机器的图像，从捕获的图像中选择一对时间分离的图像，从该对图像生成位移图像，将该机器与位移图像进行比较使用机器型号，并从位移图像与机器模型的比较中识别损坏或缺失的机器部件。该方法还可以包括提供表示损坏或丢失的机器部件的敏感输出。

10. 发明申请

WO2012177943A1 MICROORGANISMS FOR PRODUCING 1,4-BUTANEDIOL AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产1,4-丁二醇的微生物及其相关方法
公开(公告)号：WO2012177943A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043638
申请日：2012-06-21
申请人： GENOMATICA, INC. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
发明人： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
IPC分类号： C12P7/04 , C12N1/12
CPC分类号： C12N15/52 , C12N9/0008 , C12P7/16 , C12P7/18 , C12P7/42 , C12Y102/99006 , Y02E50/10
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4- hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO），4-羟基丁酰辅酶A，4-羟基丁醛或腐胺途径的非天然存在的微生物，其包含至少一种编码BDO，4-羟基丁酰辅酶A， - 羟基丁醛或腐胺通路酶以足够的量表达以产生BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺，并进一步优化BDO的表达。本发明另外提供了使用这些微生物生产BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的方法。

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