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    • 6. 发明授权
    • Protein and DNA thereof
    • 蛋白质和DNA
    • US07070975B2
    • 2006-07-04
    • US10726148
    • 2003-12-02
    • Koji YoshimuraYuichi HikichiAtsushi Nishimura
    • Koji YoshimuraYuichi HikichiAtsushi Nishimura
    • C12N9/50C12N1/20C12N15/00C07K1/00C12Q1/68
    • C12N9/6489A61K38/00C07K16/40G01N2500/00
    • The present invention relates to a novel protein belonging to an ADAM family, a partial peptide thereof or a salt thereof, a DNA encoding the protein, a recombinant vector comprising the DNA, a transformant, a method for producing the protein, a medicine comprising the protein or the DNA, an antibody against the protein, a method/kit for screening for a compound or a salt thereof which promotes or inhibits the protease activity or the extracellular metric degrading enzyme activity (preferably, the peptidoglycan degrading enzyme activity) of the protein, a compound obtained by the screening, and a medicine comprising the compound. The present protein and a DNA encoding it can be used, for example, as an agent for treating or preventing various diseases such as disc herniation, ischialgia, glomerular nephritis, diabetic nephropathy, hepatic fibrosis, pulmonary fibrosis or osteopetrosis. In addition, the present antibody can be used for quantitating the present protein in a test solution. Further, the present protein is useful as a reagent for screening for a compound which promotes or inhibits the protease activity of the present protein.
    • 本发明涉及属于ADAM家族的新蛋白,其部分肽或其盐,编码该蛋白质的DNA,包含DNA的重组载体,转化体,该蛋白质的制备方法,包含 蛋白质或DNA,针对蛋白质的抗体,用于筛选其蛋白质活性或蛋白酶活性或细胞外度量降解酶活性(优选肽聚糖降解酶活性)的化合物或其盐的方法/试剂盒 ,通过筛选获得的化合物和包含该化合物的药物。 本发明的蛋白质和编码该DNA的DNA可用于例如治疗或预防椎间盘突出症,坐骨神经痛,肾小球肾炎,糖尿病肾病,肝纤维化,肺纤维化或骨硬化等各种疾病的药剂。 此外,本抗体可用于定量试验溶液中的本发明蛋白质。 此外,本发明的蛋白质可用作筛选促进或抑制本发明蛋白质的蛋白酶活性的化合物的试剂。
    • 10. 发明授权
    • Mooring device and steering mooring mechanism using same
    • 系泊装置和转向系泊机构采用相同的方式
    • US09291239B2
    • 2016-03-22
    • US13880433
    • 2011-10-27
    • Atsushi Nishimura
    • Atsushi Nishimura
    • F16G11/00B62D1/16F16G11/02
    • F16G11/025B62D1/16F16G11/02Y10T24/318
    • It is an object to provide a mooring device capable of connecting weight members to each other easily and tightly and of preventing electric conduction between weight members and generating no noise or heat which causes malfunction. It is an object to provide a steering mooring mechanism using the mooring device. The mooring device has fixing members fixed to two electrically conductive members to be moored, and a metal connecting member connecting the fixing members, wherein at least one of the fixing members is configured as a non-conductive fixing member having a metal fixing body fixed to the member to be moored, and a coupling body made of non-conductive material for coupling the fixing body and the connecting member in a manner not to contact each other, such that the connecting member is non-conductive with respect to the member to be moored on the side of the non-conductive fixing member.
    • 本发明的目的是提供一种能够容易且紧密地连接配重构件并且防止重量构件之间的导电并且不产生引起故障的噪声或热量的系泊装置。 本发明的目的是提供使用该系泊装置的转向系泊机构。 系泊装置具有固定到要停泊的两个导电构件上的固定构件和连接固定构件的金属连接构件,其中至少一个固定构件被构造为具有金属固定体固定的非导电固定构件 待停止的构件,以及由不导电材料制成的联接体,用于以不彼此接触的方式联接固定体和连接构件,使得连接构件相对于构件不导电 系在非导电性固定件侧面。