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1. 发明申请

WO2003042250A1 COMPOSITION AND METHOD TO HOMOGENEOUSLY MODIFY OR CROSS-LINK CHITOSAN UNDER NEUTRAL CONDITIONS 审中-公开
标题翻译：在中性条件下均质地修饰或交叉链接的组合物和方法
公开(公告)号：WO2003042250A1
公开(公告)日：2003-05-22
申请号：PCT/CA2002/001756
申请日：2002-11-15
申请人： BIOSYNTECH CANADA INC. , CHENITE, Abdellatif , BERRADA, Mohammed , CHAPUT, Cyril , DABBARH, Fouad , SELMANI, Amine
发明人： CHENITE, Abdellatif , BERRADA, Mohammed , CHAPUT, Cyril , DABBARH, Fouad , SELMANI, Amine
IPC分类号： C08B37/08
CPC分类号： A61K9/0024 , A61L27/46 , A61L27/52 , C08B37/003 , C08L5/08
摘要： In accordance with the present invention there is provided a new composition and method for chemically modifying chitosan, including N-substituting or N-cross-linking, under homogeneous conditions by providing neutral aqueous chitosan solutions with enhanced reactivity. The method comprises the steps of i) preparing a clear aqueous solution of chitosan, said solution comprising 0.1 to 10% by weight of a chitosan, and 0.1 to 20% by weight of at least one buffering agent having a pKa between 6.0 and 7.6, said solution having a pH ranging from 6.8 to 7.2; and ii) dissolving homogeneously at least one reagent into the solution of step a), said reagent being reactive toward amine groups of chitosan; and said reagent being at a concentration from 0.01 to 10% by weight. The chitosan in the aqueous solution is chemically modified or cross-linked by a selective substitution on the amino group of chitosan
摘要翻译：根据本发明，提供了通过提供具有增强反应性的中性水性壳聚糖溶液在均相条件下化学改性壳聚糖（包括N-取代或N-交联）的新组合物和方法。该方法包括以下步骤：i）制备透明的壳聚糖水溶液，所述溶液包含0.1至10重量％的壳聚糖和0.1至20重量％的至少一种pKa在6.0和7.6之间的缓冲剂，所述溶液具有6.8-7.2的pH; 和ii）均匀地将至少一种试剂均匀地溶解到步骤a）的溶液中，所述试剂对壳聚糖的胺基具有反应性; 并且所述试剂的浓度为0.01至10重量％。水溶液中的壳聚糖通过壳聚糖氨基上的选择性取代被化学修饰或交联

2. 发明申请

WO0240070A2 METHOD FOR RESTORING A DAMAGED OR DEGENERATED INTERVERTEBRAL DISC 审中-公开
标题翻译：恢复损伤或变性的椎间盘的方法
公开(公告)号：WO0240070A2
公开(公告)日：2002-05-23
申请号：PCT/CA0101623
申请日：2001-11-15
申请人： BIOSYNTECH CANADA INC , DESROSIERS ERIC ANDRE , CHENITE ABDELLATIF , BERRADA MOHAMMED , CHAPUT CYRIL
发明人： DESROSIERS ERIC ANDRE , CHENITE ABDELLATIF , BERRADA MOHAMMED , CHAPUT CYRIL
IPC分类号： A61F2/30 , A61F2/44 , A61K31/722 , A61K31/728 , A61K31/737 , A61K31/765 , A61K45/06 , A61L27/00
CPC分类号： A61L27/20 , A61F2002/30677 , A61F2002/444 , A61F2002/4445 , A61F2002/445 , A61K9/0024 , A61K31/722 , A61K31/728 , A61K31/737 , A61K31/765 , A61K45/06 , A61L27/38 , A61L27/52 , A61L27/54 , A61L2300/64 , A61L2430/38 , A61K2300/00
摘要： The present invention relates to a minimally-invasive method for restoring a damaged or degenerated intervertebral disc at an early stage. The method comprises the step of administering an injectable in situ setting formulation in the nucleus pulposus of the damaged or degenerated disc of a patient. The formulation once injected combines with nucleus matters and host cells, and becomes viscous or gels in situ within the annulus fibrosus of the disc for increasing the thickness and volume of the damaged or degenerated disc. The formulation is retained within the disc for providing restoration of the damaged or degenerated disc.
摘要翻译：本发明涉及一种用于在早期阶段恢复受损或退化的椎间盘的微创方法。该方法包括在患者的损伤或退化的椎间盘的髓核髓质中施用可注射的原位置换制剂的步骤。一次注射的制剂与细胞核和宿主细胞结合，并且在椎间盘纤维环内原位粘稠或凝胶，以增加损伤或损伤的纤维的厚度和体积退化椎间盘制剂保留在盘内，以提供损坏或退化的椎间盘的恢复。

3. 发明申请

WO0240072A3 FILLER COMPOSITION FOR SOFT TISSUE AUGMENTATION AND RECONSTRUCTIVE SURGERY 审中-公开
标题翻译：填充物组合物用于软组织增生和重建手术
公开(公告)号：WO0240072A3
公开(公告)日：2002-09-19
申请号：PCT/CA0101622
申请日：2001-11-15
申请人： BIOSYNTECH CANADA INC , DESROSIERS ERIC ANDRE , CHENITE ABDELLATIF , CHAPUT CYRIL , SHIVE MATTHEW
发明人： DESROSIERS ERIC ANDRE , CHENITE ABDELLATIF , CHAPUT CYRIL , SHIVE MATTHEW
IPC分类号： A61L24/08 , A61L26/00 , A61L27/20 , A61L27/24 , A61L27/50 , A61L27/52
CPC分类号： A61L27/52 , A61K8/60 , A61K8/65 , A61K8/736 , A61K2800/91 , A61L24/08 , A61L26/0023 , A61L27/20 , A61L27/24 , A61L27/50 , A61Q19/08 , C08L5/08
摘要： The present invention relates to a filler composition for soft-tissue augmentation and reconstructive surgery comprising an effective amount of an injectable thermo-gelling solution comprising 0.1 to 5.0 % by weight of chitosan or collagen or a derivative thereof; and 1.0 to 20 % by weight of a salt of polyol or sugar selected from the group consisting of mono-phosphate dibasic salt, mono-sulfate salt and a mono-carboxylic acid salt of polyol or sugar. The solution is stable and turns into a gel within a tem-perature range from 20 to 70 DEG C. The gel has a cosmetically acceptable consistency for providing a mechanical support to surrounding soft tissues once injected therein. The composition can thus be used as filler for soft tissue augmentation and reconstructive surgery.
摘要翻译：本发明涉及用于软组织增大和再造手术的填充剂组合物，其包含有效量的可注射热胶凝溶液，所述溶液包含0.1-5.0重量％的壳聚糖或胶原或其衍生物; 和1.0至20重量％的选自多元醇或糖的单磷酸二元盐，单硫酸盐和单羧酸盐的多元醇或糖的盐。该溶液是稳定的，并且在20-70℃的温度范围内变成凝胶。该凝胶具有美容上可接受的稠度，用于一旦注入其中就为周围的软组织提供机械支撑。因此该组合物可以用作软组织填充和重建手术的填充剂。

4. 发明申请

WO2002040070A3 METHOD FOR RESTORING A DAMAGED OR DEGENERATED INTERVERTEBRAL DISC 审中-公开
公开(公告)号：WO2002040070A3
公开(公告)日：2002-05-23
申请号：PCT/CA2001/001623
申请日：2001-11-15
申请人： BIO SYNTECH CANADA INC. , DESROSIERS, Eric, André , CHENITE, Abdellatif , BERRADA, Mohammed , CHAPUT, Cyril
发明人： DESROSIERS, Eric, André , CHENITE, Abdellatif , BERRADA, Mohammed , CHAPUT, Cyril
IPC分类号： A61F2/44
摘要： The present invention relates to a minimally-invasive method for restoring a damaged or degenerated intervertebral disc at an early stage. The method comprises the step of administering an injectable in situ setting formulation in the nucleus pulposus of the damaged or degenerated disc of a patient. The formulation once injected combines with nucleus matters and host cells, and becomes viscous or gels in situ within the annulus fibrosus of the disc for increasing the thickness and volume of the damaged or degenerated disc. The formulation is retained within the disc for providing restoration of the damaged or degenerated disc.

5. 发明申请

WO1998017710A1 METHOD FOR PREPARATION OF POLYMER MICROPARTICLES FREE OF ORGANIC SOLVENT TRACES 审中-公开
标题翻译：不含有机溶剂的聚合物微球的制备方法
公开(公告)号：WO1998017710A1
公开(公告)日：1998-04-30
申请号：PCT/CA1997000797
申请日：1997-10-24
申请人： BIO SYNTECH LTD. , CHENITE, Abdellatif , CHAPUT, Cyril , SELMANI, Amine
发明人： BIO SYNTECH LTD.
IPC分类号： C08J03/12
CPC分类号： C08J3/005 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1694 , A61K9/5031 , C08J3/12 , C08J2367/02 , Y10S514/963 , Y10T428/2982 , Y10T428/2989
摘要： The present invention relates to a new method for the production of polymer microparticles. The method is carried out in the absence of organic solvent, and consists in the steps of (a) combining first and second polymers, the first and second polymers being incompatible or immiscible, (b) heating the combination obtained in step (a) so as to melt the first and second polymers; (c) shaking the melted polymers obtained in step (b) under conditions effective to produce a biphasic system, the biphasic system comprising a dispersed phase and a matrix continuous phase, the dispersed phase consisting of a dispersion of the first polymer, the matrix continuous phase comprising the second polymer, the dispersed phase containing microparticles of the first polymer dispersed in the matrix continuous phase; (d) solidifying the biphasic system obtained in step (c) so as to keep the microparticles of the first polymer dispersed in the matrix continuous phase; and (e) separating and isolating the microparticles of the first polymer from the matrix continuous phase, wherein the first polymer in said dispersed phase is water-insoluble, while the second polymer forming the continuous phase is water-soluble.
摘要翻译：本发明涉及一种生产聚合物微粒的新方法。该方法在不存在有机溶剂的情况下进行，并且包括以下步骤：（a）将第一和第二聚合物混合，第一和第二聚合物不相容或不混溶，（b）将步骤（a）中获得的组合加热以熔化第一和第二聚合物; （c）在有效产生双相系统的条件下振荡步骤（b）中获得的熔融聚合物，所述双相系统包含分散相和基质连续相，所述分散相由第一聚合物的分散体，基体连续包含第二聚合物的相，所述分散相含有分散在基体连续相中的第一聚合物的微粒; （d）固化步骤（c）中获得的双相体系，以使第一聚合物的微粒分散在基质连续相中; 和（e）从基质连续相分离和分离第一聚合物的微粒，其中所述分散相中的第一聚合物是水不溶性的，而形成连续相的第二聚合物是水溶性的。

6. 发明专利

AU4769397A Method for preparation of polymer microparticles free of organic solvent traces 未知
公开(公告)号：AU4769397A
公开(公告)日：1998-05-15
申请号：AU4769397
申请日：1997-10-24
申请人： BIOSYNTECH LTD , CHAPUT CYRIL , SELMANI AMINE
发明人： CHENITE ABDELLATIF , CHAPUT CYRIL , SELMANI AMINE
IPC分类号： A61K9/16 , A61K9/50 , C08J3/00 , C08J3/12
摘要： The present invention relates to a new method for the production of polymer microparticles. The method is carried out in the absence of organic solvent, and consists in the steps of (a) combining first and second polymers, the first and second polymers being immiscible, (b) heating the combination obtained in step (a) so as to melt the first and second polymers; (c) stirring the melted polymers obtained in step (b) under conditions effective to produce a biphasic system comprising a dispersed phase consisting of a dispersion of the first polymer and a matrix continuous phase comprising the second polymer, the dispersed phase containing microparticles of the first polymer dispersed in the matrix continuous phase; (d) solidifying the biphasic system obtained in step (c) so as to keep the microparticles of the first polymer dispersed in the matrix continuous phase; and (e) separating and isolating the microparticles of the first polymer from the matrix continuous phase, wherein the first polymer forming said dispersed phase is water-insoluble, while the second polymer forming the continuous phase is water-soluble.

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